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Access to Fluorinated Dienes through Hydrofluorination of 2-En-4-ynoates
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-12-17 DOI: 10.1039/d4qo02049a
Yue Xia, Aaron D. Charlack, Rui Guo, Nicholas W. Wade, Yiming Wang
{"title":"Access to Fluorinated Dienes through Hydrofluorination of 2-En-4-ynoates","authors":"Yue Xia, Aaron D. Charlack, Rui Guo, Nicholas W. Wade, Yiming Wang","doi":"10.1039/d4qo02049a","DOIUrl":"https://doi.org/10.1039/d4qo02049a","url":null,"abstract":"The hydrofluorination of enynes has been developed for the synthesis of fluorinated dienes. Using a pyridinium tetrafluoroborate salt that is easily prepared on large scale, this approach enabled the direct conversion of enynes to fluorinated diene targets through a vinyl cation mediated process. This approach was applied to a range of aryl-substituted enyne esters to deliver the (Z)-configured products with high levels of stereo- and regioselectivity. Mechanistic studies were conducted to provide insights into the stereochemical outcome and reaction efficiency under different reaction conditions.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"21 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanochemical Decarbonylative Transformation of Amide Group to OCF3 and CF3 Functionalities under Ruthenium Catalysis 钌催化下酰胺基向 OCF3 和 CF3 官能团的机械化学脱羰基转化
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-12-14 DOI: 10.1039/d4qo01946f
Satenik Mkrtchyan, Vishal B. Purohit, Oleksandr Shalimov, Michał Jakubczyk, Gabriela Addová, Juraj Filo, Barbora Benicka, Ronak V. Prajapati, Vaibhav D. Prajapati, Jiří Zapletal, Yevhen Karpun, Vitaliy Yepishev, Jarmila Kmeťová, Elena Kupcová, Viktor Iaroshenko
{"title":"Mechanochemical Decarbonylative Transformation of Amide Group to OCF3 and CF3 Functionalities under Ruthenium Catalysis","authors":"Satenik Mkrtchyan, Vishal B. Purohit, Oleksandr Shalimov, Michał Jakubczyk, Gabriela Addová, Juraj Filo, Barbora Benicka, Ronak V. Prajapati, Vaibhav D. Prajapati, Jiří Zapletal, Yevhen Karpun, Vitaliy Yepishev, Jarmila Kmeťová, Elena Kupcová, Viktor Iaroshenko","doi":"10.1039/d4qo01946f","DOIUrl":"https://doi.org/10.1039/d4qo01946f","url":null,"abstract":"A novel strategy has been introduced for the selective activation of N–C(O) moiety in primary aromatic amides through the utilization of pyrylium tetrafluoroborate under mechanochemical conditions, where the amide group undergoes subsequent activation and selectively substituted with the CF3 or OCF3 functionality. The scope of the present protocol includes selective transformation of diversely substituted aromatic amides to the respective trifluoromethyl and trifluoromethoxy arenes via mechanochemically induced deaminative functionalization under the synergy of a piezoelectric material barium titanate (BaTiO3), and ruthenium-catalysis. The presented mechanochemical approach unlocks new chemical spaces in pharmaceutical industries with a perspective on PASE (pot, atom, and step economy) synthesis.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"24 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modular Synthesis of β-Oxygen-containing Sulfones from Alkenes through Hexatungstate-catalyzed Cascade Hydroxysulfenylation/ Selective Oxidation
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-12-14 DOI: 10.1039/d4qo02151g
Xianghua Zeng, Jiaoxiong Li, Zhibin Zhou, Yongge Wei
{"title":"Modular Synthesis of β-Oxygen-containing Sulfones from Alkenes through Hexatungstate-catalyzed Cascade Hydroxysulfenylation/ Selective Oxidation","authors":"Xianghua Zeng, Jiaoxiong Li, Zhibin Zhou, Yongge Wei","doi":"10.1039/d4qo02151g","DOIUrl":"https://doi.org/10.1039/d4qo02151g","url":null,"abstract":"β-Oxygen-containing sulfones are versatile building blocks in pharmaceuticals and chemical industry. Despite notable advancements in reportedmethods, a sustainable and general catalytic method for the preparation of β-oxygen-containing sulfones remains elusive due to the inherent reactivity disparities and notorious metal-catalyst-poisoning capability of sulfur nucleophiles. Here, we present a distinct multifunctional hexatungstate catalytic strategy for the synthesis of β-hydroxy sulfones and β‑keto sulfones through a sequential hydroxysulfenylation of alkenes/selective oxidation process, utilizing a commerically available thiol and green hydrogen peroxide as the ‘oxy-sulfonylation reagent’. This method not only offers a practical route for delivering functionalized sulfones from readily available chemicals but also showcases its versatility through late-stage oxysulfonylation of complex substrates and concise syntheses of bioactive molecules. Moreover, this modular methodology features hydroperoxide reductant free, mild reaction conditions, water as the sole byproduct and new mechanism.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"22 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stereocontrolled desymmetrization of 2,5-cyclohexadienones via organocatalytic domino sulfa-1,6-/1,4-addition or sulfa-1,6- /1,4-/sulfa-1,4-addition reactions 通过有机催化多米诺磺胺-1,6-/1,4-加成或磺胺-1,6-/1,4-/磺胺-1,4-加成反应实现 2,5-Cyclohexadienones 的立体可控非对称化
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-12-14 DOI: 10.1039/d4qo02097a
Vanisha Sodhi, Deepak Sharma, Manisha Sharma, Pankaj Chauhan
{"title":"Stereocontrolled desymmetrization of 2,5-cyclohexadienones via organocatalytic domino sulfa-1,6-/1,4-addition or sulfa-1,6- /1,4-/sulfa-1,4-addition reactions","authors":"Vanisha Sodhi, Deepak Sharma, Manisha Sharma, Pankaj Chauhan","doi":"10.1039/d4qo02097a","DOIUrl":"https://doi.org/10.1039/d4qo02097a","url":null,"abstract":"We have developed a desymmetrization of 2,5-cyclohexadienones tethered 3-cyano-4-styrylcoumarins via the amino-squaramide catalyzed initial regio-/enantio-selective sulfa-1,6-addition to the 3-cyano-4-styrylcoumarin moiety of the substrate, followed by an intramolecular vinylogous 1,4-addition to the dienone portion. An additional sulfa-Michael addition was observed when the thiols were taken in excess to create an additional stereogenic center. With our divergent approach, the two unique classes of hydrophenanthrene skeletons have been synthesized as single diastereoisomers in good to excellent yields and enantioselectivities (up to >99.5:0.5 er).","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"336 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclizative Dearomative Rearrangement of Pyridines with Isocyanates
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-12-14 DOI: 10.1039/d4qo02111h
Xing-Zi Li, Fang-Zhou Li, Zi-Qi Wang, Hua Wu
{"title":"Cyclizative Dearomative Rearrangement of Pyridines with Isocyanates","authors":"Xing-Zi Li, Fang-Zhou Li, Zi-Qi Wang, Hua Wu","doi":"10.1039/d4qo02111h","DOIUrl":"https://doi.org/10.1039/d4qo02111h","url":null,"abstract":"Dearomatizationof pyridines is a robust synthetic method to access aza-heterocycles. Simultaneously, intermolecular cyclizative rearrangement is a recently developed new strategy toward efficiently constructing tetrasubstituted carbons. Here, we show that an effective integration of dearomatization approach with strategic cyclizative rearrangement render 2-acyl-substituted pyridines and their analogues with common isocyanates to undergo a tandem [3+2] heteroannulation followed by an extensive 1,2-carbon shift, thus providing a straightforward access to readily functionalized bicyclohydantoins. Based on the promotion of organophosphorus, different types of migrating groups, such as ester, amide, aryl and trifluoromethyl groups, are all well-tolerated in the same reaction for the first time.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"1 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tf2O-Induced Selective 1,3-Transposition/Cyclization of Ynones in DMF
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-12-14 DOI: 10.1039/d4qo01890g
Huilin Lan, Wenting Liu, Wen Liu, Jiajian Peng, Ying Bai, Xinxin Shao
{"title":"Tf2O-Induced Selective 1,3-Transposition/Cyclization of Ynones in DMF","authors":"Huilin Lan, Wenting Liu, Wen Liu, Jiajian Peng, Ying Bai, Xinxin Shao","doi":"10.1039/d4qo01890g","DOIUrl":"https://doi.org/10.1039/d4qo01890g","url":null,"abstract":"A chemo and regio-selective system for activating C=O and S=O bonds under transition metal-free conditions is described. Thus, a Tf2O-mediated 1,3-transposition of ynones in DMF has been developed, providing a versatile pathway for the downstream synthesis of diverse five- and seven-membered heterocycles. Furthermore, the catalytic migration of carbonyl functionality conjugated to an alkyne unit is investigated. In the presence of sulfoxide, which undergoes a Pummerer reaction, the in-situ generation of highly reactive sulfonium salts enables efficient access to a wide range of sulfur-containing annulated scaffolds. Importantly, 3-SCF2D chromones were obtained in high yields and D-incorporation. This divergent methodology offers a versatile platform for maximizing molecular complexity and diversity.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"10 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bifuran- and bithiophene-fused 4,6-dihydro-1,2,7-oxadiborepins as building blocks for conjugated copolymers
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-12-13 DOI: 10.1039/d4qo01964d
Jonas Bachmann, Andreas Drichel, Jonas Klopf, Abhishek Koner, Adam Slabon, Holger Helten
{"title":"Bifuran- and bithiophene-fused 4,6-dihydro-1,2,7-oxadiborepins as building blocks for conjugated copolymers","authors":"Jonas Bachmann, Andreas Drichel, Jonas Klopf, Abhishek Koner, Adam Slabon, Holger Helten","doi":"10.1039/d4qo01964d","DOIUrl":"https://doi.org/10.1039/d4qo01964d","url":null,"abstract":"The use of dithieno- (DTDB) and difuro-4,6-dihydro-1,2,7-oxadiborepins (DFDB) as components of conjugated copolymers is demonstrated. Building upon our recently developed protocol for the modular synthesis of 5,5’-dibrominated difuro-4,6-dihydro-1,2,7-oxa- and azadiborepins, we devised a scalable route to the corresponding 5,5’-dibrominated and 5,5’-distannylated DTDB derivatives, which serve as monomers for subsequent polymerizations. Combining both the difunctionalized DTDB- and the DFDB-based monomers with electron-rich benzodithiophene (BDT) and electron-poor diketopyrrolopyrrole (DPP) building blocks, respectively, gave four new copolymers, which are well-soluble and fully air- and moisture-stable. They show broad absorptions over the visible spectral range – with the bands of the DPP-containing copolymers extending into the near-IR region. DFT calculations give further insights into the electronics of the copolymers. Photoelectrochemical measurements revealed that three of the new copolymers exhibit p-type while one of them exhibits n-type semiconducting behavior.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"15 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palladium-Catalyzed Three-Component Annulation Reaction Involving Multiple C─H Activation
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-12-13 DOI: 10.1039/d4qo01857e
Shuai Yang, Xiang Zuo, Yanghui Zhang
{"title":"Palladium-Catalyzed Three-Component Annulation Reaction Involving Multiple C─H Activation","authors":"Shuai Yang, Xiang Zuo, Yanghui Zhang","doi":"10.1039/d4qo01857e","DOIUrl":"https://doi.org/10.1039/d4qo01857e","url":null,"abstract":"The Pd-catalyzed ring-forming reaction via multiple C─H activation provides an efficient strategy to access cyclic ring systems. The current reactions are primarily restricted to single and two-component reactions. Herein, we report a ring-forming reaction via palladium-catalyzed three-component multiple C─H activation. Using TsOMe as the methylating reagent, aryl iodides undergo maleimide-relayed C─H methylation. Subsequent cyclization via C(sp3)─H activation forms succinimide-fused tricyclic scaffolds. Depending on aryl iodides, the reaction involves dual or triple C─H activation to form two or three new C─C bonds. The reaction represents a new strategy for C─H methylation and offer a new synthetic method using simple and readily available substrates for succinimide-fused tricyclic scaffolds, which are crucial structural motifs found widely in organic compounds with diverse biological activities.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"21 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iminonaphthofuranone synthesis via multiple-component cyclization of 2-naphthols using only molecular oxygen
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-12-13 DOI: 10.1039/d4qo01939c
Jianyu Dong, Shaofeng Wu, Long Liu, Dan Zhou, Min Mo, Ya-Dong Gao, Lebin Su, Shuang-Feng Yin, Yongbo Zhou
{"title":"Iminonaphthofuranone synthesis via multiple-component cyclization of 2-naphthols using only molecular oxygen","authors":"Jianyu Dong, Shaofeng Wu, Long Liu, Dan Zhou, Min Mo, Ya-Dong Gao, Lebin Su, Shuang-Feng Yin, Yongbo Zhou","doi":"10.1039/d4qo01939c","DOIUrl":"https://doi.org/10.1039/d4qo01939c","url":null,"abstract":"A multiple-component oxidative cyclization of easily available 2-naphthols, anilines, and ethyl glyoxylate is successfully achieved using only molecular oxygen. The reaction enables green, efficient and highly selective synthesis of iminonaphthofuranones, a category of disperse dyes that are previously inaccessible. The products exhibit a wide spectrum of colors, adjustable from pale orange to dark purple. They are also readily transformed into naphthofuranones and highly functionalized naphthols.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"42 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoredox trifluoromethylation of isocyanides to access 2-trifluoromethylated quinolines and indoles 异氰酸酯的光氧化三氟甲基化反应生成 2-三氟甲基化的喹啉和吲哚
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-12-13 DOI: 10.1039/d4qo02105c
Jin Wang, Yaohui Liu, Jinhai Xu, Peiyuan Li, Xiaoxi Xu, Shuo Zhang, Jie Yang, Xianxiu Xu
{"title":"Photoredox trifluoromethylation of isocyanides to access 2-trifluoromethylated quinolines and indoles","authors":"Jin Wang, Yaohui Liu, Jinhai Xu, Peiyuan Li, Xiaoxi Xu, Shuo Zhang, Jie Yang, Xianxiu Xu","doi":"10.1039/d4qo02105c","DOIUrl":"https://doi.org/10.1039/d4qo02105c","url":null,"abstract":"We herein report a divergent synthesis of 2-CF₃ substituted quinolines and indoles via photoredox radical trifluoromethylation of ortho-vinylphenylisocyanides. This mild and green protocol offers a broad substrate scope and good functional group tolerance. Mechanistic investigations revealed that the trifluoromethyl radical is generated through an EDA complex between Togni’s reagent and a base under light irradiation.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"51 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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