Cationic and Homoleptic Copper(I)–Thiazol-2-ylidenes: Highly Reactive Thiazole N-Heterocyclic Carbenes σ-Lewis Acid Catalysts

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-07-31 DOI:10.1039/d5qo00772k

Ruihong Wang, Jin Zhang, Hang Yang, Yawei Zhu, Yan Guo, Xiaoxia Han, Roman Szostak, Michal Szostak

引用次数: 0

Abstract

Air- and moisture-stable cationic homoleptic Cu(I) thiazol-2-ylidene complexes are developed as highly efficient σ-Lewis acid catalysts, outperforming imidazol-2-ylidenes in the alkynylation of ketones without requiring stoichiometric Cu-acetylides. These complexes exhibit exceptional operational simplicity and robustness, enabling key C–C bond formation. Structural insights and DFT studies highlight their enhanced reactivity and stability. With their superior performance and practicality, thiazol-2-ylidenes represent a promising class of catalysts for sustainable organic synthesis.

查看原文本刊更多论文

阳离子型和同感型铜(I) -噻唑-2-酰基烯：高活性噻唑n -杂环卡宾σ-路易斯酸催化剂

在不需要化学计量量的Cu- acetyides的情况下，作为高效的σ-Lewis酸催化剂，开发了具有空气稳定性和水分稳定性的阳离子同效性Cu(I)噻唑-2- ylidee配合物，在酮的炔化反应中优于咪唑-2- ylidees。这些配合物具有特殊的操作简单性和稳健性，能够形成键C-C键。结构洞察和DFT研究强调了它们增强的反应性和稳定性。噻唑-2-吡啶具有优异的性能和实用性，是一类很有前途的可持续有机合成催化剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.