Journal of Cartilage & Joint Preservation最新文献

{"title":"Meta-analysis and systematic review of the outcome of reparative strategies for the treatment of deep joint defects of the knee in adult patients","authors":"Pieter Berger ,&nbsp;Luis F. Mendes ,&nbsp;Pieter J. Emans ,&nbsp;Roel J.H. Custers ,&nbsp;Frank P. Luyten","doi":"10.1016/j.jcjp.2024.100229","DOIUrl":"10.1016/j.jcjp.2024.100229","url":null,"abstract":"<div><h3>Introduction</h3><div>Deep joint surface defects, affecting both full-depth articular cartilage and a substantial part of subchondral bone, remain a therapeutic challenge. If left untreated, they often lead to symptomatic osteoarthritic disease and joint failure. As new treatment strategies continue to emerge, it is essential to critically evaluate existing approaches. This study aims to compare the clinical outcomes and failure rates of various surgical strategies based on current literature.</div></div><div><h3>Methods</h3><div>An analysis was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, focusing on clinical outcomes of treatments for deep osteochondral defects in the human knee. Studies from PubMed, Web of Science, and Embase were reviewed, selecting those with at least 10 adult patients and a minimum of 24-month follow-up. Quality appraisal was conducted using a modified Coleman score. Data extraction, pooling, and analysis were performed independently. The review assessed descriptive data, clinical outcomes, and failure rates of the included studies.</div></div><div><h3>Results</h3><div>Seventeen prospective cohort studies or case series and 31 retrospective studies comprising a total of 1861 patients were eligible for analysis. Overall quality of the included studies was low. The most commonly used treatment strategies were the sandwich technique, osteochondral autografts, osteochondral allografts, and scaffolds, all showing moderate treatment effects on mid- to long-term, independent from the outcome measurement tool used. Failure rates in these treatment groups varied from 0% to 38.1%.</div></div><div><h3>Conclusions</h3><div>Recommending one treatment over another for deep joint surface defects remains challenging due to various elements among which long-term sustainability is a critical one. Additional data from patient registries may offer a more representative view of daily clinical practice, which is valuable for tailoring treatments to individual patients.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No significant differences in patient-reported outcome measures in men vs women following tibial tubercle osteotomy","authors":"Ava G. Neijna,&nbsp;Julia S. Retzky,&nbsp;Andreas H. Gomoll,&nbsp;Sabrina M. Strickland","doi":"10.1016/j.jcjp.2024.100231","DOIUrl":"10.1016/j.jcjp.2024.100231","url":null,"abstract":"<div><h3>Introduction</h3><div>Sex is known to play a critical role in orthopedic surgery, but there is limited information describing the role that sex plays in outcomes following tibial tubercle osteotomy (TTO).</div></div><div><h3>Objective</h3><div>This study aimed to determine if there are any differences in patient-reported outcome measures (PROMs) between men and women following TTO.</div></div><div><h3>Methods</h3><div>A retrospective review of all patients at a single institution who underwent a primary TTO by two sports medicine fellowship-trained orthopedic surgeons between May 2015 and December 2022 was performed. Patients undergoing a primary TTO with pre- and postoperative PROMs were included. Patients with less than 1 year of follow-up were excluded. A two-sample <em>t</em> test with equal variances was performed for statistical analysis of PROMs. Two-sample Wilcoxon rank-sum statistical analysis was completed to compare operative age and body mass index (BMI).</div></div><div><h3>Results</h3><div>One hundred and twenty-two patients were included (<em>n</em> = 134 knees), with 102 female knees (76%), a median age of 31.4 [interquartile range [IQR]: 23.0, 36.4], and a median BMI of 24.3 [IQR: 22.1, 28.6]. There was no difference between the male and female cohorts with respect to age (<em>P</em> = .21), though males had a higher BMI (<em>P</em> = .044). There were no differences in preoperative, postoperative, or changes preoperatively and postoperatively in International Knee Documentation Committee (IKDC), Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain, KOOS Symptoms, KOOS Activities of Daily Living, KOOS Quality of Life, and KOOS Sport scores between men and women (<em>P</em> &gt; .05 for all).</div></div><div><h3>Conclusions</h3><div>There are no differences between men and women with respect to the preoperative, postoperative, or change in IKDC, KOOS Pain, KOOS Symptoms, KOOS Activities of Daily Living, KOOS Quality of Life, and KOOS Sport scores following TTO.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome to the second issue of JCJP 2025","authors":"Miranda Manfre,&nbsp;Rachel M. Frank","doi":"10.1016/j.jcjp.2025.100244","DOIUrl":"10.1016/j.jcjp.2025.100244","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis","authors":"Andrew S. Bi ,&nbsp;Udit Dave ,&nbsp;Trevor Poulson ,&nbsp;Jared Rubin ,&nbsp;Nicole Chang ,&nbsp;Zeeshan A. Khan ,&nbsp;Nicholas J. Lemme ,&nbsp;Jorge Chahla ,&nbsp;Adam B. Yanke ,&nbsp;Brian J. Cole","doi":"10.1016/j.jcjp.2025.100235","DOIUrl":"10.1016/j.jcjp.2025.100235","url":null,"abstract":"<div><h3>Background</h3><div>Meniscal allograft transplantation (MAT) aims to restore meniscal deficiency with cadaveric meniscal tissue.</div></div><div><h3>Objectives</h3><div>To compare MAT survivorship and conversion to arthroplasty in patients &lt;40 and ≥40 years old.</div></div><div><h3>Data sources</h3><div>Pubmed, Embase, Cochrane databases.</div></div><div><h3>Study eligibility criteria</h3><div>Studies were included if they evaluated medial or lateral MAT, evaluated survivorship or conversion to arthroplasty, reported mean patient age, and were published after 2004.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>Patient cohorts were sorted into 2 groups where mean age was lesser or greater than 40<!--> <!-->years. Data were pooled with the DerSimonian-Laird random-effects model.</div></div><div><h3>Results</h3><div>A total of 1436 studies were identified, 41 included. Each study had MINORS score ≥9 indicating low risk of bias. There were 4079 patients (59.4% male) in the &lt;40-year cohort, with mean-weighted age 31.3<!--> <!-->years, follow-up 6.4<!--> <!-->years. There were 625 patients (66.9% male) in the ≥40-year cohort, with mean-weighted age 41.2<!--> <!-->years, follow-up 8.0<!--> <!-->years. Older patients had significantly more medial MATs (300; 61.9% vs 1746; 48.4%). Patients &lt;40 had weighted mean survivorship 76.3% (95% CI: 69.1%-83.5%) and conversion rate 5.0% (95% CI: 3.5%-6.6%). Patients ≥40 had weighted mean survivorship 72.1% (95% CI: 46.9%-97.3%) and conversion rate 13.1% (95% CI: 4.2%-22.0%).</div></div><div><h3>Limitations</h3><div>Unavailability of individual data sets.</div></div><div><h3>Conclusions</h3><div>There appears to be no significant differences in MAT survivorship or conversion to arthroplasty rates in patients &lt;40 and ≥40 in appropriately indicated patients that have concomitant pathology addressed. Older patients undergoing MAT have a higher rate of medial MAT compared with younger cohorts.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100235"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICRS Fellowships and the importance of fostering scientific community","authors":"James G. Jefferies ,&nbsp;Özgür Basal ,&nbsp;Jure Serdar ,&nbsp;Giuseppe Filardo","doi":"10.1016/j.jcjp.2025.100234","DOIUrl":"10.1016/j.jcjp.2025.100234","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of fluid flow-induced shear stress on the behavior of synovial fibroblasts in a bioinspired synovium-on-chip model","authors":"Susanna Piluso ,&nbsp;Yang Li ,&nbsp;Liliana Moreira Texeira ,&nbsp;Prasanna Padmanaban ,&nbsp;Jeroen Rouwkema ,&nbsp;Jeroen Leijten ,&nbsp;René van Weeren ,&nbsp;Marcel Karperien ,&nbsp;Jos Malda","doi":"10.1016/j.jcjp.2025.100233","DOIUrl":"10.1016/j.jcjp.2025.100233","url":null,"abstract":"<div><h3>Introduction</h3><div>Due to the loading of the articular joints and the movement of the joint itself, mechanical stress is constantly exerted on the synovial cavity, which is, in turn, reflected as shear stress toward the surrounding tissues, including the synovium. Although it is known that synovial cells are sensitive to various mechanical cues, deeper understanding on how synovial fibroblasts (SFBs) respond to increased shear stress is required to gain insights on its role in the pathophysiology of osteoarthritis (OA).</div></div><div><h3>Objectives</h3><div>A synovium-on-chip model was developed to evaluate the effect of fluid flow-induced shear stress on fibroblast-like synoviocytes, and to assess the similarities with synovial inflammation during OA.</div></div><div><h3>Methods</h3><div>Patient-derived SFBs were exposed to a shear stress of 3, 8, and 15 dyne/cm² for up to 72 hours. Production of TNFα, IL-6, MMPs, and lubricin by synovial cells was analyzed.</div></div><div><h3>Results</h3><div>The levels of TNFα, IL-6, and degradative enzymes increased over time when synovial cells were exposed to a shear stress of 8 dyne/cm². In the first 8 hours, a 5-fold increase in the level of TNFα was observed when the shear stress increased from 3 to 8 dyne/cm², and a 2-fold increase from shear stress 8 to 15 dyne/cm².</div></div><div><h3>Conclusions</h3><div>High mechanical stress combined with inflammatory triggers can cause excessive production of cytokines and proteolytic enzymes. Knowledge of how SFBs respond to increasing shear stress contributes to understanding the pathophysiology of OA, in which intra-articular pressure is often elevated, and may contribute to the discovery of potentially effective therapeutic agents.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single vs triple injections of platelet-rich plasma in patients with knee osteoarthritis: a retrospective cohort study of 80 patients","authors":"Ülkü Dönmez ,&nbsp;Onur Engin","doi":"10.1016/j.jcjp.2024.100232","DOIUrl":"10.1016/j.jcjp.2024.100232","url":null,"abstract":"<div><h3>Introduction</h3><div>Osteoarthritis (OA) is a prevalent degenerative joint disorder that significantly impairs quality of life. Platelet-rich plasma (PRP) has emerged as a promising treatment option for managing symptoms of knee osteoarthritis.</div></div><div><h3>Objectives</h3><div>The aim of this study is to compare the effects of triple versus single PRP injections on pain and quality of life in individuals with knee osteoarthritis.</div></div><div><h3>Methods</h3><div>The files of 40 patients who received a single dose of PRP and 40 patients who received three doses of PRP for the treatment of knee osteoarthritis were retrospectively examined. Patients had been evaluated before the treatment and at their 6 month follow up with a Visual Analog Scale (VAS) and The Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index.</div></div><div><h3>Results</h3><div>At the 6-month examinations, there was a statistically significant decrease in the WOMAC total (single, from 64.7 ± 13.2 to 54.4 ± 17.2, <em>P</em> = .001; triple, from 67.0 ± 14.7 to 45.4 ± 19.2, <em>P</em> = .001), and VAS scores (single, from 7.1 ± 1.0 to 5.10 ± 2.0, <em>P</em> = .002; and triple, from 7.3 ± 1.0 to 3.7 ± 2.2, <em>P</em> = .001) of both the single and triple injection groups compared to the baseline. WOMAC total (<em>P</em> = .03) and VAS scores (<em>P</em> = .006) of the triple injection group were significantly better but there was no significant difference in WOMAC pain (<em>P</em> = .06), WOMAC physical (<em>P</em> = .06) and WOMAC stiffness (0.08) subscales.</div></div><div><h3>Conclusions</h3><div>This research revealed that triple PRP injections are more effective than single injections at improving functional outcomes. Furthermore, the potential to alleviate pain may be greater with multiple injections; however, this effect was not consistently observed across all pain evaluation metrics.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 2","pages":"Article 100232"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of amniotic membrane in osteoarthritis management","authors":"Zuzana Macečková ,&nbsp;Jiří Pergner ,&nbsp;Martin Krbec ,&nbsp;Milan Urban ,&nbsp;Michal Zahradníček","doi":"10.1016/j.jcjp.2024.100174","DOIUrl":"10.1016/j.jcjp.2024.100174","url":null,"abstract":"<div><h3>Introduction</h3><div>Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by articular cartilage degradation, inflammation, and pain. The current treatment options for OA are limited in their ability to provide long-term relief and restore joint function. However, recent advances in regenerative medicine have led to the exploration of alternative therapeutic strategies, including the application of amniotic membrane (AM) in OA management. AM has emerged as a promising therapeutic option due to its unique properties and regenerative potential, although the mechanism of action of AM in OA is not fully elucidated.</div></div><div><h3>Objectives</h3><div>Here, we discuss the anti-inflammatory, immunomodulatory, and regenerative properties of AM that make it an attractive candidate for OA treatment. Preclinical studies utilizing animal models have demonstrated the ability of AM to promote cartilage repair, reduce inflammation, and improve joint function. Clinical trials evaluating the safety and efficacy of AM-based therapies in OA patients have also shown promising results, with improvements in pain relief and functional outcomes.</div></div><div><h3>Conclusions</h3><div>In conclusion, while AM shows promise for OA management, additional studies and clinical trials are necessary to fully understand its therapeutic potential and establish it as a safe and effective treatment option for individuals with OA.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140279765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous matrix-induced chondrogenesis versus osteochondral autograft transfer system in patellar chondral lesions: a comparative study with a 2-year follow-up","authors":"Pedro Debieux ,&nbsp;Marcos Vinicios Rodrigues dos Santos ,&nbsp;Diego da Costa Astur ,&nbsp;Seth Lawrence Sherman ,&nbsp;Moises Cohen ,&nbsp;Camila Cohen Kaleka","doi":"10.1016/j.jcjp.2024.100189","DOIUrl":"10.1016/j.jcjp.2024.100189","url":null,"abstract":"<div><h3>Introduction</h3><div>Focal patellofemoral chondral lesions are clinically challenging, with unfavorable surgical results in the medium- and long-term; Although there is no golden standard technique to treat patellofemoral lesions, several patellar cartilage repair procedures are used with variable postoperative results.</div></div><div><h3>Objectives</h3><div>To compare functional outcomes between patients who had undergone surgical treatment with osteochondral autograft transfer system (OATS) or autologous matrix-induced chondrogenesis (AMIC) for patellar chondral lesions preoperatively and after a 2-year follow-up.</div></div><div><h3>Methods</h3><div>Forty-six patients who underwent AMIC (<em>n</em> = 12) or OATS (<em>n</em> = 34), participated in this retrospective study. Outcome measures, including the Lysholm, Kujala, Fulkerson, and Tegner scores, were collected before surgery and 2 years after surgery.</div></div><div><h3>Results</h3><div>Sex, age, laterality, or location of the patellar lesion were not significantly different between groups. The mean lesion size was greater in the AMIC group (2.18 cm²) than in the OATS group (1.13 cm²) (<em>P</em> &lt; .001). There was no difference between groups in Lysholm, Fulkerson, and Kujala scores preoperatively, although the OATS group showed a more favorable Tegner score compared to the AMIC group (6.59 vs 3.45, <em>P</em> &lt; .001). Postoperatively, the AMIC group had a higher mean Lysholm score than the OATS group, (88.3 vs 79.5, <em>P</em> = .025). Mean values of almost all clinical tests significantly increased at the end of the 2-year follow-up, in both groups, except for the Tegner score in the OATS group, which showed a mean reduction from 6.59 preoperatively to 5.47 postoperatively (<em>P</em> = .006).</div></div><div><h3>Conclusion</h3><div>OATS and AMIC are effective treatments for patellar chondral lesions, with sustainable results after a minimum follow-up period of 2 years. Patients who underwent AMIC had better clinical and functional outcomes than patients who underwent OATS for patellar chondral lesions during the follow-up period.</div></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome to the first issue of JCJP 2025","authors":"Miranda Manfre,&nbsp;Rachel M. Frank","doi":"10.1016/j.jcjp.2025.100238","DOIUrl":"10.1016/j.jcjp.2025.100238","url":null,"abstract":"","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"5 1","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}