Too sweet to be savory: how fructose elicits microglia-driven disturbance of neurodevelopment

IF 28.1 1区生物学 Q1 CELL BIOLOGY

Cell Research Pub Date : 2025-07-15 DOI:10.1038/s41422-025-01148-x

Maximilian Fliegauf, Marco Prinz

引用次数: 0

Abstract

In a pivotal study, Wang and colleagues reveal how early life high fructose exposure disrupts neurodevelopment. The publication uncovers the GLUT5-HK2 axis by which excessive fructose exposure during postnatal development impairs physiological microglial pruning.

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甜到不能入味：果糖如何引起小胶质细胞驱动的神经发育障碍

在一项关键的研究中，Wang和他的同事揭示了生命早期的高果糖暴露是如何破坏神经发育的。该出版物揭示了GLUT5-HK2轴，在出生后发育期间过量的果糖暴露会损害生理小胶质细胞修剪。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Research 生物-细胞生物学

CiteScore

53.90

自引率

0.70%

发文量

2420

审稿时长

2.3 months

期刊介绍： Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.