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Cell Regeneration最新文献

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Standard: Human gastric cancer organoids.
IF 4
Cell Regeneration Pub Date : 2024-12-27 DOI: 10.1186/s13619-024-00217-7
Ronghui Tan, Fan Hong, Ting Wang, Nanshan Zhong, Hongling Zhao, Rui-Hua Xu, Lin Shen, Yingbin Liu, Xuebiao Yao, Dongxi Xiang, Dong Gao, Jianping Xiong, Lijian Hui, Bing Zhao, Zhifeng Miao, Jie Hao, Yong Li, Shijun Hu, Boqiang Fu, Guoqiang Hua, Lei Wang, Zhao-Lei Zeng, Chong Chen, Jianmin Wu, Changlin Wang, Chunnian Wang, Xianbao Zhan, Chen Song, Zhijian Sun, Chunping Yu, Yingying Yang, Gengming Niu, Yalong Wang, Tongbiao Zhao, Ye-Guang Chen
{"title":"Standard: Human gastric cancer organoids.","authors":"Ronghui Tan, Fan Hong, Ting Wang, Nanshan Zhong, Hongling Zhao, Rui-Hua Xu, Lin Shen, Yingbin Liu, Xuebiao Yao, Dongxi Xiang, Dong Gao, Jianping Xiong, Lijian Hui, Bing Zhao, Zhifeng Miao, Jie Hao, Yong Li, Shijun Hu, Boqiang Fu, Guoqiang Hua, Lei Wang, Zhao-Lei Zeng, Chong Chen, Jianmin Wu, Changlin Wang, Chunnian Wang, Xianbao Zhan, Chen Song, Zhijian Sun, Chunping Yu, Yingying Yang, Gengming Niu, Yalong Wang, Tongbiao Zhao, Ye-Guang Chen","doi":"10.1186/s13619-024-00217-7","DOIUrl":"10.1186/s13619-024-00217-7","url":null,"abstract":"<p><p>Gastric cancer is one of the most common malignancies with poor prognosis. The use of organoids to simulate gastric cancer has rapidly developed over the past several years. Patient-derived gastric cancer organoids serve as in vitro models that closely mimics donor characteristics, offering new opportunities for both basic and applied research. The \"Human Gastric Cancer Organoid\" is part of a series of guidelines for human gastric cancer organoids in China, jointly drafted by experts from the Chinese Society for Cell Biology and its branches, and initially released on October 29, 2024. This standard outlines terminology, technical requirements, assessment protocols, and applies to production, evaluation procedures, and quality control for human gastric cancer organoids. The publication of this guideline aims to assist institutions in endorsing, establishing, and applying best practices, advancing the international standardization of human gastric cancer organoids for clinical development and therapeutic application.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"33"},"PeriodicalIF":4.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11680512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical modulation and peripheral nerve regeneration: a literature review.
IF 4
Cell Regeneration Pub Date : 2024-12-23 DOI: 10.1186/s13619-024-00215-9
Xiangwen Zhai, Yuzhong Wang
{"title":"Physical modulation and peripheral nerve regeneration: a literature review.","authors":"Xiangwen Zhai, Yuzhong Wang","doi":"10.1186/s13619-024-00215-9","DOIUrl":"10.1186/s13619-024-00215-9","url":null,"abstract":"<p><p>Peripheral nerve injury (PNI) usually causes severe motor, sensory and autonomic dysfunction. In addition to direct surgical repair, rehabilitation exercises, and traditional physical stimuli, for example, electrical stimulation, have been applied in promoting the clinical recovery of PNI for a long time but showed low efficiency. Recently, significant progress has been made in new physical modulation to promote peripheral nerve regeneration. We hereby review current progress on the mechanism of peripheral nerve regeneration after injury and summarize the new findings and evidence for the application of physical modulation, including electrical stimulation, light, ultrasound, magnetic stimulation, and mechanical stretching in experimental studies and the clinical treatment of patients with PNI.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"32"},"PeriodicalIF":4.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking lung regeneration: insights into progenitor cell dynamics and metabolic control. 揭开肺再生的神秘面纱：对祖细胞动态和代谢控制的深入了解。
IF 4
Cell Regeneration Pub Date : 2024-12-16 DOI: 10.1186/s13619-024-00212-y
Jiaying Yang, Yawen Li, Ying Huang, Huaiyong Chen, Pengfei Sui
{"title":"Unlocking lung regeneration: insights into progenitor cell dynamics and metabolic control.","authors":"Jiaying Yang, Yawen Li, Ying Huang, Huaiyong Chen, Pengfei Sui","doi":"10.1186/s13619-024-00212-y","DOIUrl":"10.1186/s13619-024-00212-y","url":null,"abstract":"<p><p>Regenerative responses are particularly important in the lungs, which are critical for gas exchange and frequently challenged by environmental insults. The lung progenitor cells play a central role in the lung regeneration response, and their dysfunction is associated with various lung diseases. Understanding the mechanisms regulating lung progenitor cell function is essential for developing new therapeutic approaches to promote lung regeneration. This review summarizes recent advancements in the field of lung regeneration, focusing on the metabolic control of lung progenitor cell function. We discuss cell lineage plasticity and cell-cell signaling under different physiological conditions. Additionally, we highlight the connection between progenitor cell dysfunction and lung diseases, emphasizing the need to develop new therapeutic strategies in regenerative medicine to improve lung regenerative capacity.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"31"},"PeriodicalIF":4.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent progress of principal techniques used in the study of Müller glia reprogramming in mice.
IF 4
Cell Regeneration Pub Date : 2024-12-12 DOI: 10.1186/s13619-024-00211-z
Zhiyuan Yin, Jiahui Kang, Haoan Xu, Shujia Huo, Haiwei Xu
{"title":"Recent progress of principal techniques used in the study of Müller glia reprogramming in mice.","authors":"Zhiyuan Yin, Jiahui Kang, Haoan Xu, Shujia Huo, Haiwei Xu","doi":"10.1186/s13619-024-00211-z","DOIUrl":"10.1186/s13619-024-00211-z","url":null,"abstract":"<p><p>In zebrafish, Müller glia (MG) cells retain the ability to proliferate and de-differentiate into retinal progenitor-like cells, subsequently differentiating into retinal neurons that can replace those damaged or lost due to retinal injury. In contrast, the reprogramming potential of MG in mammals has been lost, with these cells typically responding to retinal damage through gliosis. Considerable efforts have been dedicated to achieving the reprogramming of MG cells in mammals. Notably, significant advancements have been achieved in reprogramming MG cells in mice employing various methodologies. At the same time, some inevitable challenges have hindered identifying accurate MG cell reprogramming rather than the illusion, let alone improving the reprogramming efficiency and maturity of daughter cells. Recently, several strategies, including lineage tracking, multi-omics techniques, and functional analysis, have been developed to investigate the MG reprogramming process in mice. This review summarizes both the advantages and limitations of these novel strategies for analyzing MG reprogramming in mice, offering insights into enhancing the reliability and efficiency of MG reprogramming.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"30"},"PeriodicalIF":4.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A cellular triad for linking cardiac niche to regeneration.
IF 4
Cell Regeneration Pub Date : 2024-12-10 DOI: 10.1186/s13619-024-00213-x
Xiaokai Ma, Junjie Hou, Jing-Wei Xiong
{"title":"A cellular triad for linking cardiac niche to regeneration.","authors":"Xiaokai Ma, Junjie Hou, Jing-Wei Xiong","doi":"10.1186/s13619-024-00213-x","DOIUrl":"10.1186/s13619-024-00213-x","url":null,"abstract":"<p><p>Cardiovascular disease is the leading cause of mortality with very limited therapeutic interventions, thus holding great hope for cardiac regenerative medicine. A recent work from Martin's laboratory reports their identification of a fetal-like cardiomyocyte progenitor, adult cardiomyocyte type 2 (aCM2), and its potential interactions with C3<sup>+</sup> cardiac fibroblasts and C3ar1<sup>+</sup> macrophages to form a regenerative cellular triad, which is only present in the regenerative heart models, YAP5SA-expressing adult hearts and neonatal hearts. The complement signaling is essential for cellular interactions in this regenerative triad. This Highlight summarizes these major findings and provides brief perspectives on the impact of this regenerative niche during cardiac regeneration in the future.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"29"},"PeriodicalIF":4.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuft cells promote human intestinal epithelium regeneration as reserve stem cells after irradiation.
IF 4
Cell Regeneration Pub Date : 2024-12-09 DOI: 10.1186/s13619-024-00214-w
Yehua Li, Mengxian Zhang, Xianrun Ma, Ye-Guang Chen
{"title":"Tuft cells promote human intestinal epithelium regeneration as reserve stem cells after irradiation.","authors":"Yehua Li, Mengxian Zhang, Xianrun Ma, Ye-Guang Chen","doi":"10.1186/s13619-024-00214-w","DOIUrl":"10.1186/s13619-024-00214-w","url":null,"abstract":"<p><p>Intestinal epithelium regeneration is crucial for homeostatic maintenance of the intestinal functions. A recent study published in Nature uncovers tuft cells as an unexpected key player in the regenerative process. Human tuft cells, traditionally recognized for their involvement in immune defense and pathogen protection, were found to exhibit stem cell-like properties following radiation-induced injury. These cells not only resist damage but also have the ability to generate functional stem cells, promoting the repair of the intestinal epithelium. This finding suggests that tuft cells may function as a reserve pool of stem cells, essential for efficient intestinal regeneration after injury.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"28"},"PeriodicalIF":4.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Expression levels and stoichiometry of Hnf1β, Emx2, Pax8 and Hnf4α influence direct reprogramming of induced renal tubular epithelial cells.
IF 4
Cell Regeneration Pub Date : 2024-12-02 DOI: 10.1186/s13619-024-00210-0
Xueli Hu, Jianjian Sun, Meng Wan, Bianhong Zhang, Linhui Wang, Tao P Zhong
{"title":"Correction: Expression levels and stoichiometry of Hnf1β, Emx2, Pax8 and Hnf4α influence direct reprogramming of induced renal tubular epithelial cells.","authors":"Xueli Hu, Jianjian Sun, Meng Wan, Bianhong Zhang, Linhui Wang, Tao P Zhong","doi":"10.1186/s13619-024-00210-0","DOIUrl":"https://doi.org/10.1186/s13619-024-00210-0","url":null,"abstract":"","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"27"},"PeriodicalIF":4.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TGFβ family signaling in human stem cell self-renewal and differentiation. TGFβ 家族信号在人类干细胞自我更新和分化中的作用。
IF 4
Cell Regeneration Pub Date : 2024-11-28 DOI: 10.1186/s13619-024-00207-9
Sijia Liu, Jiang Ren, Yanmei Hu, Fangfang Zhou, Long Zhang
{"title":"TGFβ family signaling in human stem cell self-renewal and differentiation.","authors":"Sijia Liu, Jiang Ren, Yanmei Hu, Fangfang Zhou, Long Zhang","doi":"10.1186/s13619-024-00207-9","DOIUrl":"10.1186/s13619-024-00207-9","url":null,"abstract":"<p><p>Human stem cells are undifferentiated cells with the capacity for self-renewal and differentiation into distinct cell lineages, playing important role in the development and maintenance of diverse tissues and organs. The microenvironment of stem cell provides crucial factors and components that exert significant influence over the determination of cell fate. Among these factors, cytokines from the transforming growth factor β (TGFβ) superfamily, including TGFβ, bone morphogenic protein (BMP), Activin and Nodal, have been identified as important regulators governing stem cell maintenance and differentiation. In this review, we present a comprehensive overview of the pivotal roles played by TGFβ superfamily signaling in governing human embryonic stem cells, somatic stem cells, induced pluripotent stem cells, and cancer stem cells. Furthermore, we summarize the latest research and advancements of TGFβ family in various cancer stem cells and stem cell-based therapy, discussing their potential clinical applications in cancer therapy and regeneration medicine.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"26"},"PeriodicalIF":4.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineered macrophages: an "Intelligent Repair" cellular machine for heart injury. 工程巨噬细胞：治疗心脏损伤的 "智能修复 "细胞机器。
IF 4
Cell Regeneration Pub Date : 2024-11-27 DOI: 10.1186/s13619-024-00209-7
Zhuo Zhang, Hetian Du, Weijie Gao, Donghui Zhang
{"title":"Engineered macrophages: an \"Intelligent Repair\" cellular machine for heart injury.","authors":"Zhuo Zhang, Hetian Du, Weijie Gao, Donghui Zhang","doi":"10.1186/s13619-024-00209-7","DOIUrl":"10.1186/s13619-024-00209-7","url":null,"abstract":"<p><p>Macrophages are crucial in the heart's development, function, and injury. As part of the innate immune system, they act as the first line of defense during cardiac injury and repair. After events such as myocardial infarction or myocarditis, numerous macrophages are recruited to the affected areas of the heart to clear dead cells and facilitate tissue repair. This review summarizes the roles of resident and recruited macrophages in developing cardiovascular diseases. We also describe how macrophage phenotypes dynamically change within the cardiovascular disease microenvironment, exhibiting distinct pro-inflammatory and anti-inflammatory functions. Recent studies reveal the values of targeting macrophages in cardiovascular diseases treatment and the novel bioengineering technologies facilitate engineered macrophages as a promising therapeutic strategy. Engineered macrophages have strong natural tropism and infiltration for cardiovascular diseases aiming to reduce inflammatory response, inhibit excessive fibrosis, restore heart function and promote heart regeneration. We also discuss recent studies highlighting therapeutic strategies and new approaches targeting engineered macrophages, which can aid in heart injury recovery.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"25"},"PeriodicalIF":4.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of feature genes in intestinal epithelial cell types. 鉴定肠上皮细胞类型的特征基因。
IF 4
Cell Regeneration Pub Date : 2024-11-15 DOI: 10.1186/s13619-024-00208-8
Ruoyu Lou, Wanlu Song, Shicheng Yu, Xiaodan Wang, Yuan Liu, Ye-Guang Chen, Yalong Wang
{"title":"Identification of feature genes in intestinal epithelial cell types.","authors":"Ruoyu Lou, Wanlu Song, Shicheng Yu, Xiaodan Wang, Yuan Liu, Ye-Guang Chen, Yalong Wang","doi":"10.1186/s13619-024-00208-8","DOIUrl":"10.1186/s13619-024-00208-8","url":null,"abstract":"<p><p>The intestine, is responsible for food digestion, nutrient absorption, endocrine secretion, food residue excretion, and immune defense. These function performances are based on the intricate composition of intestinal epithelial cells, encompassing differentiated mature cells, rapidly proliferative cells, and intestinal stem cells. Although the characteristics of these cell types are well-documented, in-depth exploration of their representative markers and transcription factors is critical for comprehensive cell fate trajectory analysis. Here, we unveiled the feature genes in different cell types of the human and mouse gut through single-cell RNA sequencing analysis. Further, the locations of some specific transcription factors and membrane proteins were determined by immunofluorescence staining, and their role in regulating the proliferation and differentiation of intestinal epithelial cells were explored by CRISPR/Cas9 knockout. Therefore, this study not only reports new markers for various intestinal epithelial cell types but also elucidates the involvement of relevant genes in the determination of epithelial cell fate and maintenance of stem cell homeostasis, which facilitates the tracing and functional elucidation of intestinal epithelial cells.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"24"},"PeriodicalIF":4.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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