Cell Research最新文献_第5页

MitoCatch directs mitochondria delivery and prevents cell degeneration MitoCatch指导线粒体传递并防止细胞退化。

IF 31.1 1区生物学

Cell Research Pub Date : 2026-06-25 DOI: 10.1038/s41422-026-01274-0

Ana Paula Mendonça, Luca Scorrano

引用次数: 0

Structural basis of sex pheromone detection in aphids 蚜虫性信息素检测的结构基础

IF 31.1 1区生物学

Cell Research Pub Date : 2026-06-22 DOI: 10.1038/s41422-026-01267-z

Zhi Dong, Yidong Wang, Ying Tian, Zeyuan Guan, Minghui Bai, Bo Zhang, Zhongqiang Jia, Jinan Wu, Song Cao, Zhou Gong, Xincheng Zhao, Weihua Ma, Bing Wang, Guirong Wang, Ping Yin

{"title":"Structural basis of sex pheromone detection in aphids","authors":"Zhi Dong, Yidong Wang, Ying Tian, Zeyuan Guan, Minghui Bai, Bo Zhang, Zhongqiang Jia, Jinan Wu, Song Cao, Zhou Gong, Xincheng Zhao, Weihua Ma, Bing Wang, Guirong Wang, Ping Yin","doi":"10.1038/s41422-026-01267-z","DOIUrl":"10.1038/s41422-026-01267-z","url":null,"abstract":"Sex pheromones play a central role in regulating animal behavior and reproduction. In insects, these signals are perceived through specialized odorant receptors (ORs) that mediate species-specific communication and safeguard genetic integrity. However, the structural basis of sex pheromone detection remains largely unresolved. Here, we identified two ORs in the pea aphid Acyrthosiphon pisum, along with the conserved OR co-receptor (Orco), which together mediate recognition of the pheromone components nepetalactone and nepetalactol. Functional assays demonstrated that ApOR21–Orco and ApOR22–Orco specifically respond to nepetalactol and nepetalactone, respectively. Using cryo-electron microscopy, we resolved the structure of the ApOR22–Orco complex in three states — unbound closed, nepetalactone-bound closed, and nepetalactone-bound open — revealing a heterotetrameric ion channel formed by one ApOR22 and three ApOrco subunits. Ligand binding to ApOR22 triggers conformational rearrangements that induce asymmetric pore dilation, thereby enabling ion conduction. Together, these results provide a mechanistic framework for understanding sex pheromone perception in insects and establish a structural foundation for the rational development of environmentally sustainable pest-control strategies.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 8","pages":"582-594"},"PeriodicalIF":31.1,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01267-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148290483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tagging the Tank: Ubiquitin-mediated clearance of cellular energy reserves 标记坦克：泛素介导的细胞能量储备清除。

IF 31.1 1区生物学

Cell Research Pub Date : 2026-06-18 DOI: 10.1038/s41422-026-01268-y

Satpal Virdee

引用次数: 0

One-step generation of semi-cloned zebrafish carrying a defined genetic modification 半克隆斑马鱼的一步生成，携带确定的基因修饰。

IF 31.1 1区生物学

Cell Research Pub Date : 2026-06-12 DOI: 10.1038/s41422-026-01266-0

Yirui Ai, Shifeng Li, Siqi Liu, Jia Xu, Yunbin Zhang, Siyu Zhou, Zhou Zhou, Jinsong Li, Yiping Li

引用次数: 0

Cryo-EM structures of Drosophila OR67d–Orco complexes reveal insect pheromone sensing mechanism 果蝇OR67d-Orco复合物的低温电镜结构揭示昆虫信息素感知机制。

IF 31.1 1区生物学

Cell Research Pub Date : 2026-06-10 DOI: 10.1038/s41422-026-01264-2

Jiangqin Wang, Chuanyan Yang, Shenghai Chang, Dian Jiao, Jiahao Lin, Xiaotong Yang, Weijie Cai, Demin Ma, Zhong Jie Ding, Jia Huang, Jianhua Huang, Minrui Fan, Meiqin Hu, Yong Wang, Haoxing Xu, Nannan Su, Jiangtao Guo

{"title":"Cryo-EM structures of Drosophila OR67d–Orco complexes reveal insect pheromone sensing mechanism","authors":"Jiangqin Wang, Chuanyan Yang, Shenghai Chang, Dian Jiao, Jiahao Lin, Xiaotong Yang, Weijie Cai, Demin Ma, Zhong Jie Ding, Jia Huang, Jianhua Huang, Minrui Fan, Meiqin Hu, Yong Wang, Haoxing Xu, Nannan Su, Jiangtao Guo","doi":"10.1038/s41422-026-01264-2","DOIUrl":"10.1038/s41422-026-01264-2","url":null,"abstract":"Pheromones mediate intraspecific communication to regulate the physiology and behavior of animals, particularly insects. The detection of pheromones is initiated by the binding of pheromone molecules, e.g., 11-cis-vaccenyl acetate (cVA) in Drosophila, to specific receptor proteins in chemosensory neurons, but the underlying molecular mechanisms remain unclear. Here, we report structures of Drosophila pheromone receptor OR67d–Orco complexes in apo closed, pheromone-bound open, and synthetic agonist VUAA1-bound open conformations. OR67d and Orco assemble into a hetero-tetrameric channel with a 1:3 stoichiometry. In OR67d, the inverted L-shaped cVA or its analog binds into a deep and bent hydrophobic pocket, inducing both local and global conformational changes that lead to an asymmetrical opening of the channel gate. By comparison, VUAA1 binds to Orco instead of OR67d to cause a similar asymmetrical opening. Together, our studies reveal the structural basis for pheromone activation of hetero-tetrameric pheromone receptors.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 8","pages":"595-610"},"PeriodicalIF":31.1,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut serotonin regulates Kupffer cell appetite for drug carriers 肠道血清素调节库普弗细胞对药物载体的胃口。

IF 31.1 1区生物学

Cell Research Pub Date : 2026-05-27 DOI: 10.1038/s41422-026-01263-3

Peter A. A. Norris, Lili Zhai, Paul Kubes

引用次数: 0

Neurovascular coupling in the basolateral amygdala modulates negative emotions 杏仁核基底外侧的神经血管耦合调节消极情绪。

IF 31.1 1区生物学

Cell Research Pub Date : 2026-05-27 DOI: 10.1038/s41422-026-01256-2

Jiayu Ruan, Xinghua Quan, Huiqi Xie, Yiyi Zhang, Dongdong Zhang, Wentao Wang, Bingrui Zhao, Danping Lu, Yuxiao Niu, Jie-Min Jia

{"title":"Neurovascular coupling in the basolateral amygdala modulates negative emotions","authors":"Jiayu Ruan, Xinghua Quan, Huiqi Xie, Yiyi Zhang, Dongdong Zhang, Wentao Wang, Bingrui Zhao, Danping Lu, Yuxiao Niu, Jie-Min Jia","doi":"10.1038/s41422-026-01256-2","DOIUrl":"10.1038/s41422-026-01256-2","url":null,"abstract":"Emotion induces changes in regional cerebral blood flow, a manifestation of neurovascular coupling (NVC). However, whether NVC provides feedback to actively modulate emotion remains unexplored. Here, we demonstrate that NVC actively and bidirectionally modulates stress-induced negative emotions. We established bidirectional manipulations of NVC in freely moving mice by employing integrated pharmacological, genetic, and arteriolar optogenetic approaches. Our results showed that both systemic and region-specific NVC deficiencies in the basolateral amygdala (BLA) heightened emotional responses when mice transitioned from a safe, familiar environment to anxiogenic environments and that local restoration of NVC in the BLA normalized these responses. Mechanistically, NVC dysfunction impaired the capacity of BLA neuronal scaling during state transitions, manifesting as a characteristic biphasic pattern of c-Fos topology. NVC-deficient animals aberrantly adopted high-stress configurations under mild stress but regressed to low-stress templates during high-demand survival threats, thereby compromising defensive sustainability. Notably, the genetic NVC-enhancement model counteracted NVC impairments caused by chronic stress, thereby alleviating stress-driven emotional distress. These findings establish NVC in the BLA as an allostatic program that fine-tunes neural circuit activity during emotional responses, with implications for understanding and treating emotional disorders.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 9","pages":"656-679"},"PeriodicalIF":31.1,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01256-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148027639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRAC in vivo: culmination of CAR and vector engineering 体内TRAC: CAR和矢量工程的高潮。

IF 31.1 1区生物学

Cell Research Pub Date : 2026-05-25 DOI: 10.1038/s41422-026-01255-3

Annalisa Cabriolu, Michel Sadelain

引用次数: 0

Structural basis of the neuronal M-current generated by an asymmetric KCNQ2/3 assembly 不对称KCNQ2/3组装产生的神经元m电流的结构基础。

IF 31.1 1区生物学

Cell Research Pub Date : 2026-05-25 DOI: 10.1038/s41422-026-01261-5

Xinyu Cheng, Shuangyan Wan, Dexiang Jiang, Hangyu Zhang, Bin Hu, Tong Che, Yuanpeng Chen, Weiwei Nan, Zhuo Zhou, Chenxin Xiao, Ling Zhong, Yuting Zhang, Bing Xiong, Panpan Hou, Jin Zhang

引用次数: 0

Releasing the stress brake on axon regeneration 释放轴突再生的应力制动。

IF 31.1 1区生物学

Cell Research Pub Date : 2026-05-25 DOI: 10.1038/s41422-026-01258-0

Marc Hernaiz-Llorens, Binhai Zheng

引用次数: 0