Cell Research最新文献_第9页

Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice 减少功能缺陷的老年造血干细胞可减轻老年受体小鼠的衰老相关表型

IF 28.1 1区生物学

Cell Research Pub Date : 2025-01-02 DOI: 10.1038/s41422-024-01057-5

Yuting Wang, Wenhao Zhang, Chao Zhang, Hoang Q. Tran Van, Takashi Seino, Yi Zhang

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引用次数: 0

Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss Tau蛋白是一种对糖皮质激素亲和力较低的受体，是糖皮质激素诱导的骨质流失所必需的

IF 28.1 1区生物学

Cell Research Pub Date : 2025-01-02 DOI: 10.1038/s41422-024-01016-0

Wenyu Fu, Meng Chen, Kaidi Wang, Yujianan Chen, Yazhou Cui, Yangli Xie, Zi-Ning Lei, Wenhuo Hu, Guodong Sun, Guiwu Huang, Chaopeng He, Jackie Fretz, Aubryanna Hettinghouse, Ronghan Liu, Xianyi Cai, Mingshuang Zhang, Yuehong Chen, Nan Jiang, Minchun He, Daniel H. Wiznia, Huiyun Xu, Zhe-Sheng Chen, Lin Chen, Kanglai Tang, Hong Zhou, Chuan-Ju Liu

{"title":"Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss","authors":"Wenyu Fu, Meng Chen, Kaidi Wang, Yujianan Chen, Yazhou Cui, Yangli Xie, Zi-Ning Lei, Wenhuo Hu, Guodong Sun, Guiwu Huang, Chaopeng He, Jackie Fretz, Aubryanna Hettinghouse, Ronghan Liu, Xianyi Cai, Mingshuang Zhang, Yuehong Chen, Nan Jiang, Minchun He, Daniel H. Wiznia, Huiyun Xu, Zhe-Sheng Chen, Lin Chen, Kanglai Tang, Hong Zhou, Chuan-Ju Liu","doi":"10.1038/s41422-024-01016-0","DOIUrl":"10.1038/s41422-024-01016-0","url":null,"abstract":"Glucocorticoids (GCs) are the most prescribed anti-inflammatory and immunosuppressive drugs. However, their use is often limited by substantial side effects, such as GC-induced osteoporosis (GIO) with the underlying mechanisms still not fully understood. In this study, we identify Tau as a low-affinity binding receptor for GCs that plays a crucial role in GIO. Tau deficiency largely abolished bone loss induced by high-dose dexamethasone, a synthetic GC, in both inflammatory arthritis and GIO models. Furthermore, TRx0237, a Tau inhibitor identified from an FDA-approved drug library, effectively prevented GIO. Notably, combinatorial administration of TRx0237 and dexamethasone completely overcame the osteoporosis adverse effect of dexamethasone in treating inflammatory arthritis. These findings present Tau as a previously unrecognized GC receptor with low affinity, and provide potential strategies to mitigate a spectrum of GC-related adverse effects, particularly osteoporosis.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"35 1","pages":"23-44"},"PeriodicalIF":28.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41422-024-01016-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat acclimation in mice requires preoptic BDNF neurons and postsynaptic potentiation 小鼠热适应需要视前BDNF神经元和突触后增强

IF 28.1 1区生物学

Cell Research Pub Date : 2024-12-26 DOI: 10.1038/s41422-024-01064-6

Baoting Chen, Cuicui Gao, Changhao Liu, Tongtong Guo, Junwei Hu, Jialiang Xue, Kangmin Tang, Yuelai Chen, Tian Yu, Qiwei Shen, Hongbin Sun, Wen Z. Yang, Wei L. Shen

引用次数: 0

Astrocytes: emerging stars of engrams 星形胶质细胞：新生的星形细胞

IF 28.1 1区生物学

Cell Research Pub Date : 2024-12-23 DOI: 10.1038/s41422-024-01066-4

Sofiya Zbaranska, Sheena A. Josselyn

引用次数: 0

Tug of war between phosphatase and kinase during sleep 在睡眠中磷酸酶和激酶之间的拉锯战

IF 28.1 1区生物学

Cell Research Pub Date : 2024-12-20 DOI: 10.1038/s41422-024-01065-5

Niels Niethard, Jan Born

引用次数: 0

Correction: Sanofi-Cell Research outstanding paper award of 2023 更正：赛诺菲细胞研究公司2023年度优秀论文奖