Decoding NLRP3: Phase separation enters the scene

IF 28.1 1区生物学 Q1 CELL BIOLOGY

Cell Research Pub Date : 2025-04-21 DOI:10.1038/s41422-025-01120-9

Niklas A. Schmacke, Veit Hornung

引用次数: 0

Abstract

Activation of the innate immune sensor protein NLRP3 leads to the assembly of a multiprotein complex called the inflammasome, causing cell death and inflammation. In a recent paper in Cell Research, Zou et al. now provide evidence that palmitoylation of NLRP3 promotes its liquid–liquid phase separation, driving inflammasome activation.

Abstract Image

查看原文本刊更多论文

解码NLRP3：相位分离进入场景

先天免疫感应蛋白NLRP3的激活导致称为炎性体的多蛋白复合物的组装，导致细胞死亡和炎症。在Cell Research最近发表的一篇论文中，邹等人提供了证据，证明NLRP3的棕榈酰化促进了其液-液相分离，从而推动了炎症小体的激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cell Research 生物-细胞生物学

CiteScore

53.90

自引率

0.70%

发文量

2420

审稿时长

2.3 months

期刊介绍： Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.