Cell Research最新文献_第4页

Cultured human stem cells undergoing gastrulation 正在进行原肠胚形成的培养的人类干细胞

IF 25.9 1区生物学

Cell Research Pub Date : 2025-08-06 DOI: 10.1038/s41422-025-01151-2

Fan Zhang, Fan Guo

引用次数: 0

Structure and activation mechanism of human sweet taste receptor 人类甜味受体的结构与激活机制。

IF 25.9 1区生物学

Cell Research Pub Date : 2025-08-04 DOI: 10.1038/s41422-025-01156-x

Haolan Wang, Xiao Chen, Yaxin Dai, Shabareesh Pidathala, Yiming Niu, Chen Zhao, Siyu Li, Liang Wang, Chia-Hsueh Lee

引用次数: 0

Centromeres as minefields: host–virus warfare 着丝粒是雷区：宿主-病毒之战

IF 44.1 1区生物学

Cell Research Pub Date : 2025-08-01 DOI: 10.1038/s41422-025-01159-8

Chin Wei Brian Leung, Fumiko Esashi

引用次数: 0

Neutrophil maturation holds the secret to human tumor suppression 中性粒细胞成熟是人类肿瘤抑制的秘密

IF 25.9 1区生物学

Cell Research Pub Date : 2025-08-01 DOI: 10.1038/s41422-025-01160-1

Bianca Calí, Andrea Alimonti

引用次数: 0

Disturbed engram network caused by NPTX downregulation underlies aging-related contextual fear memory deficits NPTX下调引起的印痕网络紊乱是衰老相关情境恐惧记忆缺陷的基础

IF 25.9 1区生物学

Cell Research Pub Date : 2025-08-01 DOI: 10.1038/s41422-025-01157-w

Tao Jin, Yang Yang, Yu Guo, Yi Zhang, Qiumin Le, Nan Huang, Xing Liu, Jintai Yu, Lan Ma, Feifei Wang

{"title":"Disturbed engram network caused by NPTX downregulation underlies aging-related contextual fear memory deficits","authors":"Tao Jin, Yang Yang, Yu Guo, Yi Zhang, Qiumin Le, Nan Huang, Xing Liu, Jintai Yu, Lan Ma, Feifei Wang","doi":"10.1038/s41422-025-01157-w","DOIUrl":"10.1038/s41422-025-01157-w","url":null,"abstract":"Engram cells storing episodic memories are allocated to separate neuronal ensembles. However, how these ensembles maintain their stability to drive precise memory expression, and whether their destabilization contributes to aging-related memory deficits, remain elusive. Here, we show that during contextual fear memory consolidation, neuronal pentraxin 1 (NPTX1) in Fos transcription-dependent ensemble (F-RAM) of the dentate gyrus (DG) promotes memory expression in the fear context. NPTX1 facilitates Kv7.2 channel-mediated inhibition of engram cell hyperexcitability, thereby restricting the response of these cells to excitatory inputs from medial entorhinal cortex. Meanwhile, NPTX2 enhances the perisomatic inhibition of Npas4 transcription-dependent ensemble (N-RAM) by parvalbumin+ (PV+) interneurons, thereby preventing fear memory overgeneralization. Pharmacological activation of Kv7.2 channels or chemogenetic activation of PV+ interneurons repaired memory deficits caused by engram-specific NPTX depletion. Contextual fear memory precision and NPTX expression in DG engram cells were decreased in aged mice. Overexpressing NPTX1 in F-RAM ensemble or the AMPAR-binding domain of NPTX2 in N-RAM ensemble rescued contextual fear memory deficits. These findings elucidate that the coordination of NPTX1 and NPTX2 prevents engram ensembles from becoming hyperactive and provide a causal link between engram network destabilization and aging-related contextual fear memory deficits.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 9","pages":"656-674"},"PeriodicalIF":25.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-025-01157-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function. KCNQ1门控调控kcnne1 /3细胞特异性功能的机制。

IF 25.9 1区生物学

Cell Research Pub Date : 2025-07-31 DOI: 10.1038/s41422-025-01152-1

Chenxi Cui, Lu Zhao, Ali A Kermani, Shuzong Du, Tanadet Pipatpolkai, Meiqin Jiang, Sagar Chittori, Yong Zi Tan, Jingyi Shi, Lucie Delemotte, Jianmin Cui, Ji Sun

{"title":"Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function.","authors":"Chenxi Cui, Lu Zhao, Ali A Kermani, Shuzong Du, Tanadet Pipatpolkai, Meiqin Jiang, Sagar Chittori, Yong Zi Tan, Jingyi Shi, Lucie Delemotte, Jianmin Cui, Ji Sun","doi":"10.1038/s41422-025-01152-1","DOIUrl":"10.1038/s41422-025-01152-1","url":null,"abstract":"<p><p>KCNQ1 potassium channels are essential for physiological processes such as cardiac rhythm and intestinal chloride secretion. KCNE family subunits (KCNE1-5) associate with KCNQ1, conferring distinct properties across various tissues. KCNQ1 activation requires membrane depolarization and phosphatidylinositol 4,5-bisphosphate (PIP2) whose cellular levels are controlled by Gαq-coupled GPCR activation. While modulation of KCNQ1's voltage-dependent activation by KCNE1/3 is well-characterized, their effects on PIP2-dependent gating of KCNQ1 via GPCR signaling remain less understood. Here we resolved structures of KCNQ1-KCNE1 and reassessed the reported KCNQ1-KCNE3 structures with and without PIP2. We revealed that KCNQ1-KCNE1/3 complexes feature two PIP2-binding sites, with KCNE1/3 contributing to a previously overlooked, uncharacterized site involving residues critical for coupling voltage sensor and pore domains. Via this site, KCNE1 and KCNE3 distinctly modulate the PIP2-dependent gating, in addition to the voltage sensitivity, of KCNQ1. Consequently, KCNE3 converts KCNQ1 into a voltage-insensitive PIP2-gated channel governed by GPCR signaling to maintain ion homeostasis in non-excitable cells. KCNE1, by significantly enhancing KCNQ1's PIP2 affinity and resistance to GPCR regulation, forms predominantly voltage-gated channels with KCNQ1 for conducting the slow-delayed rectifier current in excitable cardiac cells. Our study highlights how KCNE1/3 modulates KCNQ1 gating in different cellular contexts, providing insights into tissue-specifically targeting multi-functional channels.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":""},"PeriodicalIF":25.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoproteasome-dependent neuronal ferroptosis in multiple sclerosis 多发性硬化症中免疫蛋白酶体依赖性神经元铁下垂

IF 44.1 1区生物学

Cell Research Pub Date : 2025-07-28 DOI: 10.1038/s41422-025-01162-z

David C. Rubinsztein

引用次数: 0

Modeling mammalian hibernation to improve organ cold preservation: Using the intestine as an example 模拟哺乳动物冬眠以改善器官低温保存：以肠道为例

IF 25.9 1区生物学

Cell Research Pub Date : 2025-07-28 DOI: 10.1038/s41422-025-01149-w

Weiya He, Ziqing He, Wenjun Deng, Chuman Wu, Wenjie Huang, Changhui Li, Yan Liang, Yifu Chen, Renjie Luo, Yifei Zhao, Jiayu Liao, Xin Zhou, Guokai Chen, Ren-He Xu, Meiling Liu, Ji Dong

引用次数: 0

Psychedelics target neuroimmune interactions to limit fear 致幻剂以神经免疫相互作用为目标来限制恐惧

IF 44.1 1区生物学

Cell Research Pub Date : 2025-07-25 DOI: 10.1038/s41422-025-01154-z

Johana Alvarez, Scott J. Russo

引用次数: 0

Antibiotics deliver a gut punch to infant immunity. 抗生素会对婴儿的免疫系统造成打击。

IF 28.1 1区生物学

Cell Research Pub Date : 2025-07-23 DOI: 10.1038/s41422-025-01158-9

Brian D Rudd

引用次数: 0