Journal of Cartilage & Joint Preservation最新文献

{"title":"Large osteochondritis dissecans lesion of the knee treated with “snowman” osteochondral allograft transplantation: a case report","authors":"Katie J. McMorrow,&nbsp;Allen A. Yazdi,&nbsp;Alexander C. Weissman,&nbsp;Sarah A. Muth,&nbsp;Stephanie A. Boden,&nbsp;Ron Gilat,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2024.100203","DOIUrl":"10.1016/j.jcjp.2024.100203","url":null,"abstract":"<div><h3>Introduction</h3><div>Symptomatic osteochondritis dissecans (OCD) is a relatively uncommon condition characterized by avascular subchondral bone, resulting in fragmentation and detachment of overlying articular cartilage. Osteochondral allograft transplantation (OCA) offers an effective solution for patients with multifocal, large, unstable, or complex OCD lesions. In certain cases, the “snowman” configuration, involving the use of multiple grafts, may be necessary due to lesion size or shape. This configuration ensures proper press-fit fixation of the grafts while restoring the topography of the articular surface. However, literature on using this technique for large OCD lesions of the lateral femoral condyle remains limited, making it difficult to draw conclusions about surgical outcomes.</div></div><div><h3>Case presentation</h3><div>Here, we present the case of a 17-year-old patient with a symptomatic, 30 mm × 20 mm OCD lesion of the lateral femoral condyle of the left knee. Initially, conservative treatment and physical therapy were pursued, but an injury during a football game resulted in exacerbation of his condition, necessitating 2 surgeries. The first procedure involved a diagnostic arthroscopy and loose body removal, while the second procedure included an OCA (using 2 plugs in a “snowman” configuration), a lateral meniscus repair, and bone marrow aspirate concentrate to saturate the graft.</div></div><div><h3>Conclusion</h3><div>The patient experienced favorable outcomes following surgery. Despite the “snowman” technique’s association with higher reoperation and failure rates compared to single or multicompartmental OCA plugs, it remains one of the few viable options for patients with large OCD lesions, enabling full defect restoration and accurate anatomical curvature of the femoral condyle.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141139552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medial femoral condyle cartilage restoration using a single-stage combined autologous-allogenic technique: a case report","authors":"Brendan Swift,&nbsp;Brian Chilelli","doi":"10.1016/j.jcjp.2024.100208","DOIUrl":"10.1016/j.jcjp.2024.100208","url":null,"abstract":"<div><h3>Introduction</h3><div>Cartilage injjuries in the knee pose a significant treatment dilemma. Multiple cartilage restoration procedures currently exist, but often come with significant cost and multistage procedures.</div></div><div><h3>Case presentation</h3><div>We report a case of a young, active female who, due to insurance limitations, was unable to undergo matrix-associated autologous chondrocyte implantation. The patient was instead treated with a single-stage combined autogenous-allogenic cartilage restoration. In the follow-up period, the patient endorsed marked improvements in Knee injury and Osteoarthritis Outcome Score, International Knee Documentation Committee Subjective Knee Form, and Western Ontario and McMaster Universities Osteoarthritis Index scores as compared to preoperative scores.</div></div><div><h3>Conclusion</h3><div>Single-stage cartilage restoration with a combined autogenous-allogenic graft technique offers an acceptable alternative to currently available cartilage techniques, with excellent short-term patient-reported outcomes.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postinjection protocols following platelet rich plasma injection for knee osteoarthritis: a systematic review of randomized controlled trials","authors":"Anna L. Park ,&nbsp;Zachary P. Bailowitz ,&nbsp;Peter M. DeJong ,&nbsp;Zainab Shirazi ,&nbsp;Nicholas Tsitsilianos ,&nbsp;Kristian J. von Rickenbach ,&nbsp;Christine E. Townsend ,&nbsp;Drew A. Lansdown ,&nbsp;Alfred C. Gellhorn ,&nbsp;Anthony Luke","doi":"10.1016/j.jcjp.2024.100201","DOIUrl":"10.1016/j.jcjp.2024.100201","url":null,"abstract":"<div><h3>Background</h3><div>There are currently no established postinjection recommendations for the use of platelet-rich plasma (PRP) as a treatment for knee osteoarthritis (OA).</div></div><div><h3>Objectives</h3><div>This paper systematically reviews postinjection protocols for randomized controlled trials of PRP for knee OA, with a particular focus on nonsteroidal anti-inflammatory drugs (NSAIDs) restrictions, activity limitations, and rehabilitation protocols.</div></div><div><h3>Data sources</h3><div>We searched the PubMed and Embase databases through February 2024 for the terms “knee osteoarthritis,” and “PRP,” “platelet rich plasma,” or “autologous,” resulting in 1156 unique articles.</div></div><div><h3>Study eligibility criteria, participants, and interventions</h3><div>Studies were included if they were randomized controlled trials with more than 10 participants using PRP for knee OA. Seventy-one studies met the inclusion criteria.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>Data on NSAID restrictions, activity limitations, and rehabilitation protocols were extracted and summarized. The risk of bias was assessed using the Cochrane Risk of Bias 2 tool.</div></div><div><h3>Results</h3><div>Exactly 54.9% of the reviewed articles provided information about postinjection NSAID restriction, with the most common time frame being longer than 4 weeks. Exactly 33.8% provided information about weight-bearing restrictions. Two studies reported detailed rehabilitation protocols.</div></div><div><h3>Limitations</h3><div>Randomized controlled trials for PRP injections for knee OA have significant variability and deficits in the reporting of postinjection protocols.</div></div><div><h3>Conclusions and implications of key findings</h3><div>Lack of reporting and potential heterogeneity in postinjection protocols limits the ability to compare results between studies.</div></div><div><h3>Systematic review registraiton number</h3><div>CRD42024509022</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100201"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141026831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of bone marrow aspirate concentrate with thrombin used for repairing osteochondral lesions of the talus","authors":"Tian Lan ,&nbsp;Karina T. Wright ,&nbsp;Nilesh Makwana ,&nbsp;Andrew Bing ,&nbsp;Charlotte H. Hulme ,&nbsp;Helen S. McCarthy","doi":"10.1016/j.jcjp.2025.100237","DOIUrl":"10.1016/j.jcjp.2025.100237","url":null,"abstract":"<div><h3>Introduction</h3><div>Bone marrow aspirate concentrate (BMAC) is an autologous biological augment used in the treatment of osteochondral lesions of the talus. Several studies have reported the short-term efficacy of BMAC for repair of osteochondral lesions of the talus, however, there is minimal regulation of the autologous products' potency and “release criteria” for clinical use. Moreover, the mechanism of action of BMAC therapy is poorly understood.</div></div><div><h3>Objectives</h3><div>This study aimed to investigate the composition of BMAC and BMAC mixed with thrombin (B+T), prepared according to commercial Complete Cartilage Regeneration kit protocols, linked to functional outcome data.</div></div><div><h3>Methods</h3><div>Bone marrow aspirate, BMAC, and B+T samples (<em>n</em> <!-->=<!--> <!-->16) were obtained for cellular analysis via a hematology analyzer and colony-forming unit-fibroblast assay. Molecular composition was assessed via a multiplex 27-cytokine assay and enzyme-linked immunosorbent assay (<em>n</em> <!-->=<!--> <!-->12). Spearman rank correlation was used to assess the relationship between both cellular and molecular composition with patient functional outcomes.</div></div><div><h3>Results</h3><div>Mesenchymal stem cells and platelets were concentrated in BMAC compared with bone marrow aspirate, but were reduced significantly after addition of thrombin. Cytokines and growth factors also decreased in concentration in B+T, however, platelet-derived growth factor-BB and interleukin-1 receptor alpha were significantly increased. Basic fibroblast growth factor, Eotaxin, IL-4, and IL-17 were found to have a positive correlation with worsening Manchester-Oxford Foot and Ankle Questionnaire (MOXFQ) 7<!--> <!-->months postoperation.</div></div><div><h3>Conclusions</h3><div>This study provides insight into the cellular and molecular characteristics of BMAC and B+T, highlighting donor heterogeneity and the importance of profiling autologous products prior to treatment.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 3","pages":"Article 100237"},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of osteochondral allograft transplantation and particulated juvenile articular cartilage to treat osteochondral defects leads to low failure rates after a minimum of 2-year follow-up","authors":"Gergo Merkely ,&nbsp;Chilan B.G. Leite ,&nbsp;Christos Papavassiliou ,&nbsp;Alec Reihl ,&nbsp;Jakob Ackermann ,&nbsp;Christian Lattermann ,&nbsp;Andreas H. Gomoll","doi":"10.1016/j.jcjp.2025.100236","DOIUrl":"10.1016/j.jcjp.2025.100236","url":null,"abstract":"<div><h3>Introduction</h3><div>Osteochondral allograft (OCA) transplantation effectively treats osteochondral defects using circular dowels. However, covering large or irregular defects with single plugs or two plug techniques sacrifices normal cartilage.</div></div><div><h3>Objectives</h3><div>To assesses failure rates of combining OCA transplantation with particulated juvenile allograft cartilage (PJAC) for treating large, irregular osteochondral lesions.</div></div><div><h3>Results</h3><div>Thirty-five patients were included. Mean age was 33.7 ± 8.8 years old (range, 15-49); follow-up 3.9 ± 1.4 years (range, 2.1-6.7); BMI 27.8 ± 5.0 kg/m²; defect size 4.9 ± 3 cm², and the mean OCA diameter was 1.9 ± 0.7 cm. PJAC was inserted around the OCA in 28 patients (80.0%), and between 2 grafts in 7 (20%) patients. Four cases of failure occurred (11.4%), with a mean time-to-failure of 3.7 ± 1.9 years (range, 2.1-6.4). Among failed cases, PJAC placement was around the OCA in 3 cases, and between 2 grafts in 1 case and defect size was larger compared to cases when graft remained intact.</div></div><div><h3>Conclusions</h3><div>Combining different methods of treatment for osteochondral defects may increase advantages and overcome drawbacks of each technique. The combination of OCA and PJAC appears to be a viable strategy for the management of large, irregular osteochondral lesions.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 3","pages":"Article 100236"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICRS Fellowships and the importance of fostering scientific community","authors":"James G. Jefferies ,&nbsp;Özgür Basal ,&nbsp;Jure Serdar ,&nbsp;Giuseppe Filardo","doi":"10.1016/j.jcjp.2025.100234","DOIUrl":"10.1016/j.jcjp.2025.100234","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis","authors":"Andrew S. Bi ,&nbsp;Udit Dave ,&nbsp;Trevor Poulson ,&nbsp;Jared Rubin ,&nbsp;Nicole Chang ,&nbsp;Zeeshan A. Khan ,&nbsp;Nicholas J. Lemme ,&nbsp;Jorge Chahla ,&nbsp;Adam B. Yanke ,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2025.100235","DOIUrl":"10.1016/j.jcjp.2025.100235","url":null,"abstract":"<div><h3>Background</h3><div>Meniscal allograft transplantation (MAT) aims to restore meniscal deficiency with cadaveric meniscal tissue.</div></div><div><h3>Objectives</h3><div>To compare MAT survivorship and conversion to arthroplasty in patients &lt;40 and ≥40 years old.</div></div><div><h3>Data sources</h3><div>Pubmed, Embase, Cochrane databases.</div></div><div><h3>Study eligibility criteria</h3><div>Studies were included if they evaluated medial or lateral MAT, evaluated survivorship or conversion to arthroplasty, reported mean patient age, and were published after 2004.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>Patient cohorts were sorted into 2 groups where mean age was lesser or greater than 40<!--> <!-->years. Data were pooled with the DerSimonian-Laird random-effects model.</div></div><div><h3>Results</h3><div>A total of 1436 studies were identified, 41 included. Each study had MINORS score ≥9 indicating low risk of bias. There were 4079 patients (59.4% male) in the &lt;40-year cohort, with mean-weighted age 31.3<!--> <!-->years, follow-up 6.4<!--> <!-->years. There were 625 patients (66.9% male) in the ≥40-year cohort, with mean-weighted age 41.2<!--> <!-->years, follow-up 8.0<!--> <!-->years. Older patients had significantly more medial MATs (300; 61.9% vs 1746; 48.4%). Patients &lt;40 had weighted mean survivorship 76.3% (95% CI: 69.1%-83.5%) and conversion rate 5.0% (95% CI: 3.5%-6.6%). Patients ≥40 had weighted mean survivorship 72.1% (95% CI: 46.9%-97.3%) and conversion rate 13.1% (95% CI: 4.2%-22.0%).</div></div><div><h3>Limitations</h3><div>Unavailability of individual data sets.</div></div><div><h3>Conclusions</h3><div>There appears to be no significant differences in MAT survivorship or conversion to arthroplasty rates in patients &lt;40 and ≥40 in appropriately indicated patients that have concomitant pathology addressed. Older patients undergoing MAT have a higher rate of medial MAT compared with younger cohorts.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of fluid flow-induced shear stress on the behavior of synovial fibroblasts in a bioinspired synovium-on-chip model","authors":"Susanna Piluso ,&nbsp;Yang Li ,&nbsp;Liliana Moreira Texeira ,&nbsp;Prasanna Padmanaban ,&nbsp;Jeroen Rouwkema ,&nbsp;Jeroen Leijten ,&nbsp;René van Weeren ,&nbsp;Marcel Karperien ,&nbsp;Jos Malda","doi":"10.1016/j.jcjp.2025.100233","DOIUrl":"10.1016/j.jcjp.2025.100233","url":null,"abstract":"<div><h3>Introduction</h3><div>Due to the loading of the articular joints and the movement of the joint itself, mechanical stress is constantly exerted on the synovial cavity, which is, in turn, reflected as shear stress toward the surrounding tissues, including the synovium. Although it is known that synovial cells are sensitive to various mechanical cues, deeper understanding on how synovial fibroblasts (SFBs) respond to increased shear stress is required to gain insights on its role in the pathophysiology of osteoarthritis (OA).</div></div><div><h3>Objectives</h3><div>A synovium-on-chip model was developed to evaluate the effect of fluid flow-induced shear stress on fibroblast-like synoviocytes, and to assess the similarities with synovial inflammation during OA.</div></div><div><h3>Methods</h3><div>Patient-derived SFBs were exposed to a shear stress of 3, 8, and 15 dyne/cm² for up to 72 hours. Production of TNFα, IL-6, MMPs, and lubricin by synovial cells was analyzed.</div></div><div><h3>Results</h3><div>The levels of TNFα, IL-6, and degradative enzymes increased over time when synovial cells were exposed to a shear stress of 8 dyne/cm². In the first 8 hours, a 5-fold increase in the level of TNFα was observed when the shear stress increased from 3 to 8 dyne/cm², and a 2-fold increase from shear stress 8 to 15 dyne/cm².</div></div><div><h3>Conclusions</h3><div>High mechanical stress combined with inflammatory triggers can cause excessive production of cytokines and proteolytic enzymes. Knowledge of how SFBs respond to increasing shear stress contributes to understanding the pathophysiology of OA, in which intra-articular pressure is often elevated, and may contribute to the discovery of potentially effective therapeutic agents.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No significant differences in patient-reported outcome measures in men vs women following tibial tubercle osteotomy","authors":"Ava G. Neijna,&nbsp;Julia S. Retzky,&nbsp;Andreas H. Gomoll,&nbsp;Sabrina M. Strickland","doi":"10.1016/j.jcjp.2024.100231","DOIUrl":"10.1016/j.jcjp.2024.100231","url":null,"abstract":"<div><h3>Introduction</h3><div>Sex is known to play a critical role in orthopedic surgery, but there is limited information describing the role that sex plays in outcomes following tibial tubercle osteotomy (TTO).</div></div><div><h3>Objective</h3><div>This study aimed to determine if there are any differences in patient-reported outcome measures (PROMs) between men and women following TTO.</div></div><div><h3>Methods</h3><div>A retrospective review of all patients at a single institution who underwent a primary TTO by two sports medicine fellowship-trained orthopedic surgeons between May 2015 and December 2022 was performed. Patients undergoing a primary TTO with pre- and postoperative PROMs were included. Patients with less than 1 year of follow-up were excluded. A two-sample <em>t</em> test with equal variances was performed for statistical analysis of PROMs. Two-sample Wilcoxon rank-sum statistical analysis was completed to compare operative age and body mass index (BMI).</div></div><div><h3>Results</h3><div>One hundred and twenty-two patients were included (<em>n</em> = 134 knees), with 102 female knees (76%), a median age of 31.4 [interquartile range [IQR]: 23.0, 36.4], and a median BMI of 24.3 [IQR: 22.1, 28.6]. There was no difference between the male and female cohorts with respect to age (<em>P</em> = .21), though males had a higher BMI (<em>P</em> = .044). There were no differences in preoperative, postoperative, or changes preoperatively and postoperatively in International Knee Documentation Committee (IKDC), Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain, KOOS Symptoms, KOOS Activities of Daily Living, KOOS Quality of Life, and KOOS Sport scores between men and women (<em>P</em> &gt; .05 for all).</div></div><div><h3>Conclusions</h3><div>There are no differences between men and women with respect to the preoperative, postoperative, or change in IKDC, KOOS Pain, KOOS Symptoms, KOOS Activities of Daily Living, KOOS Quality of Life, and KOOS Sport scores following TTO.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single vs triple injections of platelet-rich plasma in patients with knee osteoarthritis: a retrospective cohort study of 80 patients","authors":"Ülkü Dönmez ,&nbsp;Onur Engin","doi":"10.1016/j.jcjp.2024.100232","DOIUrl":"10.1016/j.jcjp.2024.100232","url":null,"abstract":"<div><h3>Introduction</h3><div>Osteoarthritis (OA) is a prevalent degenerative joint disorder that significantly impairs quality of life. Platelet-rich plasma (PRP) has emerged as a promising treatment option for managing symptoms of knee osteoarthritis.</div></div><div><h3>Objectives</h3><div>The aim of this study is to compare the effects of triple versus single PRP injections on pain and quality of life in individuals with knee osteoarthritis.</div></div><div><h3>Methods</h3><div>The files of 40 patients who received a single dose of PRP and 40 patients who received three doses of PRP for the treatment of knee osteoarthritis were retrospectively examined. Patients had been evaluated before the treatment and at their 6 month follow up with a Visual Analog Scale (VAS) and The Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index.</div></div><div><h3>Results</h3><div>At the 6-month examinations, there was a statistically significant decrease in the WOMAC total (single, from 64.7 ± 13.2 to 54.4 ± 17.2, <em>P</em> = .001; triple, from 67.0 ± 14.7 to 45.4 ± 19.2, <em>P</em> = .001), and VAS scores (single, from 7.1 ± 1.0 to 5.10 ± 2.0, <em>P</em> = .002; and triple, from 7.3 ± 1.0 to 3.7 ± 2.2, <em>P</em> = .001) of both the single and triple injection groups compared to the baseline. WOMAC total (<em>P</em> = .03) and VAS scores (<em>P</em> = .006) of the triple injection group were significantly better but there was no significant difference in WOMAC pain (<em>P</em> = .06), WOMAC physical (<em>P</em> = .06) and WOMAC stiffness (0.08) subscales.</div></div><div><h3>Conclusions</h3><div>This research revealed that triple PRP injections are more effective than single injections at improving functional outcomes. Furthermore, the potential to alleviate pain may be greater with multiple injections; however, this effect was not consistently observed across all pain evaluation metrics.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}