Cell Cycle最新文献_第3页

SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells β-catenin信号增强导致的SIRT3抑制推动糖酵解，促进缺氧诱导的肝癌细胞生长

IF 4.3 3区生物学

Cell Cycle Pub Date : 2024-04-16 DOI: 10.1080/15384101.2024.2340864

Rong Ma, Qing-Yuan Gao, Zhi-Teng Chen, Guang-Hong Liao, Shu-Tai Li, Jie-Wen Cai, Nian-Sang Luo, Hao Chen, Hai-Feng Zhang

引用次数: 0

Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth 抑制 YEATS2 可诱导肝细胞癌细胞衰老并抑制肿瘤生长

IF 4.3 3区生物学

Cell Cycle Pub Date : 2024-04-15 DOI: 10.1080/15384101.2024.2342714

Qi Wu, Quan Zheng, Lei Yuan, Dandan Gao, Yabing Hu, Xinqing Jiang, Qiaocheng Zhai, Ming Liu, Lifeng Xu, Heng Xu, Jinlin Ye, Feng Zhang

引用次数: 0

DNMT1-mediated epigenetic suppression of FBXO32 expression promoting cyclin dependent kinase 9 (CDK9) survival and esophageal cancer cell growth DNMT1 介导的表观遗传学抑制 FBXO32 的表达，促进细胞周期蛋白依赖性激酶 9 (CDK9) 的存活和食管癌细胞的生长

IF 4.3 3区生物学

Cell Cycle Pub Date : 2024-04-10 DOI: 10.1080/15384101.2024.2309022

Xian-Qiang Song, Bin-Bin Chen, Yong-Mei Jin, Chang-Yong Wang

引用次数: 0

Homologous recombination contributes to the repair of acetaldehyde-induced DNA damage 同源重组有助于修复乙醛诱导的 DNA 损伤

IF 4.3 3区生物学

Cell Cycle Pub Date : 2024-04-03 DOI: 10.1080/15384101.2024.2335028

Kosuke Yamazaki, Tomohiro Iguchi, Yutaka Kanoh, Kazuto Takayasu, Trinh Thi To Ngo, Ayaka Onuki, Hideya Kawaji, Shunji Oshima, Tomomasa Kanda, Hisao Masai, Hiroyuki Sasanuma

引用次数: 0

Identification and validation of key miRNAs and a microRNA-mRNA regulatory network associated with liver cancer 鉴定和验证与肝癌相关的关键 miRNA 和 microRNA-mRNA 调控网络

IF 4.3 3区生物学

Cell Cycle Pub Date : 2024-03-28 DOI: 10.1080/15384101.2024.2335024

Jie Tang, Song Li, Zixiao Zhou, Weicai Chang, Yongqiang Wang, Juan Mei, Shaobo Zhou

引用次数: 0

Effects of Ninjurin 2 polymorphisms on susceptibility to coronary heart disease Ninjurin 2 多态性对冠心病易感性的影响

IF 4.3 3区生物学

Cell Cycle Pub Date : 2024-03-21 DOI: 10.1080/15384101.2024.2330225

Yuping Yan, Xiaoyan Du, Xia Dou, Jingjie Li, Wenjie Zhang, Shuangyu Yang, Wenting Meng, Gang Tian

引用次数: 0

Gene expression profile of mitogen-activated kinases and microRNAs controlling their expression in HaCaT cell culture treated with lipopolysaccharide A and cyclosporine A 经脂多糖 A 和环孢素 A 处理的 HaCaT 细胞培养过程中，丝裂原活化激酶的基因表达谱以及控制其表达的 microRNAs

IF 4.3 3区生物学

Cell Cycle Pub Date : 2024-03-06 DOI: 10.1080/15384101.2024.2320508

Michał Wójcik, Nikola Zmarzły, Alicja Derkacz, Tomasz Kulpok-Bagiński, Natasza Blek, Beniamin Oskar Grabarek

引用次数: 0

Circ_0050444 represses esophageal squamous cell carcinoma progression through sponging miR-486-3p to upregulate C10orf91. Circ_0050444 通过海绵状 miR-486-3p 上调 C10orf91 来抑制食管鳞状细胞癌的进展。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2024-03-01 Epub Date: 2024-06-12 DOI: 10.1080/15384101.2024.2357909

Dongli Zhang, Yan Zhou, Chenyang Jiao, Hongfang Kong, Zhibin Zhao, Yujiang Li

{"title":"Circ_0050444 represses esophageal squamous cell carcinoma progression through sponging miR-486-3p to upregulate C10orf91.","authors":"Dongli Zhang, Yan Zhou, Chenyang Jiao, Hongfang Kong, Zhibin Zhao, Yujiang Li","doi":"10.1080/15384101.2024.2357909","DOIUrl":"10.1080/15384101.2024.2357909","url":null,"abstract":"Esophageal squamous cell carcinoma (ESCC) ranks as the fourth leading cause of tumor-related deaths in China. Circ_0050444 has been revealed to be downregulated in ESCC tissues, however, its function and molecular mechanism underlying ESCC progression is unknown. Therefore, we attempted to clarify the functional role and molecular mechanism of circ_0050444 underlying ESCC progression. RT-qPCR and RNase R digestion assays were used to evaluate circ_0050444 expression and stability characteristics in ESCC cells. Gain-of-function assays were conducted to clarify circ_0050444 role in ESCC cell malignant behaviors. Bioinformatics and mechanism experiments were performed to assess the relationship between circ_0050444 or C10orf91 and miR-486-3p in ESCC cells. Rescue assays were conducted to evaluate the regulatory function of the circ_0050444-miR-486-3p-C10orf91 axis in ESCC cellular processes. Circ_0050444 expression was found to be downregulated both in ESCC patient tissues and cell lines. Functionally, circ_0050444 overexpression repressed ESCC cell proliferative, migratory, and invasive capabilities in cultured cells. Mechanistically, circ_0050444 was found to be competitively bound with miR-486-3p to upregulate C10orf91 in ESCC cells. Moreover, the impact of circ_0050444 elevation on ESCC cell proliferation, migration, and invasion was countervailed by C10orf91 silencing. Circ_0050444 presents downregulation and functions as a tumor suppressor in ESCC progression. Circ_0050444 suppresses ESCC proliferation, migration, and invasion through sponging miR-486-3p to upregulate C10orf91, providing a potential new direction for seeking therapeutic plans for ESCC.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the multifaceted role of RASGRP1 in disease: immune, neural, metabolic, and oncogenic perspectives. 探索 RASGRP1 在疾病中的多方面作用：免疫、神经、代谢和致癌角度。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2024-03-01 Epub Date: 2024-06-12 DOI: 10.1080/15384101.2024.2366009

Shangzhi Fan, Bo Kang, Shaoqian Li, Weiyi Li, Canyu Chen, Jixiang Chen, Lijing Deng, Danjun Chen, Jiecan Zhou

{"title":"Exploring the multifaceted role of RASGRP1 in disease: immune, neural, metabolic, and oncogenic perspectives.","authors":"Shangzhi Fan, Bo Kang, Shaoqian Li, Weiyi Li, Canyu Chen, Jixiang Chen, Lijing Deng, Danjun Chen, Jiecan Zhou","doi":"10.1080/15384101.2024.2366009","DOIUrl":"10.1080/15384101.2024.2366009","url":null,"abstract":"RAS guanyl releasing protein 1 (RASGRP1) is a guanine nucleotide exchange factor (GEF) characterized by the presence of a RAS superfamily GEF domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor, specifically activating RAS through the exchange of bound GDP for GTP. Activation of RAS by RASGRP1 has a wide range of downstream effects at the cellular level. Thus, it is not surprising that many diseases are associated with RASGRP1 disorders. Here, we present an overview of the structure and function of RASGRP1, its crucial role in the development, expression, and regulation of immune cells, and its involvement in various signaling pathways. This review comprehensively explores the relationship between RASGRP1 and various diseases, elucidates the underlying molecular mechanisms of RASGRP1 in each disease, and identifies potential therapeutic targets. This study provides novel insights into the role of RASGRP1 in insulin secretion and highlights its potential as a therapeutic target for diabetes. The limitations and challenges associated with studying RASGRP1 in disease are also discussed.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of differences in expression pattern of three isoforms of the transforming growth factor beta in patients with lumbosacral stenosis. 评估腰骶椎管狭窄症患者体内转化生长因子 beta 三种同工酶表达模式的差异。

IF 4.3 3区生物学

Cell Cycle Pub Date : 2024-03-01 Epub Date: 2024-05-02 DOI: 10.1080/15384101.2024.2345484

Dawid Sobański, Paweł Bogdał, Rafał Staszkiewicz, Małgorzata Sobańska, Michał Filipowicz, Ryszard Adam Czepko, Damian Strojny, Beniamin Oskar Grabarek

{"title":"Evaluation of differences in expression pattern of three isoforms of the transforming growth factor beta in patients with lumbosacral stenosis.","authors":"Dawid Sobański, Paweł Bogdał, Rafał Staszkiewicz, Małgorzata Sobańska, Michał Filipowicz, Ryszard Adam Czepko, Damian Strojny, Beniamin Oskar Grabarek","doi":"10.1080/15384101.2024.2345484","DOIUrl":"10.1080/15384101.2024.2345484","url":null,"abstract":"The study investigates molecular changes in the lumbosacral (L/S) spine's yellow ligamentum flavum during degenerative stenosis, focusing on the role of transforming growth factor beta 1-3 (TGF-β-1-3). Sixty patients with degenerative stenosis and sixty control participants underwent molecular analysis using real-time quantitative reverse transcription reaction technique (RTqPCR), enzyme-linked immunosorbent assay (ELISA), Western blot, and immunohistochemical analysis (IHC). At the mRNA level, study samples showed reduced expression of TGF-β-1 and TGF-β-3, while TGF-β-2 increased by only 4%. Conversely, at the protein level, the study group exhibited significantly higher concentrations of TGF-β-1, TGF-β-2, and TGF-β-3 compared to controls. On the other hand, at the protein level, a statistically significant higher concentration of TGF-β-1 was observed (2139.33 pg/mL ± 2593.72 pg/mL vs. 252.45 pg/mL ± 83.89 pg/mL; p < 0.0001), TGF-β-2 (3104.34 pg/mL ± 1192.74 pg/mL vs. 258.86 pg/mL ± 82.98 pg/mL; p < 0.0001), TGF-β-3 (512.75 pg/mL ± 107.36 pg/mL vs. 55.06 pg/mL ± 9.83 pg/mL, p < 0.0001) in yellow ligaments obtained from patients of the study group compared to control samples. The study did not establish a significant correlation between TGF-β-1-3 concentrations and pain severity. The findings suggest that molecular therapy aimed at restoring the normal expression pattern of TGF-β-1-3 could be a promising strategy for treating degenerative stenosis of the L/S spine. The study underscores the potential therapeutic significance of addressing molecular changes at the TGF-β isoforms level for better understanding and managing degenerative spinal conditions.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0