Sound intensity-dependent cortical activation: implications of the electrical and vascular activity on auditory intensity.

IF 3.1 3区工程技术 Q2 NEUROSCIENCES

Cognitive Neurodynamics Pub Date : 2025-12-01 Epub Date: 2025-06-09 DOI:10.1007/s11571-025-10281-7

Vanesa Muñoz, Brenda Y Angulo-Ruiz, Carlos M Gómez

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引用次数: 0

Abstract

Recent studies combining electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) have shown promising results linking neural and vascular responses. This study analyzes the topographical effect of auditory stimulus intensity on cortical activation and explores neurovascular coupling between fNIRS hemodynamic signals and auditory-evoked potentials (AEPs), extracted from EEG. Forty healthy volunteers (13 males, 27 females; mean age = 22.27 ± 3.96 years) listened to complex tones of varying intensities (50-, 70-, and 90-dB SPL) across seven frequencies (range of 400-2750 Hz) in blocks of five, while EEG and fNIRS were recorded. PERMANOVA analysis revealed that increasing intensity modulated hemodynamic activity, leading to amplitude changes and enhanced recruitment of auditory and prefrontal cortices. To isolate stimulus-specific activity, Spearman correlations were computed on residuals-components of AEPs and fNIRS responses with individual trends removed. The N1 amplitude increase was correlated with higher superior temporal gyrus (STG) and superior frontal gyrus (SFG) activity, and reduced activity in inferior frontal gyrus (IFG) for the oxygenated hemoglobin (HbO), while the deoxygenated hemoglobin (HbR) was associated with increased activity in one channel near the Supramarginal Gyrus (SMG). P2 amplitude increase was associated with higher activation in SFG and IFG for HbO, while for HbR with the activity in SMG, angular gyrus (AnG), SFG, and IFG. Additionally, internal correlations between fNIRS channels revealed strong associations within auditory and frontal regions. These findings provide insights into existing models of neurovascular coupling by showing how stimulus properties, such as intensity, modulate the relationship between neural activity and vascular responses.

Supplementary information: The online version contains supplementary material available at 10.1007/s11571-025-10281-7.

查看原文本刊更多论文

声强依赖性皮层激活：电和血管活动对听觉强度的影响。

最近的研究结合了脑电图（EEG）和功能近红外光谱（fNIRS），显示了神经和血管反应之间的联系。本研究分析了听觉刺激强度对皮层激活的地形效应，并探讨了EEG提取的fNIRS血流动力学信号与听觉诱发电位（AEPs）之间的神经血管耦合。40名健康志愿者(男性13名，女性27名；平均年龄= 22.27±3.96岁)，在7个频率（400-2750 Hz范围）中以5个为块，听不同强度（50、70和90 db SPL）的复杂音调，同时记录脑电图和近红外光谱。PERMANOVA分析显示，强度增加可调节血流动力学活动，导致振幅变化和听觉和前额叶皮质的增强。为了分离刺激特异性活动，在去除个体趋势后，计算残差（AEPs和fNIRS反应的成分）的Spearman相关性。N1振幅增加与颞上回（STG）和额上回（SFG）活性升高相关，下额回（IFG）中氧合血红蛋白（HbO）活性降低相关，而脱氧血红蛋白（HbR）与边缘上回（SMG）附近一个通道活性升高相关。HbO组P2振幅增加与SFG和IFG的高激活相关，而HbR组则与SMG、角回（AnG）、SFG和IFG的高激活相关。此外，fNIRS通道之间的内部相关性揭示了听觉和额叶区域之间的强烈联系。这些发现通过展示刺激特性（如强度）如何调节神经活动和血管反应之间的关系，为现有的神经血管耦合模型提供了见解。补充资料：在线版本提供补充资料，网址为10.1007/s11571-025-10281-7。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cognitive Neurodynamics 医学-神经科学

CiteScore

6.90

自引率

18.90%

发文量

140

审稿时长

12 months

期刊介绍： Cognitive Neurodynamics provides a unique forum of communication and cooperation for scientists and engineers working in the field of cognitive neurodynamics, intelligent science and applications, bridging the gap between theory and application, without any preference for pure theoretical, experimental or computational models. The emphasis is to publish original models of cognitive neurodynamics, novel computational theories and experimental results. In particular, intelligent science inspired by cognitive neuroscience and neurodynamics is also very welcome. The scope of Cognitive Neurodynamics covers cognitive neuroscience, neural computation based on dynamics, computer science, intelligent science as well as their interdisciplinary applications in the natural and engineering sciences. Papers that are appropriate for non-specialist readers are encouraged. 1. There is no page limit for manuscripts submitted to Cognitive Neurodynamics. Research papers should clearly represent an important advance of especially broad interest to researchers and technologists in neuroscience, biophysics, BCI, neural computer and intelligent robotics. 2. Cognitive Neurodynamics also welcomes brief communications: short papers reporting results that are of genuinely broad interest but that for one reason and another do not make a sufficiently complete story to justify a full article publication. Brief Communications should consist of approximately four manuscript pages. 3. Cognitive Neurodynamics publishes review articles in which a specific field is reviewed through an exhaustive literature survey. There are no restrictions on the number of pages. Review articles are usually invited, but submitted reviews will also be considered.