Treatment of large chondral lesions with big bony defects: the Overlay autologous chondrocyte implantation technique

Deepak Goyal
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Abstract

Introduction

The treatment of large chondral defects is more challenging when these chondral lesions are associated with big bony defects, which may be present in the form of either multiple subchondral (SC) cysts, or necrotic area of SC bone plate and SC spongiosa or as total fragmentation of the condylar surface. Looking to the young age of such patients, preservation of the joint is essential to prevent an early onset osteoarthritis. The marrow stimulation techniques and autologous chondrocyte implantation (ACI) need healthy SC bone to regenerate cartilage, while the osteochondral cylinder transfer techniques have donor size limitations.

Objectives

A new technique to treat large chondral lesions with big bony defects is described here in step-by-step manner and is called the overlay ACI technique.

Methods

The overlay ACI technique combines principles of autogenous bone grating for the treatment of large bony defects, which is followed by an overlay of ACI in a conventional manner to treat cartilage lesion.

Results

The overlay ACI technique provides an autogenous solution in form of a pain-free biological joint without any sequelae to the host tissue and formation of the hyaline (like) cartilage.

Conclusion

The presence of large chondral lesions with big bony defects is a surgical joint preservation challenge. The overlay ACI technique is a promising technique to treat extra-large osteochondral lesions with an autogenous solution.

治疗伴有大骨缺损的大软骨病变--覆盖式 ACI 技术
导言:当软骨损伤伴有大的骨缺损时,大面积软骨缺损的治疗就更具挑战性,大面积软骨缺损可能表现为多个软骨下(SC)囊肿,或软骨下骨板和软骨下海绵体坏死区,或髁突表面完全碎裂。由于这类患者年龄较小,因此必须保护关节以防止早期骨关节炎的发生。骨髓刺激技术和自体软骨细胞植入术(ACI)需要健康的SC骨来再生软骨,而骨软骨圆柱体转移技术则有供体大小的限制。本文逐步描述了一种治疗大软骨病变伴大骨缺损的新技术,称为覆盖式ACI技术。方法覆盖式 ACI 技术结合了自体骨格栅治疗大骨缺损的原理,然后以传统方式覆盖 ACI 治疗软骨病变。结果覆盖式 ACI 技术以无痛生物关节的形式提供了一种自体解决方案,对宿主组织和透明(类)软骨的形成没有任何后遗症。覆盖式 ACI 技术是一种很有前途的技术,可通过自体解决方案治疗特大型骨软骨病损。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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