Cell Regeneration最新文献_第2页

A cellular triad for linking cardiac niche to regeneration. 连接心脏生态位与再生的细胞三位一体。

IF 4

Cell Regeneration Pub Date : 2024-12-10 DOI: 10.1186/s13619-024-00213-x

Xiaokai Ma, Junjie Hou, Jing-Wei Xiong

引用次数: 0

Tuft cells promote human intestinal epithelium regeneration as reserve stem cells after irradiation. 簇状细胞作为辐照后的储备干细胞促进人肠上皮再生。

IF 4

Cell Regeneration Pub Date : 2024-12-09 DOI: 10.1186/s13619-024-00214-w

Yehua Li, Mengxian Zhang, Xianrun Ma, Ye-Guang Chen

引用次数: 0

Correction: Expression levels and stoichiometry of Hnf1β, Emx2, Pax8 and Hnf4α influence direct reprogramming of induced renal tubular epithelial cells. 更正：Hnf1β、Emx2、Pax8和hnf1 α的表达水平和化学计量影响诱导肾小管上皮细胞的直接重编程。

IF 4

Cell Regeneration Pub Date : 2024-12-02 DOI: 10.1186/s13619-024-00210-0

Xueli Hu, Jianjian Sun, Meng Wan, Bianhong Zhang, Linhui Wang, Tao P Zhong

引用次数: 0

TGFβ family signaling in human stem cell self-renewal and differentiation. TGFβ 家族信号在人类干细胞自我更新和分化中的作用。

IF 4

Cell Regeneration Pub Date : 2024-11-28 DOI: 10.1186/s13619-024-00207-9

Sijia Liu, Jiang Ren, Yanmei Hu, Fangfang Zhou, Long Zhang

引用次数: 0

Engineered macrophages: an "Intelligent Repair" cellular machine for heart injury. 工程巨噬细胞：治疗心脏损伤的 "智能修复 "细胞机器。

IF 4

Cell Regeneration Pub Date : 2024-11-27 DOI: 10.1186/s13619-024-00209-7

Zhuo Zhang, Hetian Du, Weijie Gao, Donghui Zhang

{"title":"Engineered macrophages: an \"Intelligent Repair\" cellular machine for heart injury.","authors":"Zhuo Zhang, Hetian Du, Weijie Gao, Donghui Zhang","doi":"10.1186/s13619-024-00209-7","DOIUrl":"10.1186/s13619-024-00209-7","url":null,"abstract":"Macrophages are crucial in the heart's development, function, and injury. As part of the innate immune system, they act as the first line of defense during cardiac injury and repair. After events such as myocardial infarction or myocarditis, numerous macrophages are recruited to the affected areas of the heart to clear dead cells and facilitate tissue repair. This review summarizes the roles of resident and recruited macrophages in developing cardiovascular diseases. We also describe how macrophage phenotypes dynamically change within the cardiovascular disease microenvironment, exhibiting distinct pro-inflammatory and anti-inflammatory functions. Recent studies reveal the values of targeting macrophages in cardiovascular diseases treatment and the novel bioengineering technologies facilitate engineered macrophages as a promising therapeutic strategy. Engineered macrophages have strong natural tropism and infiltration for cardiovascular diseases aiming to reduce inflammatory response, inhibit excessive fibrosis, restore heart function and promote heart regeneration. We also discuss recent studies highlighting therapeutic strategies and new approaches targeting engineered macrophages, which can aid in heart injury recovery.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"25"},"PeriodicalIF":4.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of feature genes in intestinal epithelial cell types. 鉴定肠上皮细胞类型的特征基因。

IF 4

Cell Regeneration Pub Date : 2024-11-15 DOI: 10.1186/s13619-024-00208-8

Ruoyu Lou, Wanlu Song, Shicheng Yu, Xiaodan Wang, Yuan Liu, Ye-Guang Chen, Yalong Wang

{"title":"Identification of feature genes in intestinal epithelial cell types.","authors":"Ruoyu Lou, Wanlu Song, Shicheng Yu, Xiaodan Wang, Yuan Liu, Ye-Guang Chen, Yalong Wang","doi":"10.1186/s13619-024-00208-8","DOIUrl":"10.1186/s13619-024-00208-8","url":null,"abstract":"The intestine, is responsible for food digestion, nutrient absorption, endocrine secretion, food residue excretion, and immune defense. These function performances are based on the intricate composition of intestinal epithelial cells, encompassing differentiated mature cells, rapidly proliferative cells, and intestinal stem cells. Although the characteristics of these cell types are well-documented, in-depth exploration of their representative markers and transcription factors is critical for comprehensive cell fate trajectory analysis. Here, we unveiled the feature genes in different cell types of the human and mouse gut through single-cell RNA sequencing analysis. Further, the locations of some specific transcription factors and membrane proteins were determined by immunofluorescence staining, and their role in regulating the proliferation and differentiation of intestinal epithelial cells were explored by CRISPR/Cas9 knockout. Therefore, this study not only reports new markers for various intestinal epithelial cell types but also elucidates the involvement of relevant genes in the determination of epithelial cell fate and maintenance of stem cell homeostasis, which facilitates the tracing and functional elucidation of intestinal epithelial cells.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"24"},"PeriodicalIF":4.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application and new findings of scRNA-seq and ST-seq in prostate cancer. scRNA-seq 和 ST-seq 在前列腺癌中的应用和新发现。

IF 4

Cell Regeneration Pub Date : 2024-10-29 DOI: 10.1186/s13619-024-00206-w

Zhuang Li, Zhengnan Li, Yuanyuan Luo, Weiming Chen, Yinyi Fang, Yuliang Xiong, Qinyi Zhang, Dongbo Yuan, Bo Yan, Jianguo Zhu

引用次数: 0

Beyond resorption: osteoclasts as drivers of bone formation. 超越吸收：破骨细胞是骨形成的驱动力。

IF 4

Cell Regeneration Pub Date : 2024-10-11 DOI: 10.1186/s13619-024-00205-x

Qianfeng Xiang, Lei Li, Wei Ji, Debby Gawlitta, X Frank Walboomers, Jeroen J J P van den Beucken

{"title":"Beyond resorption: osteoclasts as drivers of bone formation.","authors":"Qianfeng Xiang, Lei Li, Wei Ji, Debby Gawlitta, X Frank Walboomers, Jeroen J J P van den Beucken","doi":"10.1186/s13619-024-00205-x","DOIUrl":"10.1186/s13619-024-00205-x","url":null,"abstract":"Emerging evidence illustrates that osteoclasts (OCs) play diverse roles beyond bone resorption, contributing significantly to bone formation and regeneration. Despite this, OCs remain mysterious cells, with aspects of their lifespan-from origin, fusion, alterations in cellular characteristics, to functions-remaining incompletely understood. Recent studies have identified that embryonic osteoclastogenesis is primarily driven by osteoclast precursors (OCPs) derived from erythromyeloid progenitors (EMPs). These precursor cells subsequently fuse into OCs essential for normal bone development and repair. Postnatally, hematopoietic stem cells (HSCs) become the primary source of OCs, gradually replacing EMP-derived OCs and assuming functional roles in adulthood. The absence of OCs during bone development results in bone structure malformation, including abnormal bone marrow cavity formation and shorter long bones. Additionally, OCs are reported to have intimate interactions with blood vessels, influencing bone formation and repair through angiogenesis regulation. Upon biomaterial implantation, activation of the innate immune system ensues immediately. OCs, originating from macrophages, closely interact with the immune system. Furthermore, evidence from material-induced bone formation events suggests that OCs are pivotal in these de novo bone formation processes. Nevertheless, achieving a pure OC culture remains challenging, and interpreting OC functions in vivo faces difficulties due to the presence of other multinucleated cells around bone-forming biomaterials. We here describe the fusion characteristics of OCPs and summarize reliable markers and morphological changes in OCs during their fusion process, providing guidance for researchers in identifying OCs both in vitro and in vivo. This review focuses on OC formation, characterization, and the roles of OCs beyond resorption in various bone pathophysiological processes. Finally, therapeutic strategies targeting OCs are discussed.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"22"},"PeriodicalIF":4.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subtype-specific neurons from patient iPSCs display distinct neuropathological features of Alzheimer's disease. 来自患者 iPSCs 的亚型特异性神经元显示出阿尔茨海默病的不同神经病理学特征。

IF 4

Cell Regeneration Pub Date : 2024-10-10 DOI: 10.1186/s13619-024-00204-y

Ran Tao, Chunmei Yue, Zhijie Guo, Wenke Guo, Yao Yao, Xianfa Yang, Zhen Shao, Chao Gao, Jianqing Ding, Lu Shen, Shengdi Chen, Naihe Jing

{"title":"Subtype-specific neurons from patient iPSCs display distinct neuropathological features of Alzheimer's disease.","authors":"Ran Tao, Chunmei Yue, Zhijie Guo, Wenke Guo, Yao Yao, Xianfa Yang, Zhen Shao, Chao Gao, Jianqing Ding, Lu Shen, Shengdi Chen, Naihe Jing","doi":"10.1186/s13619-024-00204-y","DOIUrl":"https://doi.org/10.1186/s13619-024-00204-y","url":null,"abstract":"Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by massive neuronal loss in the brain. Both cortical glutamatergic neurons and basal forebrain cholinergic neurons (BFCNs) in the AD brain are selectively vulnerable. The degeneration and dysfunction of these two subtypes of neurons are closely associated with the cognitive decline of AD patients. The determination of cellular and molecular mechanisms involved in AD pathogenesis, especially in the early stage, will largely facilitate the understanding of this disease and the development of proper intervention strategies. However, due to the inaccessibility of living neurons in the brains of patients, it remains unclear how cortical glutamatergic neurons and BFCNs respond to pathological stress in the early stage of AD. In this study, we established in vitro differentiation systems that can efficiently differentiate patient-derived iPSCs into BFCNs. We found that AD-BFCNs secreted less Aβ peptide than cortical glutamatergic neurons did, even though the Aβ42/Aβ40 ratio was comparable to that of cortical glutamatergic neurons. To further mimic the neurotoxic niche in AD brain, we treated iPSC-derived neurons with Aβ42 oligomer (AβO). BFCNs are less sensitive to AβO induced tau phosphorylation and expression than cortical glutamatergic neurons. However, AβO could trigger apoptosis in both AD-cortical glutamatergic neurons and AD-BFCNs. In addition, AD iPSC-derived BFCNs and cortical glutamatergic neurons exhibited distinct electrophysiological firing patterns and elicited different responses to AβO treatment. These observations revealed that subtype-specific neurons display distinct neuropathological changes during the progression of AD, which might help to understand AD pathogenesis at the cellular level.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"21"},"PeriodicalIF":4.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities. 针对衰老和 COVID-19 中的衰老细胞：从细胞机制到治疗机会。

IF 4

Cell Regeneration Pub Date : 2024-10-02 DOI: 10.1186/s13619-024-00201-1

Yuan Yu, Kaixuan Lin, Haoyu Wu, Mingli Hu, Xuejie Yang, Jie Wang, Johannes Grillari, Jiekai Chen

{"title":"Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities.","authors":"Yuan Yu, Kaixuan Lin, Haoyu Wu, Mingli Hu, Xuejie Yang, Jie Wang, Johannes Grillari, Jiekai Chen","doi":"10.1186/s13619-024-00201-1","DOIUrl":"10.1186/s13619-024-00201-1","url":null,"abstract":"The COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-threatening complications. Exploring the key factors associated with clinical severity highlights that key characteristics of aging, such as cellular senescence, immune dysregulation, metabolic alterations, and impaired regenerative potential, contribute to disruption of tissue homeostasis of the lung and worse clinical outcome. Senolytic and senomorphic drugs, which are anti-aging treatments designed to eliminate senescent cells or decrease the associated phenotypes, have shown promise in alleviating age-related dysfunctions and offer a novel approach to treating diseases that share certain aspects of underlying mechanisms with aging, including COVID-19. This review summarizes the current understanding of aging in COVID-19 progression, and highlights recent findings on anti-aging drugs that could be repurposed for COVID-19 treatment to complement existing therapies.","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"13 1","pages":"20"},"PeriodicalIF":4.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0