一种植物抗菌素可以分解细菌III型注射体

IF 28.1 1区生物学 Q1 CELL BIOLOGY

Cell Research Pub Date : 2025-03-31 DOI:10.1038/s41422-025-01111-w

Manman Zhang, Cheng Li, Zheng Qing Fu

{"title":"一种植物抗菌素可以分解细菌III型注射体","authors":"Manman Zhang, Cheng Li, Zheng Qing Fu","doi":"10.1038/s41422-025-01111-w","DOIUrl":null,"url":null,"abstract":"Many Gram-negative bacterial pathogens rely on the secretion system to inject effectors into their host cells, thereby suppressing host immunity and subsequently leading to diseases. In a recent Science paper, Miao et al. identified a plant secondary metabolite that dismantles type III injectisome by targeting the conserved HrcC protein within the secretion apparatus.","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"18 1","pages":""},"PeriodicalIF":28.1000,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A phytoalexin dismantles bacterial type III injectisome\",\"authors\":\"Manman Zhang, Cheng Li, Zheng Qing Fu\",\"doi\":\"10.1038/s41422-025-01111-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Many Gram-negative bacterial pathogens rely on the secretion system to inject effectors into their host cells, thereby suppressing host immunity and subsequently leading to diseases. In a recent Science paper, Miao et al. identified a plant secondary metabolite that dismantles type III injectisome by targeting the conserved HrcC protein within the secretion apparatus.\",\"PeriodicalId\":9926,\"journal\":{\"name\":\"Cell Research\",\"volume\":\"18 1\",\"pages\":\"\"},\"PeriodicalIF\":28.1000,\"publicationDate\":\"2025-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1038/s41422-025-01111-w\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41422-025-01111-w","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

许多革兰氏阴性细菌病原体依靠分泌系统将效应物注入宿主细胞，从而抑制宿主免疫力，进而导致疾病。在最近的一篇《科学》论文中，Miao 等人发现了一种植物次生代谢物，它能通过靶向分泌装置内保守的 HrcC 蛋白来瓦解 III 型注射体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A phytoalexin dismantles bacterial type III injectisome

查看原文本刊更多论文

A phytoalexin dismantles bacterial type III injectisome

Many Gram-negative bacterial pathogens rely on the secretion system to inject effectors into their host cells, thereby suppressing host immunity and subsequently leading to diseases. In a recent Science paper, Miao et al. identified a plant secondary metabolite that dismantles type III injectisome by targeting the conserved HrcC protein within the secretion apparatus.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cell Research 生物-细胞生物学

CiteScore

53.90

自引率

0.70%

发文量

2420

审稿时长

2.3 months

期刊介绍： Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.