Cell Research最新文献

{"title":"Phase separation drives the innate sluggishness of BCR-ABL1 in response to targeted therapy","authors":"Gen Li, Jun Wu, Zhijun He, Junhua Zhao, Haiyan Chen, Jiawen Zhou, Qiaolei Zhang, Zhenning Wang, Qinglin Li, Peng Jiang","doi":"10.1038/s41422-026-01286-w","DOIUrl":"10.1038/s41422-026-01286-w","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 10","pages":"822-825"},"PeriodicalIF":31.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long noncoding RNAs cross kingdoms to broaden host-pathogen dialogue.","authors":"Lida Halilovic, Hailing Jin","doi":"10.1038/s41422-026-01289-7","DOIUrl":"https://doi.org/10.1038/s41422-026-01289-7","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":31.1,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"p-LoopF is associated with chromatin looping in large introns of Ginkgo biloba","authors":"Bing He, Jianyang Li, Wei Fan, Hailin Liu, Haohan Teng, Qiang Lin, Mengjia Bu, Shigang Wu, Ruonan Li, Siwei Xiong, Yuting Bai, Fuliang Cao, Li-An Xu, Wanfei Liu, Jue Ruan, Peng Cui","doi":"10.1038/s41422-026-01290-0","DOIUrl":"10.1038/s41422-026-01290-0","url":null,"abstract":"In gymnosperms such as Ginkgo biloba, the regulatory role of large introns remains unclear. To address this, we conducted integrative multi-omics analyses of chromatin accessibility, three-dimensional chromosomal architecture, histone modifications, DNA methylation, RNA polymerase II occupancy, and gene expression in Ginkgo, complemented by laboratory experiments. We first identified a plant-specific factor, plant-Loop Factor (p-LoopF), which shares ~40% sequence similarity with human CCCTC-binding factor (CTCF). p-LoopF binds specifically to the consensus motif recognized by human CTCF and is significantly associated with chromatin looping, but it lacks canonical CTCF functional features, including motif orientation dependence, chromatin insulation activity, and statistically significant correlations with cohesin subunits. Through integrative multi-omics analyses, we propose a regulatory hypothesis in which p-LoopF-associated chromatin loops are correlated with the recruitment of distal enhancer-like regulatory regions, with large introns serving as a key regulatory context for these interactions. p-LoopF also localizes to promoters and distal intergenic regions, correlating with transcriptional regulation and local chromatin organization. We characterized large introns as regions enriched for chromatin loops, p-LoopF binding sites, and enhancer-like elements, which are strongly associated with the transcriptional regulation of their host genes. Additionally, active histone marks and DNA demethylation were enriched near the boundaries of large introns, particularly around splice sites, suggesting that splicing regulation differs between large and small introns.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 10","pages":"769-784"},"PeriodicalIF":31.1,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dark side of DNA repair: when genome maintenance runs out of fuel.","authors":"Marjolein van Sluis, Jurgen A Marteijn","doi":"10.1038/s41422-026-01285-x","DOIUrl":"10.1038/s41422-026-01285-x","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":31.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reading tumor ecosystems from routine histology.","authors":"Ludvig Bergenstråhle, Joakim Lundeberg","doi":"10.1038/s41422-026-01284-y","DOIUrl":"https://doi.org/10.1038/s41422-026-01284-y","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":31.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shiver me timbers: cold-driven lipids fuel platelet production","authors":"Yupeng Wu, Hugo ten Cate","doi":"10.1038/s41422-026-01265-1","DOIUrl":"10.1038/s41422-026-01265-1","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 9","pages":"641-642"},"PeriodicalIF":31.1,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01265-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis","authors":"Sisi Xie, Kaihong Chen, Xiaoting Sun, Ying Ye, Ruibo Chen, Chenyu Jiang, Mingjia Chen, Xue Lv, Huilan Li, Ying Liao, Weihua Chen, Lin Deng, Linli Cai, Yu Liang, Qiaoling Wei, Ji Zuo, Guohua Yu, Libo Yang, Jiansong Ji, Li Lin, Wei Tao, Chen Zhao, Yunlong Yang, Yihai Cao","doi":"10.1038/s41422-026-01280-2","DOIUrl":"10.1038/s41422-026-01280-2","url":null,"abstract":"Vein occlusion (VO), including deep venous thrombosis (DVT) and retinal vein occlusion (RVO), is a common cause of multiple diseases that severely compromise the quality of life of affected individuals. Epidemiological evidence indicates that VO prevalence increases in cold seasons, yet the underlying mechanism remains unknown. Here, we show that cold exposure markedly elevates peripheral platelet counts, thereby aggravating VO in mouse models. Cold-augmented thrombocytopoiesis depends on the activation of adipose thermogenesis and subsequent increase in circulating free fatty acid (FFA) levels. Mechanistically, FFA-β-oxidation promotes acetyl-CoA production, which upregulates and stabilizes C/EBPα by shifting the balance between p300 acetyltransferase and SIRT1 deacetylase. Acetyl-C/EBPα transcriptionally upregulates GATA-1 and NF-E2 for megakaryocyte maturation and platelet production. Depletion of adipose triglyceride lipase PNPLA2, megakaryocyte-specific knockout of key β-oxidation enzyme CPT1α, or pharmacological inhibition of CPT1α and p300 abolishes cold-augmented thrombocytopoiesis and alleviates DVT and RVO in mouse models. In healthy volunteers, tolerable cold exposure activates adipose thermogenesis, increases circulating FFA levels, and increases platelet counts. Moreover, a retrospective cohort study of 425 patients reveals elevated platelet counts and higher DVT incidence during cold seasons. Similarly, increased platelet counts are observed in 448 patients with RVO at the time of diagnosis in cold seasons. Our study provides novel mechanistic insights into the increased VO risk induced by cold exposure and proposes a new therapeutic paradigm for VO by targeting megakaryocyte metabolism.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 9","pages":"698-717"},"PeriodicalIF":31.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01280-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration","authors":"Qing Li, Xidi Yin, Chuanyin Li, Li Guo, Yingyi Wang, Yanbo Cheng, Nan Liu, Qi Yin, Yifu Ding, Meng Yan, Zihan Liu, Junyu Chen, Jin Zhang, Shuo Huang, Wangpeng Gu, Anjing Guo, Huanhuan Deng, Yuanyuan Li, Di Chen, Ian Chambers, Hui Zheng, Ronggui Hu, Man Zhang, Jinsong Li","doi":"10.1038/s41422-026-01272-2","DOIUrl":"10.1038/s41422-026-01272-2","url":null,"abstract":"During primordial germ cell (PGC) specification, repression of somatic programs is essential for the establishment of germline identity. However, mechanisms that safeguard PGC fate thereafter remain unknown. Here, we identify the E3 ubiquitin ligase TRIM37 as a critical safeguard of PGC fate during migration. Trim37 deficiency causes severe PGC defects beginning at embryonic day 9.5 (E9.5) with complete PGC depletion by E12.5, and leads to an aberrant transition toward somatic cell states. Mechanistically, TRIM37 binds TRIM28 through its MATH domain and ubiquitinates TRIM28 via its RING domain, enhancing the TRIM37–TRIM28 interaction and promoting the nuclear retention of TRIM37. Forced nuclear export of TRIM37 results in PGC loss. Moreover, disruption of TRIM37 ligase activity or mutation of TRIM28 ubiquitination sites compromises PGC maintenance. We further show that the TRIM37–TRIM28 complex, likely acting in cooperation with AP2γ, restricts chromatin accessibility and H3K27ac levels at somatic gene loci, thereby repressing somatic transcriptional programs in PGCs. Together, our findings uncover a TRIM37–TRIM28–AP2γ regulatory complex that safeguards germ cell fate by preventing the activation of somatic transcriptional programs during PGC migration.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 10","pages":"785-803"},"PeriodicalIF":31.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01272-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptotic propagation: from single-cell execution to tissue-scale death programs","authors":"Daolin Tang, Rui Kang, Guido Kroemer","doi":"10.1038/s41422-026-01283-z","DOIUrl":"10.1038/s41422-026-01283-z","url":null,"abstract":"Ferroptosis has long been regarded as a cell-autonomous form of regulated cell death driven by iron-dependent lipid peroxidation. Recent work, however, suggests that ferroptotic commitment can extend beyond the initiating cell, spreading to neighboring cells and, in some contexts, across tissue-scale distances. Multiple, non-mutually exclusive modes of contagion have now been described, including reactive oxygen species-triggered death waves, direct membrane contact-dependent transfer, and extracellular vesicle-mediated paracrine signaling. These findings redefine ferroptosis from a single-cell execution pathway into a spatially coordinated, multicellular process. In this perspective, we integrate mechanistic insights with experimental evidence on ferroptotic contagion and propose a unifying, multiscale framework in which distinct modes of transmission operate over different spatial scales, from short-range membrane transfer to longer-range oxidative and extracellular relay mechanisms. We discuss how nonlinear redox amplification, membrane biophysics, and tissue architecture together determine the dynamics, limits, and patterning of ferroptotic injury in vivo. This emerging framework has important implications for developmental tissue remodeling, the progression of organ injury, and ferroptosis-based cancer therapy. More broadly, defining how ferroptotic contagion is initiated, constrained, and manipulated therapeutically may help establish ferroptosis as a fundamental organizing principle for understanding tissue-level regulation and pathological escalation.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 9","pages":"645-655"},"PeriodicalIF":31.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01283-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ironing out a metabolic barrier to durable CAR T cell therapy.","authors":"Clare Y Slaney, Rachel Xu, Phillip K Darcy","doi":"10.1038/s41422-026-01282-0","DOIUrl":"https://doi.org/10.1038/s41422-026-01282-0","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":31.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}