Journal of Cartilage & Joint Preservation最新文献

{"title":"Extracorporeal shock wave therapy promotes cartilage repair and subchondral bone remodeling in a rat model of osteochondral lesion","authors":"Xiaokang Huang, Jinwu Chen, Ming Song, Chia-Jui Hu, Lai Yu","doi":"10.1016/j.jcjp.2026.100289","DOIUrl":"10.1016/j.jcjp.2026.100289","url":null,"abstract":"<div><h3>Introduction</h3><div>Osteochondral lesions (OCL) are a key pathological feature in osteoarthritis, necessitating effective treatments that target both cartilage and subchondral bone. Extracorporeal shock wave (ESW) therapy, a noninvasive modality, shows promise but its holistic effects on the osteochondral unit require further elucidation.</div></div><div>Osteochondral lesions (OCL) are a key pathological feature in osteoarthritis, necessitating effective treatments that target both cartilage and subchondral bone. Extracorporeal shock wave (ESW) therapy, a noninvasive modality, shows promise but its holistic effects on the osteochondral unit require further elucidation.</div><div><h3>Objectives</h3><div>This study aimed to investigate the therapeutic effects of ESW on cartilage repair and subchondral bone remodeling in a rat OCL model.</div></div><div>This study aimed to investigate the therapeutic effects of ESW on cartilage repair and subchondral bone remodeling in a rat OCL model.</div><div><h3>Methods</h3><div>Thirty-six Sprague-Dawley rats were randomized into Control, OCL (monosodium iodoacetate-induced), and OCL+ESW groups. The OCL+ESW group received weekly ESW treatment (1.0 bar, 800 impulses, 6 Hz). Functional recovery was assessed longitudinally via gait analysis (CatWalk). At end point, knee joints were analyzed using micro-computed tomography and histological staining (Safranin O-Fast Green, Toluidine Blue).</div></div><div>Thirty-six Sprague-Dawley rats were randomized into Control, OCL (monosodium iodoacetate-induced), and OCL+ESW groups. The OCL+ESW group received weekly ESW treatment (1.0 bar, 800 impulses, 6 Hz). Functional recovery was assessed longitudinally via gait analysis (CatWalk). At end point, knee joints were analyzed using micro-computed tomography and histological staining (Safranin O-Fast Green, Toluidine Blue).</div><div><h3>Results</h3><div>Micro-computed tomography revealed that ESW significantly ameliorated monosodium iodoacetate-induced subchondral bone deterioration, restoring bone mineral density, bone volume fraction (BV/TV), and trabecular number (Tb.N) toward normal levels. Gait analysis demonstrated significant functional improvement in the OCL+ESW group from week 4, with parameters like maximum contact area and intensity normalizing by week 8. Histology confirmed marked preservation of cartilage integrity, surface smoothness, and proteoglycan content in ESW-treated animals compared to the degenerative OCL group.</div></div><div>Micro-computed tomography revealed that ESW significantly ameliorated monosodium iodoacetate-induced subchondral bone deterioration, restoring bone mineral density, bone volume fraction (BV/TV), and trabecular number (Tb.N) toward normal levels. Gait analysis demonstrated significant functional improvement in the OCL+ESW group from week 4, with parameters like maximum contact area and intensity normalizing by week 8. Histology confirmed marked preservation of cartilage in","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"6 3","pages":"Article 100289"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in processing and preparation techniques of subchondral bone for the successful integration of osteochondral allografts","authors":"Thomas E. Moran,&nbsp;Alyssa D. Althoff,&nbsp;Jared P. Sachs,&nbsp;Yusuf N. Mufti,&nbsp;Chloe H. Franzia,&nbsp;Krish S. Sardesai,&nbsp;Nicholas J. Lemme,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2026.100285","DOIUrl":"10.1016/j.jcjp.2026.100285","url":null,"abstract":"<div><h3>Introduction</h3><div>Osteochondral allograft transplantation (OCA) is a well-established treatment for focal cartilage defects, yet failure to achieve graft-host bone integration remains a significant contributor to suboptimal outcomes.</div></div><div><h3>Objectives</h3><div>This narrative review aims to critically evaluate current and emerging techniques for the processing and preparation of subchondral bone in fresh OCAs, with a focus on improving graft incorporation and long-term clinical success.</div></div><div><h3>Methods</h3><div>A narrative review of preclinical and clinical literature was conducted using PubMed with inclusion criteria and search terms limited to studies addressing preservation methods (“lavage,” “CO₂,” and “centrifugation”), marrow removal techniques, and biologic augmentation (“concentrated bone marrow aspirate (cBMA)”) specific to the subchondral bone. Relevant experimental and retrieval studies were included to assess translational relevance.</div></div><div><h3>Results</h3><div>Preservation techniques such as pulse lavage, pressurized CO₂, and high-speed centrifugation show promise in reducing immunogenic marrow elements. Biologic augmentation with concentrated bone marrow aspirate may enhance osteoinduction, although clinical evidence remains mixed. Intraoperative factors, including graft depth and subchondral alignment, are critical for successful integration. Current literature lacks standardization of preparation protocols and long-term studies directly linking these interventions to improved patient outcomes.</div></div><div><h3>Conclusions</h3><div>While chondrocyte viability remains important, subchondral bone integration is increasingly recognized as a critical determinant of OCA success. A shift toward bone-focused optimization—including preparation, immunologic considerations, and biologic enhancements—may improve consistency and clinical durability in OCA transplantation.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"6 3","pages":"Article 100285"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we treat meniscal tears with injectables? A systematic review of clinical outcomes following platelet-rich plasma, corticosteroid, and other injective therapies for degenerative and traumatic meniscal lesions","authors":"Yazan Abu Salem,&nbsp;Carlotta Franceschi,&nbsp;Gregorio Alberto,&nbsp;Pietro Conte,&nbsp;Giuseppe Anzillotti,&nbsp;Daniele D’Arrigo,&nbsp;Berardo Di Matteo,&nbsp;Elizaveta Kon","doi":"10.1016/j.jcjp.2026.100284","DOIUrl":"10.1016/j.jcjp.2026.100284","url":null,"abstract":"<div><h3>Background</h3><div>Meniscal tears, whether degenerative or traumatic, are common causes of knee pain. Concerns regarding long-term joint degeneration after arthroscopic partial meniscectomy have increased interest in joint-preserving injective therapies.</div></div><div><h3>Objectives</h3><div>To systematically review clinical outcomes, imaging findings, and surgical conversion rates following standalone injective treatments for meniscal pathology.</div></div><div><h3>Data sources</h3><div>A systematic search of PubMed, Embase, and Cochrane Library was performed on August 29, 2025.</div></div><div><h3>Study eligibility criteria, participants, and interventions</h3><div>English-language clinical studies (2010–2025) evaluating standalone injective therapies for meniscal tears or degeneration were included. Interventions comprised platelet-rich plasma (PRP), corticosteroids, hyaluronic acid (HA), polynucleotides, microfragmented adipose tissue, and autologous conditioned serum.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>Data extraction and quality assessment were conducted independently. Methodological quality was assessed using the modified Coleman Methodology Score (CMS) and the Cochrane Risk of Bias 2 tool for randomized controlled trials.</div></div><div><h3>Results</h3><div>Twenty-four studies (2027 patients) met inclusion criteria. Thirteen evaluated PRP, seven corticosteroids, and four other injective therapies. The mean CMS was 46/100, indicating overall moderate-to-low quality. PRP demonstrated consistent improvements in pain and function, with surgery-free survival exceeding 80% at mid-term follow-up and limited MRI evidence of structural improvement. Corticosteroids provided short-term symptom relief without structural benefit. Other injective therapies showed promising early results but were limited by small sample sizes and heterogeneity. Adverse events and surgical conversion rates were low across treatments.</div></div><div><h3>Limitations</h3><div>Overall methodological quality was moderate-to-low, with heterogeneity in study design and protocols.</div></div><div><h3>Conclusions and implications of key findings</h3><div>Injective therapies may provide meaningful symptom relief in selected meniscal lesions. PRP shows the most consistent benefit, while other biologic injectives require higher-quality randomized trials to clarify their role.</div></div><div><h3>Systematic review registration number</h3><div>CRD420251233155.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"6 3","pages":"Article 100284"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed diagnosis of bilateral posterior shoulder dislocation with reverse Hill-Sachs lesions managed by modified McLaughlin procedure: a case report","authors":"Saad M. AlShammari,&nbsp;Mohammed A. Alqahtani,&nbsp;Marwan Alkalifah,&nbsp;Abdullah Albadran","doi":"10.1016/j.jcjp.2025.100283","DOIUrl":"10.1016/j.jcjp.2025.100283","url":null,"abstract":"<div><h3>Introduction</h3><div>Posterior shoulder dislocations are uncommon and frequently overlooked, particularly when they occur bilaterally. These injuries are typically associated with seizures, electrical trauma, or high-energy mechanisms.</div></div><div>Posterior shoulder dislocations are uncommon and frequently overlooked, particularly when they occur bilaterally. These injuries are typically associated with seizures, electrical trauma, or high-energy mechanisms.</div><div><h3>Case Presentation</h3><div>We describe a rare case of bilateral posterior glenohumeral dislocations accompanied by bilateral reverse Hill-Sachs lesions and a right osseous Bankart lesion following an epileptic seizure, with a significantly delayed diagnosis. The patient underwent staged modified McLaughlin procedures. Postoperatively, the patient demonstrated substantial improvement, regaining full range of motion with excellent Constant scores, improving from 32 and 34 preoperatively to 90 and 88, respectively.</div></div><div>We describe a rare case of bilateral posterior glenohumeral dislocations accompanied by bilateral reverse Hill-Sachs lesions and a right osseous Bankart lesion following an epileptic seizure, with a significantly delayed diagnosis. The patient underwent staged modified McLaughlin procedures. Postoperatively, the patient demonstrated substantial improvement, regaining full range of motion with excellent Constant scores, improving from 32 and 34 preoperatively to 90 and 88, respectively.</div><div><h3>Conclusion</h3><div>This case highlights the importance of early recognition, appropriate imaging, and individualized surgical planning in managing bilateral posterior shoulder dislocations. At 6-month follow-up, the patient achieved full functional recovery with excellent clinical outcomes.</div></div><div>This case highlights the importance of early recognition, appropriate imaging, and individualized surgical planning in managing bilateral posterior shoulder dislocations. At 6-month follow-up, the patient achieved full functional recovery with excellent clinical outcomes.</div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"6 3","pages":"Article 100283"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting cartilage failure or predicting biological failure? Machine learning still does not examine the patient","authors":"Francesco Pegreffi,&nbsp;Alessandro Vincenzo Carlino,&nbsp;Arcangelo Russo,&nbsp;Emilia Lo Giudice,&nbsp;Rosanna Avola,&nbsp;Valerio Mario Salerno,&nbsp;Hassan Zmerly","doi":"10.1016/j.jcjp.2026.100290","DOIUrl":"10.1016/j.jcjp.2026.100290","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"6 3","pages":"Article 100290"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical adaptations in hip and ankle following autologous bone grafting combined with spheroid-based matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee","authors":"Stephan Oehme,&nbsp;Benjamin Bartek,&nbsp;Sophie Krafzick,&nbsp;Srdan Popovic,&nbsp;Philipp Damm,&nbsp;Tobias Winkler,&nbsp;Moses K.D. El Kayali,&nbsp;Tobias Jung","doi":"10.1016/j.jcjp.2026.100301","DOIUrl":"10.1016/j.jcjp.2026.100301","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Altered knee gait mechanics have been reported in patients treated with matrix-induced autologous chondrocyte implantation combined with autologous bone grafting (MABCI) for osteochondral defects of the knee.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Altered knee gait mechanics have been reported in patients treated with matrix-induced autologous chondrocyte implantation combined with autologous bone grafting (MABCI) for osteochondral defects of the knee.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;The aim of this study was to investigate whether altered gait mechanics following MABCI extend to adjacent joints by analyzing hip and ankle gait biomechanics in comparison with matched controls.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;The aim of this study was to investigate whether altered gait mechanics following MABCI extend to adjacent joints by analyzing hip and ankle gait biomechanics in comparison with matched controls.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Gait data from 31 patients (19 males, 12 females; mean defect size 4.2 ± 2.5 cm²; mean follow-up: 43.7 ± 22.7 months) were analyzed. Hip and ankle kinematics were assessed using 3D treadmill-based gait analysis. Data were compared with a matched healthy control group. Subgroup analysis was performed based on defect size (&lt;4 cm² vs ≥4 cm²).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Gait data from 31 patients (19 males, 12 females; mean defect size 4.2 ± 2.5 cm²; mean follow-up: 43.7 ± 22.7 months) were analyzed. Hip and ankle kinematics were assessed using 3D treadmill-based gait analysis. Data were compared with a matched healthy control group. Subgroup analysis was performed based on defect size (&lt;4 cm² vs ≥4 cm²).&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Operated limbs showed a significantly steeper slope of hip extension during the loading response phase of the gait cycle compared with contralateral limbs (51.8 ± 13.7% vs 39.4 ± 16.2%, &lt;em&gt;P&lt;/em&gt; = .002) and controls (22.6 ± 11.9%, &lt;em&gt;P&lt;/em&gt; &lt; .001). During mid-stance, the slope of hip extension was significantly flatter in operated limbs (72.0 ± 11.9%) compared with contralateral (77.3 ± 12.5%, &lt;em&gt;P&lt;/em&gt; &lt; .002) and control limbs (90.8 ± 12.7%, &lt;em&gt;P&lt;/em&gt; &lt; .001). Operated limbs demonstrated greater maximum ankle dorsiflexion than contralateral limbs (13.2 ± 3.7° vs 11.9 ± 3.9°, &lt;em&gt;P&lt;/em&gt; = .005). Patients with larger defects had a significantly greater hip extension (−13.4 ± 5.5° vs −6.3 ± 7.7°, &lt;em&gt;P&lt;/em&gt; = .007) and a tendency toward steeper early hip extension slope during loading response phase in operated limbs (55.8 ± 16.1% vs 48.5 ± 10.8%, &lt;em&gt;P&lt;/em&gt; = .223).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Operated limbs showed a significantly steeper slope of hip extension during the loading response phase of the gait cycle compared with contralateral limbs (51.8 ± 13.7% vs 39.4 ± 16.2%, &lt;em&gt;P&lt;/em&gt; = .002) and controls (22.6 ± 11.9%, &lt;em&gt;P&lt;/em&gt; &lt; .001). During mid-stance, the slope of hip extension was significantly flatter in operated limbs (72.0 ± 11.9%) compared with contralateral (77.3 ± 12.5%, &lt;em&gt;P&lt;/em&gt; ","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"6 3","pages":"Article 100301"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome to the third issue of JCJP 2026","authors":"Lucienne A. Vonk,&nbsp;Elizaveta Kon","doi":"10.1016/j.jcjp.2026.100320","DOIUrl":"10.1016/j.jcjp.2026.100320","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"6 3","pages":"Article 100320"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clicks and cartilage: tracking virtual patient interest in cartilage repair procedures","authors":"Irfan A. Khan,&nbsp;Thomas E. Moran,&nbsp;Krish S. Sardesai,&nbsp;Katie Kessler,&nbsp;Jared Sachs,&nbsp;Dillon Synchef,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2026.100286","DOIUrl":"10.1016/j.jcjp.2026.100286","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Osteochondral allograft (OCA) and matrix-induced autologous chondrocyte implantation (MACI) procedures show increasing incidence, while microfracture and osteochondral autograft transfer system (OATS) show decreasing incidence. Whether public interest correlates with procedure volumes remains unclear. There is a paucity of studies evaluating readability of patient education articles on cartilage repair.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Osteochondral allograft (OCA) and matrix-induced autologous chondrocyte implantation (MACI) procedures show increasing incidence, while microfracture and osteochondral autograft transfer system (OATS) show decreasing incidence. Whether public interest correlates with procedure volumes remains unclear. There is a paucity of studies evaluating readability of patient education articles on cartilage repair.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;The objective was to evaluate public interest in cartilage restoration using Google Trends and assess readability of patient education articles. We hypothesized public interest would parallel performance trends and readability would be poor.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;The objective was to evaluate public interest in cartilage restoration using Google Trends and assess readability of patient education articles. We hypothesized public interest would parallel performance trends and readability would be poor.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Google Trends was queried for cartilage repair procedures between January 2017 and December 2024. Mean relative search volume (RSV) was obtained for \"cartilage repair\" and microfracture, OATS, OCA, and MACI [RSV ranges 0-100]. Readability of the first 25 articles from \"cartilage repair surgery\" search was assessed using Flesch-Kincaid Reading Level (FKGL) and Flesch Reading Ease Score. Statistical analysis included variance tests with significance at &lt;em&gt;P&lt;/em&gt; &lt; .05.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Google Trends was queried for cartilage repair procedures between January 2017 and December 2024. Mean relative search volume (RSV) was obtained for \"cartilage repair\" and microfracture, OATS, OCA, and MACI [RSV ranges 0-100]. Readability of the first 25 articles from \"cartilage repair surgery\" search was assessed using Flesch-Kincaid Reading Level (FKGL) and Flesch Reading Ease Score. Statistical analysis included variance tests with significance at &lt;em&gt;P&lt;/em&gt; &lt; .05.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Mean RSV for \"cartilage repair\" increased significantly (+17; &lt;em&gt;P&lt;/em&gt; &lt; .001). Microfracture had the highest mean RSV (68; &lt;em&gt;P&lt;/em&gt; &lt; .001). Despite being most searched, microfracture's RSV decreased significantly (−27; &lt;em&gt;P&lt;/em&gt; &lt; .001), as did OATS (−14; &lt;em&gt;P&lt;/em&gt; &lt; .001). Conversely, RSV increased significantly for OCA (+17; &lt;em&gt;P&lt;/em&gt; &lt; .001) and MACI (+73; &lt;em&gt;P&lt;/em&gt; &lt; .001). Mean FKGL was 10.9 and Flesch Reading Ease Score was 43.6, with no articles at American Medical Association (AMA)-recommended sixth grade level.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Mean ","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"6 3","pages":"Article 100286"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: “Predicting cartilage failure or predicting biological failure? Machine learning still does not examine the patient”","authors":"Jason E. Jesse,&nbsp;Krish S. Sardesai,&nbsp;Ron Gilat,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2026.100291","DOIUrl":"10.1016/j.jcjp.2026.100291","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"6 3","pages":"Article 100291"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface reconstruction with a biomimetic osteochondral scaffold for tibial plateau lesions: results at long-term follow-up","authors":"Lorenzo Zanasi,&nbsp;Giacomo Roveda,&nbsp;Angelo Boffa,&nbsp;Luca Andriolo,&nbsp;Stefano Zaffagnini,&nbsp;Alessandro Di Martino","doi":"10.1016/j.jcjp.2025.100281","DOIUrl":"10.1016/j.jcjp.2025.100281","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Tibial plateau osteochondral lesions represent a challenge for the orthopedic surgeon, due to their frequent progression to early osteoarthritis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Tibial plateau osteochondral lesions represent a challenge for the orthopedic surgeon, due to their frequent progression to early osteoarthritis.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;The aim of the present study was to evaluate the long-term clinical results of 11 patients affected by complex tibial plateau defects treated with the implantation of an osteochondral biomimetic scaffold.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;The aim of the present study was to evaluate the long-term clinical results of 11 patients affected by complex tibial plateau defects treated with the implantation of an osteochondral biomimetic scaffold.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Eleven patients (5 women and 6 men) with a mean age of 37.3 ± 11.0 years, affected by osteochondral lesions of the tibial plateau (5.1 ± 2.7 cm&lt;sup&gt;2&lt;/sup&gt;, ranging from 3.0 cm² to 12.5 cm²) underwent implantation of an osteochondral biomimetic collagen-hydroxyapatite scaffold. Patients were evaluated preoperatively and followed-up prospectively for a mean 15-year follow-up using the International Knee Documentation Committee (IKDC) subjective score and the Tegner activity level.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Eleven patients (5 women and 6 men) with a mean age of 37.3 ± 11.0 years, affected by osteochondral lesions of the tibial plateau (5.1 ± 2.7 cm&lt;sup&gt;2&lt;/sup&gt;, ranging from 3.0 cm² to 12.5 cm²) underwent implantation of an osteochondral biomimetic collagen-hydroxyapatite scaffold. Patients were evaluated preoperatively and followed-up prospectively for a mean 15-year follow-up using the International Knee Documentation Committee (IKDC) subjective score and the Tegner activity level.&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Nine patients (81.8%) had implant survival at the final evaluation, while 2 patients required additional surgery and were therefore considered failures. The IKDC subjective score improved from 42.5 ± 10.2 preoperatively to 67.7 ± 18.4 at 5 years (&lt;em&gt;P&lt;/em&gt; = .009), remaining higher than baseline but without statistical significance at the final follow-up (59.2 ± 19.6; &lt;em&gt;P&lt;/em&gt; = .076). The Tegner activity level improved from 2.5 ± 2.8 preoperatively to 4.4 ± 1.9 at 2 years, followed by a modest, nonsignificant decline to 3.5 ± 1.7 at the final follow-up. Kaplan-Meier analysis demonstrated sustained scaffold survival up to 18 years.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;Nine patients (81.8%) had implant survival at the final evaluation, while 2 patients required additional surgery and were therefore considered failures. The IKDC subjective score improved from 42.5 ± 10.2 preoperatively to 67.7 ± 18.4 at 5 years (&lt;em&gt;P&lt;/em&gt; = .009), remaining higher than baseline but without statistical significance at the final follow-up (59.2 ± 19.6; &lt;em&gt;P&lt;/em&gt; = .076). The Tegner activity level improved from 2.5 ± 2.8 preoperatively to 4.4 ± 1.9 at 2 years, followed by ","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"6 3","pages":"Article 100281"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}