Cell Research最新文献_第6页

Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist 苦味受体 TAS2R14 被细胞内激动剂激活和 G 蛋白组装

IF 28.1 1区生物学

Cell Research Pub Date : 2024-07-05 DOI: 10.1038/s41422-024-00995-4

Lele Tao, Dongxue Wang, Qingning Yuan, Fenghui Zhao, Yu Zhang, Tianyuan Du, Shiyi Shen, H. Eric Xu, Yi Li, Dehua Yang, Jia Duan

引用次数: 0

Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA 转运核糖核酸抑制质子激活的氯离子通道的分子见解

IF 28.1 1区生物学

Cell Research Pub Date : 2024-06-28 DOI: 10.1038/s41422-024-00993-6

Pengliang Chi, Xiang Wang, Jialu Li, Hui Yang, Kaiju Li, Yuqi Zhang, Shiyi Lin, Leiye Yu, Shiqi Liu, Lu Chen, Ruobing Ren, Jianping Wu, Zhuo Huang, Jia Geng, Dong Deng

引用次数: 0

Localized, highly efficient secretion of signaling proteins by migrasomes 迁移体局部高效分泌信号蛋白

IF 28.1 1区生物学

Cell Research Pub Date : 2024-06-25 DOI: 10.1038/s41422-024-00992-7

Haifeng Jiao, Xiaopeng Li, Ying Li, Yuting Guo, Xiaoyu Hu, Takami Sho, Yiqun Luo, Jinyu Wang, Huizhen Cao, Wanqing Du, Dong Li, Li Yu

{"title":"Localized, highly efficient secretion of signaling proteins by migrasomes","authors":"Haifeng Jiao, Xiaopeng Li, Ying Li, Yuting Guo, Xiaoyu Hu, Takami Sho, Yiqun Luo, Jinyu Wang, Huizhen Cao, Wanqing Du, Dong Li, Li Yu","doi":"10.1038/s41422-024-00992-7","DOIUrl":"10.1038/s41422-024-00992-7","url":null,"abstract":"Migrasomes, enriched with signaling molecules such as chemokines, cytokines and angiogenic factors, play a pivotal role in the spatially defined delivery of these molecules, influencing critical physiological processes including organ morphogenesis and angiogenesis. The mechanism governing the accumulation of signaling molecules in migrasomes has been elusive. In this study, we show that secretory proteins, including signaling proteins, are transported into migrasomes by secretory carriers via both the constitutive and regulated secretion pathways. During cell migration, a substantial portion of these carriers is redirected to the rear of the cell and actively transported into migrasomes, driven by the actin-dependent motor protein Myosin-5a. Once at the migrasomes, these carriers fuse with the migrasome membrane through SNARE-mediated mechanisms. Inhibiting migrasome formation significantly reduces secretion, suggesting migrasomes as a principal secretion route in migrating cells. Our findings reveal a specialized, highly localized secretion paradigm in migrating cells, conceptually paralleling the targeted neurotransmitter release observed in neuronal systems.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 8","pages":"572-585"},"PeriodicalIF":28.1,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-024-00992-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141448159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANT2: the first mammalian mitochondrial RNA transport translocon ANT2：第一个哺乳动物线粒体 RNA 转运易位子

IF 28.1 1区生物学

Cell Research Pub Date : 2024-06-24 DOI: 10.1038/s41422-024-00994-5

Huanhuan Zhu, Weiqiang Lin, Aifu Lin

引用次数: 0

Combination therapy of KRAS G12V mRNA vaccine and pembrolizumab: clinical benefit in patients with advanced solid tumors KRAS G12V mRNA疫苗与pembrolizumab的联合疗法：晚期实体瘤患者的临床获益。

IF 28.1 1区生物学

Cell Research Pub Date : 2024-06-24 DOI: 10.1038/s41422-024-00990-9

Xinjing Wang, Wei Wang, Siyi Zou, Zhiwei Xu, Dan Cao, Shuai Zhang, Minzhi Wei, Qian Zhan, Chenlei Wen, Fanlu Li, Hao Chen, Da Fu, Lingxi Jiang, Ming Zhao, Baiyong Shen

引用次数: 0

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine AMPK 以 PDZD8 为靶标，触发碳源从葡萄糖向谷氨酰胺的转移。

IF 28.1 1区生物学

Cell Research Pub Date : 2024-06-19 DOI: 10.1038/s41422-024-00985-6

Mengqi Li, Yu Wang, Xiaoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu, Yongliang Wang, Yan-Hui Liu, Jinye Xiong, Qi Qu, Yan Chen, Xiao Tian, Luming Yao, Renxiang Xie, Xiaomin Li, Siwei Chen, Xi Huang, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Baoding Zhang, Bin Jiang, Zhi-Chao Wang, Qinxi Li, Gang Li, Shu-Yong Lin, Li Yu, Hai-Long Piao, Xianming Deng, Jiahuai Han, Chen-Song Zhang, Sheng-Cai Lin

{"title":"AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine","authors":"Mengqi Li, Yu Wang, Xiaoyan Wei, Wei-Feng Cai, Jianfeng Wu, Mingxia Zhu, Yongliang Wang, Yan-Hui Liu, Jinye Xiong, Qi Qu, Yan Chen, Xiao Tian, Luming Yao, Renxiang Xie, Xiaomin Li, Siwei Chen, Xi Huang, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Baoding Zhang, Bin Jiang, Zhi-Chao Wang, Qinxi Li, Gang Li, Shu-Yong Lin, Li Yu, Hai-Long Piao, Xianming Deng, Jiahuai Han, Chen-Song Zhang, Sheng-Cai Lin","doi":"10.1038/s41422-024-00985-6","DOIUrl":"10.1038/s41422-024-00985-6","url":null,"abstract":"The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-activated protein kinase (AMPK) plays crucial roles in this metabolic adaptation. However, the underlying mechanism is not fully understood. Here, we show that PDZ domain containing 8 (PDZD8), which we identify as a new substrate of AMPK activated in low glucose, is required for the low glucose-promoted glutaminolysis. AMPK phosphorylates PDZD8 at threonine 527 (T527) and promotes the interaction of PDZD8 with and activation of glutaminase 1 (GLS1), a rate-limiting enzyme of glutaminolysis. In vivo, the AMPK-PDZD8-GLS1 axis is required for the enhancement of glutaminolysis as tested in the skeletal muscle tissues, which occurs earlier than the increase in fatty acid utilization during fasting. The enhanced glutaminolysis is also observed in macrophages in low glucose or under acute lipopolysaccharide (LPS) treatment. Consistent with a requirement of heightened glutaminolysis, the PDZD8-T527A mutation dampens the secretion of pro-inflammatory cytokines in macrophages in mice treated with LPS. Together, we have revealed an AMPK-PDZD8-GLS1 axis that promotes glutaminolysis ahead of increased fatty acid utilization under glucose shortage.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"34 10","pages":"683-706"},"PeriodicalIF":28.1,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-024-00985-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141426455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyroptosis: palmitoylation regulates GSDMD activation and pore formation 裂解：棕榈酰化调节 GSDMD 的激活和孔隙形成

IF 28.1 1区生物学

Cell Research Pub Date : 2024-06-18 DOI: 10.1038/s41422-024-00988-3

Ella Hartenian, Petr Broz

引用次数: 0

AI accurately predicting the structure of biomolecular interactions 人工智能准确预测生物分子相互作用的结构。

IF 28.1 1区生物学

Cell Research Pub Date : 2024-06-14 DOI: 10.1038/s41422-024-00991-8

Zhenling Peng, Peilong Lu, Jianyi Yang

引用次数: 0

Structural insights into VAChT neurotransmitter recognition and inhibition 有关 VAChT 神经递质识别和抑制的结构见解