Cell Regeneration最新文献_第2页

METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium. METTL3 在肠上皮细胞中通过 ATF3-cFLIP 轴限制 RIPK1 依赖性细胞死亡。

IF 4

Cell Regeneration Pub Date : 2024-08-02 DOI: 10.1186/s13619-024-00197-8

Meimei Huang, Xiaodan Wang, Mengxian Zhang, Yuan Liu, Ye-Guang Chen

{"title":"METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium.","authors":"Meimei Huang, Xiaodan Wang, Mengxian Zhang, Yuan Liu, Ye-Guang Chen","doi":"10.1186/s13619-024-00197-8","DOIUrl":"10.1186/s13619-024-00197-8","url":null,"abstract":"Intestinal epithelial cells (IECs) are pivotal for maintaining intestinal homeostasis through self-renewal, proliferation, differentiation, and regulated cell death. While apoptosis and necroptosis are recognized as distinct pathways, their intricate interplay remains elusive. In this study, we report that Mettl3-mediated m6A modification maintains intestinal homeostasis by impeding epithelial cell death. Mettl3 knockout induces both apoptosis and necroptosis in IECs. Targeting different modes of cell death with specific inhibitors unveils that RIPK1 kinase activity is critical for the cell death triggered by Mettl3 knockout. Mechanistically, this occurs via the m6A-mediated transcriptional regulation of Atf3, a transcription factor that directly binds to Cflar, the gene encoding the anti-cell death protein cFLIP. cFLIP inhibits RIPK1 activity, thereby suppressing downstream apoptotic and necroptotic signaling. Together, these findings delineate the essential role of the METTL3-ATF3-cFLIP axis in homeostatic regulation of the intestinal epithelium by blocking RIPK1 activity.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"14"},"PeriodicalIF":4.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emerging and diverse roles of F-box proteins in spermatogenesis and male infertility. F-box 蛋白在精子发生和男性不育中新出现的多种作用。

IF 4

Cell Regeneration Pub Date : 2024-06-26 DOI: 10.1186/s13619-024-00196-9

Xuan Zhuang, Jun Ruan, Canquan Zhou, Zhiming Li

引用次数: 0

Macrophages in tissue repair and regeneration: insights from zebrafish. 组织修复和再生中的巨噬细胞：斑马鱼的启示。

Cell Regeneration Pub Date : 2024-06-11 DOI: 10.1186/s13619-024-00195-w

Changlong Zhao, Zhiyong Yang, Yunbo Li, Zilong Wen

{"title":"Macrophages in tissue repair and regeneration: insights from zebrafish.","authors":"Changlong Zhao, Zhiyong Yang, Yunbo Li, Zilong Wen","doi":"10.1186/s13619-024-00195-w","DOIUrl":"10.1186/s13619-024-00195-w","url":null,"abstract":"Macrophages play crucial and versatile roles in regulating tissue repair and regeneration upon injury. However, due to their complex compositional heterogeneity and functional plasticity, deciphering the nature of different macrophage subpopulations and unraveling their dynamics and precise roles during the repair process have been challenging. With its distinct advantages, zebrafish (Danio rerio) has emerged as an invaluable model for studying macrophage development and functions, especially in tissue repair and regeneration, providing valuable insights into our understanding of macrophage biology in health and diseases. In this review, we present the current knowledge and challenges associated with the role of macrophages in tissue repair and regeneration, highlighting the significant contributions made by zebrafish studies. We discuss the unique advantages of the zebrafish model, including its genetic tools, imaging techniques, and regenerative capacities, which have greatly facilitated the investigation of macrophages in these processes. Additionally, we outline the potential of zebrafish research in addressing the remaining challenges and advancing our understanding of the intricate interplay between macrophages and tissue repair and regeneration.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New progress in roles of TGF-β signaling crosstalks in cellular functions, immunity and diseases. TGF-β 信号串在细胞功能、免疫和疾病中的作用研究取得新进展。

Cell Regeneration Pub Date : 2024-05-23 DOI: 10.1186/s13619-024-00194-x

Shuchen Gu, Rik Derynck, Ye-Guang Chen, Xin-Hua Feng

引用次数: 0

Forkhead box O proteins: steering the course of stem cell fate. 叉头盒 O 蛋白：引导干细胞命运的进程。

Cell Regeneration Pub Date : 2024-03-11 DOI: 10.1186/s13619-024-00190-1

Mengdi Cheng, Yujie Nie, Min Song, Fulin Chen, Yuan Yu

{"title":"Forkhead box O proteins: steering the course of stem cell fate.","authors":"Mengdi Cheng, Yujie Nie, Min Song, Fulin Chen, Yuan Yu","doi":"10.1186/s13619-024-00190-1","DOIUrl":"10.1186/s13619-024-00190-1","url":null,"abstract":"Stem cells are pivotal players in the intricate dance of embryonic development, tissue maintenance, and regeneration. Their behavior is delicately balanced between maintaining their pluripotency and differentiating as needed. Disruptions in this balance can lead to a spectrum of diseases, underscoring the importance of unraveling the complex molecular mechanisms that govern stem cell fate. Forkhead box O (FOXO) proteins, a family of transcription factors, are at the heart of this intricate regulation, influencing a myriad of cellular processes such as survival, metabolism, and DNA repair. Their multifaceted role in steering the destiny of stem cells is evident, as they wield influence over self-renewal, quiescence, and lineage-specific differentiation in both embryonic and adult stem cells. This review delves into the structural and regulatory intricacies of FOXO transcription factors, shedding light on their pivotal roles in shaping the fate of stem cells. By providing insights into the specific functions of FOXO in determining stem cell fate, this review aims to pave the way for targeted interventions that could modulate stem cell behavior and potentially revolutionize the treatment and prevention of diseases.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Models for calcific aortic valve disease in vivo and in vitro. 钙化性主动脉瓣疾病的体内和体外模型。

Cell Regeneration Pub Date : 2024-03-01 DOI: 10.1186/s13619-024-00189-8

Zijin Zhu, Zhirong Liu, Donghui Zhang, Li Li, Jianqiu Pei, Lin Cai

引用次数: 0

Asymmetric division of stem cells and its cancer relevance. 干细胞的非对称分裂及其与癌症的关系

Cell Regeneration Pub Date : 2024-02-27 DOI: 10.1186/s13619-024-00188-9

Shanshan Chao, Huiwen Yan, Pengcheng Bu

引用次数: 0

Reevaluating Golgi fragmentation and its implications in wound repair. 重新评估高尔基体碎片及其在伤口修复中的意义

Cell Regeneration Pub Date : 2024-02-13 DOI: 10.1186/s13619-024-00187-w

Chandra Sugiarto Wijaya, Suhong Xu

引用次数: 0

Correction: RhoA/Rock activation represents a new mechanism for inactivating Wnt/β-catenin signaling in the aging-associated bone loss. 更正：RhoA/Rock 激活是在衰老相关骨质流失中使 Wnt/β-catenin 信号失活的一种新机制。

Cell Regeneration Pub Date : 2024-02-10 DOI: 10.1186/s13619-023-00185-4

Wei Shi, Chengyun Xu, Ying Gong, Jirong Wang, Qianlei Ren, Ziyi Yan, Liu Mei, Chao Tang, Xing Ji, Xinhua Hu, Meiyu Qv, Musaddique Hussain, Ling-Hui Zeng, Ximei Wu

引用次数: 0

Mitochondrial-to-nuclear communications through multiple routes regulate cardiomyocyte proliferation. 线粒体与细胞核之间的通讯通过多种途径调节心肌细胞的增殖。

IF 4

Cell Regeneration Pub Date : 2024-01-31 DOI: 10.1186/s13619-024-00186-x

Xinhang Li, Yalin Zhu, Pilar Ruiz-Lozano, Ke Wei

{"title":"Mitochondrial-to-nuclear communications through multiple routes regulate cardiomyocyte proliferation.","authors":"Xinhang Li, Yalin Zhu, Pilar Ruiz-Lozano, Ke Wei","doi":"10.1186/s13619-024-00186-x","DOIUrl":"10.1186/s13619-024-00186-x","url":null,"abstract":"The regenerative capacity of the adult mammalian heart remains a formidable challenge in biological research. Despite extensive investigations into the loss of regenerative potential during evolution and development, unlocking the mechanisms governing cardiomyocyte proliferation remains elusive. Two recent groundbreaking studies have provided fresh perspectives on mitochondrial-to-nuclear communication, shedding light on novel factors that regulate cardiomyocyte proliferation. The studies identified two mitochondrial processes, fatty acid oxidation and protein translation, as key players in restricting cardiomyocyte proliferation. Inhibition of these processes led to increased cell cycle activity in cardiomyocytes, mediated by reduction in H3k4me3 levels through accumulated α-ketoglutarate (αKG), and activation of the mitochondrial unfolded protein response (UPRmt), respectively. In this research highlight, we discuss the novel insights into mitochondrial-to-nuclear communication presented in these studies, the broad implications in cardiomyocyte biology and cardiovascular diseases, as well as the intriguing scientific questions inspired by the studies that may facilitate future investigations into the detailed molecular mechanisms of cardiomyocyte metabolism, proliferation, and mitochondrial-to-nuclear communications.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"2"},"PeriodicalIF":4.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10828256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139641700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0