Cell Research最新文献

{"title":"A Trojan horse story: does pyroptosis open the gates to its own inhibition?","authors":"Órlaith C Henry, Luke A J O'Neill","doi":"10.1038/s41422-026-01302-z","DOIUrl":"https://doi.org/10.1038/s41422-026-01302-z","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":31.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of a magnesium-sensitive double-stranded RNA clearance machinery boosts cancer immunotherapy.","authors":"Zhirong Zhang, Lixiao Zhang, Hongdi Luo, Yujia Huo, Bohao Sun, Jiahao Shi, Sipeng Wu, Pengcheng Wang, Geng Wang","doi":"10.1038/s41422-026-01301-0","DOIUrl":"https://doi.org/10.1038/s41422-026-01301-0","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":31.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear speckle protein SON safeguards efficient splicing of GC-rich genes","authors":"Weiyi Fan,Yuenan Zhou,Xinyue Zhang,Chong Tong,Xiaoyu Li,Yafei Yin","doi":"10.1038/s41422-026-01303-y","DOIUrl":"https://doi.org/10.1038/s41422-026-01303-y","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"5 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undernutrition enhances host attractiveness to mosquitoes and transmission of mosquito-borne diseases","authors":"Mao Wang, Xiumei Song, Yibin Zhu, Jichen Niu, Gang Wang, Yicheng Wang, Hairu Xiao, Dan Lei, Taoping Wu, Long Liu, Penghua Wang, Jingwen Wang, Gong Cheng","doi":"10.1038/s41422-026-01291-z","DOIUrl":"10.1038/s41422-026-01291-z","url":null,"abstract":"Undernutrition is prevalent in regions affected by mosquito-borne diseases. Understanding how insufficient nutrition affects the transmission of mosquito-borne pathogens is critical for combating these diseases. In this study, we found that undernourished mice were more attractive to multiple mosquito vectors. Mechanistically, undernutrition impaired the secretion of antimicrobial fatty acids from dermal sebaceous glands, thereby leading to the excessive proliferation of certain skin commensal bacteria, which produced volatile aldehydes that act as potent mosquito attractants. Furthermore, undernutrition rendered mice more susceptible to mosquito-borne pathogens, such as dengue virus (DENV), thus facilitating the transmission of DENV both to and from mosquitoes. Consistently, undernourished human subjects exhibited similar skin microbiota alterations and elevated aldehyde emissions and were more attractive to mosquitoes. Our study suggests that undernutrition may be a key driver of the transmission of mosquito-borne diseases in nature and highlights the necessity of addressing undernutrition in regions where such diseases are prevalent.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 10","pages":"804-821"},"PeriodicalIF":31.1,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atlas-ing STING mutations to advance fundamental understanding and clinical translation.","authors":"Bao-Cun Zhang, Søren R Paludan","doi":"10.1038/s41422-026-01294-w","DOIUrl":"https://doi.org/10.1038/s41422-026-01294-w","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":31.1,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness","authors":"Jian Chen, Shizhen Qiu, Wentao Li, Kun Wang, Yu Zhang, Han Yang, Baichuan Liu, Guangfei Li, Li Li, Min Chen, Junjie Lan, Jiahua Niu, Peijie He, Lei Cheng, Gaofeng Fan, Xin Liu, Xianmin Song, Chenqi Xu, Haitao Wu, Haopeng Wang","doi":"10.1038/s41422-026-01296-8","DOIUrl":"10.1038/s41422-026-01296-8","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 10","pages":"830-832"},"PeriodicalIF":31.1,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01296-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolism licenses the senescence secretome","authors":"Pilar Picallos Rabina,Marco Demaria","doi":"10.1038/s41422-026-01295-9","DOIUrl":"https://doi.org/10.1038/s41422-026-01295-9","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"37 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148933744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innate immune sensors of inflammasomes and PANoptosomes: structural–mechanistic insights and therapeutic implications","authors":"Saurabh Upadhyay, Raghavendra Nagampalli, Sara Resende, Thirumala-Devi Kanneganti","doi":"10.1038/s41422-026-01287-9","DOIUrl":"10.1038/s41422-026-01287-9","url":null,"abstract":"Innate immunity provides a critical first line of defense against pathogens and homeostatic perturbations. Pattern recognition receptors detect these disruptions and initiate immune responses through multi-protein complex formation to drive inflammatory signaling and cell death pathways. Key cytosolic complexes formed by these sensors include inflammasomes and PANoptosomes. Inflammasomes induce caspase-1 activation and the subsequent maturation of interleukin (IL)-1β and IL-18, and they can act as integral components of larger PANoptosomes, whose formation and functions have been defined by genetic, biochemical, and single-cell imaging evidence. PANoptosomes induce lytic, inflammatory cell death (PANoptosis) and promote the release of damage-associated molecular patterns (DAMPs) and cytokines beyond IL-1β and IL-18, including TNF, IFNs, IL-6, and others. Given their critical functions in driving cell death and the release of cytokines and DAMPs, dysregulation of innate immune sensors is associated with a wide range of diseases, including infections, autoinflammatory syndromes, cardiovascular disorders, neurodegeneration, metabolic conditions, and cancer. Therefore, understanding innate immune sensors and how they assemble inflammasomes and PANoptosomes to drive cell death is critical for identifying therapeutic strategies. In this review, we discuss innate immune sensors that form inflammasomes and PANoptosomes, such as NLRP1, NLRP3, NLRC4, AIM2, Pyrin, and others. We highlight recent structural and mechanistic insights into these sensors, along with emerging structural studies of inflammasome assemblies and the biochemical and functional evidence supporting the formation of PANoptosomes. Given the physiological relevance of innate immune sensors and the complexes they form across the disease spectrum, an improved understanding of their structure–function relationships will be critical for informing therapeutic strategies that target these molecules, their associated complexes, and their physiological functions.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 10","pages":"747-768"},"PeriodicalIF":31.1,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01287-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD55 organizes lipid raft-LCK signaling to potentiate NK-cell antitumor immunity.","authors":"Lingyu Li, Zhaozhi Li, Yang Liu, Wei Fan, Yuhong Lei, Lei Tian, Lichao Chen, Zhihuan Qu, Yuanyuan Shi, Jianhua Yu, Yufeng Wang","doi":"10.1038/s41422-026-01288-8","DOIUrl":"https://doi.org/10.1038/s41422-026-01288-8","url":null,"abstract":"<p><p>Natural killer (NK) cells are central to antitumor immunity but rapidly lose function in the tumor microenvironment (TME). Here, we identify CD55, previously recognized as a complement regulatory protein, as an inducible membrane organizer that coordinates activating receptor signaling to potentiate NK cell-mediated antitumor responses. Upon initial tumor encounter, NK cells upregulate CD55 via an NKG2D-p65 transcriptional axis. Unlike in T-cells, where it has a known co-stimulatory role, CD55 on NK cells directly engages tumor-expressed CD97 in trans to trigger lipid raft aggregation and LCK activation, acting as a self-sufficient primary signal initiator that drives cytotoxicity. However, upon prolonged tumor exposure, CD55 expression on NK cells progressively declines, coinciding with the well‑recognized downregulation of NKG2D upon chronic exposure. Within the TME, this loss of CD55 causally impairs NK-cell function. In cancer patients, low CD55 expression in tumor-infiltrating NK cells correlates with poor clinical outcomes. Restoring CD55 expression in both conventional and chimeric antigen receptor-engineered NK cells augments LCK signaling, enhances effector function and persistence, and improves antitumor efficacy in vivo. Thus, NK cells deploy a CD55-dependent autonomous activation mechanism upon tumor encounter, whereas chronic exposure drives CD55 loss and functional dysfunction, a state that can be therapeutically reversed by CD55 restoration.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":31.1,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programmed to kill: AI-guided gasdermins eliminate virus-infected cells.","authors":"Alexis Betrancourt, Petr Broz","doi":"10.1038/s41422-026-01292-y","DOIUrl":"https://doi.org/10.1038/s41422-026-01292-y","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":31.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}