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Author Correction: Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity 作者更正:Raptin是一种睡眠诱导的下丘脑激素,可以抑制食欲和肥胖
IF 25.9 1区 生物学
Cell Research Pub Date : 2025-05-07 DOI: 10.1038/s41422-025-01123-6
Ling-Qi Xie, Biao Hu, Ren-Bin Lu, Ya-Lun Cheng, Xin Chen, Jie Wen, Yao Xiao, Yu-Ze An, Ning Peng, Yu Dai, Genqing Xie, Qi Guo, Hui Peng, Xiang-Hang Luo
{"title":"Author Correction: Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity","authors":"Ling-Qi Xie, Biao Hu, Ren-Bin Lu, Ya-Lun Cheng, Xin Chen, Jie Wen, Yao Xiao, Yu-Ze An, Ning Peng, Yu Dai, Genqing Xie, Qi Guo, Hui Peng, Xiang-Hang Luo","doi":"10.1038/s41422-025-01123-6","DOIUrl":"10.1038/s41422-025-01123-6","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 7","pages":"530-531"},"PeriodicalIF":25.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-025-01123-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysosomal EGFR functions as a GEF for Rheb 溶酶体EGFR作为Rheb的GEF
IF 25.9 1区 生物学
Cell Research Pub Date : 2025-05-07 DOI: 10.1038/s41422-025-01126-3
Tao Hou, Peiqiang Yan, Hiroyuki Inuzuka, Wenyi Wei
{"title":"Lysosomal EGFR functions as a GEF for Rheb","authors":"Tao Hou, Peiqiang Yan, Hiroyuki Inuzuka, Wenyi Wei","doi":"10.1038/s41422-025-01126-3","DOIUrl":"10.1038/s41422-025-01126-3","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 7","pages":"475-476"},"PeriodicalIF":25.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-025-01126-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural crossroads of pancreatic cancer: how nociceptors drive tumor progression and immune evasion 胰腺癌的神经交叉:伤害感受器如何驱动肿瘤进展和免疫逃避
IF 25.9 1区 生物学
Cell Research Pub Date : 2025-05-07 DOI: 10.1038/s41422-025-01124-5
Carmen Mota Reyes, Helmut Friess, Ihsan Ekin Demir
{"title":"Neural crossroads of pancreatic cancer: how nociceptors drive tumor progression and immune evasion","authors":"Carmen Mota Reyes, Helmut Friess, Ihsan Ekin Demir","doi":"10.1038/s41422-025-01124-5","DOIUrl":"10.1038/s41422-025-01124-5","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 6","pages":"393-394"},"PeriodicalIF":25.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-025-01124-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1 溶酶体表皮生长因子受体作为独立于其激酶活性的 Rheb-GEF 激活 mTORC1
IF 25.9 1区 生物学
Cell Research Pub Date : 2025-04-21 DOI: 10.1038/s41422-025-01110-x
Xiaobo He, Qiu-Xia Wang, Denghui Wei, Yujie Lin, Xia Zhang, Yuanzhong Wu, Xuexia Qian, Zhihao Lin, Beibei Xiao, Qinxue Wu, Zhen Wang, Fengtao Zhou, Zhihao Wei, Jingxuan Wang, Run Gong, Ruhua Zhang, Qingling Zhang, Ke Ding, Song Gao, Tiebang Kang
{"title":"Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1","authors":"Xiaobo He, Qiu-Xia Wang, Denghui Wei, Yujie Lin, Xia Zhang, Yuanzhong Wu, Xuexia Qian, Zhihao Lin, Beibei Xiao, Qinxue Wu, Zhen Wang, Fengtao Zhou, Zhihao Wei, Jingxuan Wang, Run Gong, Ruhua Zhang, Qingling Zhang, Ke Ding, Song Gao, Tiebang Kang","doi":"10.1038/s41422-025-01110-x","DOIUrl":"10.1038/s41422-025-01110-x","url":null,"abstract":"Oncogenic mutations in EGFR often result in EGF-independent constitutive activation and aberrant trafficking and are associated with several human malignancies, including non-small cell lung cancer. A major consequence of EGFR mutations is the activation of the mechanistic target of rapamycin complex 1 (mTORC1), which requires EGFR kinase activity and downstream PI3K/AKT signaling, resulting in increased cell proliferation. However, recent studies have elucidated kinase-independent roles of EGFR in cell survival and cancer progression. Here, we report a cis mTORC1 activation function of EGFR that is independent of its kinase activity. Our results reveal that lysosomal localization of EGFR is critical to mTORC1 activation, where EGFR physically binds Rheb, acting as a guanine exchange factor (GEF) for Rheb, with its Glu804 serving as a potential glutamic finger. Genetic knock-in of EGFR-E804K in cells reduces the level of GTP-bound Rheb, and significantly suppresses mTORC1 activation, cell proliferation and tumor growth. Different tyrosine kinase inhibitors exhibit distinct effects on EGFR-induced mTORC1 activation, with afatinib, which additionally blocks EGFR’s GEF activity, causing a much greater suppression of mTORC1 activation and cell growth, and erlotinib, which targets only kinase activity, resulting in only a slight decrease. Moreover, a novel small molecule, BIEGi-1, was designed to target both the Rheb-GEF and kinase activities of EGFR, and shows a strong inhibitory effect on the viability of cells harboring EGFR mutants. These findings unveil a fundamental event in cell growth and suggest a promising strategy against cancers with EGFR mutations.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 7","pages":"497-509"},"PeriodicalIF":25.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-025-01110-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding NLRP3: Phase separation enters the scene 解码NLRP3:相位分离进入场景
IF 25.9 1区 生物学
Cell Research Pub Date : 2025-04-21 DOI: 10.1038/s41422-025-01120-9
Niklas A. Schmacke, Veit Hornung
{"title":"Decoding NLRP3: Phase separation enters the scene","authors":"Niklas A. Schmacke, Veit Hornung","doi":"10.1038/s41422-025-01120-9","DOIUrl":"10.1038/s41422-025-01120-9","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 6","pages":"391-392"},"PeriodicalIF":25.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-025-01120-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gasdermin D pores hitch a ride: extracellular vesicles spread pyroptosis 气真皮蛋白D毛孔搭便车:细胞外囊泡扩散热亡
IF 25.9 1区 生物学
Cell Research Pub Date : 2025-04-21 DOI: 10.1038/s41422-025-01109-4
Gang Du, Hao Wu
{"title":"Gasdermin D pores hitch a ride: extracellular vesicles spread pyroptosis","authors":"Gang Du, Hao Wu","doi":"10.1038/s41422-025-01109-4","DOIUrl":"10.1038/s41422-025-01109-4","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 9","pages":"623-624"},"PeriodicalIF":25.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-025-01109-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orchestrating NTSR1 signaling from the interface 编排来自接口的NTSR1信令
IF 25.9 1区 生物学
Cell Research Pub Date : 2025-04-21 DOI: 10.1038/s41422-025-01121-8
Xianglin Huang, Brian E. Krumm, Bryan L. Roth
{"title":"Orchestrating NTSR1 signaling from the interface","authors":"Xianglin Huang, Brian E. Krumm, Bryan L. Roth","doi":"10.1038/s41422-025-01121-8","DOIUrl":"10.1038/s41422-025-01121-8","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 6","pages":"395-396"},"PeriodicalIF":25.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-025-01121-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spliceosome-associated quality control 剪接体相关质量控制
IF 25.9 1区 生物学
Cell Research Pub Date : 2025-04-21 DOI: 10.1038/s41422-025-01118-3
Nikita Sharaev, Jiangfeng Zhao, Wojciech P. Galej
{"title":"Spliceosome-associated quality control","authors":"Nikita Sharaev, Jiangfeng Zhao, Wojciech P. Galej","doi":"10.1038/s41422-025-01118-3","DOIUrl":"10.1038/s41422-025-01118-3","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 6","pages":"397-398"},"PeriodicalIF":25.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-025-01118-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyrimidine synthase CAD deamidates and inactivates p53 嘧啶合酶CAD使p53脱酰胺并失活。
IF 25.9 1区 生物学
Cell Research Pub Date : 2025-04-17 DOI: 10.1038/s41422-025-01112-9
Yue Qi, Zizheng Tan, Hanyu Chen, Ziqi Xiao, Liang Zhang, Boxuan Wu, Chennan Liu, Yunqian Gao, Xueyan Yang, Lingqian Wu, Lei Lu, Hongyan Wang
{"title":"Pyrimidine synthase CAD deamidates and inactivates p53","authors":"Yue Qi, Zizheng Tan, Hanyu Chen, Ziqi Xiao, Liang Zhang, Boxuan Wu, Chennan Liu, Yunqian Gao, Xueyan Yang, Lingqian Wu, Lei Lu, Hongyan Wang","doi":"10.1038/s41422-025-01112-9","DOIUrl":"10.1038/s41422-025-01112-9","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 7","pages":"520-523"},"PeriodicalIF":25.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Structural and functional evidence that GPR30 is not a direct estrogen receptor 作者更正:结构和功能证据表明GPR30不是直接雌激素受体。
IF 25.9 1区 生物学
Cell Research Pub Date : 2025-04-16 DOI: 10.1038/s41422-025-01113-8
Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xinheng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H. Eric Xu
{"title":"Author Correction: Structural and functional evidence that GPR30 is not a direct estrogen receptor","authors":"Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xinheng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H. Eric Xu","doi":"10.1038/s41422-025-01113-8","DOIUrl":"10.1038/s41422-025-01113-8","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 7","pages":"532-534"},"PeriodicalIF":25.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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