Journal of Cartilage & Joint Preservation最新文献

{"title":"Erratum to “Double-blinded prospective randomized clinical trial in knee joint osteoarthritis treatment: safety assessment and performance of trehalose hyaluronic acid versus standard infiltrative therapy based on medium-weight sodium hyaluronate” [J Cartil Joint Preserv 2 (2022) 100043]","authors":"","doi":"10.1016/j.jcjp.2024.100167","DOIUrl":"10.1016/j.jcjp.2024.100167","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140402914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based machine learning algorithm to predict failure following cartilage procedures in the knee","authors":"","doi":"10.1016/j.jcjp.2023.100161","DOIUrl":"10.1016/j.jcjp.2023.100161","url":null,"abstract":"<div><h3>Introduction</h3><div>Clinical decision-making is highly based on expert opinion. Machine learning is increasingly used to develop patient-specific risk prediction analysis to improve patient selection prior to surgery.</div></div><div><h3>Objectives</h3><div>To develop machine learning algorithms to predict failure of surgical procedures that address cartilage defects of the knee and detect variables associated with failure.</div></div><div><h3>Methods</h3><div>An institutional database was queried for cartilage procedures performed between 2000 and 2018. Failure was defined as revision cartilage surgery or knee arthroplasty. One hundred and one preoperative and intraoperative features were evaluated as potential predictors. Four machine learning algorithms were trained and internally validated.</div></div><div><h3>Results</h3><div>One thousand and ninety-one patients with a minimum follow-up of 2 years were included and underwent chondroplasty (<em>n</em> = 560; 51%), osteochondral allograft transplantation (<em>n</em> = 306; 28%), microfracture (<em>n</em> = 150; 14%), autologous chondrocyte implantation (<em>n</em> = 39; 4%), or osteochondral autograft transplantation (<em>n</em> = 36; 3%). The Random Forest algorithm was the best-performing algorithm, with an area under the curve of 0.765 and a Brier score of 0.135. The most important features for predicting failure were symptom duration, age, body mass index, lesion grade, and total lesion area. Local Interpretable Model-agnostic Explanations analysis provided patient-specific comparisons for the risk of failure of an individual patient being assigned various types of cartilage procedures.</div></div><div><h3>Conclusions</h3><div>Machine learning algorithms were accurate in predicting the risk of failure following cartilage procedures of the knee, with the most important features in descending order being symptom duration, age, body mass index, lesion grade, and total lesion area. Machine learning algorithms may be used to compare the risk of failure of specific patient-procedure combinations in the treatment of cartilage defects of the knee.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative capacity of morselized cartilage in vitro and in an osteochondral defect model","authors":"","doi":"10.1016/j.jcjp.2024.100182","DOIUrl":"10.1016/j.jcjp.2024.100182","url":null,"abstract":"<div><h3>Introduction</h3><div>Numerous treatment modalities for focal articular cartilage defects exist. However, the use of consistent and reproducible minced cartilage morsels to heal these lesions, especially with a scaffold, has not been investigated.</div></div><div><h3>Objectives</h3><div>To investigate the effect of consistently sized minced cartilage morsels on the healing of focal articular cartilage defects.</div></div><div><h3>Methods</h3><div>Cartilage was harvested and morselized into 0.5, 1.0, and 5.0 mm diameters, and cultured. Cell viability and chondrogenic gene expression were analyzed. Minced cartilage morsels of 0.5 mm were harvested and used to produce the implant paste. The NC paste was filled into a rabbit articular cartilage defect, and histology was used to assess cartilage repair.</div></div><div><h3>Results</h3><div>Chondrocyte viability of the morsels was highly maintained. Chondrogenic and proliferative genes like ACAN, COL2, COMP, PCNA, SOX9, and PRG4 all increased expression to a varying degree as morsel size decreased. Morsels of 0.5 mm exhibited the highest chondrogenic potential. Also, NC paste containing 0.5 mm morsels resulted in complete defect closure unlike marrow stimulation alone. Safranin-O staining demonstrated superior cartilage formation in the defect area.</div></div><div><h3>Conclusions</h3><div>Smaller consistent morsel size was found to be linked to increased chondrogenic potential. However, since PRG4 expression was highest in 1 mm morsels and MMP-13 gene expression was significantly decreased in only 0.5 mm morsels, this demonstrates the need to adjust morsel size to optimize gene expression of interest. NC paste mixed with 0.5 mm morsels produced the greatest regenerative capacity. Exploring the regenerative potential of unique hydrogels and chondron morsel sizes is warranted.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Knee cartilage injuries—an international Delphi consensus","authors":"","doi":"10.1016/j.jcjp.2024.100204","DOIUrl":"10.1016/j.jcjp.2024.100204","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141137017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latin American consensus for the treatment of focal chondral lesions of the knee","authors":"","doi":"10.1016/j.jcjp.2024.100202","DOIUrl":"10.1016/j.jcjp.2024.100202","url":null,"abstract":"<div><h3>Introduction</h3><div>A consensus is useful for topics that can be common in clinical practice and controversial in some aspects of its treatment.</div></div><div><h3>Objectives</h3><div>To establish a consensus among the Latin American society of arthroscopy, articular reconstruction and sports medicine (SLARD) for treating focal chondral lesions of the knee.</div></div><div><h3>Methods</h3><div>A formal consensus was conducted among 3 groups of surgeons from SLARD with a special interest in cartilage. First, the steering group (<em>n</em> = 9) created a list of 21 statements on controversial topics and compiled a review of the literature for each topic. Second, the rating group (<em>n</em> = 19) gave a score to each statement according to their agreement with it, over 2 rounds (score: 1-9). Median scores and agreement levels were calculated and each statement was categorized as inappropriate, uncertain, or appropriate. Finally, the lecture group (<em>n</em> = 24) evaluated the appropriateness and clinical relevance of each statement.</div></div><div><h3>Results</h3><div>During the first round, there was strong agreement on 5% of the statements, relative agreement on 14%, and lack of consensus on 81% of statements. After the second round, there was strong agreement on 57% of statements, with 43% having relative agreement and no statement having a lack of consensus. The lecture group approved all the statements.</div></div><div><h3>Conclusions</h3><div>SLARD arrived at a consensus on the 21 statements proposed. This consensus includes a literature review and clinical experience, which represents the expert opinion of a society. Strong agreement was found in the advantages of using arthroscopy to diagnose chondral lesions, preinjury level as an age modification of treatment, superiority of nanofractures compared to microfractures, advantages of adding scaffolds, benefits of platelet-rich plasma in the midterm and faster return to sport with osteochondral autografts.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone marrow stimulation for knee cartilage injuries—an international Delphi consensus statement","authors":"","doi":"10.1016/j.jcjp.2024.100195","DOIUrl":"10.1016/j.jcjp.2024.100195","url":null,"abstract":"<div><h3>Introduction</h3><div>Articular cartilage injuries of the knee are a complex and challenging clinical pathology.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to establish consensus statements via a Delphi process on bone marrow stimulation (BMS) for knee cartilage injuries.</div></div><div><h3>Methods</h3><div>A consensus process on knee cartilage injuries utilizing a modified Delphi technique was conducted. Seventy-nine surgeons across 17 countries participated in these consensus statements. Fourteen questions were generated on BMS, with 3 rounds of questionnaires and final voting occurring. Consensus was defined as achieving 80% to 89% agreement, whereas strong consensus was defined as 90% to 99% agreement, and unanimous consensus was defined as 100% agreement with a proposed statement.</div></div><div><h3>Results</h3><div>Of the 14 total questions and consensus statements on BMS developed from 3 rounds of voting, 0 achieved unanimous consensus, 3 achieved strong consensus, 4 achieved consensus, and 7 did not achieve consensus.</div></div><div><h3>Conclusions</h3><div>The statements that achieved strong consensus related to lesion site preparation, ability to differentiate healthy/damaged cartilage, and distance between BMS holes. The statements that did not achieve consensus were primarily related to the indications for BMS, as well as the instrumentation and whether orthobiologics/scaffolds should be utilized.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141024585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of large chondral lesions with big bony defects: the Overlay autologous chondrocyte implantation technique","authors":"Deepak Goyal","doi":"10.1016/j.jcjp.2024.100178","DOIUrl":"10.1016/j.jcjp.2024.100178","url":null,"abstract":"<div><h3>Introduction</h3><p>The treatment of large chondral defects is more challenging when these chondral lesions are associated with big bony defects, which may be present in the form of either multiple subchondral (SC) cysts, or necrotic area of SC bone plate and SC spongiosa or as total fragmentation of the condylar surface. Looking to the young age of such patients, preservation of the joint is essential to prevent an early onset osteoarthritis. The marrow stimulation techniques and autologous chondrocyte implantation (ACI) need healthy SC bone to regenerate cartilage, while the osteochondral cylinder transfer techniques have donor size limitations.</p></div><div><h3>Objectives</h3><p>A new technique to treat large chondral lesions with big bony defects is described here in step-by-step manner and is called the overlay ACI technique.</p></div><div><h3>Methods</h3><p>The overlay ACI technique combines principles of autogenous bone grating for the treatment of large bony defects, which is followed by an overlay of ACI in a conventional manner to treat cartilage lesion.</p></div><div><h3>Results</h3><p>The overlay ACI technique provides an autogenous solution in form of a pain-free biological joint without any sequelae to the host tissue and formation of the hyaline (like) cartilage.</p></div><div><h3>Conclusion</h3><p>The presence of large chondral lesions with big bony defects is a surgical joint preservation challenge. The overlay ACI technique is a promising technique to treat extra-large osteochondral lesions with an autogenous solution.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254524000143/pdfft?md5=30e83da397ecde20c42ca190c97be0fc&pid=1-s2.0-S2667254524000143-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-stage autologous chondrocyte coimplantation on a hyaluronan scaffold for the treatment of knee cartilage lesions: a case series of 16 patients with clinical outcomes up to 5 years","authors":"Emmanouil T. Papakostas ,&nbsp;Efthymios Papasoulis ,&nbsp;Willem Cornelis de Jong ,&nbsp;Aristotelis S. Sideridis ,&nbsp;Argiris Karavelis ,&nbsp;Konstantinos Epameinontidis ,&nbsp;Ioannis P. Terzidis","doi":"10.1016/j.jcjp.2024.100170","DOIUrl":"10.1016/j.jcjp.2024.100170","url":null,"abstract":"<div><h3>Introduction</h3><p>The direct reimplantation of autologous primary articular chondrocytes in a single-stage procedure for knee cartilage lesions is a novel approach, yet to be extensively reported. This study aimed to evaluate the clinical outcomes and reinterventions over a 5-year period post-surgery.</p></div><div><h3>Methods</h3><p>A prospective case series involving 16 patients (4 female, 12 male) with single or multiple focal knee cartilage lesions was conducted. The mean age at baseline was 36.8 (±11.5) years. The mean total lesion size was 4.5 (±2.3) cm² Patients underwent surgery where articular chondrocytes and mononuclear bone marrow cells were isolated, mixed, and seeded onto a hyaluronan-based scaffold within the lesion. A structured physical therapy regimen was followed, and patients were assessed using Knee injury and Osteoarthritis Outcome Score (KOOS) and International Knee Documentation Committee (IKDC) Subjective questionnaires at various intervals. Overall, patient-reported outcomes improved over the first 3 years post-surgery, with slight declines thereafter.</p></div><div><h3>Results</h3><p>Significant improvements over baseline were noted for various KOOS parameters and IKDC Subjective scores at different follow-up points. Reinterventions were required for two patients, one receiving intra-articular injections with mesenchymal stromal cells and another undergoing knee washout for septic arthritis while a meniscus implant was removed. Patient satisfaction at final follow-up was generally favorable. Despite a significant intraoperative cell isolation time of approximately 1.5 hours, the procedure demonstrated safety and efficacy, with an average of ±0.9 million articular chondrocytes obtained per case.</p></div><div><h3>Conclusions</h3><p>This study underscores the potential of coimplantation of intraoperatively isolated articular chondrocytes and bone marrow cells on a hyaluronan scaffold as a promising strategy for treating symptomatic knee cartilage lesions.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254524000064/pdfft?md5=0ab2bdba63f5a05ef4eeabbe6b271be6&pid=1-s2.0-S2667254524000064-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness of various treatments for cartilage defects compared with microfracture: a network meta-analysis of randomized controlled trials","authors":"Sathish Muthu ,&nbsp;Vibhu Krishnan Viswanathan ,&nbsp;Girinivasan Chellamuthu ,&nbsp;Mohammad Thabrez","doi":"10.1016/j.jcjp.2023.100163","DOIUrl":"https://doi.org/10.1016/j.jcjp.2023.100163","url":null,"abstract":"<div><h3>Background</h3><p>Advancements have been made in the realm of cartilage-regenerative techniques in the past decades. However, their comparative advantage has not yet been fully studied.</p></div><div><h3>Objectives</h3><p>To comparatively analyze the functional, radiological and histological outcomes, and complications of various procedures available for the treatment of cartilage defects.</p></div><div><h3>Data sources</h3><p>PubMed, Embase, Web of Science, Cochrane, and Scopus.</p></div><div><h3>Study eligibility criteria, participants, and interventions</h3><p>Randomized controlled trials reporting functional, radiological, histological outcomes, or complications of various methods were utilized in the management of cartilage defects. Patients with cartilage defects. Treatment methods include microfracture (MFX), autologous chondrocyte implantation (ACI), osteochondral allograft/autograft transplantation (OAT), mosaicplasty, or acellular implants.</p></div><div><h3>Study appraisal and synthesis methods</h3><p>Cochrane’s Confidence in Network meta-analysis approach. Network meta-analysis was conducted in Stata. Random effects model was used for forest plots.</p></div><div><h3>Results</h3><p>Three thousand one hundred ninety-three patients from 54 randomized controlled trials were included in the analysis. The mean age of included patients was 37.9 (±9.46) years. MFX-I was used as a constant comparator. Among the restorative methods, OAT-II offered significantly better functional outcome at 5 years (weighted mean difference [WMD] = 16.00, 95% confidence interval [CI] [11.66, 20.34], <em>P</em> &lt; .001) and 10 years (WMD = 16.00, 95% CI [10.42, 21.58], <em>P</em> &lt; .001), while OAT-I offered significantly better pain relief (WMD = −1.74, 95% CI [−3.45, −0.02], <em>P</em> = .042), and retained hyaline histology (odds ratio = 8.12, 95% CI [4.17, 12.07], <em>P</em> = .001) at 1 year with least-reported adverse events and failures. Among the regenerative methods, MFX-III (WMD = −10.0, 95% CI [−13.07, −6.93], <em>P</em> = .008) offered significantly better functional outcomes at 5 years, while ACI-III (odds ratio = 0.89, 95% CI [0.03, 1.76], <em>P</em> = .032) demonstrated significantly better radiological outcomes at 2 years.</p></div><div><h3>Limitations</h3><p>Heterogeneity in reporting of diverse functional outcome measures.</p></div><div><h3>Conclusions and implications of key findings</h3><p>Compared with MFX-I, OAT-II demonstrated significantly better long-term functional outcome (10 years), while ACI-III and MFX-III demonstrated significantly better functional outcomes only till midterm (5 years), and there is a paucity of long-term data on these treatment methods.</p></div><div><h3>Systematic review registration number</h3><p>CRD42022338329.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254523000690/pdfft?md5=dd2499475cea1a5c66e2ed9b66356327&pid=1-s2.0-S2667254523000690-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141243913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next generation approaches for cartilage repair and joint preservation","authors":"Akira Tsujii ,&nbsp;Tomoki Ohori ,&nbsp;Hiroto Hanai ,&nbsp;Norimasa Nakamura","doi":"10.1016/j.jcjp.2024.100177","DOIUrl":"10.1016/j.jcjp.2024.100177","url":null,"abstract":"<div><h3>Introduction</h3><p>Articular cartilage plays an important role in the normal biological functions of joints, such as shock absorption and lubrication. Unfortunately, although cartilage is supplied with nutrients, it has a low self-healing capacity owing to the lack of direct blood supply; thus, various treatments have been used to improve the healing of cartilage tissue. Recent treatment strategies in the field of orthobiologics and biomaterials are expected to improve the healing rate of cartilage tissue.</p></div><div><h3>Objective</h3><p>To provide the latest research and clinical results related to cartilage therapy and to clarify their efficacy and expected future role.</p></div><div><h3>Methods</h3><p>A literature search was conducted in October 2023 using the keywords “cartilage therapy, next generation” and a narrative review was conducted separately for nonoperative and operative treatments.</p></div><div><h3>Results</h3><p>Orthobiologics already used in clinical practice include platelet-rich plasma- and mesenchymal stem cell-based therapies. Recent studies using exosomes derived from cell cultures have reported promising nonoperative therapies. Biomaterial-based operative therapy, which eliminates donor-site morbidity, can also be useful. In addition, a therapeutic strategy using induced pluripotent stem cells is also being promoted, and future developments are expected.</p></div><div><h3>Conclusions</h3><p>Various types of orthobiologic-based or biomaterials-based therapeutic strategies have been reported, including cell-free and stem cell-based methods; however, new methods using exosomes or induced pluripotent stem cells have not yet been applied clinically and are expected to be developed in the future. Well-designed clinical trials would reveal its true usefulness and we hope that it will be established as a treatment that can actually be offered to patients.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254524000131/pdfft?md5=85113d48ce0fb021c8a85190649ab302&pid=1-s2.0-S2667254524000131-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}