Journal of Cartilage & Joint Preservation最新文献

{"title":"Lateral meniscal allograft transplantation with concomitant osteochondral allograft of the lateral femoral condyle and trochlea: a mid-term outcome case report","authors":"Molly Canfield,&nbsp;Katie McMorrow,&nbsp;Andrew S. Bi,&nbsp;Joshua Wright-Chisem,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2024.100230","DOIUrl":"10.1016/j.jcjp.2024.100230","url":null,"abstract":"<div><h3>Introduction</h3><div>Meniscal deficiency and osteochondral defects of the knee are difficult pathologies to treat in isolation for knee preservationists. In conjunction, surgical treatment options may appear limited or daunting; however recent literature has demonstrated the feasibility of performing both meniscal allograft transplantation and osteochondral allograft in the same surgical setting.</div></div><div><h3>Case presentation</h3><div>In this case report, we present a 31-year-old male who underwent lateral meniscal allograft transplantation with concomitant osteochondral allograft of both the lateral trochlea and lateral femoral condyle, including surgical technique, postoperative rehabilitation, and 8-year clinical follow-up with patient-reported outcomes.</div></div><div><h3>Conclusion</h3><div>Concomitant lateral meniscal allograft transplantation and double osteochondral allograft procedures demonstrate promising clinical outcomes and graft incorporation, as evidenced by an 8-year follow-up showing excellent graft survival and favorable patient-reported outcomes. This case highlights the potential of combined surgical approaches as a feasible option for addressing meniscal deficiency and multiple osteochondral defects of the knee.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 3","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis and systematic review of the outcome of reparative strategies for the treatment of deep joint defects of the knee in adult patients","authors":"Pieter Berger ,&nbsp;Luis F. Mendes ,&nbsp;Pieter J. Emans ,&nbsp;Roel J.H. Custers ,&nbsp;Frank P. Luyten","doi":"10.1016/j.jcjp.2024.100229","DOIUrl":"10.1016/j.jcjp.2024.100229","url":null,"abstract":"<div><h3>Introduction</h3><div>Deep joint surface defects, affecting both full-depth articular cartilage and a substantial part of subchondral bone, remain a therapeutic challenge. If left untreated, they often lead to symptomatic osteoarthritic disease and joint failure. As new treatment strategies continue to emerge, it is essential to critically evaluate existing approaches. This study aims to compare the clinical outcomes and failure rates of various surgical strategies based on current literature.</div></div><div><h3>Methods</h3><div>An analysis was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, focusing on clinical outcomes of treatments for deep osteochondral defects in the human knee. Studies from PubMed, Web of Science, and Embase were reviewed, selecting those with at least 10 adult patients and a minimum of 24-month follow-up. Quality appraisal was conducted using a modified Coleman score. Data extraction, pooling, and analysis were performed independently. The review assessed descriptive data, clinical outcomes, and failure rates of the included studies.</div></div><div><h3>Results</h3><div>Seventeen prospective cohort studies or case series and 31 retrospective studies comprising a total of 1861 patients were eligible for analysis. Overall quality of the included studies was low. The most commonly used treatment strategies were the sandwich technique, osteochondral autografts, osteochondral allografts, and scaffolds, all showing moderate treatment effects on mid- to long-term, independent from the outcome measurement tool used. Failure rates in these treatment groups varied from 0% to 38.1%.</div></div><div><h3>Conclusions</h3><div>Recommending one treatment over another for deep joint surface defects remains challenging due to various elements among which long-term sustainability is a critical one. Additional data from patient registries may offer a more representative view of daily clinical practice, which is valuable for tailoring treatments to individual patients.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors for response to viscosupplementation in patients with knee osteoarthritis: an analysis of clinical and imaging factors","authors":"Gustavo Rossanese Pinto ,&nbsp;Guilherme Conforto Gracitelli ,&nbsp;Fernando Cury Rezende ,&nbsp;Claudio Gattas ,&nbsp;Thais Cristina Pereira Vasques ,&nbsp;Flavio Duarte Silva ,&nbsp;Carlos Eduardo da Silveira Franciozi ,&nbsp;Marcus Vinicius Malheiros Luzo","doi":"10.1016/j.jcjp.2024.100181","DOIUrl":"10.1016/j.jcjp.2024.100181","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite the widespread use of viscosupplementation (VS) in the treatment of knee arthritis, the factors that may influence its effectiveness or failure are still controversial and little explored in the literature.</div></div><div><h3>Objectives</h3><div>To identify clinical, radiographic, and magnetic resonance imaging predictive factors associated with VS failure in the treatment of knee osteoarthritis.</div></div><div><h3>Methods</h3><div>In this prospective study, patients with knee osteoarthritis were evaluated for predictive factors before the intervention, including radiographic images (Kellgren-Lawrence [KL] classification and femorotibial angle), magnetic resonance images Osteoarthritis Knee Score (MOAKS) and meniscal extrusion, joint effusion, body mass index, previous surgery, sex, and age. All patients received a single intra-articular dose of Synolis-VA 4 mL (80 mg hyaluronic acid<!--> <!-->+<!--> <!-->160 mg sorbitol). The WOMAC (Western Ontario Mcmaster Universities Arthritis Index), Visual Analog Scale, and SF-12v2 questionnaires were administered at baseline, 15<!--> <!-->days, 3<!--> <!-->months, and 6<!--> <!-->months of clinical follow-up.</div></div><div><h3>Results</h3><div>The results showed a significant reduction in WOMAC and Visual Analog Scale scores for all evaluated times after VS compared to baseline. Using the OMERACT-OARSI (Outcome Measures in Rheumatoid Arthritis Clinical Trials-Osteoarthritis Research Society International) criteria, 53 patients were classified as the \"success group\" and 55 patients as the \"failure group.\" The KL classification and MOAKS score showed a significant difference between these 2 groups, <em>P</em> = .042 and <em>P</em> = .009, respectively. Univariate logistic regression analysis revealed that a KL classification of 3 or 4 and MOAKS score predicted a higher risk of failure.</div></div><div><h3>Conclusions</h3><div>Patients with a KL classification of 3 or 4 or a high MOAKS score were more likely to fail VS, while the other analyzed factors showed no significant difference.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome to the final issue of JCJP 2024","authors":"Miranda Manfre,&nbsp;Rachel M. Frank","doi":"10.1016/j.jcjp.2024.100225","DOIUrl":"10.1016/j.jcjp.2024.100225","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articular cartilage debridement results in short-term significant improvements in patient-reported outcomes for large areas of cartilage loss of the femur in the setting of mild to moderate knee osteoarthritis","authors":"Yusuf Mufti,&nbsp;Jared P. Sachs,&nbsp;Andrew S. Bi,&nbsp;Chloe Franzia,&nbsp;John Ebersole,&nbsp;Taylor Giordano,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2024.100221","DOIUrl":"10.1016/j.jcjp.2024.100221","url":null,"abstract":"<div><h3>Introduction</h3><div>Chondroplasty is a surgical option for chondral defects, but its effect on larger cartilage defects in the setting of knee osteoarthritis remains unclear.</div></div><div><h3>Objectives</h3><div>This study aims to evaluate patient-reported outcomes (PROs) following chondroplasty in patients with larger chondral defects (≥2 cm²) of the femur in the setting of osteoarthritis.</div></div><div><h3>Materials and methods</h3><div>Retrospective review of patients who underwent chondroplasty of the femur. All patients had Kellgren-Lawrence (KL) grades of 2 or 3 and a minimum of 1-year postoperative follow-up. Chondral loss was estimated by arthroscopic measurements and by Magnetic Resonance Imaging (MRI). PROs included the International Knee Documentation Committee, Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, and the Veterans Rand-12 Item. Statistical analysis was performed using paired <em>t</em> tests to compare baseline and follow-up data, as well as linear regressions to correlate lesion size with symptom improvement.</div></div><div><h3>Results</h3><div>39 patients with 20 KL grade 2 and 19 KL grade 3 knees were included. At both 1- and 2-year follow-ups, significant improvements were noted in International Knee Documentation Committee (34.9 ± 13.5 preoperative, 55.6 ± 18.8 at 2 years, <em>P</em> = .0025), Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (56.3 ± 14.7 preoperative, 64.5 ± 17.0 at 2 years, <em>P</em> = .0243), and Veterans Rand-12 Item Physical Component Scores (38.0 ± 12.7 preoperative, 43.8 ± 8.6 at 2 years, <em>P</em> = .0044). Four (10.3%) conversions to arthroplasty were noted at most recent follow-up.</div></div><div><h3>Conclusions</h3><div>Articular cartilage debridement for large areas of cartilage loss of the femur in the setting of mild to moderate osteoarthritis results in significant improvements in physical function and knee-specific PROs at 1- and 2-year follow-ups.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical potential of meniscal progenitor cells","authors":"Wan-Ting Yan ,&nbsp;Jing-Song Wang ,&nbsp;Peng-Zhou Fan ,&nbsp;Sally Roberts ,&nbsp;Karina Wright ,&nbsp;Zheng-Zheng Zhang","doi":"10.1016/j.jcjp.2024.100166","DOIUrl":"10.1016/j.jcjp.2024.100166","url":null,"abstract":"<div><h3>Introduction</h3><div>The meniscus is an important cushioning structure of the knee joint, with the maintenance of its normal structure and function playing a crucial role in protecting the joint from early degeneration. Stem/progenitor cells could be the key to help researchers to have a deeper understanding of the biological process of meniscal injury repair and may be important in the meniscus tissue regeneration processes. To the best of our knowledge, there is currently a lack of comprehensive reviews on existing research about the meniscus progenitor cells (MPCs).</div></div><div><h3>Objectives</h3><div>By reviewing the existing MPC literature, we aim to provide insights for future research on meniscus regeneration.</div></div><div><h3>Methods</h3><div>The isolation methods, biological characteristics and the translational application of MPCs were summarized.</div></div><div><h3>Results</h3><div>MPCs could be isolated according to their colony-forming ability, marker expression, migration ability, and differential adhesion to fibronectin. Most existing studies on surface markers of MPCs have largely followed the paradigm of mesenchymal stromal/stem cell research. Based on the information provided by their surface markers and expression profile, researchers located MPCs in the peripheral surface area of the meniscus. Few researches have investigated the translation and application of MPCs, with most studies being limited to MPCs extraction and subsequent reimplantation in vivo.</div></div><div><h3>Conclusions</h3><div>MPCs are a group of meniscus-resident cells, which exhibit certain stem/progenitor cell characteristics, such as the ability to undergo multilineage differentiation in in vitro culture.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139966021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes from the synovial microenvironment in joint homeostasis and osteoarthritis","authors":"Pooja N. Swami ,&nbsp;Henintsoa Fanjaniaina Andriamifidy ,&nbsp;Shabirul Haque ,&nbsp;Timothy Reed ,&nbsp;Azhar Khan ,&nbsp;Daniel A. Grande","doi":"10.1016/j.jcjp.2024.100220","DOIUrl":"10.1016/j.jcjp.2024.100220","url":null,"abstract":"<div><h3>Introduction</h3><div>Orthobiologics, such as mesenchymal stem cells (MSCs), known for their multipotency, are key players in stem cell therapy. One of the ways MSCs realize their therapeutic potential is through the release of extracellular vesicles (EVs), small lipid-membrane–bound structures that carry bioactive materials from their progenitor cells.</div></div><div><h3>Objectives</h3><div>This review aims to provide an overview of EVs in and from the synovial joint in both physiological and pathological context specifically in osteoarthritis.</div></div><div><h3>Methods</h3><div>This narrative review synthesizes findings from PubMed using keywords—orthobiologics, EVs, synovial joint EVs, osteoarthritis, and synovial fluid. This review focuses on the potential of EVs isolated from different sources of MSCs found in the synovial joint, evaluating their differentiation capacity and contributions to joint health and osteoarthritis.</div></div><div><h3>Results</h3><div>EVs from various MSC types show promising results for osteochondral regeneration. However, the differentiation potential and therapeutic efficacy vary among cell types. Understanding the dynamic nature of the biological function of these cell types that serve as sources of EVs is essential for predicting their therapeutic actions. The synovium itself is identified as a significant source of EVs, which may offer unique applications for treating osteoarthritis and cartilage defects.</div></div><div><h3>Conclusions</h3><div>EVs and exosomes play a critical role in cartilage and osteochondral defect repair. They exhibit preservative and restorative benefits for tissue injuries, highlighting their potential in treating osteoarthritis and cartilage defects. Additionally, the synovium, as a source of EVs and exosomes, presents unique therapeutic applications as orthobiologic.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee valgus deformity: indications and outcomes for a high tibial medial closing-wedge osteotomy","authors":"Clayton W. Nuelle,&nbsp;João Bourbon de Albuquerque II,&nbsp;Maurício Kfuri","doi":"10.1016/j.jcjp.2024.100212","DOIUrl":"10.1016/j.jcjp.2024.100212","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditionally, knee valgus deformities have been corrected through distal femur osteotomies. The advances in preoperative planning allow surgeons to understand the leading site of deformity better and, therefore, propose corrections at the appropriate anatomical location.</div></div><div><h3>Objectives</h3><div>The purpose of this evaluation is to present a case of a knee valgus deformity where most of the deformity resulted from the joint and the proximal tibia. A medial closing wedge tibial osteotomy corrected the proximal tibia deformity, while a fresh osteochondral allograft aimed to improve the surface of the lateral compartment of the knee, optimizing the joint lateral convergence angle. In addition, indications, outcomes and a scoping review of the literature for closing wedge high tibial osteotomy for knee valgus deformity is reviewed.</div></div><div><h3>Methods</h3><div>A clinical case report example of a patient with knee valgus deformity requiring closing wedge high tibial osteotomy is presented. Detailed discussion of preoperative templating, planning and surgical completion is reviewed. A systematic review of previous studies and outcomes after closing wedge high tibial osteotomy was undertaken and summarized.</div></div><div><h3>Results</h3><div>The case presented demonstrates an example of a valgus knee deformity with alignment correction vis a proximal tibial ostetomy. A review of and summary of previous case reports and outcomes studies for similar pathology demonstrates a high degree of success for this surgical approach.</div></div><div><h3>Conclusions</h3><div>Closing wedge high tibial osteotomy is a viable treatment option for knee valgus deformity with an abnormal mechanical medial proximal tibial angle (mMPTA). A thorough evaluation of joint orientation angles is necessary to appropriately address limb deformity at the specific locations(s) of significant anatomic abnormality.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very-high-molecular-weight vs high-molecular-weight hyaluronic acid injections show long-term sustained benefits in the treatment of osteoarthritis of the knee: a 15-year Indian cohort study","authors":"Anish Kumar Aggarwal ,&nbsp;Nakul Aggarwal ,&nbsp;Jane Fitzpatrick","doi":"10.1016/j.jcjp.2024.100213","DOIUrl":"10.1016/j.jcjp.2024.100213","url":null,"abstract":"<div><h3>Introduction</h3><div>Lack of confidence in intra-articular hyaluronic acid injections for osteoarthritis (OA) may result from conflicting guidelines and pooling of results for different molecular weight products.</div></div><div><h3>Objectives</h3><div>The objectives were to determine responder rates to injections of very-high-molecular-weight hyaluronic acid (VHMW-HA) vs high-molecular-weight hyaluronic acid (HMW-HA) for knee OA and treatment efficacy measured by the interval between follow-up injections.</div></div><div><h3>Methods</h3><div>A retrospective analysis of a 15-year cohort from a single center. Inclusion criteria: adults with Kellgren-Lawrence Grade III or IV knee OA treated with hyaluronic acid injections. Subjects were stratified into 2 groups based on the molecular weight of the hyaluronic acid. Outcome measures were responder rates with improvement in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores of &gt;30% from baseline vs nonresponders; those with a response lasting &gt;6 months after each injection were considered sustained responders.</div></div><div><h3>Results</h3><div>In total, 2037 (female 1467 [72.02%] and male 570 [27.98%]) patients were treated. The overall primary responder rate was 73.44% (1496). VHMW-HA had significantly higher primary responders (75.21% vs 70.22%, <em>P</em> = .015) and significantly lower nonresponders (24.79% vs 29.78%, <em>P</em> = .015). As a subset of primary responders, the sustained responders had greater responses with VHMW-HA vs HMW-HA (85.54% vs 67.06%, <em>P</em> &lt; .0001) and lower dropouts (14.46% vs 32.94%, <em>P</em> &lt; .0001). The average interval between the first and the third injections was longer for VHMW-HA vs HMW-HA—5.67 vs 1.95 years (<em>P</em> &lt; .0001).</div></div><div><h3>Conclusions</h3><div>About 73.44% of subjects responded to treatment with intra-articular hyaluronic acid. The sustained response was greater in VHMW-HA vs HMW-HA and VHMW-HA has a longer duration of effect than HMW-HA.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of the cellular content of platelet-rich plasma harvested after injection of filgrastim versus pegfilgrastim biosimilars: a prospective, single-center, crossover study","authors":"Mohammadreza Abbasian,&nbsp;Eric Branch,&nbsp;Ali Parsa,&nbsp;Jessica Truett,&nbsp;Joshua J. Cook,&nbsp;Charlkesha A. Rahming,&nbsp;Adam W. Anz","doi":"10.1016/j.jcjp.2024.100211","DOIUrl":"10.1016/j.jcjp.2024.100211","url":null,"abstract":"<div><h3>Introduction</h3><div>Hematopoietic stem cells (HSCs) appear in peripheral blood (PB) following mobilization due to external events or pharmaceutical agents like filgrastim and pegfilgrastim. Concentration of these into platelet-rich plasma (PRP) can be used in orthopedics.</div></div><div><h3>Objectives</h3><div>This prospective, single-center, controlled laboratory study aimed to compare safety profiles of filgrastim and pegfilgrastim administration, quantifying the cellular content of PRP derived from PB post-administration. We hypothesized comparable rates and severity of adverse events (AEs) among participants, along with similar cellular content in the PRP products.</div></div><div><h3>Methods</h3><div>Ten healthy male participants underwent a crossover design with 2 interventions separated by a washout period. PB was collected before and after each intervention, producing PRP for cellular comparison in vitro. AEs were monitored for severity and frequency throughout study.</div></div><div><h3>Results</h3><div>Significant AEs for filgrastim included fatigue (36%), myalgia (36%), and back pain (9.1%), compared to pegfilgrastim, which included myalgia (31%), fatigue (23%), and back pain (23%). There were no significant differences between AE occurrences (<em>P</em> = .49) nor relationship to study drug (<em>P</em> &gt; .99). Regarding total nucleated cell count (TNC), statistical significance was found in TNC count (<em>P</em> = .010) and TNC concentration (<em>P</em> = .004). All PRP products expressed high levels (&gt;88%) of hematopoietic progenitor cell/HSC-specific CD45+, CD34+, CD45dim+, and hematopoietic progenitor cell/HSC+ markers.</div></div><div><h3>Conclusions</h3><div>This study demonstrated that filgrastim and pegfilgrastim administration appear safe. Pegfilgrastim is equivalent to filgrastim for the mobilization of white blood cells and cells expressing hematopoietic cell-surface markers into the PB and consequently, into the derived PRP product.</div></div><div><h3>Clinical relevance</h3><div>This study presents pegfilgrastim as a single-injection alternative to filgrastim for the mobilization of HSCs into the PB and subsequent PB-derived PRP, which is more convenient and less invasive for patients.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 4","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}