Palladium/photoredox-catalysis in decarboxylative radical C(sp3)-C(sp3) cross-coupling reaction of γ-methylidene-δ-valerolactones with alkyl carboxylic acids

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-08-14 DOI:10.1039/d5qo01005e

Ran Song, Jiaxing Li, Lin Li, Huaixi Mu, Wei Feng, Daoshan Yang, Wen Si, Jian Lv

引用次数: 0

Abstract

Developing applicable methods to forge linkages between sp3 and sp3-hydridized carbons is of great significance in drug discovery. Here a radical decarboxylative C(sp3)-C(sp3) cross-coupling of γ-methylidene-δ-valerolactones (GMDVs) and alkyl carboxylic acids was developed by combining photocatalysis and palladium catalysis, providing the target products in good to excellent yields (up to 97% yield). The reaction exhibited broad substrate scope and wide functional group compatibility.

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钯/光氧化催化γ-甲基-δ-戊内酯与烷基羧酸脱羧自由基C(sp3)-C（sp3）交叉偶联反应

开发适用于sp3和sp3氢化碳之间形成键的方法在药物发现中具有重要意义。本文通过光催化和钯催化合成了γ-亚甲基-δ-戊内酯（GMDVs）与烷基羧酸的自由基脱羧C(sp3)-C（sp3）交叉偶联反应，得到了收率高达97%的目标产物。该反应具有广泛的底物范围和广泛的官能团相容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.