Bridging the gap: how sperm’s core structure explains male infertility

IF 28.1 1区生物学 Q1 CELL BIOLOGY

Cell Research Pub Date : 2025-07-15 DOI:10.1038/s41422-025-01150-3

Thibault Legal, Khanh Huy Bui

引用次数: 0

Abstract

The central apparatus plays a crucial role in regulating the motility of sperm flagella by coordinating dynein activity and waveform symmetry. A recent study published in Cell Research resolves the in situ structure of the central apparatus in mouse sperm using cryo-electron tomography, builds an atomic model with AlphaFold, and reveals the structural and functional roles of the bridge protein CFAP47, linking its disruption to novel mutations identified in asthenozoospermic patients.

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弥合鸿沟：精子的核心结构如何解释男性不育

该中心器官通过协调动力蛋白活性和波形对称，在精子鞭毛运动调节中起着至关重要的作用。最近发表在Cell Research上的一项研究使用冷冻电子断层扫描解决了小鼠精子中心装置的原位结构，用AlphaFold建立了一个原子模型，并揭示了桥蛋白CFAP47的结构和功能作用，将其破坏与在弱动精子症患者中发现的新突变联系起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Research 生物-细胞生物学

CiteScore

53.90

自引率

0.70%

发文量

2420

审稿时长

2.3 months

期刊介绍： Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.