羊膜在骨关节炎治疗中的应用

Zuzana Macečková , Jiří Pergner , Martin Krbec , Milan Urban , Michal Zahradníček
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引用次数: 0

摘要

骨关节炎(OA)是一种常见的退行性关节疾病,以关节软骨退化、炎症和疼痛为特征。目前OA的治疗方案在提供长期缓解和恢复关节功能方面是有限的。然而,再生医学的最新进展导致了对替代治疗策略的探索,包括羊膜(AM)在OA治疗中的应用。由于其独特的特性和再生潜力,AM已成为一种有前景的治疗选择,尽管AM在OA中的作用机制尚未完全阐明。在这里,我们讨论了AM的抗炎、免疫调节和再生特性,使其成为OA治疗的一个有吸引力的候选者。利用动物模型进行的临床前研究表明,AM具有促进软骨修复、减少炎症和改善关节功能的能力。评估基于am的治疗在OA患者中的安全性和有效性的临床试验也显示出有希望的结果,在疼痛缓解和功能结果方面有所改善。综上所述,虽然AM在OA治疗中表现出了希望,但还需要进一步的研究和临床试验来充分了解其治疗潜力,并将其作为OA患者的安全有效的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Application of amniotic membrane in osteoarthritis management

Application of amniotic membrane in osteoarthritis management

Introduction

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by articular cartilage degradation, inflammation, and pain. The current treatment options for OA are limited in their ability to provide long-term relief and restore joint function. However, recent advances in regenerative medicine have led to the exploration of alternative therapeutic strategies, including the application of amniotic membrane (AM) in OA management. AM has emerged as a promising therapeutic option due to its unique properties and regenerative potential, although the mechanism of action of AM in OA is not fully elucidated.

Objectives

Here, we discuss the anti-inflammatory, immunomodulatory, and regenerative properties of AM that make it an attractive candidate for OA treatment. Preclinical studies utilizing animal models have demonstrated the ability of AM to promote cartilage repair, reduce inflammation, and improve joint function. Clinical trials evaluating the safety and efficacy of AM-based therapies in OA patients have also shown promising results, with improvements in pain relief and functional outcomes.

Conclusions

In conclusion, while AM shows promise for OA management, additional studies and clinical trials are necessary to fully understand its therapeutic potential and establish it as a safe and effective treatment option for individuals with OA.
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