Cell Research最新文献_第5页

Author Correction: Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4 作者更正：双特异性组蛋白去甲基酶KIAA1718 （KDM7A）通过FGF4调节神经分化

IF 25.9 1区生物学

Cell Research Pub Date : 2025-07-10 DOI: 10.1038/s41422-025-01143-2

Chengyang Huang, Yang Xiang, Yanru Wang, Xia Li, Longyong Xu, Ziqi Zhu, Ting Zhang, Qingqing Zhu, Kejing Zhang, Naihe Jing, Charlie Degui Chen

引用次数: 0

Escaping ageing through Cell Annealing—a phenomenological model 通过细胞退火来逃避衰老——一个现象学模型

IF 25.9 1区生物学

Cell Research Pub Date : 2025-07-08 DOI: 10.1038/s41422-025-01138-z

Sebastian Memczak, Juan Carlos Izpisua Belmonte, Thore Graepel

引用次数: 0

A patient-derived organoid model captures fetal-like plasticity in colorectal cancer 患者来源的类器官模型捕获结肠直肠癌胎儿样可塑性。

IF 25.9 1区生物学

Cell Research Pub Date : 2025-07-04 DOI: 10.1038/s41422-025-01139-y

Liang Xiong, Ying Xu, Zhaoya Gao, Jingyi Shi, Yunfan Wang, Xiaodong Wang, Wensheng Huang, Ming Li, Longteng Wang, Jun Xu, Cheng Li, Jin Gu, Hongkui Deng, Molong Qu

{"title":"A patient-derived organoid model captures fetal-like plasticity in colorectal cancer","authors":"Liang Xiong, Ying Xu, Zhaoya Gao, Jingyi Shi, Yunfan Wang, Xiaodong Wang, Wensheng Huang, Ming Li, Longteng Wang, Jun Xu, Cheng Li, Jin Gu, Hongkui Deng, Molong Qu","doi":"10.1038/s41422-025-01139-y","DOIUrl":"10.1038/s41422-025-01139-y","url":null,"abstract":"Phenotypic plasticity is a hallmark feature driving cancer progression, metastasis, and therapy resistance. Fetal-like transcriptional programs have been increasingly implicated in promoting plastic cell states, yet their roles remain difficult to study due to limitations of existing culture models. Here, we establish a chemically defined patient-derived organoid system that enables long-term expansion of colorectal cancer (CRC) cells while preserving fetal-like features associated with phenotypic plasticity. Using this model, we identify an oncofetal state (OnFS) that is enriched in advanced tumors and linked to key features of plasticity, including epithelial-mesenchymal plasticity, as well as increased metastasis and treatment resistance. Mechanistically, we show that FGF2-AP-1 signaling maintains the OnFS program and associated phenotypic plasticity in CRC. This model offers a powerful platform for studying the fetal-like features underlying cancer cell plasticity and their role in tumor progression and treatment resistance in CRC.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 9","pages":"642-655"},"PeriodicalIF":25.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiation therapy with hepatocyte nuclear factor 4α for patients with hepatocellular carcinoma 肝细胞核因子4α对肝癌患者的分化治疗。

IF 25.9 1区生物学

Cell Research Pub Date : 2025-07-04 DOI: 10.1038/s41422-025-01142-3

Chuan Yin, Wen-Ping Xu, Wei-Hua Dong, Chen-Hong Ding, Jia-Rong Cai, Xin Zeng, Si-Han Wu, Pei-Mei Shi, Xin Zhang, Wei-Fen Xie

引用次数: 0

Phrixotoxin-3 binds to three distinct antagonistic sites on human Nav1.6 Phrixotoxin-3结合到人类Nav1.6上的三个不同的拮抗位点。

IF 25.9 1区生物学

Cell Research Pub Date : 2025-07-04 DOI: 10.1038/s41422-025-01141-4

Xiao Fan, Jiaofeng Chen, Xiaoshuang Huang, Zhanfeng Hou, Yuzhen Xie, Zigang Li, Nieng Yan, Jian Huang

引用次数: 0

Deubiquitinase-dependent transcriptional silencing controls inflammation 去泛素酶依赖的转录沉默控制炎症

IF 25.9 1区生物学

Cell Research Pub Date : 2025-07-03 DOI: 10.1038/s41422-025-01140-5

Yuxin Yi, Wenjie Xu, Pengcheng Mi, Siliang Ye, Li Chen, Neal M. Alto, Zixu Liu

{"title":"Deubiquitinase-dependent transcriptional silencing controls inflammation","authors":"Yuxin Yi, Wenjie Xu, Pengcheng Mi, Siliang Ye, Li Chen, Neal M. Alto, Zixu Liu","doi":"10.1038/s41422-025-01140-5","DOIUrl":"10.1038/s41422-025-01140-5","url":null,"abstract":"Transcriptional control is crucial for the regulation of inflammation. While it is well-established that inducible transcriptional repressors are synthesized de novo through signal-dependent transcriptional upregulation, it remains unclear whether post-translational modification mechanisms, such as deubiquitination, also contribute to this process. We previously identified developmentally silenced sine oculis (SIX) transcription factors that are reactivated to control inflammatory gene transcription in differentiated immune cells under chronic microbial infections. However, the molecular mechanisms by which this transcriptional silencing process is regulated remain unclear. Here, we report that USP2, a deubiquitinase localized in the nucleus and induced by inflammatory signals, stabilizes SIX proteins through deubiquitination under inflammatory conditions. Consequently, the USP2-SIX complex acts in concert to control NF-κB-mediated inflammatory gene transcription by directly targeting gene promoters. Supporting this mechanism, Usp2−/− mice exhibit higher mortality during H1N1 infections, which phenocopies Six1−/− mice, attributed to elevated levels of life-threatening inflammatory mediators and exacerbated pathology. This study establishes a deubiquitinase-dependent transcriptional control of the inflammatory response to prevent immunopathology, offering new therapeutic avenues for combating infectious diseases.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 9","pages":"675-686"},"PeriodicalIF":25.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CNS gatekeepers: IFNγ-activated dendritic cells control leptomeningeal metastasis. 中枢神经系统守门人：ifn γ激活的树突状细胞控制脑膜轻脑膜转移。

IF 44.1 1区生物学

Cell Research Pub Date : 2025-06-26 DOI: 10.1038/s41422-025-01144-1

Alberto Hernández-Barranco,Johanna A Joyce

引用次数: 0

Gut microbiota fuels clonal hematopoiesis 肠道微生物群为克隆造血提供燃料

IF 44.1 1区生物学

Cell Research Pub Date : 2025-06-13 DOI: 10.1038/s41422-025-01137-0

Francisco Caiado, Markus G. Manz

引用次数: 0

Niche-generated taurine is leukemic fuel 小众生成的牛磺酸是白血病的燃料

IF 44.1 1区生物学

Cell Research Pub Date : 2025-06-09 DOI: 10.1038/s41422-025-01136-1

Christina Mayerhofer, David T. Scadden

引用次数: 0

In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia 小鼠精子中心装置的原位结构揭示了弱精子症的机制见解。

IF 25.9 1区生物学

Cell Research Pub Date : 2025-06-05 DOI: 10.1038/s41422-025-01135-2

Yun Zhu, Tingting Lin, Guoliang Yin, Linhua Tai, Lianwan Chen, Jing Ma, Guoning Huang, Yi Lu, Zhiyong Zhang, Binbin Wang, Suren Chen, Fei Sun

{"title":"In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia","authors":"Yun Zhu, Tingting Lin, Guoliang Yin, Linhua Tai, Lianwan Chen, Jing Ma, Guoning Huang, Yi Lu, Zhiyong Zhang, Binbin Wang, Suren Chen, Fei Sun","doi":"10.1038/s41422-025-01135-2","DOIUrl":"10.1038/s41422-025-01135-2","url":null,"abstract":"The central apparatus (CA) within the sperm axoneme is vital for sperm motility, yet its molecular architecture and functional mechanisms remain incompletely understood. Combining cryo-electron tomography and AlphaFold2, we resolved the in-cell structure of mouse sperm CA at a subnanometer resolution and built a near-complete atomic model. Our analysis identified 39 CA-associated proteins, including eight previously unreported components. By presenting the full-length structures of CFAP47 and HYDIN, we elucidate their molecular roles in tethering the C1 and C2 microtubules within the CA. Specifically, HYDIN forms a semicircular chain that encircles C1 and C2, with its N-terminal half driving the C1–C2 connection and its C-terminal half providing axial support in C2. CFAP47, the core structural component of the bridge, binds C1 through its N-terminal domains, interacts with HYDIN via its central CFAP47-ring, and anchors to C2 through its C-terminal region. The significantly reduced sperm motility and impaired CA structure observed in Cfap47-knockout mice confirmed the important role of CFAP47. Furthermore, genetic analysis of infertile Chinese men with asthenozoospermia identified previously unreported mutations in the CFAP47. The CA structural model elucidates the pathogenic mechanisms of these mutations, establishing a direct link between CFAP47 dysfunction and impaired sperm motility. Therefore, our study provides mechanistic insights into CA-related fertility disorders.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 8","pages":"551-567"},"PeriodicalIF":25.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0