Bone marrow signal abnormalities in arthritis and trauma

David C. Gimarc , Mary K. Jesse Lowry
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引用次数: 0

Abstract

Joint pain and dysfunction are common presenting symptoms of both younger and older patients, resulting in significant cost and burden to the healthcare system. In both the acute and chronic setting, the advanced imaging evaluation for assessing joint dysfunction most commonly utilizes magnetic resonance imaging that allows for detailed evaluation of all components of a joint, including the cartilage, bone, fibrocartilage, and ligamentous components. Signal alterations of the subchondral bone and marrow have been recently recognized as an important component in both trauma and arthritis and modern treatment strategies focus on addressing both the cartilage and bone in an attempt to optimize joint preservation and restore function. The presence of bone marrow signal abnormalities is often associated with patient symptoms, cartilage loss, and risk of disease progression. A thorough understanding of the unique anatomy and biomechanics of the chondro-osseous junction can help to explain the many marrow signal abnormalities and clinical implications that are commonly encountered by imagers. In this review article, we will describe the anatomy and basic physiology of the subchondral bone, and discuss multiple pathologic appearances of the bone with an emphasis on edema-like signal changes seen in the setting of osteoarthritis and trauma.

关节炎和创伤中的骨髓信号异常
关节疼痛和功能障碍是年轻和年长患者的常见症状,给医疗系统带来了巨大的成本和负担。在急性和慢性情况下,评估关节功能障碍的先进成像评估最常用的是磁共振成像,它可以详细评估关节的所有组成部分,包括软骨、骨、纤维软骨和韧带组成部分。软骨下骨和骨髓的信号改变最近被认为是创伤和关节炎的重要组成部分,现代治疗策略主要针对软骨和骨,试图优化关节保护和恢复功能。骨髓信号异常通常与患者症状、软骨损失和疾病进展风险有关。透彻了解软骨-骨关节交界处的独特解剖和生物力学,有助于解释成像人员经常遇到的多种骨髓信号异常和临床影响。在这篇综述文章中,我们将描述软骨下骨的解剖和基本生理学,并讨论骨的多种病理表现,重点是在骨关节炎和创伤情况下出现的水肿样信号变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
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