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Gut microbiota fuels clonal hematopoiesis 肠道微生物群为克隆造血提供燃料
IF 44.1 1区 生物学
Cell Research Pub Date : 2025-06-13 DOI: 10.1038/s41422-025-01137-0
Francisco Caiado, Markus G. Manz
{"title":"Gut microbiota fuels clonal hematopoiesis","authors":"Francisco Caiado, Markus G. Manz","doi":"10.1038/s41422-025-01137-0","DOIUrl":"https://doi.org/10.1038/s41422-025-01137-0","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"9 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Niche-generated taurine is leukemic fuel 小众生成的牛磺酸是白血病的燃料
IF 44.1 1区 生物学
Cell Research Pub Date : 2025-06-09 DOI: 10.1038/s41422-025-01136-1
Christina Mayerhofer, David T. Scadden
{"title":"Niche-generated taurine is leukemic fuel","authors":"Christina Mayerhofer, David T. Scadden","doi":"10.1038/s41422-025-01136-1","DOIUrl":"https://doi.org/10.1038/s41422-025-01136-1","url":null,"abstract":"<p><b>A new study by Sharma et al. shows that taurine supplied by osteolineage cells in the bone marrow niche, is hijacked by myeloid leukemia to fuel mTOR-driven glycolysis and resist BCL-2 inhibition. Inhibiting taurine uptake or synthesis in niche cells prevents leukemia progression supporting the idea of a niche-directed therapeutic approach</b>.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"38 9 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia. 小鼠精子中心装置的原位结构揭示了弱精子症的机制见解。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-06-05 DOI: 10.1038/s41422-025-01135-2
Yun Zhu, Tingting Lin, Guoliang Yin, Linhua Tai, Lianwan Chen, Jing Ma, Guoning Huang, Yi Lu, Zhiyong Zhang, Binbin Wang, Suren Chen, Fei Sun
{"title":"In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia.","authors":"Yun Zhu, Tingting Lin, Guoliang Yin, Linhua Tai, Lianwan Chen, Jing Ma, Guoning Huang, Yi Lu, Zhiyong Zhang, Binbin Wang, Suren Chen, Fei Sun","doi":"10.1038/s41422-025-01135-2","DOIUrl":"https://doi.org/10.1038/s41422-025-01135-2","url":null,"abstract":"<p><p>The central apparatus (CA) within the sperm axoneme is vital for sperm motility, yet its molecular architecture and functional mechanisms remain incompletely understood. Combining cryo-electron tomography and AlphaFold2, we resolved the in-cell structure of mouse sperm CA at a subnanometer resolution and built a near-complete atomic model. Our analysis identified 39 CA-associated proteins, including eight previously unreported components. By presenting the full-length structures of CFAP47 and HYDIN, we elucidate their molecular roles in tethering the C1 and C2 microtubules within the CA. Specifically, HYDIN forms a semicircular chain that encircles C1 and C2, with its N-terminal half driving the C1-C2 connection and its C-terminal half providing axial support in C2. CFAP47, the core structural component of the bridge, binds C1 through its N-terminal domains, interacts with HYDIN via its central CFAP47-ring, and anchors to C2 through its C-terminal region. The significantly reduced sperm motility and impaired CA structure observed in Cfap47-knockout mice confirmed the important role of CFAP47. Furthermore, genetic analysis of infertile Chinese men with asthenozoospermia identified previously unreported mutations in the CFAP47. The CA structural model elucidates the pathogenic mechanisms of these mutations, establishing a direct link between CFAP47 dysfunction and impaired sperm motility. Therefore, our study provides mechanistic insights into CA-related fertility disorders.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling 作者更正：spsb1介导的HnRNP A1泛素化调节EGF信号中的选择性剪接和细胞迁移
IF 44.1 1区 生物学
Cell Research Pub Date : 2025-06-04 DOI: 10.1038/s41422-025-01132-5
Feng Wang, Xing Fu, Peng Chen, Ping Wu, Xiaojuan Fan, Na Li, Hong Zhu, Ting-Ting Jia, Hongbin Ji, Zefeng Wang, Catherine C. L. Wong, Ronggui Hu, Jingyi Hui
{"title":"Author Correction: SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling","authors":"Feng Wang, Xing Fu, Peng Chen, Ping Wu, Xiaojuan Fan, Na Li, Hong Zhu, Ting-Ting Jia, Hongbin Ji, Zefeng Wang, Catherine C. L. Wong, Ronggui Hu, Jingyi Hui","doi":"10.1038/s41422-025-01132-5","DOIUrl":"https://doi.org/10.1038/s41422-025-01132-5","url":null,"abstract":"<p>Correction to: <i>Cell Research</i> https://doi.org/10.1038/cr.2017.7, published online 13 January 2017</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"31 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes. 作者更正：通过植入诱导的人类功能性肝细胞的生物人工肝装置提高猪急性肝衰竭的存活率。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-06-01 DOI: 10.1038/s41422-025-01108-5
Xiao-Lei Shi, Yimeng Gao, Yupeng Yan, Hucheng Ma, Lulu Sun, Pengyu Huang, Xuan Ni, Ludi Zhang, Xin Zhao, Haozhen Ren, Dan Hu, Yan Zhou, Feng Tian, Yuan Ji, Xin Cheng, Guoyu Pan, Yi-Tao Ding, Lijian Hui
{"title":"Author Correction: Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes.","authors":"Xiao-Lei Shi, Yimeng Gao, Yupeng Yan, Hucheng Ma, Lulu Sun, Pengyu Huang, Xuan Ni, Ludi Zhang, Xin Zhao, Haozhen Ren, Dan Hu, Yan Zhou, Feng Tian, Yuan Ji, Xin Cheng, Guoyu Pan, Yi-Tao Ding, Lijian Hui","doi":"10.1038/s41422-025-01108-5","DOIUrl":"10.1038/s41422-025-01108-5","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":"469-470"},"PeriodicalIF":28.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural basis of stepwise proton sensing-mediated GPCR activation. 质子感应介导的GPCR逐步激活的结构基础。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-06-01 Epub Date: 2025-04-11 DOI: 10.1038/s41422-025-01092-w
Xiaolei Yue, Li Peng, Shenhui Liu, Bingjie Zhang, Xiaodan Zhang, Hao Chang, Yuan Pei, Xiaoting Li, Junlin Liu, Wenqing Shui, Lijie Wu, Huji Xu, Zhi-Jie Liu, Tian Hua
{"title":"Structural basis of stepwise proton sensing-mediated GPCR activation.","authors":"Xiaolei Yue, Li Peng, Shenhui Liu, Bingjie Zhang, Xiaodan Zhang, Hao Chang, Yuan Pei, Xiaoting Li, Junlin Liu, Wenqing Shui, Lijie Wu, Huji Xu, Zhi-Jie Liu, Tian Hua","doi":"10.1038/s41422-025-01092-w","DOIUrl":"10.1038/s41422-025-01092-w","url":null,"abstract":"<p><p>The regulation of pH homeostasis is crucial in many biological processes vital for survival, growth, and function of life. The pH-sensing G protein-coupled receptors (GPCRs), including GPR4, GPR65 and GPR68, play a pivotal role in detecting changes in extracellular proton concentrations, impacting both physiological and pathological states. However, comprehensive understanding of the proton sensing mechanism is still elusive. Here, we determined the cryo-electron microscopy structures of GPR4 and GPR65 in various activation states across different pH levels, coupled with G<sub>s</sub>, G<sub>q</sub> or G<sub>13</sub> proteins, as well as a small molecule NE52-QQ57-bound inactive GPR4 structure. These structures reveal the dynamic nature of the extracellular loop 2 and its signature conformations in different receptor states, and disclose the proton sensing mechanism mediated by networks of extracellular histidine and carboxylic acid residues. Notably, we unexpectedly captured partially active intermediate states of both GPR4-G<sub>s</sub> and GPR4-G<sub>q</sub> complexes, and identified a unique allosteric binding site for NE52-QQ57 in GPR4. By integrating prior investigations with our structural analysis and mutagenesis data, we propose a detailed atomic model for stepwise proton sensation and GPCR activation. These insights may pave the way for the development of selective ligands and targeted therapeutic interventions for pH sensing-relevant diseases.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":"423-436"},"PeriodicalIF":28.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H. 人类snf2型atp酶SNF2H的染色质重塑机制。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-06-01 Epub Date: 2025-04-03 DOI: 10.1038/s41422-025-01103-w
Deepshikha Malik, Ashish Deshmukh, Silvija Bilokapic, Mario Halic
{"title":"Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H.","authors":"Deepshikha Malik, Ashish Deshmukh, Silvija Bilokapic, Mario Halic","doi":"10.1038/s41422-025-01103-w","DOIUrl":"10.1038/s41422-025-01103-w","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":"465-468"},"PeriodicalIF":28.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FUSTer than stress granules: a prion-like domain warns plants of heat 比压力颗粒更严重：一个类似朊病毒的区域警告植物热
IF 44.1 1区 生物学
Cell Research Pub Date : 2025-05-29 DOI: 10.1038/s41422-025-01133-4
Panagiotis N. Moschou, Peter V. Bozhkov
{"title":"FUSTer than stress granules: a prion-like domain warns plants of heat","authors":"Panagiotis N. Moschou, Peter V. Bozhkov","doi":"10.1038/s41422-025-01133-4","DOIUrl":"https://doi.org/10.1038/s41422-025-01133-4","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"62 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Expression of Concern: p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity. 编辑关注：p53的线粒体易位和MOMP作用独立于Puma和Bax，严重破坏线粒体膜的完整性。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-05-29 DOI: 10.1038/s41422-025-01129-0
Sonja Wolff, Susan Erster, Gustavo Palacios, Ute M Moll
{"title":"Editorial Expression of Concern: p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity.","authors":"Sonja Wolff, Susan Erster, Gustavo Palacios, Ute M Moll","doi":"10.1038/s41422-025-01129-0","DOIUrl":"https://doi.org/10.1038/s41422-025-01129-0","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis. 作者更正：在拟南芥中，一个热传感器FUST1通过生物分子凝结启动热诱导应激颗粒的形成。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-05-29 DOI: 10.1038/s41422-025-01134-3
Pan Geng, Changxuan Li, Xuebo Quan, Jiaxuan Peng, Zhiying Yao, Yunhe Wang, Ming Yang, Yanning Wang, Yunfan Jin, Yan Xiong, Hongtao Liu, Yijun Qi, Peiguo Yang, Kai Huang, Xiaofeng Fang
{"title":"Author Correction: A thermosensor FUST1 primes heat-induced stress granule formation via biomolecular condensation in Arabidopsis.","authors":"Pan Geng, Changxuan Li, Xuebo Quan, Jiaxuan Peng, Zhiying Yao, Yunhe Wang, Ming Yang, Yanning Wang, Yunfan Jin, Yan Xiong, Hongtao Liu, Yijun Qi, Peiguo Yang, Kai Huang, Xiaofeng Fang","doi":"10.1038/s41422-025-01134-3","DOIUrl":"10.1038/s41422-025-01134-3","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":28.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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