Tao Hou, Peiqiang Yan, Hiroyuki Inuzuka, Wenyi Wei
{"title":"Lysosomal EGFR functions as a GEF for Rheb","authors":"Tao Hou, Peiqiang Yan, Hiroyuki Inuzuka, Wenyi Wei","doi":"10.1038/s41422-025-01126-3","DOIUrl":null,"url":null,"abstract":"<p><b>A recent study published in</b> <b><i>Cell Research</i></b> <b>revealed that lysosome-localized epidermal growth factor receptor (EGFR) directly binds to and activates Rheb, a key activator of mTORC1, in a kinase activity-independent manner. Mechanistically, EGFR utilizes its Glu804 residue, which likely functions as a catalytic “glutamic finger”, to exert a novel role as a guanine nucleotide exchange factor for Rheb.</b></p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"11 1","pages":""},"PeriodicalIF":28.1000,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41422-025-01126-3","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A recent study published inCell Researchrevealed that lysosome-localized epidermal growth factor receptor (EGFR) directly binds to and activates Rheb, a key activator of mTORC1, in a kinase activity-independent manner. Mechanistically, EGFR utilizes its Glu804 residue, which likely functions as a catalytic “glutamic finger”, to exert a novel role as a guanine nucleotide exchange factor for Rheb.
期刊介绍:
Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.