工程技术最新文献

{"title":"Mifnet: a MamBa-based interactive frequency convolutional neural network for motor imagery decoding.","authors":"Luoqian Yang, Weina Zhu","doi":"10.1007/s11571-025-10287-1","DOIUrl":"10.1007/s11571-025-10287-1","url":null,"abstract":"<p><p>Motor imagery (MI) decoding remains a critical challenge in brain-computer interface (BCI) systems due to the low signal-to-noise ratio, non-stationarity, and complex spatiotemporal dynamics of electroencephalography (EEG) signals. Although deep learning architectures have advanced MI-EEG decoding, existing approaches-including convolutional neural networks (CNNs), Transformers, and recurrent neural networks (RNNs)-still face limitations in capturing global temporal dependencies, maintaining positional coherence, and ensuring computational efficiency. To address these challenges, we propose MIFNet, a MamBa-based Interactive Frequency Convolutional Neural Network that systematically integrates spectral, spatial, and temporal feature extraction. Specifically, MIFNet incorporates: non-overlapping frequency decomposition, which selectively extracts motor imagery-related mu (8-12 Hz) and beta (12-32 Hz) rhythms; a ConvEncoder module, which autonomously learns to fuse spectral-spatial features from both frequency bands; and a MamBa-based temporal module, leveraging selective state-space models (SSMs) to efficiently capture long-range dependencies with linear complexity. Extensive experiments on three public MI-EEG datasets (BCIC-IV-2A, OpenBMI, and High Gamma) demonstrate that MIFNet outperforms existing models, achieving an average classification accuracy improvement of 12.3%, 8.3%, 4.7%, and 5.5% over EEGNet, FBCNet, IFNet, and Conformer, respectively. Ablation studies further validate the necessity of each component, with the MamBa module contributing a 5.5% improvement in accuracy on the BCIC-IV-2A dataset. Moreover, MIFNet exhibits strong generalization performance in cross-validation settings, establishing a robust foundation for real-time BCI applications. Our findings highlight the potential of hybridizing CNNs with state-space models (SSMs) for improving EEG decoding performance, effectively bridging the gap between localized feature extraction and global temporal modeling.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"106"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pnky Modulates Neural Stem Cell Proliferation and Differentiation Through Activation of Wnt/β-Catenin Signaling Pathway.","authors":"Haidong Wu, Jing Huang, Xiaojing Li, Yali Song, Xuxiang Chen, Yajie Guo","doi":"10.1080/15476278.2025.2519641","DOIUrl":"10.1080/15476278.2025.2519641","url":null,"abstract":"<p><p>Neural stem cell (NSC) possess the essential properties of pluripotency and self-renewal, making them promising candidates for the treatment of neurological disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), and spinal cord injuries. While previous studies have identified the long non-coding RNAs (lncRNAs) Pnky as a regulator of NSC differentiation into neurons via RNA splicing, its role in NSC differentiation and proliferation through the Wnt/β-catenin pathway remains unclear. In this study, we investigated the mechanism by which Pnky influences the Wnt/β-catenin pathway to promote NSC differentiation into neurons. Using cck8 assays, western blot analysis, and quantitative polymerase chain reaction (qPCR), we found that Pnky knockdown significantly enhanced NSC proliferation and promoted their differentiation into neurons. Additionally, Pnky knockdown resulted in the downregulation of the neural stem cell marker Nestin and upregulation of the neuronal marker β3-Tubulin, through activation of the β-catenin signaling pathway. Conversely, inhibiting the β-catenin pathway hindered both NSC differentiation and proliferation. These findings suggest that targeting the Pnky-mediated Wnt/β-catenin pathway may offer novel strategies for the treatment, diagnosis, and drug development of central nervous system diseases.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"21 1","pages":"2519641"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baicalein Alleviates Lithium-Pilocarpine-Induced Status Epilepticus by Regulating DNMT1/GABRD Pathway in Rats.","authors":"Zhenggang Wu, Jing Liu, Deju Yin, Jing Huang, Yujing Huang, Pengfei Wang","doi":"10.1080/15476278.2025.2519607","DOIUrl":"10.1080/15476278.2025.2519607","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy is a common disease of the nervous system. Recent advances in epigenetics have revealed DNA methylation as a key mechanism in epilepsy pathogenesis, particularly through dysregulation of GABAergic signaling. Baicalein has been shown to have anticonvulsant and neuroprotective effects. However, its epigenetic regulatory effects on GABA receptor function remain unexplored.</p><p><strong>Methods: </strong>The status epilepticus (SE) model was induced by lithium chloride-pilocarpine (LiCl-PILO) in Sprague-Dawley (SD) rats. The rats were divided into control group, epileptic SE group and baicalein intervention group. Morris water maze (MWM) test, Nissl staining, immunofluorescence and enzyme-linked immunosorbent assay (ELISA) were used to detect cognitive functions and neuronal damage. Online sites, chromatin immunoprecipitation (ChIP) and western blotting were used to identify DNA methyltransferase 1 (DNMT1)-mediated methylation of gamma-aminobutyric acid type A receptor subunit delta (GABRD) promoter region.</p><p><strong>Results: </strong>Baicalein treatment significantly prolonged the latency of SE onset and seizure onset, and improved the development of epilepsy. Meanwhile, baicalein improved the cognitive impairment in rats induced by LiCl-PILO. After treatment with baicalein, a sustained elevation in the number of neurons and NeuN levels was observed, along with a decrease in the contents of tumor necrosis factor -alpha (TNF-α), interleukin-1β (IL-1β), and ionized calcium-binding adapter molecule 1 (Iba-1) in the hippocampus. Mechanistically, baicalein interacted with DNMT1 to suppress GABRD promoter region methylation, thus increasing GABRD protein level in the hippocampus of rats induced by LiCl-PILO.</p><p><strong>Conclusion: </strong>This study identifies DNMT1/GABRD axis as a novel epigenetic target for epilepsy intervention. Baicalein's ability to enhance tonic inhibition through demethylation of GABRD provides a groundbreaking strategy for drug-resistant epilepsy.</p>","PeriodicalId":19596,"journal":{"name":"Organogenesis","volume":"21 1","pages":"2519607"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-decomposition method for event-triggered finite-time synchronization control of complex-valued memristive neural networks.","authors":"Hui Lin, Yanchao Shi, Jun Guo, Xiaoya He","doi":"10.1007/s11571-025-10306-1","DOIUrl":"https://doi.org/10.1007/s11571-025-10306-1","url":null,"abstract":"<p><p>This paper investigates the finite-time synchronization of complex-valued memristive neural networks (CVMNNs) with time-varying delays using an event-triggered control approach. The analysis is conducted in a holistic manner, utilizing the one-norm and sign functions of complex numbers, thereby eliminating the need for decomposition. To alleviate communication pressure, an event-triggered controller is introduced, accompanied by specific conditions and criteria to guarantee synchronization within a finite time frame. Additionally, a direct estimate of the synchronization time is provided, and a positive lower bound on the minimum event interval is derived to prevent Zeno behavior. Building on this event-triggered strategy, a self-triggered mechanism is designed to eliminate the necessity for continuous monitoring. The proposed method is straightforward and easily implementable, with its effectiveness demonstrated through illustrative examples and simulation results.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"115"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/21691401.2025.2476906","DOIUrl":"https://doi.org/10.1080/21691401.2025.2476906","url":null,"abstract":"","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"104"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statement of Retraction: Myricetin nanoliposomes induced SIRT3-mediated glycolytic metabolism leading to glioblastoma cell death.","authors":"","doi":"10.1080/21691401.2025.2465942","DOIUrl":"https://doi.org/10.1080/21691401.2025.2465942","url":null,"abstract":"","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"56"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome and nutritional composition analysis of stacked transgenic maize with insect resistance and herbicide tolerance.","authors":"Xiaoxing Yu, Hongyu Gao, Pengfei Wang","doi":"10.1080/21645698.2025.2472451","DOIUrl":"10.1080/21645698.2025.2472451","url":null,"abstract":"<p><p>The safety assessment of stacked transgenic crops is essential for their commercial cultivation. A crucial element of safety assessment is the nutritional evaluation of transgenic crops. Currently, profiling methods like transcriptome are employed as supplemental analytical tools to find the unintended effects of transgenic crops. In this study, stacked transgenic maize ZDRF8×nCX-1 was produced by crossing of two transgenic maize events ZDRF8 and nCX-1. This stacked transgenic maize expresses five genes: <i>cry1Ab</i>, <i>cry2Ab</i> and <i>g10evo-epsps</i> (from ZDRF8), as well as <i>cp4 epsps</i> and <i>P450-N-Z1</i> (from nCX-1). Molecular analysis showed that the insertion sites of target genes were not changed during stack breeding, and the target genes are effectively expressed at both RNA and protein levels in ZDRF8×nCX-1. Target trait analysis showed that ZDRF8×nCX-1 exhibits tolerant to glyphosate, flazasulfuron and MCPA, and is resistant to damage by corn borers. Transcriptome analysis revealed that gene-stacked maize ZDRF8×nCX-1 did not significantly alter transcriptome profiles compared to the transgenic maize events ZDRF8 and nCX-1. Nutritional composition analysis showed that the grain profile of ZDRF8×nCX-1 was substantially equivalent to that of the non-transgenic counterpart. These results suggest that hybrid stacking does not cause significantly unintended effects beyond providing the intended beneficial traits.</p>","PeriodicalId":54282,"journal":{"name":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","volume":"16 1","pages":"216-234"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late blight field resistance in potatoes carrying <i>Solanum americanum</i> resistance genes (Rpi-amr3 and Rpi-amr1).","authors":"Svante Resjö, Iqra, Nam P Kieu, Muhammad Awais Zahid, Marit Lenman, Björn Andersson, Erik Andreasson","doi":"10.1080/21645698.2025.2479913","DOIUrl":"10.1080/21645698.2025.2479913","url":null,"abstract":"<p><p>Potato (<i>Solanum tuberosum</i> L.) is an important global crop, but its production is severely impacted by late blight, caused by the pathogen <i>Phytophthora infestans</i>. The economic burden of this disease is significant, and current control strategies rely mainly on fungicides, which face increasing regulatory and environmental constraints. To address this challenge, potatoes with resistance genes from wild potato relatives offer a promising solution. This study evaluated field resistance to late blight in potato lines (Maris Piper) containing the <i>Solanum americanum</i> resistance genes <i>Rpi-amr3</i> and <i>Rpi-amr1</i> across three years (2018-2020) in Sweden. Field trials were conducted under natural infection conditions to assess disease resistance. Results showed that the transgenic lines conferred strong resistance to late blight compared to the susceptible control. However, slight late blight symptoms were observed in the transgenic lines. These results highlight the effectiveness of <i>S. americanum</i> resistance genes in providing strong resistance, and emphasize the potential of stacking multiple R genes, including these genes to maintain efficacy. This research supports the development of resistant potato varieties as a sustainable alternative to chemical control, promoting food security and environmentally friendly agriculture.</p>","PeriodicalId":54282,"journal":{"name":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","volume":"16 1","pages":"263-271"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purinergic ecto-enzymes in human and ovine aortic valves: indicators of bacterial nanocellulose scaffold cellularization.","authors":"Barbara Kutryb-Zając, Ada Kawecka, Gabriela Harasim, Michał Bieńkowski, Klaudia Stawarska, Krzysztof Urbanowicz, Ryszard T Smoleński, Maciej M Kowalik, Magdalena Kołaczkowska, Piotr Siondalski","doi":"10.1080/21691401.2025.2502033","DOIUrl":"https://doi.org/10.1080/21691401.2025.2502033","url":null,"abstract":"<p><p>Purinergic signalling pathways play a vital role in the biological functions of the aortic valve (AV) through nucleotide and adenosine-dependent receptor effects. This study focused on characterizing a side-specific purinergic cascade in human non-stenotic and stenotic AVs, ovine native AVs and a novel bacterial nanocellulose (BNC) bio-prosthesis in an ovine model. Human stenotic AVs were collected during replacement surgeries, while non-stenotic AVs came from heart transplant patients. Ovine native AVs were sourced from domestic sheep, and the BNC prosthesis was implanted in the ovine aorta for six months, with hemodynamic monitoring throughout. Biochemical assessments revealed a beneficial ecto-enzyme pattern in non-stenotic and native AVs, contrasting with a detrimental pattern in stenotic valves. The BNC prosthesis demonstrated significantly lower nucleotide conversion activities than native valves and displayed increased peripheral blood mononuclear cell adhesion on its aortic surface. These findings suggest that nucleotide-converting ecto-enzymes could serve as markers for the biological activity of AV prostheses, highlighting the need for further studies to enhance the cellularization of BNC prostheses, potentially through adenosine-releasing scaffold modifications.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"53 1","pages":"219-230"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations of synaptic plasticity and brain oscillation are associated with autophagy induced synaptic pruning during adolescence.","authors":"Hui Wang, Xiaxia Xu, Zhuo Yang, Tao Zhang","doi":"10.1007/s11571-024-10185-y","DOIUrl":"10.1007/s11571-024-10185-y","url":null,"abstract":"<p><p>Adolescent brain development is characterized by significant anatomical and physiological alterations, but little is known whether and how these alterations impact the neural network. Here we investigated the development of functional networks by measuring synaptic plasticity and neural synchrony of local filed potentials (LFPs), and further explored the underlying mechanisms. LFPs in the hippocampus were recorded in young (21 ~ 25 days), adolescent (1.5 months) and adult (3 months) rats. Long term potentiation (LTP) and neural synchrony were analyzed. The results showed that the LTP was the lowest in adolescent rats. During development, the theta coupling strength was increased progressively but there was no significant change of gamma coupling between young rats and adolescent rats. The density of dendrite spines was decreased progressively during development. The lowest levels of NR2A, NR2B and PSD95 were detected in adolescent rats. Importantly, it was found that the expression levels of autophagy markers were the highest during adolescent compared to that in other developmental stages. Moreover, there were more co-localization of autophagosome and PSD95 in adolescent rats. It suggests that autophagy is possibly involved in synaptic elimination during adolescence, and further impacts synaptic plasticity and neural synchrony.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"2"},"PeriodicalIF":3.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11688264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}