"软骨修复和关节保护的新一代方法

Pedro Debieux , Enzo Salviato Mameri , Giovanna Medina , Keng Lin Wong , Camila Cohen Keleka
{"title":"\"软骨修复和关节保护的新一代方法","authors":"Pedro Debieux ,&nbsp;Enzo Salviato Mameri ,&nbsp;Giovanna Medina ,&nbsp;Keng Lin Wong ,&nbsp;Camila Cohen Keleka","doi":"10.1016/j.jcjp.2024.100180","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Full-thickness knee cartilage defects are a potential source of significant morbidity for patients and incur an increased risk for early degenerative joint disease. Recent decades have seen several advancements in the field of cartilage repair, among which osteochondral allograft transplantation and autologous chondrocyte implantation stand out as the options with the most durable and effective results. There are several limitations, however, to the current generation of cartilage repair options, spanning from cost and availability-related issues to the inherent implications of 2-stage surgery, and potentially limited capacity for tissue regeneration.</p></div><div><h3>Objectives</h3><p>The present review aims to offer an overview of next-generation approaches for cartilage repair, providing the rationale and available evidence for novel acellular scaffolds, cell-based therapies, mesenchymal stem cells, extra-cellularextracellular vesicles (exosomes), allogenic therapies, and gene therapies.</p></div><div><h3>Methods</h3><p>This article reviews current literature regarding innovations in the repair of chondral and osteochondral injuries.</p></div><div><h3>Results</h3><p>Emerging approaches the so-called next generation of cartilage repair are numerous and aim to harness the optimal biological environment and structural support needed to potentially enhance clinical outcomes.</p></div><div><h3>Conclusion</h3><p>The next generation of care for cartilage injuries aims to enhance the quality of scaffolds, cell types, cell viability, and integration with the receptor; and to introduce new technologies such as three dimensional bioprinting scaffolds, acellular and gene therapies.</p></div>","PeriodicalId":100760,"journal":{"name":"Journal of Cartilage & Joint Preservation","volume":"4 2","pages":"Article 100180"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667254524000167/pdfft?md5=204fa1e72c13991bae7ff3934ac164fb&pid=1-s2.0-S2667254524000167-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Acellular scaffolds, cellular therapy and next generation approaches for knee cartilage repair\",\"authors\":\"Pedro Debieux ,&nbsp;Enzo Salviato Mameri ,&nbsp;Giovanna Medina ,&nbsp;Keng Lin Wong ,&nbsp;Camila Cohen Keleka\",\"doi\":\"10.1016/j.jcjp.2024.100180\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Full-thickness knee cartilage defects are a potential source of significant morbidity for patients and incur an increased risk for early degenerative joint disease. Recent decades have seen several advancements in the field of cartilage repair, among which osteochondral allograft transplantation and autologous chondrocyte implantation stand out as the options with the most durable and effective results. There are several limitations, however, to the current generation of cartilage repair options, spanning from cost and availability-related issues to the inherent implications of 2-stage surgery, and potentially limited capacity for tissue regeneration.</p></div><div><h3>Objectives</h3><p>The present review aims to offer an overview of next-generation approaches for cartilage repair, providing the rationale and available evidence for novel acellular scaffolds, cell-based therapies, mesenchymal stem cells, extra-cellularextracellular vesicles (exosomes), allogenic therapies, and gene therapies.</p></div><div><h3>Methods</h3><p>This article reviews current literature regarding innovations in the repair of chondral and osteochondral injuries.</p></div><div><h3>Results</h3><p>Emerging approaches the so-called next generation of cartilage repair are numerous and aim to harness the optimal biological environment and structural support needed to potentially enhance clinical outcomes.</p></div><div><h3>Conclusion</h3><p>The next generation of care for cartilage injuries aims to enhance the quality of scaffolds, cell types, cell viability, and integration with the receptor; and to introduce new technologies such as three dimensional bioprinting scaffolds, acellular and gene therapies.</p></div>\",\"PeriodicalId\":100760,\"journal\":{\"name\":\"Journal of Cartilage & Joint Preservation\",\"volume\":\"4 2\",\"pages\":\"Article 100180\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2667254524000167/pdfft?md5=204fa1e72c13991bae7ff3934ac164fb&pid=1-s2.0-S2667254524000167-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cartilage & Joint Preservation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667254524000167\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cartilage & Joint Preservation","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667254524000167","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

导言全厚膝关节软骨缺损是导致患者严重发病的潜在原因,并增加了早期退行性关节病的风险。近几十年来,软骨修复领域取得了多项进展,其中骨软骨异体移植和自体软骨细胞植入是效果最持久、最有效的方法。本综述旨在概述下一代软骨修复方法,提供新型细胞支架、细胞疗法、间充质干细胞、细胞外液泡(外泌体)、异基因疗法和基因疗法的原理和可用证据。方法本文回顾了目前有关软骨和骨软骨损伤修复创新的文献。结果所谓下一代软骨修复的新兴方法有很多,旨在利用所需的最佳生物环境和结构支持来提高临床疗效。结论下一代软骨损伤治疗旨在提高支架、细胞类型、细胞活力和与受体整合的质量,并引入新技术,如三维生物打印支架、细胞外治疗和基因治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acellular scaffolds, cellular therapy and next generation approaches for knee cartilage repair

Introduction

Full-thickness knee cartilage defects are a potential source of significant morbidity for patients and incur an increased risk for early degenerative joint disease. Recent decades have seen several advancements in the field of cartilage repair, among which osteochondral allograft transplantation and autologous chondrocyte implantation stand out as the options with the most durable and effective results. There are several limitations, however, to the current generation of cartilage repair options, spanning from cost and availability-related issues to the inherent implications of 2-stage surgery, and potentially limited capacity for tissue regeneration.

Objectives

The present review aims to offer an overview of next-generation approaches for cartilage repair, providing the rationale and available evidence for novel acellular scaffolds, cell-based therapies, mesenchymal stem cells, extra-cellularextracellular vesicles (exosomes), allogenic therapies, and gene therapies.

Methods

This article reviews current literature regarding innovations in the repair of chondral and osteochondral injuries.

Results

Emerging approaches the so-called next generation of cartilage repair are numerous and aim to harness the optimal biological environment and structural support needed to potentially enhance clinical outcomes.

Conclusion

The next generation of care for cartilage injuries aims to enhance the quality of scaffolds, cell types, cell viability, and integration with the receptor; and to introduce new technologies such as three dimensional bioprinting scaffolds, acellular and gene therapies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
0.90
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信