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Borrowed mitochondria, spared neurons. 借来的线粒体，留下的神经元。
IF 25.9 1区 生物学
Cell Research Pub Date : 2026-03-04 DOI: 10.1038/s41422-026-01230-y
Gwang-Bum Im, Juan M Melero-Martin
{"title":"Borrowed mitochondria, spared neurons.","authors":"Gwang-Bum Im, Juan M Melero-Martin","doi":"10.1038/s41422-026-01230-y","DOIUrl":"https://doi.org/10.1038/s41422-026-01230-y","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":25.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Light sensing enhances thermotolerance and competitive fitness via serotonergic signaling in an eyeless organism 光感应增强无眼生物的耐热性和竞争适应性，通过血清素能信号传导
IF 25.9 1区 生物学
Cell Research Pub Date : 2026-03-01 DOI: 10.1038/s41422-026-01223-x
Liankui Zhou, Ying Liu
{"title":"Light sensing enhances thermotolerance and competitive fitness via serotonergic signaling in an eyeless organism","authors":"Liankui Zhou, Ying Liu","doi":"10.1038/s41422-026-01223-x","DOIUrl":"10.1038/s41422-026-01223-x","url":null,"abstract":"Organisms leverage environmental cues to anticipate and adapt to changing conditions. Here, we show that Caenorhabditis elegans, despite being eyeless, utilizes photoperception as an anticipatory cue to enhance survival under thermal stress. Exposure to low-intensity light activates a heat-shock response via the photoreceptor LITE-1, triggering serotonin signaling that promotes thermotolerance through the serotonin receptor SER-5 in the intestine and muscle. Beyond acute stress protection, light perception modulates reproductive behavior by delaying egg laying under unfavorable conditions and induces intergenerational thermotolerance, enhancing progeny survival at elevated temperatures. Photoperception also improves population competitiveness, providing a competitive advantage in dynamic environments. These findings reveal a previously unrecognized role for photoperception in a non-photosynthetic animal and establish it as a key mechanism for thermal adaptation and fitness.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 4","pages":"286-299"},"PeriodicalIF":25.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147320045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eyeless light sensing promotes thermotolerance 无眼光感应促进耐热性。
IF 25.9 1区 生物学
Cell Research Pub Date : 2026-02-26 DOI: 10.1038/s41422-026-01228-6
Roger Pocock
{"title":"Eyeless light sensing promotes thermotolerance","authors":"Roger Pocock","doi":"10.1038/s41422-026-01228-6","DOIUrl":"10.1038/s41422-026-01228-6","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 4","pages":"243-244"},"PeriodicalIF":25.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IRES–cargo interplay structurally modulates circular RNA translation IRES-cargo相互作用在结构上调节环状RNA翻译。
IF 25.9 1区 生物学
Cell Research Pub Date : 2026-02-26 DOI: 10.1038/s41422-026-01233-9
Youkui Huang, Yao-Qi Chen, Si-Yu Lou, Xiang Gao, Yu-Xin Liu, Yu-Lu Zhang, Fang Nan, Ling-Ling Chen, Li Yang
{"title":"IRES–cargo interplay structurally modulates circular RNA translation","authors":"Youkui Huang, Yao-Qi Chen, Si-Yu Lou, Xiang Gao, Yu-Xin Liu, Yu-Lu Zhang, Fang Nan, Ling-Ling Chen, Li Yang","doi":"10.1038/s41422-026-01233-9","DOIUrl":"10.1038/s41422-026-01233-9","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 5","pages":"377-380"},"PeriodicalIF":25.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01233-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A moonlighting function: the methionine cycle rewires RNA methylation 一个兼职功能：蛋氨酸循环重新连接RNA甲基化。
IF 25.9 1区 生物学
Cell Research Pub Date : 2026-02-23 DOI: 10.1038/s41422-026-01231-x
Zhaoxu Xu, Jianjun Chen
{"title":"A moonlighting function: the methionine cycle rewires RNA methylation","authors":"Zhaoxu Xu, Jianjun Chen","doi":"10.1038/s41422-026-01231-x","DOIUrl":"10.1038/s41422-026-01231-x","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 4","pages":"241-242"},"PeriodicalIF":25.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polycomb Repressive Complex 1 primes non-growing oocytes for growth and early embryogenesis 多梳抑制复合体1启动非生长卵母细胞的生长和早期胚胎发生。
IF 25.9 1区 生物学
Cell Research Pub Date : 2026-02-23 DOI: 10.1038/s41422-026-01232-w
Mengwen Hu, Yasuhisa Munakata, Yu-Han Yeh, Raissa G. Dani, Han Wang, Neil Hunter, Richard M. Schultz, Satoshi H. Namekawa
{"title":"Polycomb Repressive Complex 1 primes non-growing oocytes for growth and early embryogenesis","authors":"Mengwen Hu, Yasuhisa Munakata, Yu-Han Yeh, Raissa G. Dani, Han Wang, Neil Hunter, Richard M. Schultz, Satoshi H. Namekawa","doi":"10.1038/s41422-026-01232-w","DOIUrl":"10.1038/s41422-026-01232-w","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 4","pages":"300-303"},"PeriodicalIF":25.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial double-stranded RNA drives aging-associated cognitive decline 线粒体双链RNA驱动衰老相关的认知能力下降。
IF 25.9 1区 生物学
Cell Research Pub Date : 2026-02-16 DOI: 10.1038/s41422-026-01224-w
Lixiao Zhang, Xiang Li, Hongdi Luo, Yujia Huo, Guangkeng Zhou, Pengcheng Wang, Sipeng Wu, Xinyong Lin, Kai Dai, Jiahao Shi, Zebao Wang, Jiaxin Xu, Renjian Li, Siyi Chen, Zhe Sun, Chunlin Zhao, Zizhuo Zhou, Zhenhong Wang, Chensi Liang, Jun Zhu, Xingjun Chen, Jintao Luo, Yong Yu, Zhirong Zhang, Geng Wang
{"title":"Mitochondrial double-stranded RNA drives aging-associated cognitive decline","authors":"Lixiao Zhang, Xiang Li, Hongdi Luo, Yujia Huo, Guangkeng Zhou, Pengcheng Wang, Sipeng Wu, Xinyong Lin, Kai Dai, Jiahao Shi, Zebao Wang, Jiaxin Xu, Renjian Li, Siyi Chen, Zhe Sun, Chunlin Zhao, Zizhuo Zhou, Zhenhong Wang, Chensi Liang, Jun Zhu, Xingjun Chen, Jintao Luo, Yong Yu, Zhirong Zhang, Geng Wang","doi":"10.1038/s41422-026-01224-w","DOIUrl":"10.1038/s41422-026-01224-w","url":null,"abstract":"Aging is the primary cause of cognitive decline. Despite extensive study, the molecular mechanisms driving aging-associated cognitive decline remain unclear. Here, we describe a proteostasis-independent function of SEC61A1 and its involvement in aging-associated cognitive decline. SEC61A1 regulates ER–mitochondria contact sites, affecting mitochondrial DNA and RNA synthesis and subsequently leading to changes in innate immune signaling mediated by mitochondrial double-stranded RNA (mt-dsRNA). This pathway is activated in aged wild-type mice, Alzheimer’s disease patients, and 5×FAD mice. Tissue-specific overexpression of Sec61a1 in the mouse cortex (Sec61a1Tg) is sufficient to induce cognitive decline without affecting motor activity. Knockdown of Sec61a1 or Mavs ablates mt-dsRNA-mediated innate immune signaling and alleviates cognitive decline in naturally aging wild-type mice. These results reveal a molecular mechanism of aging- and disease-associated cognitive decline and provide a potential therapeutic tool for intervention.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 5","pages":"322-339"},"PeriodicalIF":25.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymmetric division rejuvenates stem cell lineages 不对称分裂使干细胞谱系恢复活力。
IF 25.9 1区 生物学
Cell Research Pub Date : 2026-02-16 DOI: 10.1038/s41422-026-01226-8
Jianlong Wang
{"title":"Asymmetric division rejuvenates stem cell lineages","authors":"Jianlong Wang","doi":"10.1038/s41422-026-01226-8","DOIUrl":"10.1038/s41422-026-01226-8","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 4","pages":"239-240"},"PeriodicalIF":25.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13013559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extrachromosomal DNA drives cancer evolution. 染色体外DNA驱动癌症进化。
IF 25.9 1区 生物学
Cell Research Pub Date : 2026-02-09 DOI: 10.1038/s41422-026-01225-9
Ilio Vitale, Alessandro D'Ambrosio, Lorenzo Galluzzi
{"title":"Extrachromosomal DNA drives cancer evolution.","authors":"Ilio Vitale, Alessandro D'Ambrosio, Lorenzo Galluzzi","doi":"10.1038/s41422-026-01225-9","DOIUrl":"https://doi.org/10.1038/s41422-026-01225-9","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":25.9,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymmetric division in a two-cell-like state rejuvenates embryonic stem cells 两细胞样状态下的不对称分裂使胚胎干细胞恢复活力
IF 25.9 1区 生物学
Cell Research Pub Date : 2026-02-03 DOI: 10.1038/s41422-026-01221-z
Xinyi Wang, Hong Fu, Qingyang Sun, Boyan Huang, Zhe Xu, Xuzhao Zhai, Chuncao Deng, Laru Peng, Mengdan Zhang, Tianran Peng, An Gong, Jiasui Liu, Zhengzhi Zou, Guangjin Pan, Jiekai Chen, Guangming Wu, Man Zhang, Mingwei Min
{"title":"Asymmetric division in a two-cell-like state rejuvenates embryonic stem cells","authors":"Xinyi Wang, Hong Fu, Qingyang Sun, Boyan Huang, Zhe Xu, Xuzhao Zhai, Chuncao Deng, Laru Peng, Mengdan Zhang, Tianran Peng, An Gong, Jiasui Liu, Zhengzhi Zou, Guangjin Pan, Jiekai Chen, Guangming Wu, Man Zhang, Mingwei Min","doi":"10.1038/s41422-026-01221-z","DOIUrl":"10.1038/s41422-026-01221-z","url":null,"abstract":"A fundamental question in biology is whether all cells age. Embryonic stem cells (ESCs) defy the norm as rare normal cells capable of indefinite in vitro passage. However, the mechanisms underlying ESC lineage immortality remain unresolved. Using long-term live-cell imaging to follow the fates of single ESCs, we show that ESC lineage renewal is achieved through sporadic entry into a state characterized by the expression of two-cell embryo-specific markers. During this state, cells undergo asymmetric fate divisions, enriching accumulated DNA damage into one daughter lineage that is destined for elimination, while producing a second lineage that reverts to the pluripotent state. Importantly, the latter lineage exhibits signs of rejuvenation, including reduced DNA damage and enhanced chimeric efficiency. These findings underscore the crucial role of asymmetric cell division in maintaining the long-term health of the ESC lineage against mounting damage within individual cells and provide a potential model for studying cellular aging and rejuvenation in mammalian cells.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 3","pages":"219-232"},"PeriodicalIF":25.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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