Journal of Cartilage & Joint Preservation最新文献

{"title":"The role of Periostin as a biomarker of anterior cruciate ligament injury and potential therapeutic target to alleviate post-traumatic cartilage degeneration","authors":"","doi":"10.1016/j.jcjp.2024.100176","DOIUrl":"10.1016/j.jcjp.2024.100176","url":null,"abstract":"<div><h3>Introduction</h3><div>Periostin, a matricellular protein, has emerged as a potential biomarker for anterior cruciate ligament (ACL) injury and has been associated with cartilage degeneration and the development of post-traumatic osteoarthritis (PTOA).</div></div><div><h3>Objectives</h3><div>This review aims to comprehensively examine and synthesize the existing literature concerning the role of Periostin in the aftermath of ACL injury, particularly its involvement in subsequent cartilage degradation processes within the knee joint.</div></div><div><h3>Methods</h3><div>Conducting a scoping review, we systematically searched Medline, Scopus, and Embase, focusing on human and animal studies investigating Periostin in the context of ACL injury or PTOA.</div></div><div><h3>Results</h3><div>Analysis of Periostin expression in human synovial fluid and ACL tissue reveals distinctive temporal profiles, with peak levels observed at a minimum of 1-month post-ACL injury. In vitro data suggests that injured ACL tissue promotes Periostin expression in human chondrocytes. Animal studies demonstrate that recombinant Periostin application leads to increased cartilage degeneration, potentially mediated by enhanced Wnt signaling and MMP-13 expression. Conversely, Periostin knockdown studies indicate a mitigating effect on cartilage degradation.</div></div><div><h3>Conclusions</h3><div>Periostin exhibits robust associations with biomarkers of cartilage degeneration in humans and progression of osteoarthritis in animals. However, the precise impact of Periostin in the context of ACL injury and its potential causal relationship with the onset of PTOA remain uncertain.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140273379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative capacity of morselized cartilage in vitro and in an osteochondral defect model","authors":"","doi":"10.1016/j.jcjp.2024.100182","DOIUrl":"10.1016/j.jcjp.2024.100182","url":null,"abstract":"<div><h3>Introduction</h3><div>Numerous treatment modalities for focal articular cartilage defects exist. However, the use of consistent and reproducible minced cartilage morsels to heal these lesions, especially with a scaffold, has not been investigated.</div></div><div><h3>Objectives</h3><div>To investigate the effect of consistently sized minced cartilage morsels on the healing of focal articular cartilage defects.</div></div><div><h3>Methods</h3><div>Cartilage was harvested and morselized into 0.5, 1.0, and 5.0 mm diameters, and cultured. Cell viability and chondrogenic gene expression were analyzed. Minced cartilage morsels of 0.5 mm were harvested and used to produce the implant paste. The NC paste was filled into a rabbit articular cartilage defect, and histology was used to assess cartilage repair.</div></div><div><h3>Results</h3><div>Chondrocyte viability of the morsels was highly maintained. Chondrogenic and proliferative genes like ACAN, COL2, COMP, PCNA, SOX9, and PRG4 all increased expression to a varying degree as morsel size decreased. Morsels of 0.5 mm exhibited the highest chondrogenic potential. Also, NC paste containing 0.5 mm morsels resulted in complete defect closure unlike marrow stimulation alone. Safranin-O staining demonstrated superior cartilage formation in the defect area.</div></div><div><h3>Conclusions</h3><div>Smaller consistent morsel size was found to be linked to increased chondrogenic potential. However, since PRG4 expression was highest in 1 mm morsels and MMP-13 gene expression was significantly decreased in only 0.5 mm morsels, this demonstrates the need to adjust morsel size to optimize gene expression of interest. NC paste mixed with 0.5 mm morsels produced the greatest regenerative capacity. Exploring the regenerative potential of unique hydrogels and chondron morsel sizes is warranted.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based machine learning algorithm to predict failure following cartilage procedures in the knee","authors":"","doi":"10.1016/j.jcjp.2023.100161","DOIUrl":"10.1016/j.jcjp.2023.100161","url":null,"abstract":"<div><h3>Introduction</h3><div>Clinical decision-making is highly based on expert opinion. Machine learning is increasingly used to develop patient-specific risk prediction analysis to improve patient selection prior to surgery.</div></div><div><h3>Objectives</h3><div>To develop machine learning algorithms to predict failure of surgical procedures that address cartilage defects of the knee and detect variables associated with failure.</div></div><div><h3>Methods</h3><div>An institutional database was queried for cartilage procedures performed between 2000 and 2018. Failure was defined as revision cartilage surgery or knee arthroplasty. One hundred and one preoperative and intraoperative features were evaluated as potential predictors. Four machine learning algorithms were trained and internally validated.</div></div><div><h3>Results</h3><div>One thousand and ninety-one patients with a minimum follow-up of 2 years were included and underwent chondroplasty (<em>n</em> = 560; 51%), osteochondral allograft transplantation (<em>n</em> = 306; 28%), microfracture (<em>n</em> = 150; 14%), autologous chondrocyte implantation (<em>n</em> = 39; 4%), or osteochondral autograft transplantation (<em>n</em> = 36; 3%). The Random Forest algorithm was the best-performing algorithm, with an area under the curve of 0.765 and a Brier score of 0.135. The most important features for predicting failure were symptom duration, age, body mass index, lesion grade, and total lesion area. Local Interpretable Model-agnostic Explanations analysis provided patient-specific comparisons for the risk of failure of an individual patient being assigned various types of cartilage procedures.</div></div><div><h3>Conclusions</h3><div>Machine learning algorithms were accurate in predicting the risk of failure following cartilage procedures of the knee, with the most important features in descending order being symptom duration, age, body mass index, lesion grade, and total lesion area. Machine learning algorithms may be used to compare the risk of failure of specific patient-procedure combinations in the treatment of cartilage defects of the knee.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Double-blinded prospective randomized clinical trial in knee joint osteoarthritis treatment: safety assessment and performance of trehalose hyaluronic acid versus standard infiltrative therapy based on medium-weight sodium hyaluronate” [J Cartil Joint Preserv 2 (2022) 100043]","authors":"","doi":"10.1016/j.jcjp.2024.100167","DOIUrl":"10.1016/j.jcjp.2024.100167","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140402914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and research follow-up for knee cartilage injuries—an international consensus statement","authors":"","doi":"10.1016/j.jcjp.2024.100192","DOIUrl":"10.1016/j.jcjp.2024.100192","url":null,"abstract":"<div><h3>Introduction</h3><div>Articular cartilage injuries of the knee are a complex and challenging clinical pathology.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to establish consensus statements via a Delphi process on clinical and research follow-up for knee cartilage injuries.</div></div><div><h3>Methods</h3><div>A consensus process on knee cartilage injuries utilizing a modified Delphi technique was conducted. Seventy-seven surgeons across 17 countries were invited to participate in these consensus statements. Nine questions were generated on clinical and research follow-up, with 3 rounds of questionnaires and final voting occurring. Consensus was defined as achieving 80% to 89% agreement, whereas strong consensus was defined as 90% to 99% agreement, and unanimous consensus was defined as 100% agreement with a proposed statement.</div></div><div><h3>Results</h3><div>Of the 9 total questions and consensus statements on clinical and research follow-up developed from 3 rounds of voting, 1 achieved unanimous consensus, 5 achieved strong consensus, 1 achieved consensus, and 2 did not achieve consensus.</div></div><div><h3>Conclusions</h3><div>The statement that achieved unanimous consensus was on physical examination findings. The statements that achieved strong consensus were related to defining and monitoring treatment success, patient-reported outcomes, research follow-up, and second-look arthroscopy in the setting of recurrence. The statements that did not achieve consensus were related to routine imaging and length of clinical follow-up after operative intervention.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100192"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141034509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The Latin American Society of Arthroscopy, Articular Replacement and Sports Injuries (SLARD) consensus for the treatment of focal chondral lesions of the knee","authors":"Richard M. Danilkowicz ,&nbsp;Eoghan T. Hurley ,&nbsp;Rachel M. Frank","doi":"10.1016/j.jcjp.2024.100210","DOIUrl":"10.1016/j.jcjp.2024.100210","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141698407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Knee cartilage injuries—an international Delphi consensus","authors":"","doi":"10.1016/j.jcjp.2024.100204","DOIUrl":"10.1016/j.jcjp.2024.100204","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100204"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141137017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latin American consensus for the treatment of focal chondral lesions of the knee","authors":"","doi":"10.1016/j.jcjp.2024.100202","DOIUrl":"10.1016/j.jcjp.2024.100202","url":null,"abstract":"<div><h3>Introduction</h3><div>A consensus is useful for topics that can be common in clinical practice and controversial in some aspects of its treatment.</div></div><div><h3>Objectives</h3><div>To establish a consensus among the Latin American society of arthroscopy, articular reconstruction and sports medicine (SLARD) for treating focal chondral lesions of the knee.</div></div><div><h3>Methods</h3><div>A formal consensus was conducted among 3 groups of surgeons from SLARD with a special interest in cartilage. First, the steering group (<em>n</em> = 9) created a list of 21 statements on controversial topics and compiled a review of the literature for each topic. Second, the rating group (<em>n</em> = 19) gave a score to each statement according to their agreement with it, over 2 rounds (score: 1-9). Median scores and agreement levels were calculated and each statement was categorized as inappropriate, uncertain, or appropriate. Finally, the lecture group (<em>n</em> = 24) evaluated the appropriateness and clinical relevance of each statement.</div></div><div><h3>Results</h3><div>During the first round, there was strong agreement on 5% of the statements, relative agreement on 14%, and lack of consensus on 81% of statements. After the second round, there was strong agreement on 57% of statements, with 43% having relative agreement and no statement having a lack of consensus. The lecture group approved all the statements.</div></div><div><h3>Conclusions</h3><div>SLARD arrived at a consensus on the 21 statements proposed. This consensus includes a literature review and clinical experience, which represents the expert opinion of a society. Strong agreement was found in the advantages of using arthroscopy to diagnose chondral lesions, preinjury level as an age modification of treatment, superiority of nanofractures compared to microfractures, advantages of adding scaffolds, benefits of platelet-rich plasma in the midterm and faster return to sport with osteochondral autografts.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone marrow stimulation for knee cartilage injuries—an international Delphi consensus statement","authors":"","doi":"10.1016/j.jcjp.2024.100195","DOIUrl":"10.1016/j.jcjp.2024.100195","url":null,"abstract":"<div><h3>Introduction</h3><div>Articular cartilage injuries of the knee are a complex and challenging clinical pathology.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to establish consensus statements via a Delphi process on bone marrow stimulation (BMS) for knee cartilage injuries.</div></div><div><h3>Methods</h3><div>A consensus process on knee cartilage injuries utilizing a modified Delphi technique was conducted. Seventy-nine surgeons across 17 countries participated in these consensus statements. Fourteen questions were generated on BMS, with 3 rounds of questionnaires and final voting occurring. Consensus was defined as achieving 80% to 89% agreement, whereas strong consensus was defined as 90% to 99% agreement, and unanimous consensus was defined as 100% agreement with a proposed statement.</div></div><div><h3>Results</h3><div>Of the 14 total questions and consensus statements on BMS developed from 3 rounds of voting, 0 achieved unanimous consensus, 3 achieved strong consensus, 4 achieved consensus, and 7 did not achieve consensus.</div></div><div><h3>Conclusions</h3><div>The statements that achieved strong consensus related to lesion site preparation, ability to differentiate healthy/damaged cartilage, and distance between BMS holes. The statements that did not achieve consensus were primarily related to the indications for BMS, as well as the instrumentation and whether orthobiologics/scaffolds should be utilized.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 3","pages":"Article 100195"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141024585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of large chondral lesions with big bony defects: the Overlay autologous chondrocyte implantation technique","authors":"Deepak Goyal","doi":"10.1016/j.jcjp.2024.100178","DOIUrl":"10.1016/j.jcjp.2024.100178","url":null,"abstract":"<div><h3>Introduction</h3><p>The treatment of large chondral defects is more challenging when these chondral lesions are associated with big bony defects, which may be present in the form of either multiple subchondral (SC) cysts, or necrotic area of SC bone plate and SC spongiosa or as total fragmentation of the condylar surface. Looking to the young age of such patients, preservation of the joint is essential to prevent an early onset osteoarthritis. The marrow stimulation techniques and autologous chondrocyte implantation (ACI) need healthy SC bone to regenerate cartilage, while the osteochondral cylinder transfer techniques have donor size limitations.</p></div><div><h3>Objectives</h3><p>A new technique to treat large chondral lesions with big bony defects is described here in step-by-step manner and is called the overlay ACI technique.</p></div><div><h3>Methods</h3><p>The overlay ACI technique combines principles of autogenous bone grating for the treatment of large bony defects, which is followed by an overlay of ACI in a conventional manner to treat cartilage lesion.</p></div><div><h3>Results</h3><p>The overlay ACI technique provides an autogenous solution in form of a pain-free biological joint without any sequelae to the host tissue and formation of the hyaline (like) cartilage.</p></div><div><h3>Conclusion</h3><p>The presence of large chondral lesions with big bony defects is a surgical joint preservation challenge. The overlay ACI technique is a promising technique to treat extra-large osteochondral lesions with an autogenous solution.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254524000143/pdfft?md5=30e83da397ecde20c42ca190c97be0fc&pid=1-s2.0-S2667254524000143-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140271395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}