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Lysosomal EGFR functions as a GEF for Rheb 溶酶体EGFR作为Rheb的GEF
IF 44.1 1区 生物学
Cell Research Pub Date : 2025-05-07 DOI: 10.1038/s41422-025-01126-3
Tao Hou, Peiqiang Yan, Hiroyuki Inuzuka, Wenyi Wei
{"title":"Lysosomal EGFR functions as a GEF for Rheb","authors":"Tao Hou, Peiqiang Yan, Hiroyuki Inuzuka, Wenyi Wei","doi":"10.1038/s41422-025-01126-3","DOIUrl":"https://doi.org/10.1038/s41422-025-01126-3","url":null,"abstract":"<p><b>A recent study published in</b> <b><i>Cell Research</i></b> <b>revealed that lysosome-localized epidermal growth factor receptor (EGFR) directly binds to and activates Rheb, a key activator of mTORC1, in a kinase activity-independent manner. Mechanistically, EGFR utilizes its Glu804 residue, which likely functions as a catalytic “glutamic finger”, to exert a novel role as a guanine nucleotide exchange factor for Rheb.</b></p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"11 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity 作者更正：Raptin是一种睡眠诱导的下丘脑激素，可以抑制食欲和肥胖
IF 44.1 1区 生物学
Cell Research Pub Date : 2025-05-07 DOI: 10.1038/s41422-025-01123-6
Ling-Qi Xie, Biao Hu, Ren-Bin Lu, Ya-Lun Cheng, Xin Chen, Jie Wen, Yao Xiao, Yu-Ze An, Ning Peng, Yu Dai, Genqing Xie, Qi Guo, Hui Peng, Xiang-Hang Luo
{"title":"Author Correction: Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity","authors":"Ling-Qi Xie, Biao Hu, Ren-Bin Lu, Ya-Lun Cheng, Xin Chen, Jie Wen, Yao Xiao, Yu-Ze An, Ning Peng, Yu Dai, Genqing Xie, Qi Guo, Hui Peng, Xiang-Hang Luo","doi":"10.1038/s41422-025-01123-6","DOIUrl":"https://doi.org/10.1038/s41422-025-01123-6","url":null,"abstract":"<p>Correction to: <i>Cell Research</i> https://doi.org/10.1038/s41422-025-01078-8, published online 29 January 2025</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"14 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural crossroads of pancreatic cancer: how nociceptors drive tumor progression and immune evasion 胰腺癌的神经交叉：伤害感受器如何驱动肿瘤进展和免疫逃避
IF 44.1 1区 生物学
Cell Research Pub Date : 2025-05-07 DOI: 10.1038/s41422-025-01124-5
Carmen Mota Reyes, Helmut Friess, Ihsan Ekin Demir
{"title":"Neural crossroads of pancreatic cancer: how nociceptors drive tumor progression and immune evasion","authors":"Carmen Mota Reyes, Helmut Friess, Ihsan Ekin Demir","doi":"10.1038/s41422-025-01124-5","DOIUrl":"https://doi.org/10.1038/s41422-025-01124-5","url":null,"abstract":"<p><b>Nociceptor neurons actively promote pancreatic ductal adenocarcinoma progression by suppressing immune responses through interactions with cancer-associated fibroblasts. Targeting their signaling pathways offers a novel strategy for enhancing anti-tumor immunity and managing cancer pain.</b></p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"137 1","pages":""},"PeriodicalIF":44.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural basis of augmenting taurine uptake by the taurine transporter in alleviating cellular senescence. 通过牛磺酸转运体增加牛磺酸摄取以减轻细胞衰老的结构基础。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-05-01 Epub Date: 2025-03-20 DOI: 10.1038/s41422-025-01090-y
Heng Zhang, Nana Cui, Xiong Ma, H Eric Xu
{"title":"Structural basis of augmenting taurine uptake by the taurine transporter in alleviating cellular senescence.","authors":"Heng Zhang, Nana Cui, Xiong Ma, H Eric Xu","doi":"10.1038/s41422-025-01090-y","DOIUrl":"10.1038/s41422-025-01090-y","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":"385-388"},"PeriodicalIF":28.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Encoding immune responses: the moonlighting function of alanyl-tRNA synthetase. 编码免疫反应：丙烯酰trna合成酶的兼职功能。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-05-01 DOI: 10.1038/s41422-024-01055-7
Pin Wang, Xiaoyu Hu
{"title":"Encoding immune responses: the moonlighting function of alanyl-tRNA synthetase.","authors":"Pin Wang, Xiaoyu Hu","doi":"10.1038/s41422-024-01055-7","DOIUrl":"10.1038/s41422-024-01055-7","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":"332-333"},"PeriodicalIF":28.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grow AI virtual cells: three data pillars and closed-loop learning. 培育人工智能虚拟细胞：三大数据支柱和闭环学习。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-05-01 DOI: 10.1038/s41422-025-01101-y
Liujia Qian, Zhen Dong, Tiannan Guo
{"title":"Grow AI virtual cells: three data pillars and closed-loop learning.","authors":"Liujia Qian, Zhen Dong, Tiannan Guo","doi":"10.1038/s41422-025-01101-y","DOIUrl":"10.1038/s41422-025-01101-y","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":"319-321"},"PeriodicalIF":28.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transport and inhibition mechanism for human TauT-mediated taurine uptake. 人tau介导的牛磺酸摄取的运输和抑制机制。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-05-01 Epub Date: 2025-01-21 DOI: 10.1038/s41422-025-01076-w
Yulin Chao, Zixuan Zhou, Hao Xia, Chuanhui Yang, Tingting Li, Yi-Quan Tang, Yilai Shu, Qian Ba, Jiaxu Hong, Dianfan Li, Qianhui Qu
{"title":"Transport and inhibition mechanism for human TauT-mediated taurine uptake.","authors":"Yulin Chao, Zixuan Zhou, Hao Xia, Chuanhui Yang, Tingting Li, Yi-Quan Tang, Yilai Shu, Qian Ba, Jiaxu Hong, Dianfan Li, Qianhui Qu","doi":"10.1038/s41422-025-01076-w","DOIUrl":"10.1038/s41422-025-01076-w","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":"381-384"},"PeriodicalIF":28.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyroptosis: molecular mechanisms and roles in disease. 焦亡：分子机制及其在疾病中的作用。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-05-01 Epub Date: 2025-04-03 DOI: 10.1038/s41422-025-01107-6
Petr Broz
{"title":"Pyroptosis: molecular mechanisms and roles in disease.","authors":"Petr Broz","doi":"10.1038/s41422-025-01107-6","DOIUrl":"10.1038/s41422-025-01107-6","url":null,"abstract":"<p><p>Pyroptosis is a type of programmed necrosis triggered by the detection of pathogens or endogenous danger signals in the cytosol. Pyroptotic cells exhibit a swollen, enlarged morphology and ultimately undergo lysis, releasing their cytosolic contents - such as proteins, metabolites, and nucleic acids - into the extracellular space. These molecules can function as danger-associated molecular patterns (DAMPs), triggering inflammation when detected by neighboring cells. Mechanistically, pyroptosis is initiated by members of the gasdermin protein family, which were identified a decade ago as pore-forming executors of cell death. Mammalian gasdermins consist of a cytotoxic N-terminal domain, a flexible linker, and a C-terminal regulatory domain that binds to and inhibits the N-terminus. Proteolytic cleavage within the linker releases the N-terminal domain, enabling it to target various cellular membranes, including nuclear, mitochondrial, and plasma membranes, where it forms large transmembrane pores. Gasdermin pores in the plasma membrane disrupt the electrochemical gradient, leading to water influx and cell swelling. Their formation also activates the membrane protein ninjurin-1 (NINJ1), which oligomerizes to drive complete plasma membrane rupture and the release of large DAMPs. Since their discovery as pore-forming proteins, gasdermins have been linked to pyroptosis not only in host defense but also in various pathological conditions. This review explores the history of pyroptosis, recent insights into gasdermin activation, the cellular consequences of pore formation, and the physiological roles of pyroptosis.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":"334-344"},"PeriodicalIF":28.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechano-pharmacology of T cell receptor specificity. T细胞受体特异性的机械药理学。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-05-01 DOI: 10.1038/s41422-025-01105-8
Panyu Fei, Michael L Dustin
{"title":"Mechano-pharmacology of T cell receptor specificity.","authors":"Panyu Fei, Michael L Dustin","doi":"10.1038/s41422-025-01105-8","DOIUrl":"10.1038/s41422-025-01105-8","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":"324-325"},"PeriodicalIF":28.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Broad H3K4me3 domains orchestrate temporal control of gene expression. 广泛的H3K4me3结构域协调基因表达的时间控制。
IF 28.1 1区 生物学
Cell Research Pub Date : 2025-05-01 DOI: 10.1038/s41422-025-01104-9
Yuka Kitamura, Mengwen Hu, Satoshi H Namekawa
{"title":"Broad H3K4me3 domains orchestrate temporal control of gene expression.","authors":"Yuka Kitamura, Mengwen Hu, Satoshi H Namekawa","doi":"10.1038/s41422-025-01104-9","DOIUrl":"10.1038/s41422-025-01104-9","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":" ","pages":"322-323"},"PeriodicalIF":28.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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