作为前交叉韧带损伤的生物标志物和缓解创伤后软骨退化的潜在治疗靶点的包膜组织蛋白的作用。

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引用次数: 0

摘要

前交叉韧带(ACL)损伤的潜在生物标志物,并与软骨退化和创伤后骨关节炎(PTOA)的发生有关。本综述旨在全面研究和综合现有文献中有关前交叉韧带损伤后前皮生长因子(Periostin)的作用,特别是其在膝关节软骨退化过程中的作用。结果对人体滑液和前交叉韧带组织中的Periostin表达进行分析后发现,前交叉韧带损伤后至少1个月时,Periostin的表达水平达到峰值。体外数据表明,受伤的前交叉韧带组织会促进软骨细胞中的Periostin表达。动物研究表明,应用重组的 Periostin 会导致软骨退化加剧,这可能是由于 Wnt 信号传导和 MMP-13 表达增强所致。结论Periostin与人类软骨退化的生物标志物和动物骨关节炎的进展密切相关。然而,Periostin 在前交叉韧带损伤中的确切影响及其与 PTOA 发病的潜在因果关系仍不确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of Periostin as a biomarker of anterior cruciate ligament injury and potential therapeutic target to alleviate post-traumatic cartilage degeneration

Introduction

Periostin, a matricellular protein, has emerged as a potential biomarker for anterior cruciate ligament (ACL) injury and has been associated with cartilage degeneration and the development of post-traumatic osteoarthritis (PTOA).

Objectives

This review aims to comprehensively examine and synthesize the existing literature concerning the role of Periostin in the aftermath of ACL injury, particularly its involvement in subsequent cartilage degradation processes within the knee joint.

Methods

Conducting a scoping review, we systematically searched Medline, Scopus, and Embase, focusing on human and animal studies investigating Periostin in the context of ACL injury or PTOA.

Results

Analysis of Periostin expression in human synovial fluid and ACL tissue reveals distinctive temporal profiles, with peak levels observed at a minimum of 1-month post-ACL injury. In vitro data suggests that injured ACL tissue promotes Periostin expression in human chondrocytes. Animal studies demonstrate that recombinant Periostin application leads to increased cartilage degeneration, potentially mediated by enhanced Wnt signaling and MMP-13 expression. Conversely, Periostin knockdown studies indicate a mitigating effect on cartilage degradation.

Conclusions

Periostin exhibits robust associations with biomarkers of cartilage degeneration in humans and progression of osteoarthritis in animals. However, the precise impact of Periostin in the context of ACL injury and its potential causal relationship with the onset of PTOA remain uncertain.
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