Orchestrating NTSR1 signaling from the interface

IF 28.1 1区生物学 Q1 CELL BIOLOGY

Cell Research Pub Date : 2025-04-21 DOI:10.1038/s41422-025-01121-8

Xianglin Huang, Brian E. Krumm, Bryan L. Roth

引用次数: 0

Abstract

Biased allosteric modulators provide great therapeutic potential by selectively directing signal bias in the presence of endogenous ligand under (patho)physiological conditions. In a recent Cell Research paper, Sun et al. revealed the structural mechanisms underlying the biased allosteric modulation exerted by SBI-533 directly at the neurotensin receptor 1–β-arrestin1 interface.

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编排来自接口的NTSR1信令

偏置变张力调节剂在（病理）生理条件下，通过选择性地指导内源性配体存在的信号偏置，提供了巨大的治疗潜力。在最近的Cell Research论文中，Sun等人揭示了SBI-533直接作用于神经紧张素受体1 -β-arrestin1界面的偏性变构调节的结构机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Research 生物-细胞生物学

CiteScore

53.90

自引率

0.70%

发文量

2420

审稿时长

2.3 months

期刊介绍： Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.