Journal of Cartilage & Joint Preservation最新文献

{"title":"ICRS Fellowships and the importance of fostering scientific community","authors":"James G. Jefferies , Özgür Basal , Jure Serdar , Giuseppe Filardo","doi":"10.1016/j.jcjp.2025.100234","DOIUrl":"10.1016/j.jcjp.2025.100234","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis","authors":"Andrew S. Bi ,&nbsp;Udit Dave ,&nbsp;Trevor Poulson ,&nbsp;Jared Rubin ,&nbsp;Nicole Chang ,&nbsp;Zeeshan A. Khan ,&nbsp;Nicholas J. Lemme ,&nbsp;Jorge Chahla ,&nbsp;Adam B. Yanke ,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2025.100235","DOIUrl":"10.1016/j.jcjp.2025.100235","url":null,"abstract":"<div><h3>Background</h3><div>Meniscal allograft transplantation (MAT) aims to restore meniscal deficiency with cadaveric meniscal tissue.</div></div><div><h3>Objectives</h3><div>To compare MAT survivorship and conversion to arthroplasty in patients &lt;40 and ≥40 years old.</div></div><div><h3>Data sources</h3><div>Pubmed, Embase, Cochrane databases.</div></div><div><h3>Study eligibility criteria</h3><div>Studies were included if they evaluated medial or lateral MAT, evaluated survivorship or conversion to arthroplasty, reported mean patient age, and were published after 2004.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>Patient cohorts were sorted into 2 groups where mean age was lesser or greater than 40<!--> <!-->years. Data were pooled with the DerSimonian-Laird random-effects model.</div></div><div><h3>Results</h3><div>A total of 1436 studies were identified, 41 included. Each study had MINORS score ≥9 indicating low risk of bias. There were 4079 patients (59.4% male) in the &lt;40-year cohort, with mean-weighted age 31.3<!--> <!-->years, follow-up 6.4<!--> <!-->years. There were 625 patients (66.9% male) in the ≥40-year cohort, with mean-weighted age 41.2<!--> <!-->years, follow-up 8.0<!--> <!-->years. Older patients had significantly more medial MATs (300; 61.9% vs 1746; 48.4%). Patients &lt;40 had weighted mean survivorship 76.3% (95% CI: 69.1%-83.5%) and conversion rate 5.0% (95% CI: 3.5%-6.6%). Patients ≥40 had weighted mean survivorship 72.1% (95% CI: 46.9%-97.3%) and conversion rate 13.1% (95% CI: 4.2%-22.0%).</div></div><div><h3>Limitations</h3><div>Unavailability of individual data sets.</div></div><div><h3>Conclusions</h3><div>There appears to be no significant differences in MAT survivorship or conversion to arthroplasty rates in patients &lt;40 and ≥40 in appropriately indicated patients that have concomitant pathology addressed. Older patients undergoing MAT have a higher rate of medial MAT compared with younger cohorts.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of fluid flow-induced shear stress on the behavior of synovial fibroblasts in a bioinspired synovium-on-chip model","authors":"Susanna Piluso ,&nbsp;Yang Li ,&nbsp;Liliana Moreira Texeira ,&nbsp;Prasanna Padmanaban ,&nbsp;Jeroen Rouwkema ,&nbsp;Jeroen Leijten ,&nbsp;René van Weeren ,&nbsp;Marcel Karperien ,&nbsp;Jos Malda","doi":"10.1016/j.jcjp.2025.100233","DOIUrl":"10.1016/j.jcjp.2025.100233","url":null,"abstract":"<div><h3>Introduction</h3><div>Due to the loading of the articular joints and the movement of the joint itself, mechanical stress is constantly exerted on the synovial cavity, which is, in turn, reflected as shear stress toward the surrounding tissues, including the synovium. Although it is known that synovial cells are sensitive to various mechanical cues, deeper understanding on how synovial fibroblasts (SFBs) respond to increased shear stress is required to gain insights on its role in the pathophysiology of osteoarthritis (OA).</div></div><div><h3>Objectives</h3><div>A synovium-on-chip model was developed to evaluate the effect of fluid flow-induced shear stress on fibroblast-like synoviocytes, and to assess the similarities with synovial inflammation during OA.</div></div><div><h3>Methods</h3><div>Patient-derived SFBs were exposed to a shear stress of 3, 8, and 15 dyne/cm² for up to 72 hours. Production of TNFα, IL-6, MMPs, and lubricin by synovial cells was analyzed.</div></div><div><h3>Results</h3><div>The levels of TNFα, IL-6, and degradative enzymes increased over time when synovial cells were exposed to a shear stress of 8 dyne/cm². In the first 8 hours, a 5-fold increase in the level of TNFα was observed when the shear stress increased from 3 to 8 dyne/cm², and a 2-fold increase from shear stress 8 to 15 dyne/cm².</div></div><div><h3>Conclusions</h3><div>High mechanical stress combined with inflammatory triggers can cause excessive production of cytokines and proteolytic enzymes. Knowledge of how SFBs respond to increasing shear stress contributes to understanding the pathophysiology of OA, in which intra-articular pressure is often elevated, and may contribute to the discovery of potentially effective therapeutic agents.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No significant differences in patient-reported outcome measures in men vs women following tibial tubercle osteotomy","authors":"Ava G. Neijna,&nbsp;Julia S. Retzky,&nbsp;Andreas H. Gomoll,&nbsp;Sabrina M. Strickland","doi":"10.1016/j.jcjp.2024.100231","DOIUrl":"10.1016/j.jcjp.2024.100231","url":null,"abstract":"<div><h3>Introduction</h3><div>Sex is known to play a critical role in orthopedic surgery, but there is limited information describing the role that sex plays in outcomes following tibial tubercle osteotomy (TTO).</div></div><div><h3>Objective</h3><div>This study aimed to determine if there are any differences in patient-reported outcome measures (PROMs) between men and women following TTO.</div></div><div><h3>Methods</h3><div>A retrospective review of all patients at a single institution who underwent a primary TTO by two sports medicine fellowship-trained orthopedic surgeons between May 2015 and December 2022 was performed. Patients undergoing a primary TTO with pre- and postoperative PROMs were included. Patients with less than 1 year of follow-up were excluded. A two-sample <em>t</em> test with equal variances was performed for statistical analysis of PROMs. Two-sample Wilcoxon rank-sum statistical analysis was completed to compare operative age and body mass index (BMI).</div></div><div><h3>Results</h3><div>One hundred and twenty-two patients were included (<em>n</em> = 134 knees), with 102 female knees (76%), a median age of 31.4 [interquartile range [IQR]: 23.0, 36.4], and a median BMI of 24.3 [IQR: 22.1, 28.6]. There was no difference between the male and female cohorts with respect to age (<em>P</em> = .21), though males had a higher BMI (<em>P</em> = .044). There were no differences in preoperative, postoperative, or changes preoperatively and postoperatively in International Knee Documentation Committee (IKDC), Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain, KOOS Symptoms, KOOS Activities of Daily Living, KOOS Quality of Life, and KOOS Sport scores between men and women (<em>P</em> &gt; .05 for all).</div></div><div><h3>Conclusions</h3><div>There are no differences between men and women with respect to the preoperative, postoperative, or change in IKDC, KOOS Pain, KOOS Symptoms, KOOS Activities of Daily Living, KOOS Quality of Life, and KOOS Sport scores following TTO.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single vs triple injections of platelet-rich plasma in patients with knee osteoarthritis: a retrospective cohort study of 80 patients","authors":"Ülkü Dönmez ,&nbsp;Onur Engin","doi":"10.1016/j.jcjp.2024.100232","DOIUrl":"10.1016/j.jcjp.2024.100232","url":null,"abstract":"<div><h3>Introduction</h3><div>Osteoarthritis (OA) is a prevalent degenerative joint disorder that significantly impairs quality of life. Platelet-rich plasma (PRP) has emerged as a promising treatment option for managing symptoms of knee osteoarthritis.</div></div><div><h3>Objectives</h3><div>The aim of this study is to compare the effects of triple versus single PRP injections on pain and quality of life in individuals with knee osteoarthritis.</div></div><div><h3>Methods</h3><div>The files of 40 patients who received a single dose of PRP and 40 patients who received three doses of PRP for the treatment of knee osteoarthritis were retrospectively examined. Patients had been evaluated before the treatment and at their 6 month follow up with a Visual Analog Scale (VAS) and The Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index.</div></div><div><h3>Results</h3><div>At the 6-month examinations, there was a statistically significant decrease in the WOMAC total (single, from 64.7 ± 13.2 to 54.4 ± 17.2, <em>P</em> = .001; triple, from 67.0 ± 14.7 to 45.4 ± 19.2, <em>P</em> = .001), and VAS scores (single, from 7.1 ± 1.0 to 5.10 ± 2.0, <em>P</em> = .002; and triple, from 7.3 ± 1.0 to 3.7 ± 2.2, <em>P</em> = .001) of both the single and triple injection groups compared to the baseline. WOMAC total (<em>P</em> = .03) and VAS scores (<em>P</em> = .006) of the triple injection group were significantly better but there was no significant difference in WOMAC pain (<em>P</em> = .06), WOMAC physical (<em>P</em> = .06) and WOMAC stiffness (0.08) subscales.</div></div><div><h3>Conclusions</h3><div>This research revealed that triple PRP injections are more effective than single injections at improving functional outcomes. Furthermore, the potential to alleviate pain may be greater with multiple injections; however, this effect was not consistently observed across all pain evaluation metrics.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis and systematic review of the outcome of reparative strategies for the treatment of deep joint defects of the knee in adult patients","authors":"Pieter Berger ,&nbsp;Luis F. Mendes ,&nbsp;Pieter J. Emans ,&nbsp;Roel J.H. Custers ,&nbsp;Frank P. Luyten","doi":"10.1016/j.jcjp.2024.100229","DOIUrl":"10.1016/j.jcjp.2024.100229","url":null,"abstract":"<div><h3>Introduction</h3><div>Deep joint surface defects, affecting both full-depth articular cartilage and a substantial part of subchondral bone, remain a therapeutic challenge. If left untreated, they often lead to symptomatic osteoarthritic disease and joint failure. As new treatment strategies continue to emerge, it is essential to critically evaluate existing approaches. This study aims to compare the clinical outcomes and failure rates of various surgical strategies based on current literature.</div></div><div><h3>Methods</h3><div>An analysis was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, focusing on clinical outcomes of treatments for deep osteochondral defects in the human knee. Studies from PubMed, Web of Science, and Embase were reviewed, selecting those with at least 10 adult patients and a minimum of 24-month follow-up. Quality appraisal was conducted using a modified Coleman score. Data extraction, pooling, and analysis were performed independently. The review assessed descriptive data, clinical outcomes, and failure rates of the included studies.</div></div><div><h3>Results</h3><div>Seventeen prospective cohort studies or case series and 31 retrospective studies comprising a total of 1861 patients were eligible for analysis. Overall quality of the included studies was low. The most commonly used treatment strategies were the sandwich technique, osteochondral autografts, osteochondral allografts, and scaffolds, all showing moderate treatment effects on mid- to long-term, independent from the outcome measurement tool used. Failure rates in these treatment groups varied from 0% to 38.1%.</div></div><div><h3>Conclusions</h3><div>Recommending one treatment over another for deep joint surface defects remains challenging due to various elements among which long-term sustainability is a critical one. Additional data from patient registries may offer a more representative view of daily clinical practice, which is valuable for tailoring treatments to individual patients.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors for response to viscosupplementation in patients with knee osteoarthritis: an analysis of clinical and imaging factors","authors":"Gustavo Rossanese Pinto ,&nbsp;Guilherme Conforto Gracitelli ,&nbsp;Fernando Cury Rezende ,&nbsp;Claudio Gattas ,&nbsp;Thais Cristina Pereira Vasques ,&nbsp;Flavio Duarte Silva ,&nbsp;Carlos Eduardo da Silveira Franciozi ,&nbsp;Marcus Vinicius Malheiros Luzo","doi":"10.1016/j.jcjp.2024.100181","DOIUrl":"10.1016/j.jcjp.2024.100181","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite the widespread use of viscosupplementation (VS) in the treatment of knee arthritis, the factors that may influence its effectiveness or failure are still controversial and little explored in the literature.</div></div><div><h3>Objectives</h3><div>To identify clinical, radiographic, and magnetic resonance imaging predictive factors associated with VS failure in the treatment of knee osteoarthritis.</div></div><div><h3>Methods</h3><div>In this prospective study, patients with knee osteoarthritis were evaluated for predictive factors before the intervention, including radiographic images (Kellgren-Lawrence [KL] classification and femorotibial angle), magnetic resonance images Osteoarthritis Knee Score (MOAKS) and meniscal extrusion, joint effusion, body mass index, previous surgery, sex, and age. All patients received a single intra-articular dose of Synolis-VA 4 mL (80 mg hyaluronic acid<!--> <!-->+<!--> <!-->160 mg sorbitol). The WOMAC (Western Ontario Mcmaster Universities Arthritis Index), Visual Analog Scale, and SF-12v2 questionnaires were administered at baseline, 15<!--> <!-->days, 3<!--> <!-->months, and 6<!--> <!-->months of clinical follow-up.</div></div><div><h3>Results</h3><div>The results showed a significant reduction in WOMAC and Visual Analog Scale scores for all evaluated times after VS compared to baseline. Using the OMERACT-OARSI (Outcome Measures in Rheumatoid Arthritis Clinical Trials-Osteoarthritis Research Society International) criteria, 53 patients were classified as the \"success group\" and 55 patients as the \"failure group.\" The KL classification and MOAKS score showed a significant difference between these 2 groups, <em>P</em> = .042 and <em>P</em> = .009, respectively. Univariate logistic regression analysis revealed that a KL classification of 3 or 4 and MOAKS score predicted a higher risk of failure.</div></div><div><h3>Conclusions</h3><div>Patients with a KL classification of 3 or 4 or a high MOAKS score were more likely to fail VS, while the other analyzed factors showed no significant difference.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome to the final issue of JCJP 2024","authors":"Miranda Manfre,&nbsp;Rachel M. Frank","doi":"10.1016/j.jcjp.2024.100225","DOIUrl":"10.1016/j.jcjp.2024.100225","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articular cartilage debridement results in short-term significant improvements in patient-reported outcomes for large areas of cartilage loss of the femur in the setting of mild to moderate knee osteoarthritis","authors":"Yusuf Mufti,&nbsp;Jared P. Sachs,&nbsp;Andrew S. Bi,&nbsp;Chloe Franzia,&nbsp;John Ebersole,&nbsp;Taylor Giordano,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2024.100221","DOIUrl":"10.1016/j.jcjp.2024.100221","url":null,"abstract":"<div><h3>Introduction</h3><div>Chondroplasty is a surgical option for chondral defects, but its effect on larger cartilage defects in the setting of knee osteoarthritis remains unclear.</div></div><div><h3>Objectives</h3><div>This study aims to evaluate patient-reported outcomes (PROs) following chondroplasty in patients with larger chondral defects (≥2 cm²) of the femur in the setting of osteoarthritis.</div></div><div><h3>Materials and methods</h3><div>Retrospective review of patients who underwent chondroplasty of the femur. All patients had Kellgren-Lawrence (KL) grades of 2 or 3 and a minimum of 1-year postoperative follow-up. Chondral loss was estimated by arthroscopic measurements and by Magnetic Resonance Imaging (MRI). PROs included the International Knee Documentation Committee, Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, and the Veterans Rand-12 Item. Statistical analysis was performed using paired <em>t</em> tests to compare baseline and follow-up data, as well as linear regressions to correlate lesion size with symptom improvement.</div></div><div><h3>Results</h3><div>39 patients with 20 KL grade 2 and 19 KL grade 3 knees were included. At both 1- and 2-year follow-ups, significant improvements were noted in International Knee Documentation Committee (34.9 ± 13.5 preoperative, 55.6 ± 18.8 at 2 years, <em>P</em> = .0025), Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (56.3 ± 14.7 preoperative, 64.5 ± 17.0 at 2 years, <em>P</em> = .0243), and Veterans Rand-12 Item Physical Component Scores (38.0 ± 12.7 preoperative, 43.8 ± 8.6 at 2 years, <em>P</em> = .0044). Four (10.3%) conversions to arthroplasty were noted at most recent follow-up.</div></div><div><h3>Conclusions</h3><div>Articular cartilage debridement for large areas of cartilage loss of the femur in the setting of mild to moderate osteoarthritis results in significant improvements in physical function and knee-specific PROs at 1- and 2-year follow-ups.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical potential of meniscal progenitor cells","authors":"Wan-Ting Yan ,&nbsp;Jing-Song Wang ,&nbsp;Peng-Zhou Fan ,&nbsp;Sally Roberts ,&nbsp;Karina Wright ,&nbsp;Zheng-Zheng Zhang","doi":"10.1016/j.jcjp.2024.100166","DOIUrl":"10.1016/j.jcjp.2024.100166","url":null,"abstract":"<div><h3>Introduction</h3><div>The meniscus is an important cushioning structure of the knee joint, with the maintenance of its normal structure and function playing a crucial role in protecting the joint from early degeneration. Stem/progenitor cells could be the key to help researchers to have a deeper understanding of the biological process of meniscal injury repair and may be important in the meniscus tissue regeneration processes. To the best of our knowledge, there is currently a lack of comprehensive reviews on existing research about the meniscus progenitor cells (MPCs).</div></div><div><h3>Objectives</h3><div>By reviewing the existing MPC literature, we aim to provide insights for future research on meniscus regeneration.</div></div><div><h3>Methods</h3><div>The isolation methods, biological characteristics and the translational application of MPCs were summarized.</div></div><div><h3>Results</h3><div>MPCs could be isolated according to their colony-forming ability, marker expression, migration ability, and differential adhesion to fibronectin. Most existing studies on surface markers of MPCs have largely followed the paradigm of mesenchymal stromal/stem cell research. Based on the information provided by their surface markers and expression profile, researchers located MPCs in the peripheral surface area of the meniscus. Few researches have investigated the translation and application of MPCs, with most studies being limited to MPCs extraction and subsequent reimplantation in vivo.</div></div><div><h3>Conclusions</h3><div>MPCs are a group of meniscus-resident cells, which exhibit certain stem/progenitor cell characteristics, such as the ability to undergo multilineage differentiation in in vitro culture.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}