Cell Cycle最新文献_第3页

Migrasomes: the "functional footprints" left by cell migration. 迁移体：细胞迁移留下的“功能性足迹”。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2025-12-10 DOI: 10.1080/15384101.2025.2601237

Yue Liu, Xingwen Chen, Jun Zhou, Qian Wang, Yongbin Ma, Kai Zhao

{"title":"Migrasomes: the \"functional footprints\" left by cell migration.","authors":"Yue Liu, Xingwen Chen, Jun Zhou, Qian Wang, Yongbin Ma, Kai Zhao","doi":"10.1080/15384101.2025.2601237","DOIUrl":"10.1080/15384101.2025.2601237","url":null,"abstract":"Migrasomes are membrane-bound vesicles that form on the retraction fibers at the trailing edge of migrating cells and are deposited along the migration path upon the rupture of these fibers. As inherently signal-rich complexes enriched with diverse bioactive components, migrasomes not only mediate intercellular communication and microenvironmental regulation but also provide novel mechanisms and potential targets for understanding physiological and pathological processes. Although research on migrasome functions is still in its infancy, accumulating evidence suggests that they not only expand existing biological knowledge systems but also exhibit unique potential in elucidating disease mechanisms, developing diagnostic biomarkers, and exploring therapeutic targets. This review summarizes the discovery, biogenesis, biological functions, and methodological advances in migrasome research, with a particular focus on their emerging roles in disease. Additionally, we discuss prevailing challenges and future directions, concluding with a perspective on the clinical translation of migrasomes in diagnostics and therapeutics.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"1-22"},"PeriodicalIF":3.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of transposable elements activity in genomic instability and their relationship to aging process. 转座因子活性在基因组不稳定性中的作用及其与衰老过程的关系。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-01-18 DOI: 10.1080/15384101.2025.2611968

Jingran Hu, Tianhao Mao, Kainan Huang, Shangzhi Yang, Wenrui Yu, Jiacheng Huang, Shiqi Jin, Chuanyu Sun, Zeyidan Jiapaer, Xianli Wang

{"title":"The role of transposable elements activity in genomic instability and their relationship to aging process.","authors":"Jingran Hu, Tianhao Mao, Kainan Huang, Shangzhi Yang, Wenrui Yu, Jiacheng Huang, Shiqi Jin, Chuanyu Sun, Zeyidan Jiapaer, Xianli Wang","doi":"10.1080/15384101.2025.2611968","DOIUrl":"10.1080/15384101.2025.2611968","url":null,"abstract":"Transposable elements (TEs) are mobile DNA sequences capable of self-replication (especially retrotransposons) within the genome, which may lead to various forms of DNA damage. The introduction of this review encompasses the diverse classes and subclasses of TEs, particularly emphasizing the most active TEs present in the human genome. An analysis of the retrotransposition process of TEs is presented, illustrating how this mechanism can result in DNA damage and gene rearrangements. Furthermore, the review meticulously examines the implications of TE insertions on gene expression and genomic organization, which may contribute to the development of various diseases, including cancer. The relationship between TE activation and the aging process is also explored, with an emphasis on that epigenetic modifications associated with aging can lead to the derepression of TEs, thereby promoting genomic instability and inflammation. These factors may play a significant role in the pathogenesis of age-related diseases, such as cancer, cardiovascular disorders, and neurodegenerative conditions. Finally, the review considers potential therapeutic approaches aimed at targeting TE activity to alleviate the impacts of aging and associated diseases.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"1-33"},"PeriodicalIF":3.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond translation: systematic insight of the multifaceted roles of GARS1 in cellular biology and disease. 超越翻译：GARS1在细胞生物学和疾病中的多方面作用的系统见解。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2025-12-15 DOI: 10.1080/15384101.2025.2594015

Gabriela Coronel Vargas, Erika Iervasi, Kateryna Tkachenko, Deianira Bellitto, Matteo Raineri, Tiziana Bachetti, Camillo Rosano

{"title":"Beyond translation: systematic insight of the multifaceted roles of GARS1 in cellular biology and disease.","authors":"Gabriela Coronel Vargas, Erika Iervasi, Kateryna Tkachenko, Deianira Bellitto, Matteo Raineri, Tiziana Bachetti, Camillo Rosano","doi":"10.1080/15384101.2025.2594015","DOIUrl":"10.1080/15384101.2025.2594015","url":null,"abstract":"Human glycyl-tRNA synthetase (GARS), encoded by the GARS1 gene, is a key protein within the aminoacyl-tRNA synthetases family, responsible for catalyzing the attachment of glycine to its corresponding tRNA during protein synthesis. While aminoacyl-tRNA synthetases are primarily known for their role in translation, emerging evidence indicates that they also have non-canonical functions in physiological and pathological processes, including metabolism, angiogenesis, immune responses, and inflammation. This review integrates glycyl-tRNA synthetase evolutionary origins, isoform biology, structure function relationships, immune roles, and cellular stress evidence across bladder, prostate, breast, colorectal, and hepatocellular tumors. Unlike prior papers about GARS, we (i) distinguish cytosolic vs mitochondrial GARS isoforms and their detection pitfalls; (ii) synthesize non-canonical mechanisms (neddylation interfaces, extracellular vesicles-mediated C-ter and N-ter peptides, CDH6-dependent signaling); and (iii) provide a comparative reliability map across cancers, identifying urinary bladder cancer as the most substantiated indication with convergent transcriptomic, proteomic, metabolic, and preliminary translational evidence. Current literature is dominated by correlative and in-vitro studies, and prospective clinical validation is scarce. GARS is a promising but incompletely defined oncologic and immunobiologic node; targeted, standardized, and clinically anchored studies are now feasible and necessary.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"1-26"},"PeriodicalIF":3.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Migrasomes: new communicators between cells. 迁移体：细胞间新的通讯工具。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-04-08 DOI: 10.1080/15384101.2026.2655296

Junxian He, Jiazu Sa, Zhengjun Zhou, Ming Wang, Tao Li, Ligang Chen, Jie Zhou

{"title":"Migrasomes: new communicators between cells.","authors":"Junxian He, Jiazu Sa, Zhengjun Zhou, Ming Wang, Tao Li, Ligang Chen, Jie Zhou","doi":"10.1080/15384101.2026.2655296","DOIUrl":"10.1080/15384101.2026.2655296","url":null,"abstract":"Migrasomes are a recently discovered class of organelles, typically generated at the intersections and tips of retraction fibers (RFs) in migrating cells. These monolayer vesicular structures encapsulate a variety of bioactive molecules and have been shown to participate in essential physiological processes, including intercellular communication, embryonic development, immune microenvironment modulation, and mitochondrial homeostasis. Beyond their physiological roles, accumulating evidence has revealed that migrasomes are also closely associated with the pathogenesis of various diseases. These include kidney and retinal damage, vascular disorders, as well as the initiation and progression of multiple tumors such as glioma, osteosarcoma, liver cancer, and pancreatic cancer. Given their emerging significance in both normal physiology and disease, migrasomes hold promise as novel biomarkers and therapeutic targets, offering new avenues for research in cell biology and translational medicine.In this review, we summarize recent advances in migrasome research, with a particular emphasis on their involvement in disease mechanisms - an area of growing importance given the current limitations in clinical treatment. We also provide perspectives on future research directions and the potential translational applications of migrasomes.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"1-20"},"PeriodicalIF":3.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13064567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional relevance of piRNA-PIWI axis in cancers: diagnostic and therapeutic avenues. piRNA-PIWI轴在癌症中的功能相关性：诊断和治疗途径。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-04-17 DOI: 10.1080/15384101.2026.2657402

Narendra Kumar Sharma, Sonam Chawla, Nitya Tiwari, Kavita R, Shefali Gulliya, Pawan Kumar Maurya, Tikam Chand Dakal

{"title":"Functional relevance of piRNA-PIWI axis in cancers: diagnostic and therapeutic avenues.","authors":"Narendra Kumar Sharma, Sonam Chawla, Nitya Tiwari, Kavita R, Shefali Gulliya, Pawan Kumar Maurya, Tikam Chand Dakal","doi":"10.1080/15384101.2026.2657402","DOIUrl":"10.1080/15384101.2026.2657402","url":null,"abstract":"Piwi-interacting RNAs (piRNAs) and PIWI proteins are emerging key players in the regulation of cancer gene expression and tumor biology. piRNAs (24-31 nucleotides), interact with PIWI proteins to regulate gene expression via epigenetic mechanisms, modulating cell proliferation, apoptosis, and metastasis. Dysregulated piRNA-PIWI axis is implicated across cancer types - breast, colorectal, genitourinary, etc., and correlates with tumor progression and poor patient outcomes. Notably, piRNAs influence cancer stem cell maintenance, contributing to tumor aggressiveness and therapeutic resistance. We also highlight the significant diagnostic and prognostic potential of piRNAs (e.g. piRNA-823) due to their unique expression profiles in cancerous tissues potentially contributing to early detection and disease monitoring. Additionally, noninvasive detection of piRNAs in extracellular vesicles offers promise for liquid biopsy applications, enabling real-time monitoring of cancer progression and treatment response. On the therapeutic front, piRNA-PIWI protein axis offers innovative avenues - modulating piRNA expression or restoring normal PIWI function can limit tumor growth, metastasis, etc. Despite cumulative evidence supporting their role in cancer, challenges remain in translating piRNA research into clinical practice (lack of standardized protocols, effective therapeutic strategies). Ongoing studies into elucidating molecular implications of piRNA-PIWI axis are crucial for tapping this axis for diagnostic and therapeutic applications.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"1-23"},"PeriodicalIF":3.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-01-21 DOI: 10.1080/15384101.2026.2614889

引用次数: 0

Continuous growth hormone (GH) liver impact during the growth period in non-GH-deprived mice. 持续生长激素（GH）对非GH剥夺小鼠生长期间肝脏的影响。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-01-18 DOI: 10.1080/15384101.2026.2614018

Verónica G Piazza, Nadia S Cicconi, Mariana A Bojorge, Santiago De La Fuente, José L Aparicio, Belén E Berin, Myriam Núñez, Johanna G Miquet, Ana I Sotelo

{"title":"Continuous growth hormone (GH) liver impact during the growth period in non-GH-deprived mice.","authors":"Verónica G Piazza, Nadia S Cicconi, Mariana A Bojorge, Santiago De La Fuente, José L Aparicio, Belén E Berin, Myriam Núñez, Johanna G Miquet, Ana I Sotelo","doi":"10.1080/15384101.2026.2614018","DOIUrl":"10.1080/15384101.2026.2614018","url":null,"abstract":"Growth hormone (GH) is given to GH-deficient but also to non-GH-deprived children to promote growth. Since standard treatment requires tedious daily injections, long-release formulations are sought. However, non-GH-deficient conditions require higher dosing, which could entail cancer risk. To evaluate the hepatic pro-oncogenic potential of continuous GH under non-GH-deprived conditions, mice were implanted with osmotic minipumps for 5 wk during the growth period. GH secretion and hepatic actions are sexually dimorphic, thus both sexes were studied. Body growth was assessed since birth, whereas the impact on liver, a major GH target organ, was evaluated upon treatment ending, at 8 wk of age. Used dose, 6 µg/g BW, effective when given intermittently, failed to promote growth when infused continuously. Hepatocytes presented higher PCNA-stain, indicative of proliferation, in GH-treated males. STAT5 phosphorylation, related to somatic growth and metabolic GH actions, was not affected by continuous GH levels, whereas STAT3, associated with cellular growth and proliferation, was activated in females. In males, continuous GH treatment induced a female-like hepatic expression of IGF1 and cyclin D1, as well as that of MUPs and EGFR, showing that they are regulated by GH but, moreover, by the GH continuous concentration pattern. GHR and SOCS2 mRNA levels were upregulated by continuous GH in both sexes, whereas c-myc and CIS mRNA were mainly induced in female liver. These results indicate that although continuous GH administration in the used dose is not sufficient to promote growth in non-GH-deprived conditions, it may foster hepatic molecular signatures associated with potentially prooncogenic signaling in mice.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"1-19"},"PeriodicalIF":3.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145997178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celebrating 25 years of unraveling the mysteries of the cell cycle: a silver jubilee of cell biology. 庆祝揭开细胞周期之谜25周年：细胞生物学的银禧年。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-02-19 DOI: 10.1080/15384101.2026.2633023

Gaetano Santulli

引用次数: 0

Cell cycle-regulated expression of Fam72a from the |Srgap2-Fam72a| master gene leads to Mis18a downregulation. Srgap2-Fam72a|主基因在细胞周期中调控Fam72a的表达，导致Mis18a下调。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2025-12-18 DOI: 10.1080/15384101.2025.2602824

Tuan Hoang Anh Nguyen, Pok-Son Kim, Arne Kutzner, Klaus Heese

{"title":"Cell cycle-regulated expression of Fam72a from the |Srgap2-Fam72a| master gene leads to Mis18a downregulation.","authors":"Tuan Hoang Anh Nguyen, Pok-Son Kim, Arne Kutzner, Klaus Heese","doi":"10.1080/15384101.2025.2602824","DOIUrl":"10.1080/15384101.2025.2602824","url":null,"abstract":"The novel |Srgap2-Fam72a| master gene, comprising SLIT-ROBO Rho GTPase-activating protein 2 (Srgap2) and family with sequence similarity 72 member A (Fam72a), has attracted attention for its potential role in regulating brain plasticity and supporting advanced cognitive functions in humans. Moreover, recent studies have identified Fam72a as a new cell cycle-regulated gene. In this study, we investigated the activity of the intergenic region (IGR) between the native Srgap2 and Fam72a gene pair and the signaling pathways of Fam72a upon mitogen epidermal growth factor (Egf) stimulation. We found that, under mitogen Egf stimulation, the IGR functions as a divergent promoter, simultaneously driving the transcription of Srgap2 and Fam72a in opposite directions. Furthermore, Fam72a downregulates MIS18 kinetochore protein A (Mis18a), a tightly cell cycle-regulated gene, and interferes with the RAC-alpha serine/threonine-protein kinase (Akt1) signaling pathway by downregulating phosphorylated Akt1 at Serine 473, thereby favoring the more direct mitogen activated protein kinase 1 (Mapk1) route to promote cellular proliferation. These findings provide insight into the role of Fam72a during the cell cycle and suggest that it may contribute to the proliferation of neural stem cells (NSCs).","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"1-13"},"PeriodicalIF":3.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A paradox in the evolution of HipHop-HOAP and telomere integrity. HipHop-HOAP和端粒完整性进化中的悖论。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-01-18 DOI: 10.1080/15384101.2026.2618667

Qi Cao, Yuange Duan

引用次数: 0