Luca Andriolo , Luca De Marziani , Alessandro Di Martino , Angelo Boffa , Stefano Zaffagnini , Giuseppe Filardo
{"title":"用于软骨和骨软骨损伤的无细胞仿生支架:定制和标准化植入手术技术","authors":"Luca Andriolo , Luca De Marziani , Alessandro Di Martino , Angelo Boffa , Stefano Zaffagnini , Giuseppe Filardo","doi":"10.1016/j.jcjp.2024.100173","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Cell-free chondral and osteochondral scaffolds have been introduced to address lesions of the articular surface. A proper implantation technique is key to favor scaffold integration, regenerative processes, and positive clinical outcomes.</p></div><div><h3>Objectives</h3><p>The purpose of this article is to describe indications and surgical steps for both the custom traditional free-hand implantation approach and an innovative minimally invasive technique for the standardized implantation of this biomimetic cell-free scaffold (MaioRegen; Fin-Ceramica Faenza Spa).</p></div><div><h3>Methods</h3><p>Indications and contraindications for this scaffold implantation have been provided. The required steps for surgical preparation, implantation technique, and postoperative management have been described as well to address articular surface lesions of the knee.</p></div><div><h3>Results</h3><p>A dedicated instrumentation for circular implants of different sizes has been developed to allow more precise preparation of the depth and width of the defect, reducing the invasiveness and increasing implant stability. The custom free-hand technique with chisels and osteotomes remains useful when the lesion does not allow the use of the standardized instrumented technique. In case further stability of the implant is needed, fibrin glue addition should be considered.</p></div><div><h3>Conclusions</h3><p>By guiding the readers with the key perioperative and intraoperative steps, chondral and osteochondral defects can be addressed with the use of a cell-free scaffold, maximizing implant stability.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100173"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266725452400009X/pdfft?md5=88c34609da3d3d4d0570d11da9082792&pid=1-s2.0-S266725452400009X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Cell-free biomimetic scaffold for chondral and osteochondral lesions: surgical technique for custom and standardized implantation\",\"authors\":\"Luca Andriolo , Luca De Marziani , Alessandro Di Martino , Angelo Boffa , Stefano Zaffagnini , Giuseppe Filardo\",\"doi\":\"10.1016/j.jcjp.2024.100173\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Cell-free chondral and osteochondral scaffolds have been introduced to address lesions of the articular surface. A proper implantation technique is key to favor scaffold integration, regenerative processes, and positive clinical outcomes.</p></div><div><h3>Objectives</h3><p>The purpose of this article is to describe indications and surgical steps for both the custom traditional free-hand implantation approach and an innovative minimally invasive technique for the standardized implantation of this biomimetic cell-free scaffold (MaioRegen; Fin-Ceramica Faenza Spa).</p></div><div><h3>Methods</h3><p>Indications and contraindications for this scaffold implantation have been provided. The required steps for surgical preparation, implantation technique, and postoperative management have been described as well to address articular surface lesions of the knee.</p></div><div><h3>Results</h3><p>A dedicated instrumentation for circular implants of different sizes has been developed to allow more precise preparation of the depth and width of the defect, reducing the invasiveness and increasing implant stability. The custom free-hand technique with chisels and osteotomes remains useful when the lesion does not allow the use of the standardized instrumented technique. In case further stability of the implant is needed, fibrin glue addition should be considered.</p></div><div><h3>Conclusions</h3><p>By guiding the readers with the key perioperative and intraoperative steps, chondral and osteochondral defects can be addressed with the use of a cell-free scaffold, maximizing implant stability.</p></div>\",\"PeriodicalId\":100760,\"journal\":{\"name\":\"Journal of Cartilage & Joint Preservation\",\"volume\":\"4 2\",\"pages\":\"Article 100173\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S266725452400009X/pdfft?md5=88c34609da3d3d4d0570d11da9082792&pid=1-s2.0-S266725452400009X-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cartilage & Joint Preservation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S266725452400009X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cartilage & Joint Preservation","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S266725452400009X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cell-free biomimetic scaffold for chondral and osteochondral lesions: surgical technique for custom and standardized implantation
Introduction
Cell-free chondral and osteochondral scaffolds have been introduced to address lesions of the articular surface. A proper implantation technique is key to favor scaffold integration, regenerative processes, and positive clinical outcomes.
Objectives
The purpose of this article is to describe indications and surgical steps for both the custom traditional free-hand implantation approach and an innovative minimally invasive technique for the standardized implantation of this biomimetic cell-free scaffold (MaioRegen; Fin-Ceramica Faenza Spa).
Methods
Indications and contraindications for this scaffold implantation have been provided. The required steps for surgical preparation, implantation technique, and postoperative management have been described as well to address articular surface lesions of the knee.
Results
A dedicated instrumentation for circular implants of different sizes has been developed to allow more precise preparation of the depth and width of the defect, reducing the invasiveness and increasing implant stability. The custom free-hand technique with chisels and osteotomes remains useful when the lesion does not allow the use of the standardized instrumented technique. In case further stability of the implant is needed, fibrin glue addition should be considered.
Conclusions
By guiding the readers with the key perioperative and intraoperative steps, chondral and osteochondral defects can be addressed with the use of a cell-free scaffold, maximizing implant stability.