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Cell Regeneration最新文献

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Therapeutic application of chick early amniotic fluid: effective rescue of acute myocardial ischemic injury by intravenous administration 早期羊水在治疗急性心肌缺血性损伤中的应用
Cell Regeneration Pub Date : 2022-04-01 DOI: 10.1186/s13619-022-00110-1
Baiping Cui, Yufan Zheng, Xiang Gao, Lihong Zhang, Borui Li, Jia Chen, Xinyan Zhou, Mengyuan Cai, Wenrui Sun, Yuting Zhang, Keejong Chang, Jiayi Xu, Fuyin Zhu, Yan Luo, T. Sun, J. Qian, Ning Sun
{"title":"Therapeutic application of chick early amniotic fluid: effective rescue of acute myocardial ischemic injury by intravenous administration","authors":"Baiping Cui, Yufan Zheng, Xiang Gao, Lihong Zhang, Borui Li, Jia Chen, Xinyan Zhou, Mengyuan Cai, Wenrui Sun, Yuting Zhang, Keejong Chang, Jiayi Xu, Fuyin Zhu, Yan Luo, T. Sun, J. Qian, Ning Sun","doi":"10.1186/s13619-022-00110-1","DOIUrl":"https://doi.org/10.1186/s13619-022-00110-1","url":null,"abstract":"","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46849760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Chchd10 is dispensable for myogenesis but critical for adipose browning Chchd10对肌生成可有可无，但对脂肪褐变至关重要
Cell Regeneration Pub Date : 2022-04-01 DOI: 10.1186/s13619-022-00111-0
W. Xia, Jiamin Qiu, Ying Peng, Madigan M Snyder, Lijie Gu, Kuilong Huang, Nanjian Luo, Feng Yue, S. Kuang
{"title":"Chchd10 is dispensable for myogenesis but critical for adipose browning","authors":"W. Xia, Jiamin Qiu, Ying Peng, Madigan M Snyder, Lijie Gu, Kuilong Huang, Nanjian Luo, Feng Yue, S. Kuang","doi":"10.1186/s13619-022-00111-0","DOIUrl":"https://doi.org/10.1186/s13619-022-00111-0","url":null,"abstract":"","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49441213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Correction to: Hepatocyte generation in liver homeostasis, repair, and regeneration. 修正:肝细胞在肝脏稳态、修复和再生中的生成。
Cell Regeneration Pub Date : 2022-03-23 DOI: 10.1186/s13619-022-00115-w
Wenjuan Pu, Bin Zhou
{"title":"Correction to: Hepatocyte generation in liver homeostasis, repair, and regeneration.","authors":"Wenjuan Pu, Bin Zhou","doi":"10.1186/s13619-022-00115-w","DOIUrl":"https://doi.org/10.1186/s13619-022-00115-w","url":null,"abstract":"","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":" ","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8943064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40315251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors. 利用基因编码荧光生物传感器监测生物体发育过程中NAD(H)和NADP(H)的动态。
Cell Regeneration Pub Date : 2022-02-01 DOI: 10.1186/s13619-021-00105-4
Ting Li, Yejun Zou, Shuning Liu, Yi Yang, Zhuo Zhang, Yuzheng Zhao
{"title":"Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors.","authors":"Ting Li,&nbsp;Yejun Zou,&nbsp;Shuning Liu,&nbsp;Yi Yang,&nbsp;Zhuo Zhang,&nbsp;Yuzheng Zhao","doi":"10.1186/s13619-021-00105-4","DOIUrl":"https://doi.org/10.1186/s13619-021-00105-4","url":null,"abstract":"<p><p>Cell metabolism plays vital roles in organismal development, but it has been much less studied than transcriptional and epigenetic control of developmental programs. The difficulty might be largely attributed to the lack of in situ metabolite assays. Genetically encoded fluorescent sensors are powerful tools for noninvasive metabolic monitoring in living cells and in vivo by highly spatiotemporal visualization. Among all living organisms, the NAD(H) and NADP(H) pools are essential for maintaining redox homeostasis and for modulating cellular metabolism. Here, we introduce NAD(H) and NADP(H) biosensors, present example assays in developing organisms, and describe promising prospects for how sensors contribute to developmental biology research.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":" ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8807777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39877495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
OSKM-mediated reversible reprogramming of cardiomyocytes regenerates injured myocardium. oskm介导的心肌细胞可逆重编程可再生损伤心肌。
Cell Regeneration Pub Date : 2022-01-17 DOI: 10.1186/s13619-021-00106-3
Gregory Farber, Jiandong Liu, Li Qian
{"title":"OSKM-mediated reversible reprogramming of cardiomyocytes regenerates injured myocardium.","authors":"Gregory Farber,&nbsp;Jiandong Liu,&nbsp;Li Qian","doi":"10.1186/s13619-021-00106-3","DOIUrl":"https://doi.org/10.1186/s13619-021-00106-3","url":null,"abstract":"<p><p>Cellular reprogramming has rapidly become a promising methodology to generate new cardiomyocytes from non-cardiomyocyte cell types. Using the transient expression of OSKM factors, Chen et al. demonstrate a unique reprogramming strategy involving the modulation of the resident adult cardiomyocyte identity to an immature proliferative state (Science 373:1537-40, 2021). This OSKM-mediated reversion results in the adoption by adult murine cardiomyocytes of a transcriptional profile similar to cardiomyocytes found in developing hearts, as well as increased proliferative capacity of these reprogrammed cardiomyocytes compared to mature cardiomyocytes. Furthermore, this novel approach enhances the regeneration of adult murine hearts post-myocardial injury. Although concerns and questions remain, the encouraging results of this study advance the field of cardiac regeneration by providing a new technique to generate cardiomyocytes as well as insights into cardiomyocyte dedifferentiation and its relation to proliferation.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":" ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39828842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human embryos in a dish - modeling early embryonic development with pluripotent stem cells. 人类胚胎在培养皿中用多能干细胞模拟早期胚胎发育。
Cell Regeneration Pub Date : 2022-01-14 DOI: 10.1186/s13619-022-00107-w
Xiukun Wang, Guang Hu
{"title":"Human embryos in a dish - modeling early embryonic development with pluripotent stem cells.","authors":"Xiukun Wang,&nbsp;Guang Hu","doi":"10.1186/s13619-022-00107-w","DOIUrl":"https://doi.org/10.1186/s13619-022-00107-w","url":null,"abstract":"<p><p>Stem cell-based embryo models present new opportunities to study early embryonic development. In a recent study, Kagawa et al. identified an approach to create human pluripotent stem cell-based blastoids that resemble the human blastocysts. These blastoids efficiently generated analogs of the EPI, TE, PrE lineages with transcriptomes highly similar to those found in vivo. Furthermore, the formation of these lineages followed the same sequence and pace of blastocyst development, and was also dependent on the same pathways required for lineage specification. Finally, the blastoids were capable of attaching to stimulated endometrial cells to mimic the process of implantation. While more comprehensive analysis is needed to confirm its validity and usefulness, this new blastoid system presents the latest development in the attempt to model early human embryogenesis in vitro.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":" ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39697658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
TAD reorganization: a new mechanism for cell fate determination. TAD重组:细胞命运决定的新机制。
Cell Regeneration Pub Date : 2021-12-02 DOI: 10.1186/s13619-021-00100-9
Zhou Songyang
{"title":"TAD reorganization: a new mechanism for cell fate determination.","authors":"Zhou Songyang","doi":"10.1186/s13619-021-00100-9","DOIUrl":"https://doi.org/10.1186/s13619-021-00100-9","url":null,"abstract":"","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"10 1","pages":"37"},"PeriodicalIF":0.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39683534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Diverse biological and engineering strategies towards organ regeneration. 器官再生的多种生物和工程策略。
Cell Regeneration Pub Date : 2021-11-02 DOI: 10.1186/s13619-021-00098-0
Junjie Hou, Qinchao Zhou, Xiaojun Zhu, Jinrong Peng, Jing-Wei Xiong
{"title":"Diverse biological and engineering strategies towards organ regeneration.","authors":"Junjie Hou,&nbsp;Qinchao Zhou,&nbsp;Xiaojun Zhu,&nbsp;Jinrong Peng,&nbsp;Jing-Wei Xiong","doi":"10.1186/s13619-021-00098-0","DOIUrl":"https://doi.org/10.1186/s13619-021-00098-0","url":null,"abstract":"<p><p>Organ regeneration is an important, fascinating, and old topic while much remains unknown in spite of extensive investigations for decades. From March 25th to 27th, 2021, the Third Chinese Symposium on Organ Regeneration took place in the beautiful ocean city of Zhoushan, Zhejiang, China. This biennial conference attracted ~ 300 academic attendees: students, postdoctoral fellows, and principal investigators, in addition to few industrial investigators. The mixed live and virtual talks covered the broad field of organ regeneration from different animal organisms to human organoids, and concluded with some impressive advances on inflammatory signaling, regenerative signaling mechanisms, new technologies, and applications for organ regeneration.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"10 1","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2021-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39582470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Single-cell analysis defines the lineage plasticity of stem cells in cervix epithelium. 单细胞分析确定了子宫颈上皮干细胞的谱系可塑性。
Cell Regeneration Pub Date : 2021-11-01 DOI: 10.1186/s13619-021-00096-2
Zixian Zhao, Yujia Wang, Yingchuan Wu, Dandan Li, Ting Zhang, Yu Ma, Xiaoming Teng, Wei Zuo
{"title":"Single-cell analysis defines the lineage plasticity of stem cells in cervix epithelium.","authors":"Zixian Zhao,&nbsp;Yujia Wang,&nbsp;Yingchuan Wu,&nbsp;Dandan Li,&nbsp;Ting Zhang,&nbsp;Yu Ma,&nbsp;Xiaoming Teng,&nbsp;Wei Zuo","doi":"10.1186/s13619-021-00096-2","DOIUrl":"https://doi.org/10.1186/s13619-021-00096-2","url":null,"abstract":"<p><p>Information about the dynamic change and post-injury regeneration of cervical epithelium is relatively rare, even though it is tightly related to gynecologic malignancy. Here, using a feeder cell-based culturing system, we stably cloned mouse and human P63 and KRT5 expressing cells from the adult cervix as putative cervical stem/progenitor cells (CVSCs). When subjected to differentiation, the cultured cells gave rise to mature cervical epithelium by differentiating into squamous or glandular cells. The ability of endogenous mouse CVSCs to reconstitute cervical epithelium after injury was also evident from the genetic lineage tracing experiments. Single-cell transcriptomic analysis further classified the CVSCs into three subtypes and delineated their bi-lineage differentiation roadmap by pseudo-time analysis. We also tracked the real-time differentiation routes of two representing single CVSC lines in vitro and found that they recapitulated the predicted roadmap in pseudo-time analysis. Signaling pathways including Wnt, TGF-beta, Notch and EGFR were found to regulate the cervical epithelial hierarchy and implicated the different roles of distinct types of cells in tissue homeostasis and tumorigenesis. Collectively, the above data provide a cloning system to achieve stable in vitro culture of a bi-lineage stem/progenitor cell population in the cervix, which has profound implications for our understanding of the cervix stem/progenitor cell function in homeostasis, regeneration, and disease and could be helpful for developing stem cell-based therapies in future.</p>","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"10 1","pages":"36"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39578047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Correction to: CRISPR/Cas: a potential gene-editing tool in the nervous system. CRISPR/Cas:神经系统中潜在的基因编辑工具。
Cell Regeneration Pub Date : 2021-10-13 DOI: 10.1186/s13619-021-00095-3
Yanxia Gao, Kexin Gao, Hui Yang
{"title":"Correction to: CRISPR/Cas: a potential gene-editing tool in the nervous system.","authors":"Yanxia Gao,&nbsp;Kexin Gao,&nbsp;Hui Yang","doi":"10.1186/s13619-021-00095-3","DOIUrl":"https://doi.org/10.1186/s13619-021-00095-3","url":null,"abstract":"","PeriodicalId":9811,"journal":{"name":"Cell Regeneration","volume":"10 1","pages":"35"},"PeriodicalIF":0.0,"publicationDate":"2021-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39513648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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