Cell Research最新文献

{"title":"SUS(d6)pending MHC class I peptide presentation for cancer immunoevasion","authors":"Devin Dersh, Jonathan W. Yewdell","doi":"10.1038/s41422-023-00882-4","DOIUrl":"10.1038/s41422-023-00882-4","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 2","pages":"97-98"},"PeriodicalIF":44.1,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-023-00882-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41193068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An idle PHGDH takes control of cell fate","authors":"Linchong Sun, Ping Gao","doi":"10.1038/s41422-023-00883-3","DOIUrl":"10.1038/s41422-023-00883-3","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"33 12","pages":"894-895"},"PeriodicalIF":44.1,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10709640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41193065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural basis for activation and filamentation of glutaminase","authors":"Chen-Jun Guo, Zi-Xuan Wang, Ji-Long Liu","doi":"10.1038/s41422-023-00886-0","DOIUrl":"10.1038/s41422-023-00886-0","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 1","pages":"76-79"},"PeriodicalIF":44.1,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-023-00886-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41193067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A broadly neutralizing antibody inhibits SARS-CoV-2 variants through a novel mechanism of disrupting spike trimer integrity","authors":"Yunping Ma, Qiyu Mao, Yingdan Wang, Zhaoyong Zhang, Jiali Chen, Aihua Hao, Palizhati Rehati, Yanqun Wang, Yumei Wen, Lu Lu, Zhenguo Chen, Jincun Zhao, Fan Wu, Lei Sun, Jinghe Huang","doi":"10.1038/s41422-023-00880-6","DOIUrl":"10.1038/s41422-023-00880-6","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"33 12","pages":"975-978"},"PeriodicalIF":44.1,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41111294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromosomal instability drives immunosuppression and metastatic dissemination","authors":"Ilio Vitale, Claudia Galassi, Lorenzo Galluzzi","doi":"10.1038/s41422-023-00876-2","DOIUrl":"10.1038/s41422-023-00876-2","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 1","pages":"7-8"},"PeriodicalIF":44.1,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-023-00876-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41133147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FSP1 oxidizes NADPH to suppress ferroptosis","authors":"Sitao Zhang, Shengsong Gou, Qian Zhang, Xin Yong, Boyi Gan, Da Jia","doi":"10.1038/s41422-023-00879-z","DOIUrl":"10.1038/s41422-023-00879-z","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"33 12","pages":"967-970"},"PeriodicalIF":44.1,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Isolation and proteomic analysis of the SYP61 compartment reveal its role in exocytic trafficking in Arabidopsis.","authors":"Georgia Drakakaki, Wilhelmina van de Ven, Songqin Pan, Yansong Miao, Junqi Wang, Nana F Keinath, Brent Weatherly, Liwen Jiang, Karin Schumacher, Glenn Hicks, Natasha Raikhel","doi":"10.1038/s41422-023-00865-5","DOIUrl":"https://doi.org/10.1038/s41422-023-00865-5","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":44.1,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41103920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning human liver biology in humanized mice","authors":"Brandon M. Lehrich, Satdarshan P. Monga","doi":"10.1038/s41422-023-00877-1","DOIUrl":"10.1038/s41422-023-00877-1","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 1","pages":"9-10"},"PeriodicalIF":44.1,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-023-00877-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41127717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LICOB: a powerful organoid platform for drug discovery","authors":"Haojie Jin, Zhen Sun, René Bernards","doi":"10.1038/s41422-023-00878-0","DOIUrl":"10.1038/s41422-023-00878-0","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 1","pages":"11-12"},"PeriodicalIF":44.1,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-023-00878-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41111742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate","authors":"Yu-Qing Wu, Chen-Song Zhang, Jinye Xiong, Dong-Qi Cai, Chen-Zhe Wang, Yu Wang, Yan-Hui Liu, Yu Wang, Yiming Li, Jian Wu, Jianfeng Wu, Bin Lan, Xuefeng Wang, Siwei Chen, Xianglei Cao, Xiaoyan Wei, Hui-Hui Hu, Huiling Guo, Yaxin Yu, Abdul Ghafoor, Changchuan Xie, Yaying Wu, Zheni Xu, Cixiong Zhang, Mingxia Zhu, Xi Huang, Xiufeng Sun, Shu-Yong Lin, Hai-Long Piao, Jianyin Zhou, Sheng-Cai Lin","doi":"10.1038/s41422-023-00874-4","DOIUrl":"10.1038/s41422-023-00874-4","url":null,"abstract":"Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in controlling cell fate remains unexplored. Here, we find that low levels of glycolytic metabolite 3-phosphoglycerate (3-PGA) can switch phosphoglycerate dehydrogenase (PHGDH) from cataplerosis serine synthesis to pro-apoptotic activation of p53. PHGDH is a p53-binding protein, and when unoccupied by 3-PGA interacts with the scaffold protein AXIN in complex with the kinase HIPK2, both of which are also p53-binding proteins. This leads to the formation of a multivalent p53-binding complex that allows HIPK2 to specifically phosphorylate p53-Ser46 and thereby promote apoptosis. Furthermore, we show that PHGDH mutants (R135W and V261M) that are constitutively bound to 3-PGA abolish p53 activation even under low glucose conditions, while the mutants (T57A and T78A) unable to bind 3-PGA cause constitutive p53 activation and apoptosis in hepatocellular carcinoma (HCC) cells, even in the presence of high glucose. In vivo, PHGDH-T57A induces apoptosis and inhibits the growth of diethylnitrosamine-induced mouse HCC, whereas PHGDH-R135W prevents apoptosis and promotes HCC growth, and knockout of Trp53 abolishes these effects above. Importantly, caloric restriction that lowers whole-body glucose levels can impede HCC growth dependent on PHGDH. Together, these results unveil a mechanism by which glucose availability autonomously controls p53 activity, providing a new paradigm of cell fate control by metabolic substrate availability.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"33 11","pages":"835-850"},"PeriodicalIF":44.1,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41111806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}