Cell Research最新文献

{"title":"Flying under the radar: immune-evasive DNA for genome engineering","authors":"Frances Y. Tsai, Samuel H. Sternberg","doi":"10.1038/s41422-026-01257-1","DOIUrl":"10.1038/s41422-026-01257-1","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 8","pages":"561-562"},"PeriodicalIF":31.1,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01257-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A neuronal basis for mental imagery","authors":"Stephen M. Fleming, Nadine Dijkstra","doi":"10.1038/s41422-026-01260-6","DOIUrl":"10.1038/s41422-026-01260-6","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 9","pages":"643-644"},"PeriodicalIF":31.1,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01260-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA writes the nucleolus","authors":"Archit Gupta, Eliezer Calo","doi":"10.1038/s41422-026-01259-z","DOIUrl":"10.1038/s41422-026-01259-z","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 7","pages":"473-474"},"PeriodicalIF":31.1,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01259-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compression-induced metabolic adaptation drives confined tumor cell migration and distant metastasis via malate-dependent microtubule reinforcement","authors":"Min Liu, Bing Liu, Chen Chen, Yi-Ran Wang, Xiaoyan Li, Yajuan Zhang, Xinyang Liu, Dingpei Zhou, Hong Gao, Yijun Qi, Chen Su, Dong Gao, Yun Zhao, Yan-Jun Liu, Quanlin Li, Weiwei Yang","doi":"10.1038/s41422-026-01254-4","DOIUrl":"10.1038/s41422-026-01254-4","url":null,"abstract":"Metastasis, responsible for > 90% of cancer-related mortality, represents the most lethal yet least mechanistically understood phase of cancer progression. A critical bottleneck is tumor cell migration through physically confined environments, including dense extracellular matrix, narrow capillaries and endothelial gaps. Although tumor cells reprogram their metabolism to facilitate cancer progression, it remains unclear how specific metabolic adaptations enable them to overcome the unique physical challenges posed by these confined spaces, thereby promoting distant metastasis. We conducted a CRISPR screen targeting 1685 metabolic enzymes and identified dihydrolipoamide dehydrogenase (DLD), a mitochondrial enzyme involved in energy metabolism, as essential for confined migration of tumor cells. Depletion or pharmacological inhibition of DLD suppressed CRC metastasis by impairing tumor cell migration through capillaries and endothelial gaps. Upon mechanical compression, heterogeneous nuclear ribonucleoprotein A0 (hnRNPA0) binds to the adenylate uridylate-rich element (ARE) in the 3′UTR of DLD, enhancing its mRNA stability and upregulating DLD expression in tumor cells during confined migration. Elevated DLD expression enhances tricarboxylic acid (TCA) cycle metabolism, increasing malate levels. Malate interacts with tubulin alpha-1B chain (TUBA1B) to promote microtubule assembly, facilitating confined migration and metastasis. Knock-in of an ARE-deleted DLD mutant (DLD ΔARE) or disruption of the malate–TUBA1B interaction significantly suppressed tumor metastasis. In CRC patients, DLD expression was upregulated in tumor cells within capillaries of primary tumors and correlated with metastatic recurrence. Our findings reveal that compressive forces drive metastatic dissemination by epigenetically reprogramming mitochondrial metabolism, which in turn fuels cytoskeletal remodeling.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 7","pages":"513-530"},"PeriodicalIF":31.1,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allelic variation in UVR8 modulates thermotolerance-yield tradeoffs in plants","authors":"Zeqi Li, Yi Zhang, Shiquan Li, Chengyi Qu, Daren Luo, Pei Ni, Yuan Zong, Xiaoxiao Li, Tong Sun, Ruiqiang Ye, Rui Sun, Yi Zhu, Tiannan Guo, Zeng Tao, Lu Chen, Kexing Su, Yuanbin Zhang, Wei Li, Xiaobo Zhao, Jie Dong, Jian Zhang, Yuanyuan Tan, Xianwen Zhang, Faming Dong, Lizhong Xiong, Xi Huang, Jen Sheen, Hao Du","doi":"10.1038/s41422-026-01253-5","DOIUrl":"10.1038/s41422-026-01253-5","url":null,"abstract":"Industrial activities have driven stratospheric ozone depletion, increasing surface UV-B radiation while exacerbating global warming. These changes limit crop productivity, alter species distributions, and disrupt plant metabolic processes, but the mechanisms linking energy signaling to heat-stress responses remain unclear. Here, we identify the photoreceptor UV RESISTANCE LOCUS 8b (OsUVR8b) as a substrate of SNF1-related protein kinase 1 (SnRK1) in rice and reveal a natural variation at its SnRK1-mediated phosphorylation site (Ser177) that is correlated with adaptation to tropical climates. The thermotolerant OsUVR8bAla177 accessions show geographic enrichment in low-latitude regions with elevated temperatures. Functional validation through prime editing demonstrated that a Ser177-to-Ala177 substitution enhances heat tolerance, whereas the reverse edit compromises it. Mechanistically, OsUVR8bSer177 exhibits reduced stability and an impaired capacity for scavenging reactive oxygen species under heat stress. The regulatory function of the OsUVR8b Ser177 phosphorylation site, a molecular switch that governs UVR8 stability and thermotolerance, can be functionally re-established across rice, Arabidopsis, tobacco, and soybean, indicating its preservation during domestication. Notably, OsUVR8bSer177 maintains higher fertility and yield under non-stress conditions, indicating a tradeoff between heat adaptation and productivity. Our findings thus establish this switch as a key regulator of the yield-resilience balance and a promising target for breeding of climate-resilient crops.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 7","pages":"499-512"},"PeriodicalIF":31.1,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphatidylserine exposure and cancer immune evasion","authors":"Manuel Beltrán-Visiedo, Kerry S. Campbell, Lorenzo Galluzzi","doi":"10.1038/s41422-026-01252-6","DOIUrl":"10.1038/s41422-026-01252-6","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 7","pages":"471-472"},"PeriodicalIF":31.1,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01252-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and functional insights into HBx–Smc6 targeting for HBV inhibition","authors":"Tong Cheng, Jinhong Zhou, Wenjun Huang, Lili Du, Pengyu He, Renzheng Yang, Yan Gao, Menghan Hao, Kongying Hu, Jieliang Chen, Hongxia Wang, Zihe Rao, Zhenghong Yuan, Lanfeng Wang","doi":"10.1038/s41422-026-01251-7","DOIUrl":"10.1038/s41422-026-01251-7","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 8","pages":"629-632"},"PeriodicalIF":31.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clearer view of PRSS56 in eyes with myopia","authors":"Nga T. Nguyen, Jeremy A. Guggenheim","doi":"10.1038/s41422-026-01250-8","DOIUrl":"10.1038/s41422-026-01250-8","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 8","pages":"557-558"},"PeriodicalIF":31.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01250-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GSK3α functions as a stemness checkpoint across multiple stem cell states","authors":"Duo Wang, Xiukun Wang, Safia Malki, Yanpui Chan, Brian Bennett, Joshua Feng, Jiaqi Tang, Xi Chen, Daniel McKim, Chao Zhang, Litao Tao, Jie Xu, Y. Eugene Chen, Guang Hu, Qi-Long Ying","doi":"10.1038/s41422-026-01245-5","DOIUrl":"10.1038/s41422-026-01245-5","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 8","pages":"633-636"},"PeriodicalIF":31.1,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01245-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting non-coding variant effects with AlphaGenome","authors":"Alan E. Murphy, Masayuki Nagai, Peter K. Koo","doi":"10.1038/s41422-026-01249-1","DOIUrl":"10.1038/s41422-026-01249-1","url":null,"abstract":"","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 7","pages":"467-468"},"PeriodicalIF":31.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01249-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}