Access to Chiral α-Methyl-α-Aryl Carboxylic Acids via Phosphoric Acid-Catalyzed Kinetic Resolution of Biaryl Oxazepines

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-07-25 DOI:10.1039/d5qo00953g

Guimei Dai, Yifei Ma, Weiwei Tan, Ting Tu, Bowen Zhu, Zhikang Wei, Liejin Zhou, Shi-Chao Ren, Xing Yang

引用次数: 0

Abstract

We disclose herein a chiral phosphoric acid-catalyzed kinetic resolution of racemic biaryl oxazepines with alcohols, giving a series of biaryl oxazepines and imidate products bearing a chiral center in good yields and enantioselectivities. The racemic biaryl oxazepine substrates could be readily synthesized from racemic carboxylic acids. Hydrolysis of the chiral imidate products afforded α-methyl-α-aryl carboxylic acids in high yields and enantioselectivities.

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手性α-甲基-α-芳基羧酸的磷酸催化动力学拆分

我们在此公开了手性磷酸催化的外消旋联芳基恶氮平与醇的动力学拆分，得到了一系列手性中心的联芳基恶氮平和咪唑产品，收率高，对映选择性好。外消旋羧酸可以很容易地合成外消旋二芳基恶氮平底物。手性酰亚咪酯水解产物产率高，对映选择性强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.