Cell Research最新文献_第8页

Lysosomal magneto-mechanics rewire immunity 溶酶体磁力学重塑免疫力。

IF 25.9 1区生物学

Cell Research Pub Date : 2026-03-17 DOI: 10.1038/s41422-026-01236-6

Seyed Hossein Helalat, Marja Jäättelä

引用次数: 0

Mapping brain cell-type-specific diversity of lysosomal proteins 绘制脑细胞类型特异性溶酶体蛋白的多样性。

IF 25.9 1区生物学

Cell Research Pub Date : 2026-03-16 DOI: 10.1038/s41422-026-01242-8

Adriana E. Golding, Raffaella De Pace

引用次数: 0

Assembly and gating mechanism of native AMPA receptors from the cerebellum 小脑天然AMPA受体的组装和门控机制。

IF 25.9 1区生物学

Cell Research Pub Date : 2026-03-16 DOI: 10.1038/s41422-026-01234-8

Xiaojing Li, Renjie Li, Yiqing Wei, Jiexin Chen, Jiaojiao Zhao, Jun Zhao, Wei Wang, Na Li, Lili Wang, Tuo Hu, Yanli Dong, Yongping Zhu, Chao Wei, Long Li, Wei Zhang, Zhuo Huang, Yan Zhao

{"title":"Assembly and gating mechanism of native AMPA receptors from the cerebellum","authors":"Xiaojing Li, Renjie Li, Yiqing Wei, Jiexin Chen, Jiaojiao Zhao, Jun Zhao, Wei Wang, Na Li, Lili Wang, Tuo Hu, Yanli Dong, Yongping Zhu, Chao Wei, Long Li, Wei Zhang, Zhuo Huang, Yan Zhao","doi":"10.1038/s41422-026-01234-8","DOIUrl":"10.1038/s41422-026-01234-8","url":null,"abstract":"AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission throughout the central nervous system. Calcium-permeable AMPARs and GluA4-containing receptors are critical for cerebellar functions, such as motor learning, associative memory, auditory processing, and synaptic plasticity. In contrast to the well-characterized, predominantly GluA2-containing AMPARs of the hippocampus and cortex, cerebellar AMPARs contain a higher proportion of GluA4 and remain poorly understood. Here, we generated a highly GluA4-specific antibody. Using this antibody in combination with antibodies specifically recognizing GluA1 and GluA2, we purified native AMPARs and determined the subunit compositions of both calcium-impermeable and calcium-permeable native AMPARs in the cerebellum. The isolated cerebellar AMPARs that contained both GluA1 and GluA4 were calcium-permeable, with GluA4 occupying mainly the B/D positions, GluA1 occupying the A/C positions, and the complex associated primarily with cornichon 3 (CNIH3). We determined the structures of the complex in distinct functional states, including the resting, active, and desensitized states, and characterized the conformational transitions that underlie its activity. During desensitization, the receptor adopts a pseudo-4-fold configuration of the ligand-binding domain layer, which may be important for its functional properties. This study provides a blueprint for the subunit compositions of AMPARs in the cerebellum and clarifies the gating mechanism of the calcium-permeable native AMPARA1A4–CNIH3 complex, providing significant insight into AMPAR-mediated synaptic transmission in the cerebellum.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 6","pages":"426-439"},"PeriodicalIF":25.9,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To β or not to β: think zinc (again)! β或不β：想想锌（再次）！

IF 25.9 1区生物学

Cell Research Pub Date : 2026-03-16 DOI: 10.1038/s41422-026-01238-4

Omar Zabad, Kathrin Maedler

引用次数: 0

Carnitine biosynthesis governs fuel switching 肉毒碱的生物合成控制着燃料转换。

IF 25.9 1区生物学

Cell Research Pub Date : 2026-03-06 DOI: 10.1038/s41422-026-01229-5

Kyounghee Min, Philipp E. Scherer

引用次数: 0

40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway 40hz闪烁光通过视网膜-杏仁核通路中的腺苷信号减轻慢性疼痛

IF 25.9 1区生物学

Cell Research Pub Date : 2026-03-04 DOI: 10.1038/s41422-026-01227-7

Jiawang Chen, Tao Xu, Chenchen Zhang, Li Li, Yan He, Zhaoxia Sun, Jiasheng He, Zhimo Yao, Peng Cai, Yipeng Huang, Fenfen Ye, Wei Guo, Manli Jia, Jia Qu, Jiang-Fan Chen, Yi Zhang

{"title":"40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway","authors":"Jiawang Chen, Tao Xu, Chenchen Zhang, Li Li, Yan He, Zhaoxia Sun, Jiasheng He, Zhimo Yao, Peng Cai, Yipeng Huang, Fenfen Ye, Wei Guo, Manli Jia, Jia Qu, Jiang-Fan Chen, Yi Zhang","doi":"10.1038/s41422-026-01227-7","DOIUrl":"10.1038/s41422-026-01227-7","url":null,"abstract":"Chronic pain affects over 20% of the global population, yet frontline treatments remain limited in efficacy and are often hampered by serious side effects. In search of novel and effective neuromodulation alternatives, we discovered that 40 Hz flickering light effectively alleviates inflammatory and neuropathic pain in mice. We identified the retina-central amygdala (CeA) pathway as a critical conduit for the analgesic effects of 40 Hz flickering light. Using circuit-specific manipulations, we demonstrated that activation of the retina-CeA pathway is both sufficient to mimic and necessary to mediate the analgesic outcomes of 40 Hz light stimulation. In terms of mechanism, we found that 40 Hz light flickering significantly increases extracellular adenosine levels in the CeA. Local pharmacological blockade of equilibrative nucleoside transporters prevented this adenosine increase and abolished the analgesic effects of 40 Hz light flickering, whereas focal adenosine infusion phenocopied the light-induced analgesia. Both interventions required A2A receptor signaling to suppress nociceptive responses. Furthermore, we found that hyperalgesia could be destabilized in the CeA and reversed by 40 Hz light stimulation or adenosine infusion, mirroring memory reconsolidation processes and implicating the CeA as a key locus for pain memory erasure. Collectively, our findings demonstrate the multifaceted therapeutic benefits of 40 Hz light flickering as a novel non-invasive approach for pain management and reveal a distinct retina-CeA circuit and adenosine signaling mechanism for control of chronic pain and pain memory.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"36 6","pages":"440-461"},"PeriodicalIF":25.9,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41422-026-01227-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Borrowed mitochondria, spared neurons 借来的线粒体，留下的神经元。

IF 25.9 1区生物学

Cell Research Pub Date : 2026-03-04 DOI: 10.1038/s41422-026-01230-y

Gwang-Bum Im, Juan M. Melero-Martin

引用次数: 0

Light sensing enhances thermotolerance and competitive fitness via serotonergic signaling in an eyeless organism 光感应增强无眼生物的耐热性和竞争适应性，通过血清素能信号传导

IF 25.9 1区生物学

Cell Research Pub Date : 2026-03-01 DOI: 10.1038/s41422-026-01223-x

Liankui Zhou, Ying Liu

引用次数: 0

Eyeless light sensing promotes thermotolerance 无眼光感应促进耐热性。