发布求助
文献互助 智能选刊 最新文献

Organic Chemistry Frontiers最新文献

筛选
英文 中文
Catalyst-Free Synthesis of Unsymmetrical ureas from COS and Amines: a Strategy for Selectivity Regulation 无催化剂合成 COS 和胺类不对称脲：一种选择性调节策略
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-11-19 DOI: 10.1039/d4qo01553c
Siliu Cheng, Yunzhe Du, Huijie Jia, Shuyi Li, Yian Feng, Ning Zhu
{"title":"Catalyst-Free Synthesis of Unsymmetrical ureas from COS and Amines: a Strategy for Selectivity Regulation","authors":"Siliu Cheng, Yunzhe Du, Huijie Jia, Shuyi Li, Yian Feng, Ning Zhu","doi":"10.1039/d4qo01553c","DOIUrl":"https://doi.org/10.1039/d4qo01553c","url":null,"abstract":"A novel and mild method for the highly selective synthesis of asymmetric urea from amines and COS has been established. This method effectively synthesizes asymmetric urea from combinations of aliphatic primary amines and aliphatic secondary amines, as well as from sterically hindered aliphatic primary amines and aromatic primary amines. This breakthrough overcomes the previous limitation of using only aromatic amines and secondary amines for selective synthesis of asymmetric urea. Moreover, the method accommodates a wide range of substrates and demonstrates high tolerance to various functional groups, yielding diverse asymmetric ureas with good to excellent yields and selectivity. Mechanistic investigations reveal that the high selectivity is due to two-stage temperature regulation, the selection of specific substrate structures and ratios, and the appropriate amount of COS. Additionally, the H2S produced during the reaction is efficiently captured by the substrate or solvent, forming useful chemical products. This efficient synthetic methodology provides a mild and selective pathway for the preparation of asymmetric urea derivatives.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"22 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
N-Aryl/Heteroaryl Oxaziridines: From Photochemical Synthesis to Reactivity Investigation in Heteroatom Transfer Reactions N-芳基/杂芳基恶嗪：从光化学合成到杂原子转移反应中的反应性研究
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-11-19 DOI: 10.1039/d4qo01758g
Bao-Gui Cai, Hui Mao, Kun Wang, Jun Xuan
{"title":"N-Aryl/Heteroaryl Oxaziridines: From Photochemical Synthesis to Reactivity Investigation in Heteroatom Transfer Reactions","authors":"Bao-Gui Cai, Hui Mao, Kun Wang, Jun Xuan","doi":"10.1039/d4qo01758g","DOIUrl":"https://doi.org/10.1039/d4qo01758g","url":null,"abstract":"The reactivity of oxaziridines is significantly influenced by the substituents on the nitrogen atom. Despite extensive studies since their discovery by Emmons in 1956, research on the reactivity of N-aryl/heteroaryl oxaziridines remains limited. This limitation is likely due to the lack of efficient synthetic methods. In this study, a visible -light-induced photochemical strategy was developed to address this challenge. First, a series of stable biaryl-substituted N-heteroaryl oxaziridines were synthesized and isolated via the photochemical reaction of aryl/aryl diazoalkanes with nitrosoarenes. Further studies showed that some unstable N-aryl/heteroaryl oxaziridines, generated in-situ from the photochemical rearrangement of nitrones, show remarkable heteroatom transfer reactivities. These oxaziridines can act as both oxygen and nitrogen atom transfer reagents, depending on the nucleophiles involved. Moreover, the synthetic potential of this method was further highlighted through the successful modification of complex natural products and pharmaceutical derivatives. This study provides valuable insights into the synthesis and application of N-aryl/heteroaryl oxaziridines, thereby enhancing their utility in synthetic chemistry.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"11 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct Aminosulfonylation of Electron-rich (hetero)Arenes Utilizing tert-Butyl Chlorosulfonylcarbamate with Diisopropylethylamine 利用氯磺酰氨基甲酸叔丁酯和二异丙基乙胺对富电子（杂）烯进行直接氨基磺酰化反应
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-11-19 DOI: 10.1039/d4qo01731e
Xiaofei Zhang, Jiangtao Tan, Yuanchen Zhong, Zhen Zhuang, Qian He, Min Jiang, Chunhao Yang
{"title":"Direct Aminosulfonylation of Electron-rich (hetero)Arenes Utilizing tert-Butyl Chlorosulfonylcarbamate with Diisopropylethylamine","authors":"Xiaofei Zhang, Jiangtao Tan, Yuanchen Zhong, Zhen Zhuang, Qian He, Min Jiang, Chunhao Yang","doi":"10.1039/d4qo01731e","DOIUrl":"https://doi.org/10.1039/d4qo01731e","url":null,"abstract":"Sulfonamides, especially primary aryl sulfonamides are very important scaffolds not only because of the wide applications as pharmacophores in drugs, but also the derivatization for other sulfonamides and different sulfur-containing compounds. Among the aryl sulfonamides, most syntheses of electron-rich (hetero)aryl sulfonamides are still severely limited by the classic chlorosulfonation or oxidative chlorination reactions with significant drawbacks. In this work, by the proposed and unique tert-butyl sulfonylcarbamate intermediate generated in situ from easily accessed tert-butyl chlorosulfonylcarbamate and diisopropylethylamine, a catalyst-free, mild and very pratical aminosulfonylation protocol for a wide scope of electron-rich (hetero)arene substrates with good to excellent yields was reported.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"12 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viologen–Cycloparaphenylene Hybrids: Luminescent Molecular Nanocarbons for Anion Binding and Specific Vapor Sorption† Viologen-Cycloparaphenylene Hybrids：用于阴离子结合和特定蒸汽吸附的发光分子纳米碳†.
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-11-19 DOI: 10.1039/d4qo01993h
Marcin Stępień, Rafał Frydrych, Kabali Senthilkumar, Katarzyna Ślusarek, Mateusz Waliczek, Wojciech Bury, Piotr J. Chmielewski, Joanna Cybińska
{"title":"Viologen–Cycloparaphenylene Hybrids: Luminescent Molecular Nanocarbons for Anion Binding and Specific Vapor Sorption†","authors":"Marcin Stępień, Rafał Frydrych, Kabali Senthilkumar, Katarzyna Ślusarek, Mateusz Waliczek, Wojciech Bury, Piotr J. Chmielewski, Joanna Cybińska","doi":"10.1039/d4qo01993h","DOIUrl":"https://doi.org/10.1039/d4qo01993h","url":null,"abstract":"Two viologen-like macrocyclic receptors, [1]2+ and [2]2+, merging a bent oligophenylene loop with a (para-xylylene)bispyridinium moiety were designed and synthesized. Both dications were derived from the same precursor: the more strained cycloparaphenylene analogue [1]2+ was obtained using a reductive aromatization, whereas the less curved, meta-phenylene-containing [2]2+ was generated using a double eliminative rearrangement. [1]2+ is active as a receptor toward pyrene-1,3,6,8-tetrasulfonate, displaying a 2:1 binding interaction, with K11 = 7.4(3) × 103 M–1. In the solid state, [1][TFA]2 shows differential sorption of C6 hydrocarbons and shows reversible sorption of water. [1]2+ displays yellow emission in solution (λmaxem = 544 nm in DMF), which is considerably red shifted in the solid state (λmaxem = 644 nm for dry samples). Both [1]2+ and [2]2+ undergo electrochemical reduction, yielding transient viologen-like radical cations and diradicals.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"13 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ligand-Controlled Rh(I) -Catalyzed Intramolecular Alkyne Sila-Cyclization: Divergent Catalysis and Mechanistic Studies 配体控制的 Rh(I) 催化分子内炔硅烷环化：差异催化和机理研究
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-11-19 DOI: 10.1039/d4qo02119c
Wei-Ke Zhu, Jia-Wei Si, Sui-Fang Peng, Li Li, Fei Ye, Zheng Xu, Li-Wen Xu
{"title":"Ligand-Controlled Rh(I) -Catalyzed Intramolecular Alkyne Sila-Cyclization: Divergent Catalysis and Mechanistic Studies","authors":"Wei-Ke Zhu, Jia-Wei Si, Sui-Fang Peng, Li Li, Fei Ye, Zheng Xu, Li-Wen Xu","doi":"10.1039/d4qo02119c","DOIUrl":"https://doi.org/10.1039/d4qo02119c","url":null,"abstract":"The synthesis of structurally diverse silacycles is crucial for the silicon-containing drug and agrochemical development. However, catalytic synthesis of dense-functionalized silacycles that based on selectively cleavage and reconstruction of the carbon–silicon bond in the organosilicon precursors remain largely elusive. Herein we report a divergent catalysis of ring-reconstruction transformation of silacycles based on rhodium-promoted Si-C bond cleavage whereby the cyclic silylmetal intermediates undergo a highly efficient and novel intramolecular Si-C bond-forming reactions under mild conditions. Under the ligand-controlled Rh-catalyzed intramolecular silacyclization, two different pathways of new Si-C bond -forming transformations were established through intramolecular sila-cyclization reaction between alkyne moieties and silacyclobutane moieties, resulting into structurally diverse chromane-like silacycles. Furthermore, the DFT calculations supported that bulky P-ligand P5 and the TADDOL-derived phosphonite ligand L1 played different roles to control the pathway in Rh-catalyzed intramolecular silacyclization and subsequent olefin migration process.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"40 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catalytic enantioselective and site-specific Friedel−Crafts alkylation of 4-aminoindoles with β,γ-alkynyl-α-ketoimines for the synthesis of C7-functionalized indoles 催化对映体选择性和位点特异性 Friedel-Crafts 烷基化 4-氨基吲哚与 β、γ-炔基-α-酮亚胺合成 C7 功能化吲哚
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-11-19 DOI: 10.1039/d4qo01856g
Lei Yang, Xue-Man Zhang, Juan Liao, Yan-Ping Zhang, Zhen-Hua Wang, Yong You, Jian-Qiang Zhao, Wei-Cheng Yuan
{"title":"Catalytic enantioselective and site-specific Friedel−Crafts alkylation of 4-aminoindoles with β,γ-alkynyl-α-ketoimines for the synthesis of C7-functionalized indoles","authors":"Lei Yang, Xue-Man Zhang, Juan Liao, Yan-Ping Zhang, Zhen-Hua Wang, Yong You, Jian-Qiang Zhao, Wei-Cheng Yuan","doi":"10.1039/d4qo01856g","DOIUrl":"https://doi.org/10.1039/d4qo01856g","url":null,"abstract":"Chiral phosphoric acid-catalyzed enantioselective Friedel−Crafts alkylation of 4‑aminoindoles with β,γ-alkynyl-α-ketoimines has been developed. A range of optically pure C7-functionalized indoles bearing a quaternary α-amino acid or trifluoromethylated tetrasubstituted alkylamine motif were obtained with up to 98% yield and 99% ee. This protocol effectively incorporates the site-specific Friedel-Crafts alkylation at the C7 site of 4‑aminoindoles and regio-specific quaternary stereocenter construction at the α-position of β,γ-alkynyl-α-ketoimines, and opens a new avenue to access chiral C7-functionalized indoles.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"99 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lewis Acids Catalyzed Regiodivergent N-alkylation of Indazoles with Donor-Acceptor Cyclopropanes 路易斯酸催化吲唑与供体-受体环丙烷的N-烷基化反应
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-11-19 DOI: 10.1039/d4qo01493f
Xiaoyan Zhang, Yujiao Xiang, Xiangyang Zhao, Xin Zhou, Weiliang Chen, Yungui Peng
{"title":"Lewis Acids Catalyzed Regiodivergent N-alkylation of Indazoles with Donor-Acceptor Cyclopropanes","authors":"Xiaoyan Zhang, Yujiao Xiang, Xiangyang Zhao, Xin Zhou, Weiliang Chen, Yungui Peng","doi":"10.1039/d4qo01493f","DOIUrl":"https://doi.org/10.1039/d4qo01493f","url":null,"abstract":"N-alkyl Indazoles are highly privileged skeleton in pharmaceutical applications. Generally, N1 and N2-alkyl indazoles represents distinct pharmaceutical and biological activities due to their molecular shape and electrostatic distribution. Herein, we described a regiodivergent N-alkylation of indazoles via nucleophilic ring opening of D-A cyclopropanes by employing different Lewis acid catalysts. Under the catalysis of Al(OTf)3, kinetic controlled N2-alkyl indazoles were achieved, while Co(NTf2)2 facilitated the formation of N1-alkyl indazoles. The methodology exhibited a broad substrate scope, affording the corresponding N1 and N2 alkylation products selectively in high yields with good to excellent regioselectivities.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"26 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142671030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deuterium Exchange of Pyrrolic NH Protons Accelerated by Fluoride and Bicarbonate in CDCl3, CD3CN, and DMSO-d6 氟化物和碳酸氢盐加速 CDCl3、CD3CN 和 DMSO-d6 中吡咯烷 NH 质子的氘交换
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-11-18 DOI: 10.1039/d4qo01855a
Sung Kuk Kim, Nam Jung Heo, Ju Hyun Oh, Jonathan L. Sessler
{"title":"Deuterium Exchange of Pyrrolic NH Protons Accelerated by Fluoride and Bicarbonate in CDCl3, CD3CN, and DMSO-d6","authors":"Sung Kuk Kim, Nam Jung Heo, Ju Hyun Oh, Jonathan L. Sessler","doi":"10.1039/d4qo01855a","DOIUrl":"https://doi.org/10.1039/d4qo01855a","url":null,"abstract":"The anion binding features of pyrrole- and benzene-strapped calix[4]pyrroles <strong>1</strong> and <strong>2</strong>, in particular, for F<small><sup>–</sup></small> and HCO<small><sub>3</sub></small><small><sup>–</sup></small> have been examined by means of NMR spectroscopy in DMSO-<em>d<small><sub>6</sub></small></em>, CDCl<small><sub>3</sub></small>, and CD<small><sub>3</sub></small>CN, respectively. Receptors <strong>1</strong> and <strong>2</strong> were found to bind F<small><sup>–</sup></small> and HCO<small><sub>3</sub></small><small><sup>–</sup></small> tightly via slow binding/release equilibria in these solvents. A combination of <small><sup>1</sup></small>H and <small><sup>19</sup></small>F NMR spectroscopic analyses with mass spectrometry revealed that contacting calix[4]pyrroles <strong>1</strong> and <strong>2</strong> with F<small><sup>–</sup></small> and HCO<small><sub>3</sub></small><small><sup>–</sup></small> salts prompts deuterium exchange of the NH protons in the three nominally aprotic deuterated solvents considered in this study.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"6 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chiral CpxRhIII-Catalyzed Enantioselective C-H Annulation to Access Fused Tricyclic Sulfur-Stereogenic and Medium-sized aza-Heterocycles 手性 CpxRhIII 催化对映体选择性 C-H 嵌合，获得融合的三环立体硫和中型氮杂环
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-11-15 DOI: 10.1039/d4qo01749h
Yuping Xiong, Muhammad Suleman, Shujuan Xu, Zhiyuan Chen
{"title":"Chiral CpxRhIII-Catalyzed Enantioselective C-H Annulation to Access Fused Tricyclic Sulfur-Stereogenic and Medium-sized aza-Heterocycles","authors":"Yuping Xiong, Muhammad Suleman, Shujuan Xu, Zhiyuan Chen","doi":"10.1039/d4qo01749h","DOIUrl":"https://doi.org/10.1039/d4qo01749h","url":null,"abstract":"We report herein a chiral CpxRhIII-catalyzed asymmetric sp2 C-H bond activation/annulation reaction of free NH-sulfoximines with hypervalent iodonium ylides under external ligand-free conditions was reported. Efficient kinetic resolution (KR) was observed for the reactions of racemic sulfoximines bearing an asymmetric S-aryl-S-alkyl moiety, which also delivered the expected fused tricyclic (S)-aza-heterocycles and the corresponding chiral (R)-NH-sulfoximines in mostly good yields and excellent enatioselectivities. By use of this catalytic protocol, structurally unprecedented 10-membered S-stereogenic benzothiazecines with nice enantioselectivities could be achieved upon one-pot multi-step oxidation reactions. Mechanistically, an enantiodetermined C−H cleavage and the subsequent formation of a chiral five-membered rhodacycle intermediate were supposed through systematic deuterium (D) labeled studies.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"30 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iridium-Catalyzed Highly Enantioselective and Chemodivergent Coupling Reaction of Vinyl Azides and Vinyl Benzoxazinones 铱催化的乙烯基叠氮化物和乙烯基苯并噁嗪酮的高对映选择性和化学发散性偶联反应
IF 5.4 1区 化学
Organic Chemistry Frontiers Pub Date : 2024-11-15 DOI: 10.1039/d4qo01862a
Deli Gan, Sumei Zhao, Min Yang, Minghui Xu, Bin Chen, Wenhao Yu, Hai-Liang Ni, Bi-Qin Wang, Ping Hu, Peng Cao
{"title":"Iridium-Catalyzed Highly Enantioselective and Chemodivergent Coupling Reaction of Vinyl Azides and Vinyl Benzoxazinones","authors":"Deli Gan, Sumei Zhao, Min Yang, Minghui Xu, Bin Chen, Wenhao Yu, Hai-Liang Ni, Bi-Qin Wang, Ping Hu, Peng Cao","doi":"10.1039/d4qo01862a","DOIUrl":"https://doi.org/10.1039/d4qo01862a","url":null,"abstract":"The first Iridium-catalyzed enantioselective coupling reaction of vinyl azides and vinyl benzoxazinones is presented. Vinyl azides underwent a tandem allylic alkylation/interrupted Schmidt rearrangement process to produce enantioenriched 3,4-dihydroquinolin-2(1H)-imines, a new class of N-heterocyles. In the presence of CH3CO2H, a conventional asymmetric allylic substitution occurred to provide access to nonracemic allylic amides. The synthetic transformations of product were implemented to construct chiral amine, amide and N-hetero polycycle.","PeriodicalId":97,"journal":{"name":"Organic Chemistry Frontiers","volume":"4 1","pages":""},"PeriodicalIF":5.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信