Organic & Biomolecular Chemistry最新文献_第6页

Unlocking nature's antioxidants: a novel method for synthesising plasmalogens. 揭开大自然抗氧化剂的神秘面纱：合成质体蛋白的新方法。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-09-05 DOI: 10.1039/d4ob01233j

Jay Tromans, Bian Zhang, Bernard T Golding

引用次数: 0

Visible light-mediated radical addition cascade cyclization of aryl isocyanides with tricarbonyls: rapid access to substituted phenanthridines and isoquinolines. 可见光介导的芳基异氰酸酯与三羰基的自由基加成级联环化反应：快速获得取代的菲啶类和异喹啉类化合物。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-09-05 DOI: 10.1039/d4ob01405g

Sabyasachi Manna, Rahul Halanuru Sreedhara, Kandikere Ramaiah Prabhu

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High-throughput optimization of the C-H arylation of oxetanes via Ni/aldehyde photocatalysis. 通过镍/醛光催化技术高通量优化氧杂环丁烷的 C-H 芳基化反应。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-09-05 DOI: 10.1039/d4ob01271b

Justin B Diccianni, Bo Hao, Wei Liu, Iulia I Strambeanu

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Outstanding Reviewers for Organic & Biomolecular Chemistry in 2023 2023 年《有机与生物分子化学》杰出审稿人。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-09-05 DOI: 10.1039/D4OB90098G

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Photochemistry of 2-(2-formylphenyloxy)acetic acid derivatives: synthesis of hydroxychromanones and benzofuranones. 2-(2-formylphenyloxy)acetic acid 衍生物的光化学：羟基色满酮和苯并呋喃酮的合成。

IF 2.9 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-09-04 DOI: 10.1039/d4ob01194e

Ekaterina A Zhigileva, Victoria E Opryshko, Artur V Eshtukov-Shcheglov, Dmitrii S Ivanov, Daniil I Rudik, Andrey A Mikhaylov, Igor A Ivanov, Alexander Yu Smirnov, Mikhail S Baranov

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C–N cleavage of secondary amide to access primary amide by a Co(II)/Oxone oxidation system Co(II)/Oxone 氧化系统通过 C-N 裂解仲酰胺以获得伯酰胺

IF 3.2 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-09-04 DOI: 10.1039/d4ob00974f

Haixing Zhang, Chaoyue Sun, Xuan Zhang, Xuan Cheng, Guiwen Guo, Wang Geng, Peiwei Gong, Shumiao Zhang, Mianran Chao, Duyi Shen

{"title":"C–N cleavage of secondary amide to access primary amide by a Co(II)/Oxone oxidation system","authors":"Haixing Zhang, Chaoyue Sun, Xuan Zhang, Xuan Cheng, Guiwen Guo, Wang Geng, Peiwei Gong, Shumiao Zhang, Mianran Chao, Duyi Shen","doi":"10.1039/d4ob00974f","DOIUrl":"https://doi.org/10.1039/d4ob00974f","url":null,"abstract":"Cleavage of the C–N bond of a secondary amide could provide alternative access to primary amides; however, this strategy remains challenging due to oxidation resistance of the amide. Herein, we employed the cobalt(II)/Oxone catalytic system, one of the advanced oxidation processes (AOPs), to make it available to break the strong C–N bond of various secondary (sulfon)amides, especially those bearing electron-poor or ortho-substituted N-arenes, en route to desirable primary (sulfon)amides. Control experiments showed that it was probably not the generally-considered persulfate anion radical in the cobalt/peroxymonosulfate (Co/PMS) system but the proposed high-valent cobalt-oxo intermediate that should be the major active species for the initial N–H oxidation of N-aryl amides. In the case of N-alkylated secondary amides, the α-C–H bond, rather than the N–H bond, should be oxidized first by both the reactive radicals and high-valent cobalt-oxo species. This work not only establishes an efficient method for removing the N-substituents of secondary amides at low cost, with readily available and eco-friendly reagents, but also demonstrates further synthetic application and provides more insight into intermediates for metal-based AOPs in environmental remediation.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and biological evaluation of natural Lachnophyllum methyl ester, Lachnophyllum lactone and their synthetic analogs 天然叶黄素甲酯、叶黄素内酯及其合成类似物的合成和生物学评价

IF 3.2 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-09-04 DOI: 10.1039/d4ob01224k

Kodjo Adande, Oudjaniyobi Simalou, Juline Ardanuy, Kodjo Eloh, Chérine Mehalla, Patricia Constant, Isabelle Fabing, Yves Génisson, Stéphanie Ballereau

{"title":"Synthesis and biological evaluation of natural Lachnophyllum methyl ester, Lachnophyllum lactone and their synthetic analogs","authors":"Kodjo Adande, Oudjaniyobi Simalou, Juline Ardanuy, Kodjo Eloh, Chérine Mehalla, Patricia Constant, Isabelle Fabing, Yves Génisson, Stéphanie Ballereau","doi":"10.1039/d4ob01224k","DOIUrl":"https://doi.org/10.1039/d4ob01224k","url":null,"abstract":"(2Z)-Lachnophyllum methyl ester and (4Z)-Lachnophyllum lactone were recently identified as major components in essential oils and extracts of Conyza bonariensis from Togo. Extended biological evaluation of these acetylenic compounds was however hampered by the reduced amounts isolated. A synthetic route was designed providing access to larger quantities of these two natural products as well as to original non-natural analogs with the prospect of exploring for the first time the structure–activity relationships in this series. Using LC/MS analysis, synthetic samples allowed confirming the presence of the two previously isolated natural products in plant extracts obtained by the accelerated solvent extraction technique. The nematocidal activity of the synthesized compounds confirmed the potency of the natural products, which remain the most active among all analogs tested. The synthesized compounds were also assessed against Leishmania infantum axenic amastigotes and the Mycobacterium tuberculosis H37Rv pathogenic strain. (2Z)-Lachnophyllum methyl ester, (4Z)-Lachnophyllum lactone and lactone analogs exhibited the strongest antileishmanial potency. As expected, a longer alkyl chain was necessary to observe significant antimycobacterial activity. The lactone analog bearing a C10 lipophilic appendage displayed the highest antimycobacterial potency. The notable activities of lactones, naturally occurring or analogs, either nematicidal, antileishmanial or antimycobacterial, were compared to their cytotoxicity for mammalian cells and revealed moderate selectivity index values. In this regard, the innocuous (2Z)-Lachnophyllum methyl ester and its analogs open up more promising perspectives for the discovery of bioactive agents to protect both agricultural crops and human health.","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142202355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regioselective synthesis of 2-aminophenols from N-arylhydroxylamines 从 N-芳基羟胺中区域选择性合成 2-氨基苯酚

IF 3.2 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-09-04 DOI: 10.1039/d4ob01281j

Zhiwei Gao, Zhiguo Hou, Hongyin Gao

引用次数: 0

Ternary deep eutectic solvents for esterification of 2-methylpropenoic acid with alcohols 用于 2-甲基丙烯酸与醇酯化的三元深共晶溶剂

IF 3.2 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-09-04 DOI: 10.1039/d4ob01180e

Jiani Huang, Yanyan Li, Ruonan Zhang, Liran Wang, Ming Bao, Xiaoqiang Yu

引用次数: 0

Organic synthesis in flow mode by selective liquid-phase hydrogenation over heterogeneous non-noble metal catalysts 在多相非贵金属催化剂上通过选择性液相氢化在流动模式下进行有机合成

IF 3.2 3区化学

Organic & Biomolecular Chemistry Pub Date : 2024-09-03 DOI: 10.1039/d4ob00873a

Alexey L. Nuzhdin, Marina V. Bukhtiyarova, Galina A. Bukhtiyarova

{"title":"Organic synthesis in flow mode by selective liquid-phase hydrogenation over heterogeneous non-noble metal catalysts","authors":"Alexey L. Nuzhdin, Marina V. Bukhtiyarova, Galina A. Bukhtiyarova","doi":"10.1039/d4ob00873a","DOIUrl":"https://doi.org/10.1039/d4ob00873a","url":null,"abstract":"Flow hydrogenation performed over heterogeneous catalysts makes organic synthesis more economical, safe and environmentally friendly. Over the past two decades, a significant amount of research with a major focus on noble metal catalysts has been carried out in this area. However, catalysts based on non-noble metals (Ni, Cu, Co, etc.) are more promising for practical use due to their low cost and high availability. This review article discusses the use of supported and bulk non-noble metal catalysts for the liquid-phase hydrogenation of bi- and polyfunctional organic compounds in flow mode. The main attention is paid to the selective reduction of one functional group (NO2, C<img alt=\"[double bond, length as m-dash]\" border=\"0\" src=\"https://www.rsc.org/images/entities/char_e001.gif\">C, C<img alt=\"[triple bond, length as m-dash]\" border=\"0\" src=\"https://www.rsc.org/images/entities/char_e002.gif\">N, C<img alt=\"[double bond, length as m-dash]\" border=\"0\" src=\"https://www.rsc.org/images/entities/char_e001.gif\">O, and C<img alt=\"[double bond, length as m-dash]\" border=\"0\" src=\"https://www.rsc.org/images/entities/char_e001.gif\">N) in the presence of other substituents. In addition, cascade synthetic protocols involving hydrogenation are presented.</img></img></img></img>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142202210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0