Journal of Cartilage & Joint Preservation最新文献

{"title":"Welcome to the final issue of JCJP 2024","authors":"Miranda Manfre, Rachel M. Frank","doi":"10.1016/j.jcjp.2024.100225","DOIUrl":"10.1016/j.jcjp.2024.100225","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articular cartilage debridement results in short-term significant improvements in patient-reported outcomes for large areas of cartilage loss of the femur in the setting of mild to moderate knee osteoarthritis","authors":"Yusuf Mufti,&nbsp;Jared P. Sachs,&nbsp;Andrew S. Bi,&nbsp;Chloe Franzia,&nbsp;John Ebersole,&nbsp;Taylor Giordano,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2024.100221","DOIUrl":"10.1016/j.jcjp.2024.100221","url":null,"abstract":"<div><h3>Introduction</h3><div>Chondroplasty is a surgical option for chondral defects, but its effect on larger cartilage defects in the setting of knee osteoarthritis remains unclear.</div></div><div><h3>Objectives</h3><div>This study aims to evaluate patient-reported outcomes (PROs) following chondroplasty in patients with larger chondral defects (≥2 cm²) of the femur in the setting of osteoarthritis.</div></div><div><h3>Materials and methods</h3><div>Retrospective review of patients who underwent chondroplasty of the femur. All patients had Kellgren-Lawrence (KL) grades of 2 or 3 and a minimum of 1-year postoperative follow-up. Chondral loss was estimated by arthroscopic measurements and by Magnetic Resonance Imaging (MRI). PROs included the International Knee Documentation Committee, Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, and the Veterans Rand-12 Item. Statistical analysis was performed using paired <em>t</em> tests to compare baseline and follow-up data, as well as linear regressions to correlate lesion size with symptom improvement.</div></div><div><h3>Results</h3><div>39 patients with 20 KL grade 2 and 19 KL grade 3 knees were included. At both 1- and 2-year follow-ups, significant improvements were noted in International Knee Documentation Committee (34.9 ± 13.5 preoperative, 55.6 ± 18.8 at 2 years, <em>P</em> = .0025), Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (56.3 ± 14.7 preoperative, 64.5 ± 17.0 at 2 years, <em>P</em> = .0243), and Veterans Rand-12 Item Physical Component Scores (38.0 ± 12.7 preoperative, 43.8 ± 8.6 at 2 years, <em>P</em> = .0044). Four (10.3%) conversions to arthroplasty were noted at most recent follow-up.</div></div><div><h3>Conclusions</h3><div>Articular cartilage debridement for large areas of cartilage loss of the femur in the setting of mild to moderate osteoarthritis results in significant improvements in physical function and knee-specific PROs at 1- and 2-year follow-ups.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical potential of meniscal progenitor cells","authors":"Wan-Ting Yan ,&nbsp;Jing-Song Wang ,&nbsp;Peng-Zhou Fan ,&nbsp;Sally Roberts ,&nbsp;Karina Wright ,&nbsp;Zheng-Zheng Zhang","doi":"10.1016/j.jcjp.2024.100166","DOIUrl":"10.1016/j.jcjp.2024.100166","url":null,"abstract":"<div><h3>Introduction</h3><div>The meniscus is an important cushioning structure of the knee joint, with the maintenance of its normal structure and function playing a crucial role in protecting the joint from early degeneration. Stem/progenitor cells could be the key to help researchers to have a deeper understanding of the biological process of meniscal injury repair and may be important in the meniscus tissue regeneration processes. To the best of our knowledge, there is currently a lack of comprehensive reviews on existing research about the meniscus progenitor cells (MPCs).</div></div><div><h3>Objectives</h3><div>By reviewing the existing MPC literature, we aim to provide insights for future research on meniscus regeneration.</div></div><div><h3>Methods</h3><div>The isolation methods, biological characteristics and the translational application of MPCs were summarized.</div></div><div><h3>Results</h3><div>MPCs could be isolated according to their colony-forming ability, marker expression, migration ability, and differential adhesion to fibronectin. Most existing studies on surface markers of MPCs have largely followed the paradigm of mesenchymal stromal/stem cell research. Based on the information provided by their surface markers and expression profile, researchers located MPCs in the peripheral surface area of the meniscus. Few researches have investigated the translation and application of MPCs, with most studies being limited to MPCs extraction and subsequent reimplantation in vivo.</div></div><div><h3>Conclusions</h3><div>MPCs are a group of meniscus-resident cells, which exhibit certain stem/progenitor cell characteristics, such as the ability to undergo multilineage differentiation in in vitro culture.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis","authors":"Pooja N. Swami ,&nbsp;Henintsoa Fanjaniaina Andriamifidy ,&nbsp;Shabirul Haque ,&nbsp;Timothy Reed ,&nbsp;Azhar Khan ,&nbsp;Daniel A. Grande","doi":"10.1016/j.jcjp.2024.100220","DOIUrl":"10.1016/j.jcjp.2024.100220","url":null,"abstract":"<div><h3>Introduction</h3><div>Orthobiologics, such as mesenchymal stem cells (MSCs), known for their multipotency, are key players in stem cell therapy. One of the ways MSCs realize their therapeutic potential is through the release of extracellular vesicles (EVs), small lipid-membrane–bound structures that carry bioactive materials from their progenitor cells.</div></div><div><h3>Objectives</h3><div>This review aims to provide an overview of EVs in and from the synovial joint in both physiological and pathological context specifically in osteoarthritis.</div></div><div><h3>Methods</h3><div>This narrative review synthesizes findings from PubMed using keywords—orthobiologics, EVs, synovial joint EVs, osteoarthritis, and synovial fluid. This review focuses on the potential of EVs isolated from different sources of MSCs found in the synovial joint, evaluating their differentiation capacity and contributions to joint health and osteoarthritis.</div></div><div><h3>Results</h3><div>EVs from various MSC types show promising results for osteochondral regeneration. However, the differentiation potential and therapeutic efficacy vary among cell types. Understanding the dynamic nature of the biological function of these cell types that serve as sources of EVs is essential for predicting their therapeutic actions. The synovium itself is identified as a significant source of EVs, which may offer unique applications for treating osteoarthritis and cartilage defects.</div></div><div><h3>Conclusions</h3><div>EVs and exosomes play a critical role in cartilage and osteochondral defect repair. They exhibit preservative and restorative benefits for tissue injuries, highlighting their potential in treating osteoarthritis and cartilage defects. Additionally, the synovium, as a source of EVs and exosomes, presents unique therapeutic applications as orthobiologic.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee valgus deformity: indications and outcomes for a high tibial medial closing-wedge osteotomy","authors":"Clayton W. Nuelle,&nbsp;João Bourbon de Albuquerque II,&nbsp;Maurício Kfuri","doi":"10.1016/j.jcjp.2024.100212","DOIUrl":"10.1016/j.jcjp.2024.100212","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditionally, knee valgus deformities have been corrected through distal femur osteotomies. The advances in preoperative planning allow surgeons to understand the leading site of deformity better and, therefore, propose corrections at the appropriate anatomical location.</div></div><div><h3>Objectives</h3><div>The purpose of this evaluation is to present a case of a knee valgus deformity where most of the deformity resulted from the joint and the proximal tibia. A medial closing wedge tibial osteotomy corrected the proximal tibia deformity, while a fresh osteochondral allograft aimed to improve the surface of the lateral compartment of the knee, optimizing the joint lateral convergence angle. In addition, indications, outcomes and a scoping review of the literature for closing wedge high tibial osteotomy for knee valgus deformity is reviewed.</div></div><div><h3>Methods</h3><div>A clinical case report example of a patient with knee valgus deformity requiring closing wedge high tibial osteotomy is presented. Detailed discussion of preoperative templating, planning and surgical completion is reviewed. A systematic review of previous studies and outcomes after closing wedge high tibial osteotomy was undertaken and summarized.</div></div><div><h3>Results</h3><div>The case presented demonstrates an example of a valgus knee deformity with alignment correction vis a proximal tibial ostetomy. A review of and summary of previous case reports and outcomes studies for similar pathology demonstrates a high degree of success for this surgical approach.</div></div><div><h3>Conclusions</h3><div>Closing wedge high tibial osteotomy is a viable treatment option for knee valgus deformity with an abnormal mechanical medial proximal tibial angle (mMPTA). A thorough evaluation of joint orientation angles is necessary to appropriately address limb deformity at the specific locations(s) of significant anatomic abnormality.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very-high-molecular-weight vs high-molecular-weight hyaluronic acid injections show long-term sustained benefits in the treatment of osteoarthritis of the knee: a 15-year Indian cohort study","authors":"Anish Kumar Aggarwal ,&nbsp;Nakul Aggarwal ,&nbsp;Jane Fitzpatrick","doi":"10.1016/j.jcjp.2024.100213","DOIUrl":"10.1016/j.jcjp.2024.100213","url":null,"abstract":"<div><h3>Introduction</h3><div>Lack of confidence in intra-articular hyaluronic acid injections for osteoarthritis (OA) may result from conflicting guidelines and pooling of results for different molecular weight products.</div></div><div><h3>Objectives</h3><div>The objectives were to determine responder rates to injections of very-high-molecular-weight hyaluronic acid (VHMW-HA) vs high-molecular-weight hyaluronic acid (HMW-HA) for knee OA and treatment efficacy measured by the interval between follow-up injections.</div></div><div><h3>Methods</h3><div>A retrospective analysis of a 15-year cohort from a single center. Inclusion criteria: adults with Kellgren-Lawrence Grade III or IV knee OA treated with hyaluronic acid injections. Subjects were stratified into 2 groups based on the molecular weight of the hyaluronic acid. Outcome measures were responder rates with improvement in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores of &gt;30% from baseline vs nonresponders; those with a response lasting &gt;6 months after each injection were considered sustained responders.</div></div><div><h3>Results</h3><div>In total, 2037 (female 1467 [72.02%] and male 570 [27.98%]) patients were treated. The overall primary responder rate was 73.44% (1496). VHMW-HA had significantly higher primary responders (75.21% vs 70.22%, <em>P</em> = .015) and significantly lower nonresponders (24.79% vs 29.78%, <em>P</em> = .015). As a subset of primary responders, the sustained responders had greater responses with VHMW-HA vs HMW-HA (85.54% vs 67.06%, <em>P</em> &lt; .0001) and lower dropouts (14.46% vs 32.94%, <em>P</em> &lt; .0001). The average interval between the first and the third injections was longer for VHMW-HA vs HMW-HA—5.67 vs 1.95 years (<em>P</em> &lt; .0001).</div></div><div><h3>Conclusions</h3><div>About 73.44% of subjects responded to treatment with intra-articular hyaluronic acid. The sustained response was greater in VHMW-HA vs HMW-HA and VHMW-HA has a longer duration of effect than HMW-HA.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of the cellular content of platelet-rich plasma harvested after injection of filgrastim versus pegfilgrastim biosimilars: a prospective, single-center, crossover study","authors":"Mohammadreza Abbasian,&nbsp;Eric Branch,&nbsp;Ali Parsa,&nbsp;Jessica Truett,&nbsp;Joshua J. Cook,&nbsp;Charlkesha A. Rahming,&nbsp;Adam W. Anz","doi":"10.1016/j.jcjp.2024.100211","DOIUrl":"10.1016/j.jcjp.2024.100211","url":null,"abstract":"<div><h3>Introduction</h3><div>Hematopoietic stem cells (HSCs) appear in peripheral blood (PB) following mobilization due to external events or pharmaceutical agents like filgrastim and pegfilgrastim. Concentration of these into platelet-rich plasma (PRP) can be used in orthopedics.</div></div><div><h3>Objectives</h3><div>This prospective, single-center, controlled laboratory study aimed to compare safety profiles of filgrastim and pegfilgrastim administration, quantifying the cellular content of PRP derived from PB post-administration. We hypothesized comparable rates and severity of adverse events (AEs) among participants, along with similar cellular content in the PRP products.</div></div><div><h3>Methods</h3><div>Ten healthy male participants underwent a crossover design with 2 interventions separated by a washout period. PB was collected before and after each intervention, producing PRP for cellular comparison in vitro. AEs were monitored for severity and frequency throughout study.</div></div><div><h3>Results</h3><div>Significant AEs for filgrastim included fatigue (36%), myalgia (36%), and back pain (9.1%), compared to pegfilgrastim, which included myalgia (31%), fatigue (23%), and back pain (23%). There were no significant differences between AE occurrences (<em>P</em> = .49) nor relationship to study drug (<em>P</em> &gt; .99). Regarding total nucleated cell count (TNC), statistical significance was found in TNC count (<em>P</em> = .010) and TNC concentration (<em>P</em> = .004). All PRP products expressed high levels (&gt;88%) of hematopoietic progenitor cell/HSC-specific CD45+, CD34+, CD45dim+, and hematopoietic progenitor cell/HSC+ markers.</div></div><div><h3>Conclusions</h3><div>This study demonstrated that filgrastim and pegfilgrastim administration appear safe. Pegfilgrastim is equivalent to filgrastim for the mobilization of white blood cells and cells expressing hematopoietic cell-surface markers into the PB and consequently, into the derived PRP product.</div></div><div><h3>Clinical relevance</h3><div>This study presents pegfilgrastim as a single-injection alternative to filgrastim for the mobilization of HSCs into the PB and subsequent PB-derived PRP, which is more convenient and less invasive for patients.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in knee cartilage repair procedures in the United States, 2010 to 2020","authors":"Akshar P. Thakkar ,&nbsp;Ting Zhang ,&nbsp;Michael Bodine ,&nbsp;Aaron A. Bare ,&nbsp;Michael B. Ellman ,&nbsp;Sanjeev Bhatia ,&nbsp;Andreas H. Gomoll ,&nbsp;Brian J. Chilelli","doi":"10.1016/j.jcjp.2024.100219","DOIUrl":"10.1016/j.jcjp.2024.100219","url":null,"abstract":"<div><h3>Introduction</h3><div>Surgical intervention of knee articular cartilage injuries may prevent degeneration in symptomatic patients.</div></div><div><h3>Objectives</h3><div>This study aims to analyze trends, demographics, and yearly incidence of 4 different knee cartilage repair procedures in the United States from 2010-2020.</div></div><div><h3>Methods</h3><div>The PearlDiver database was queried for patients who underwent knee microfracture, autologous chondrocyte implantation (ACI), osteochondral autograft transfer (OAT), and osteochondral allograft (OCA) transplantation procedures from 2010-2020. Student <em>t</em> and <em>χ</em>² tests were used for statistical comparisons and analysis of data trends. Regression models and compound annual growth rates further assessed the trends of each procedure.</div></div><div><h3>Results</h3><div>A total of 220,674 patients from 2010-2020 were included in this study. Microfracture incurred a 62.4% decrease in occurrence (<em>P</em> &lt; .001). Incidence of OCA trended upward (37.7%; <em>P</em> = .065) while OAT procedures significantly decline (53.9%; <em>P</em> &lt; .001). ACI procedure numbers remained relatively stable (11.2% increase; <em>P</em> = .847).</div></div><div><h3>Conclusions</h3><div>The incidence of microfracture significantly decreased in the United States from 2010-2020. There was a positive trend in the incidence of OCA cases, while the number of OAT cases decreased significantly. The number of ACI cases performed per year did not change significantly over the study period with the exception of an increase from 2017-2019. Microfracture procedures were performed in an older patient population than the other cartilage procedures. Males were more likely to undergo the 4 cartilage preservation surgeries compared to females. Similar studies should be carried out in other large health databases to confirm the external validity of these trends across the United States.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation and return-to-play following knee cartilage injuries-an international Delphi consensus statement","authors":"","doi":"10.1016/j.jcjp.2024.100193","DOIUrl":"10.1016/j.jcjp.2024.100193","url":null,"abstract":"<div><h3>Introduction</h3><div>Articular cartilage injuries of the knee are a complex and challenging clinical pathology.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to establish consensus statements via a Delphi process on rehabilitation and return to play (RTP) following knee cartilage injuries.</div></div><div><h3>Methods</h3><div>A consensus process on knee cartilage injuries utilizing a modified Delphi technique was conducted. Seventy-nine surgeons across 17 countries participated in these consensus statements. Eleven questions were generated on rehabilitation and RTP, with 3 rounds of questionnaires and final voting occurring. Consensus was defined as achieving 80% to 89% agreement, whereas strong consensus was defined as 90% to 99% agreement, and unanimous consensus was defined as 100% agreement with a proposed statement.</div></div><div><h3>Results</h3><div>Of the 11 total questions and consensus statements on rehabilitation and RTP developed from 3 rounds of voting, 0 achieved unanimous consensus, 2 achieved strong consensus, 4 achieved consensus, and 5 did not achieve consensus.</div></div><div><h3>Conclusions</h3><div>The statements achieving consensus were related to the benefits of early motion and that concomitant procedures may alter the rehabilitation process. RTP following cartilage-related procedures typically follows a rehabilitation guideline largely dependent on the type of cartilage procedure. The statements that did not reach a consensus were related to specific timing to meet goals.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100193"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fixation for knee cartilage injuries—an international Delphi consensus statement","authors":"","doi":"10.1016/j.jcjp.2024.100199","DOIUrl":"10.1016/j.jcjp.2024.100199","url":null,"abstract":"<div><h3>Introduction</h3><div>Articular cartilage injuries of the knee are a complex and challenging clinical pathology.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to establish consensus statements via a Delphi process on cartilage fixation techniques and indications.</div></div><div><h3>Methods</h3><div>A consensus process on knee cartilage injuries utilizing a modified Delphi technique was conducted. Seventy-nine surgeons across 17 countries participated in these consensus statements. Fourteen questions were generated on cartilage fixation, with 3 rounds of questionnaires and final voting occurring. Consensus was defined as achieving 80% to 89% agreement, whereas strong consensus was defined as 90% to 99% agreement, and unanimous consensus was defined as 100% agreement with a proposed statement.</div></div><div><h3>Results</h3><div>Of the 14 total questions and consensus statements on cartilage fixation developed from 3 rounds of voting, 0 achieved unanimous consensus, 8 achieved strong consensus, 3 achieved consensus, and 3 did not achieve consensus.</div></div><div><h3>Conclusions</h3><div>The statements achieving strong consensus related to indications and contraindications, the expectation that younger patients experience better outcomes, and an agreement that procedures should be done as soon as possible but no limit on timeframe, cartilage preparation techniques, and the use of fragment stability to guide cartilage fixation techniques. The statements that did not achieve consensus related to the minimum size of cartilage fragments that can be fixed, if purely cartilaginous lesions can be fixed, and the fixation techniques.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100199"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141031434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}