Cell Research最新文献

{"title":"Structure and genome editing activity of the novel CRISPR-Cas12o1 effector.","authors":"Zhiqiang Duan, Xi Zhang, Jun-Tao Zhang, Xingkun Ji, Ruiheng Liu, Ying Chen, Shanshan Li, Nannan Jia, Huizhi Gao, Yu Xin, Ning Jia, Jian-Kang Zhu","doi":"10.1038/s41422-024-01050-y","DOIUrl":"https://doi.org/10.1038/s41422-024-01050-y","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-species foundation model for single cells","authors":"Korbinian Traeuble, Matthias Heinig","doi":"10.1038/s41422-024-01045-9","DOIUrl":"10.1038/s41422-024-01045-9","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 12","pages":"818-819"},"PeriodicalIF":28.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-024-01045-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural insight into GPR55 ligand recognition and G-protein coupling","authors":"Ruixue Xia, Qingning Yuan, Na Wang, Li Hou, Junpei Abe, Jing Song, Yukishige Ito, H. Eric Xu, Yuanzheng He","doi":"10.1038/s41422-024-01044-w","DOIUrl":"https://doi.org/10.1038/s41422-024-01044-w","url":null,"abstract":"<p>Dear Editor,</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"213 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure basis of ligand recognition and activation of GPR55","authors":"Hao Chang, Xiaoting Li, Ling Shen, Xuanrui Ge, Shuming Hao, Lijie Wu, Shenhui Liu, Junlin Liu, Vadim Cherezov, Tian Hua","doi":"10.1038/s41422-024-01046-8","DOIUrl":"https://doi.org/10.1038/s41422-024-01046-8","url":null,"abstract":"<p>Dear Editor,</p><p>Human G protein-coupled receptor 55 (GPR55) is an orphan GPCR, termed an atypical cannabinoid receptor, CB₃R.¹ This classification was further supported by studies demonstrating that the endogenous ligands anandamide (AEA) and 2-arachidonoylglycerol (2-AG) of CB₁R and CB₂R, along with their synthetic agonist CP55940, could activate GPR55.² Interestingly, CB₁R antagonists such as rimonabant and AM251 were also reported to exhibit activity on GPR55, although reports on rimonabant’s effect on GPR55 are inconsistent across different laboratories.^2,3 Unlike CB₁R or CB₂R, which primarily couple with G_i prtoein,⁴ GPR55 activation induces diverse cellular responses by coupling with G_12/13 or G_q protein.^2,3 However, recent studies suggest that lysophosphatidylinositol (LPI) and its 2-arachidonyl analogs, rather than endocannabinoids, may serve as endogenous agonists of GPR55.^5,6 Therefore, the deorphanization of GPR55 still remains debatable. GPR55 is mainly expressed in the spinal cord and large-diameter dorsal root ganglia (DRG) and is reported to be involved in modulating nociceptor excitability and axon growth.^5,6,7 Additionally, GPR55 is also involved in metabolic diseases, cancer, and atherosclerosis. These physiological and pathophysiological processes underscore the therapeutic potential of GPR55. Notably, GPR55 was reported to form heterodimers with CB₁R or CB₂R in certain tissues, adding complexity to its pharmacological profile.⁸ However, the molecular mechanisms of ligand recognition and signaling remain puzzling due to the lack of a three-dimensional (3D) structure of GPR55.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"6 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanism of bacterial defense system DdmDE from Lactobacillus casei","authors":"Pingping Huang,&nbsp;Purui Yan,&nbsp;Lijie Guo,&nbsp;Wenying Fei,&nbsp;Zhaoxing Li,&nbsp;Jingxian Liu,&nbsp;Jianping Kong,&nbsp;Yue Yao,&nbsp;Meiling Lu,&nbsp;Yibei Xiao,&nbsp;Meirong Chen","doi":"10.1038/s41422-024-01042-y","DOIUrl":"10.1038/s41422-024-01042-y","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 12","pages":"873-876"},"PeriodicalIF":28.1,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nucleophagy repairs toxic DNA lesions","authors":"Ines Tomaskovic, Cristian Prieto-Garcia, Ivan Dikic","doi":"10.1038/s41422-024-01043-x","DOIUrl":"https://doi.org/10.1038/s41422-024-01043-x","url":null,"abstract":"<p><b>In a recent study in</b> <b><i>Cell</i></b><b>, Lascaux et al. revealed a novel pathway to repair toxic DNA lesions, providing a direct link between nucleophagy, a type of selective autophagy, and the resolution of damaged DNA.</b></p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"6 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-wide DNA methylation polymorphisms at single-nucleotide resolution in 207 cotton accessions reveal epigenomic contributions to complex traits","authors":"Ting Zhao,&nbsp;Xueying Guan,&nbsp;Yan Hu,&nbsp;Ziqian Zhang,&nbsp;Han Yang,&nbsp;Xiaowen Shi,&nbsp;Jin Han,&nbsp;Huan Mei,&nbsp;Luyao Wang,&nbsp;Lei Shao,&nbsp;Hongyu Wu,&nbsp;Qianqian Chen,&nbsp;Yongyan Zhao,&nbsp;Jiaying Pan,&nbsp;Yupeng Hao,&nbsp;Zeyu Dong,&nbsp;Xuan Long,&nbsp;Qian Deng,&nbsp;Shengjun Zhao,&nbsp;Mengke Zhang,&nbsp;Yumeng Zhu,&nbsp;Xiaowei Ma,&nbsp;Zequan Chen,&nbsp;Yayuan Deng,&nbsp;Zhanfeng Si,&nbsp;Xin Li,&nbsp;Tianzhen Zhang,&nbsp;Fei Gu,&nbsp;Xiaofeng Gu,&nbsp;Lei Fang","doi":"10.1038/s41422-024-01027-x","DOIUrl":"10.1038/s41422-024-01027-x","url":null,"abstract":"DNA methylation plays multiple regulatory roles in crop development. However, the relationships of methylation polymorphisms with genetic polymorphisms, gene expression, and phenotypic variation in natural crop populations remain largely unknown. Here, we surveyed high-quality methylomes, transcriptomes, and genomes obtained from the 20-days-post-anthesis (DPA) cotton fibers of 207 accessions and extended the classical framework of population genetics to epigenetics. Over 287 million single methylation polymorphisms (SMPs) were identified, 100 times more than the number of single nucleotide polymorphisms (SNPs). These SMPs were significantly enriched in intragenic regions while depleted in transposable elements. Association analysis further identified a total of 5,426,782 cis-methylation quantitative trait loci (cis-meQTLs), 5078 cis-expression quantitative trait methylation (cis-eQTMs), and 9157 expression quantitative trait loci (eQTLs). Notably, 36.39% of cis-eQTM genes were not associated with genetic variation, indicating that a large number of SMPs associated with gene expression variation are independent of SNPs. In addition, out of the 1715 epigenetic loci associated with yield and fiber quality traits, only 36 (2.10%) were shared with genome-wide association study (GWAS) loci. The construction of multi-omics regulatory networks revealed 43 cis-eQTM genes potentially involved in fiber development, which cannot be identified by GWAS alone. Among these genes, the role of one encoding CBL-interacting protein kinase 10 in fiber length regulation was successfully validated through gene editing. Taken together, our findings prove that DNA methylation data can serve as an additional resource for breeding purposes and can offer opportunities to enhance and expedite the crop improvement process.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 12","pages":"859-872"},"PeriodicalIF":28.1,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-024-01027-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunity hubs orchestrating antiviral defense.","authors":"Linnan Zhu, Zemin Zhang","doi":"10.1038/s41422-024-01036-w","DOIUrl":"https://doi.org/10.1038/s41422-024-01036-w","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowing when to stop: MICL self-regulates neutrophil NETosis","authors":"Hanjoo Brian Shim, Justin François Deniset, Paul Kubes","doi":"10.1038/s41422-024-01037-9","DOIUrl":"https://doi.org/10.1038/s41422-024-01037-9","url":null,"abstract":"<p><b>In a recent study published in</b> <b><i>Nature</i></b><i>,</i> <b>Malamud et al. identified how neutrophil MICL recognizes neutrophil extracellular traps (NETs). This recognition suppresses further neutrophil activation and NET production, thereby preventing a vicious cycle of inflammation</b>.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"31 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142430542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fine-tuning protein hunger: sex- and mating-dependent setpoint control","authors":"Yangkyun Oh, Won-Jae Lee","doi":"10.1038/s41422-024-01039-7","DOIUrl":"https://doi.org/10.1038/s41422-024-01039-7","url":null,"abstract":"<p><b>While a balanced intake of macronutrients — carbohydrates, fats, and proteins — is essential for metabolic homeostasis, animals need higher protein intake during critical life stages like pregnancy. A recent paper in</b> <b><i>Cell</i></b> <b>by Wu et al. introduces the novel concept of adjusting protein intake setpoints based on sex and mating status, using two opposing G protein-coupled receptor (GPCR) signaling pathways that regulate protein appetite-controlling neurons in the fruit fly,</b> <b><i>Drosophila melanogaster</i></b>.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"193 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142430543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}