Kazunori Shimomura , Keng Lin Wong , Samundeeswari Saseendar , Sathish Muthu , Sebastian Concaro , Tiago Lazzaretti Fernandes , Ansar Mahmood
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Extracellular vesicles (EVs) have been suggested to explain the positive and sometimes curative effect, through the paracrine stimulation of the resident progenitor cells to aid in repair.</p></div><div><h3>Objectives</h3><p>To give a narrative review of the current evidence for MSC-derived EV’s potential therapeutic effects and future perspectives for the treatment of OA.</p></div><div><h3>Methods</h3><p>A literature search was conducted using the MEDLINE databases in November 2023. A total of 24 animal studies describing EV, including exosomes utilized in cartilage and OA treatments were identified and analyzed.</p></div><div><h3>Results</h3><p>Preclinical animal studies indicated that EVs could enhance the therapeutic effects for the treatment of OA, although the purification methods for EVs and their cell sources would be highly relevant to therapeutic efficacy. In contrast, there have been no published clinical studies regarding EVs for the treatment of OA, and thus, properly controlled clinical trials and regulations are essential steps in future clinical applications.</p></div><div><h3>Conclusions</h3><p>The current evidences suggest that the administration of MSC-derived EVs into damaged joints could effectively reduce cartilage loss and alleviate the progression of OA. In contrast, there are still several potential problems to be solved, including their classification, safety and toxicity in clinical use, as well as optimal dosage and frequency for human administration.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100184"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254524000209/pdfft?md5=7691bdef97dc2adbd01d0448c6558dae&pid=1-s2.0-S2667254524000209-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Exploring the potential of mesenchymal stem/stromal cell-derived extracellular vesicles as cell-free therapy for osteoarthritis: a narrative review\",\"authors\":\"Kazunori Shimomura , Keng Lin Wong , Samundeeswari Saseendar , Sathish Muthu , Sebastian Concaro , Tiago Lazzaretti Fernandes , Ansar Mahmood\",\"doi\":\"10.1016/j.jcjp.2024.100184\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Mesenchymal stem/stromal cell (MSC)-based therapies in cartilage repair and osteoarthritis (OA) treatment have gained attention. Recently, there has been increasing evidence to suggest that MSCs secrete a wide range of trophic factors to modulate the injured tissue environment. Extracellular vesicles (EVs) have been suggested to explain the positive and sometimes curative effect, through the paracrine stimulation of the resident progenitor cells to aid in repair.</p></div><div><h3>Objectives</h3><p>To give a narrative review of the current evidence for MSC-derived EV’s potential therapeutic effects and future perspectives for the treatment of OA.</p></div><div><h3>Methods</h3><p>A literature search was conducted using the MEDLINE databases in November 2023. A total of 24 animal studies describing EV, including exosomes utilized in cartilage and OA treatments were identified and analyzed.</p></div><div><h3>Results</h3><p>Preclinical animal studies indicated that EVs could enhance the therapeutic effects for the treatment of OA, although the purification methods for EVs and their cell sources would be highly relevant to therapeutic efficacy. In contrast, there have been no published clinical studies regarding EVs for the treatment of OA, and thus, properly controlled clinical trials and regulations are essential steps in future clinical applications.</p></div><div><h3>Conclusions</h3><p>The current evidences suggest that the administration of MSC-derived EVs into damaged joints could effectively reduce cartilage loss and alleviate the progression of OA. In contrast, there are still several potential problems to be solved, including their classification, safety and toxicity in clinical use, as well as optimal dosage and frequency for human administration.</p></div>\",\"PeriodicalId\":100760,\"journal\":{\"name\":\"Journal of Cartilage & Joint Preservation\",\"volume\":\"4 2\",\"pages\":\"Article 100184\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2667254524000209/pdfft?md5=7691bdef97dc2adbd01d0448c6558dae&pid=1-s2.0-S2667254524000209-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cartilage & Joint Preservation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667254524000209\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cartilage & Joint Preservation","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667254524000209","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
导言基于间充质干/基质细胞(MSC)的软骨修复和骨关节炎(OA)治疗方法已受到关注。近来,越来越多的证据表明间充质干细胞可分泌多种营养因子来调节损伤组织的环境。研究结果表明,细胞外囊泡(EVs)可通过旁分泌刺激驻留祖细胞来帮助修复,从而产生积极的、有时甚至是治疗性的效果。研究目的对目前有关间充质干细胞衍生的EVs潜在治疗效果的证据以及治疗OA的未来前景进行叙述性综述。研究方法于2023年11月使用MEDLINE数据库进行文献检索。结果临床前动物研究表明,EVs 可增强治疗 OA 的疗效,但 EVs 的纯化方法及其细胞来源与疗效密切相关。结论 目前的证据表明,在受损关节中施用间充质干细胞衍生的 EVs 可有效减少软骨流失并缓解 OA 的进展。相比之下,仍有几个潜在问题有待解决,包括其分类、临床应用的安全性和毒性,以及人体给药的最佳剂量和频率。
Exploring the potential of mesenchymal stem/stromal cell-derived extracellular vesicles as cell-free therapy for osteoarthritis: a narrative review
Introduction
Mesenchymal stem/stromal cell (MSC)-based therapies in cartilage repair and osteoarthritis (OA) treatment have gained attention. Recently, there has been increasing evidence to suggest that MSCs secrete a wide range of trophic factors to modulate the injured tissue environment. Extracellular vesicles (EVs) have been suggested to explain the positive and sometimes curative effect, through the paracrine stimulation of the resident progenitor cells to aid in repair.
Objectives
To give a narrative review of the current evidence for MSC-derived EV’s potential therapeutic effects and future perspectives for the treatment of OA.
Methods
A literature search was conducted using the MEDLINE databases in November 2023. A total of 24 animal studies describing EV, including exosomes utilized in cartilage and OA treatments were identified and analyzed.
Results
Preclinical animal studies indicated that EVs could enhance the therapeutic effects for the treatment of OA, although the purification methods for EVs and their cell sources would be highly relevant to therapeutic efficacy. In contrast, there have been no published clinical studies regarding EVs for the treatment of OA, and thus, properly controlled clinical trials and regulations are essential steps in future clinical applications.
Conclusions
The current evidences suggest that the administration of MSC-derived EVs into damaged joints could effectively reduce cartilage loss and alleviate the progression of OA. In contrast, there are still several potential problems to be solved, including their classification, safety and toxicity in clinical use, as well as optimal dosage and frequency for human administration.