Cell Cycle最新文献_第4页

Functions of exosomal microRNAs from adipose tissue in diabetes mellitus and related cardiovascular pathologies. 脂肪组织外泌体microrna在糖尿病和相关心血管疾病中的作用。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2025-11-17 DOI: 10.1080/15384101.2025.2590058

Yong-Zhen Li, Yu-Tao Zhang, Xiao-Hong Li

{"title":"Functions of exosomal microRNAs from adipose tissue in diabetes mellitus and related cardiovascular pathologies.","authors":"Yong-Zhen Li, Yu-Tao Zhang, Xiao-Hong Li","doi":"10.1080/15384101.2025.2590058","DOIUrl":"10.1080/15384101.2025.2590058","url":null,"abstract":"Adipose tissue is central to energy homeostasis and endocrine function, and its dysregulation is a key driver of metabolic disorders. Exosomes, serving as critical intercellular messengers, mediate systemic metabolic responses by delivering bioactive cargo, including nucleic acids, proteins, and lipids. Mounting evidence identifies adipose-derived exosomes as potent mediators of obesity-related inflammation and glucose metabolic dysfunction, thereby contributing to insulin resistance and diabetic complications. This review summarizes the pivotal roles of exosomal microRNAs (miRNAs) and highlights their significant potential as a novel class of small RNA therapeutics. Unlike synthetic delivery systems, exosomal miRNAs constitute an inherent delivery vehicle that synergizes natural targeting efficiency with potent gene regulatory functions. This unique combination enables the precise coordination of complex gene networks involved in metabolic disease, offering a distinct advantage over conventional single-target approaches. Consequently, exosomal miRNAs are positioned as promising candidates for pioneering RNA-based therapies against pervasive conditions such as diabetes and cardiovascular disease.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"1-19"},"PeriodicalIF":3.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-04-26 DOI: 10.1080/15384101.2026.2664293

引用次数: 0

Expression of Concern: Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition. 关注表达：DNA拓扑异构酶1抑制后，Rad18 E3泛素连接酶活性介导范可尼贫血途径激活和细胞存活。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-02-09 DOI: 10.1080/15384101.2026.2626210

引用次数: 0

Circular RNAs in tumorigenesis: an insight into recent research in biogenesis and targeted tumor therapy. 环状rna在肿瘤发生中的作用：生物发生和靶向肿瘤治疗的最新研究。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-05-18 DOI: 10.1080/15384101.2026.2630878

Zahra Shafaghat, Pezhman Golshanrad, Saber Saharkhiz, Anna Leśniak, David Mikeladze, Nelly Datukishvili, Marzieh Ramezani Farani, Iraj Alipourfard

{"title":"Circular RNAs in tumorigenesis: an insight into recent research in biogenesis and targeted tumor therapy.","authors":"Zahra Shafaghat, Pezhman Golshanrad, Saber Saharkhiz, Anna Leśniak, David Mikeladze, Nelly Datukishvili, Marzieh Ramezani Farani, Iraj Alipourfard","doi":"10.1080/15384101.2026.2630878","DOIUrl":"10.1080/15384101.2026.2630878","url":null,"abstract":"Circular RNAs (circRNAs) are eukaryotic RNA molecules that are covalently closed and have the characteristics of high stability, tissue-specific expression, and cell-specific expression. The majority of circRNAs are produced from pre-mRNAs that also result in linear RNA, and they have expression patterns that are similar to those of their host mRNAs. Despite their abundance, circRNAs are typically expressed at lower levels than mRNAs. These molecules are often dysregulated in Cancer and play important roles during the beginning and progression of tumors, according to mounting data. Dysregulated circRNAs unique to Cancer may be used as biomarkers for cancer diagnosis and prognosis since certain circRNAs from cancer tissues have been shown to go through the bloodstream and be persistently present in sera. It has been discovered that circRNAs not only influence tumor immunity and play a major role in tumor indicators, tumor development, and prognosis, but they may also be expressed improperly in various tumors.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"2630878"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13185442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147962413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Migrasomes: the "functional footprints" left by cell migration. 迁移体：细胞迁移留下的“功能性足迹”。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2025-12-10 DOI: 10.1080/15384101.2025.2601237

Yue Liu, Xingwen Chen, Jun Zhou, Qian Wang, Yongbin Ma, Kai Zhao

{"title":"Migrasomes: the \"functional footprints\" left by cell migration.","authors":"Yue Liu, Xingwen Chen, Jun Zhou, Qian Wang, Yongbin Ma, Kai Zhao","doi":"10.1080/15384101.2025.2601237","DOIUrl":"10.1080/15384101.2025.2601237","url":null,"abstract":"Migrasomes are membrane-bound vesicles that form on the retraction fibers at the trailing edge of migrating cells and are deposited along the migration path upon the rupture of these fibers. As inherently signal-rich complexes enriched with diverse bioactive components, migrasomes not only mediate intercellular communication and microenvironmental regulation but also provide novel mechanisms and potential targets for understanding physiological and pathological processes. Although research on migrasome functions is still in its infancy, accumulating evidence suggests that they not only expand existing biological knowledge systems but also exhibit unique potential in elucidating disease mechanisms, developing diagnostic biomarkers, and exploring therapeutic targets. This review summarizes the discovery, biogenesis, biological functions, and methodological advances in migrasome research, with a particular focus on their emerging roles in disease. Additionally, we discuss prevailing challenges and future directions, concluding with a perspective on the clinical translation of migrasomes in diagnostics and therapeutics.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"1-22"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of transposable elements activity in genomic instability and their relationship to aging process. 转座因子活性在基因组不稳定性中的作用及其与衰老过程的关系。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-01-18 DOI: 10.1080/15384101.2025.2611968

Jingran Hu, Tianhao Mao, Kainan Huang, Shangzhi Yang, Wenrui Yu, Jiacheng Huang, Shiqi Jin, Chuanyu Sun, Zeyidan Jiapaer, Xianli Wang

{"title":"The role of transposable elements activity in genomic instability and their relationship to aging process.","authors":"Jingran Hu, Tianhao Mao, Kainan Huang, Shangzhi Yang, Wenrui Yu, Jiacheng Huang, Shiqi Jin, Chuanyu Sun, Zeyidan Jiapaer, Xianli Wang","doi":"10.1080/15384101.2025.2611968","DOIUrl":"10.1080/15384101.2025.2611968","url":null,"abstract":"Transposable elements (TEs) are mobile DNA sequences capable of self-replication (especially retrotransposons) within the genome, which may lead to various forms of DNA damage. The introduction of this review encompasses the diverse classes and subclasses of TEs, particularly emphasizing the most active TEs present in the human genome. An analysis of the retrotransposition process of TEs is presented, illustrating how this mechanism can result in DNA damage and gene rearrangements. Furthermore, the review meticulously examines the implications of TE insertions on gene expression and genomic organization, which may contribute to the development of various diseases, including cancer. The relationship between TE activation and the aging process is also explored, with an emphasis on that epigenetic modifications associated with aging can lead to the derepression of TEs, thereby promoting genomic instability and inflammation. These factors may play a significant role in the pathogenesis of age-related diseases, such as cancer, cardiovascular disorders, and neurodegenerative conditions. Finally, the review considers potential therapeutic approaches aimed at targeting TE activity to alleviate the impacts of aging and associated diseases.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"1-33"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of SGK3 regulates hyperplastic scar development in rats through the MAPK/ERK signaling pathway. 抑制SGK3通过MAPK/ERK信号通路调节大鼠增生性瘢痕的发展。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-02-12 DOI: 10.1080/15384101.2026.2627904

Fuyong Wang, Duanxiang Wang, Weidong Wang, Huaqiang Li

{"title":"Inhibition of SGK3 regulates hyperplastic scar development in rats through the MAPK/ERK signaling pathway.","authors":"Fuyong Wang, Duanxiang Wang, Weidong Wang, Huaqiang Li","doi":"10.1080/15384101.2026.2627904","DOIUrl":"10.1080/15384101.2026.2627904","url":null,"abstract":"Hypertrophic scars (HS) frequently result from severe burns, surgical procedures and other causes of deep skin damage. The impact of serum/glucocorticoid regulated kinase family member 3 (SGK3) on the formation of HS remains unclear. HS model rats were constructed by the scalding method. In addition, tissue samples from clinical patients were collected to detect the SGK3 levels in normal skin and HS tissues by RT-qPCR and western blotting. Human-derived HS fibroblasts (HSFBs) were isolated and identified using immunofluorescence. Cell Counting Kit-8, 5-Ethynyl-2'-deoxyuridine staining and scratch assays were applied to test the ability of the HSFBs to proliferate and migrate. The influence of an SGK3 inhibitor on wound healing in rats was assessed using hematoxylin and eosin staining, Masson staining, immunofluorescence and immunohistochemistry. In addition, the levels of collagen and the proteins involved in the mitogen-activated protein kinase (MAPK)/extracellular regulated protein kinase (ERK) pathway were measured by western blotting. SGK3 was highly expressed in HS tissues. Knockdown of SGK3 resulted in reduced SGK3 levels in HSFBs. Knockdown of SGK3 reduced the proliferation and migration ability of HSFBs and suppressed cellular fibrosis. Injection with an SGK3 inhibitor reduced the burn scar area, decreased epithelial thickness and inhibited collagen deposition in rats. This inhibitor also resulted in the downregulation of collagen and MAPK/ERK pathway-related proteins. In addition, MAPK/ERK pathway agonists attenuated the effect of SGK3 inhibition, promoting HS formation while inhibiting wound healing in rats; however, MAPK inhibitors had the opposite effect. In conclusion, inhibition of SGK3 reduces the proliferation, migration and fibrosis abilities of HSFBs as well as promotes wound healing and inhibits HS formation in rats by downregulating the MAPK/ERK pathway.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"1-16"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FCGR2B drives immunosuppressive M2 polarization of tumor-associated macrophages via metabolic reprogramming of fatty acid oxidation. FCGR2B通过脂肪酸氧化的代谢重编程驱动肿瘤相关巨噬细胞的免疫抑制M2极化。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-06-14 DOI: 10.1080/15384101.2026.2684942

Zexu Han, Pei Rao, Fuzhou Wang, Yunying Xing, Xueling Guo, Chao Du, Yingze Wang

{"title":"FCGR2B drives immunosuppressive M2 polarization of tumor-associated macrophages via metabolic reprogramming of fatty acid oxidation.","authors":"Zexu Han, Pei Rao, Fuzhou Wang, Yunying Xing, Xueling Guo, Chao Du, Yingze Wang","doi":"10.1080/15384101.2026.2684942","DOIUrl":"10.1080/15384101.2026.2684942","url":null,"abstract":"FCGR2B, the only inhibitory receptor in the Fcγ receptor family, plays a crucial role in both innate and adaptive immunity. In this study, we observed high FCGR2B expression in tumor-associated macrophages (TAMs) induced by B16 melanoma cells. Knockdown of Fcgr2b in these TAMs suppressed their M2 polarization, as evidenced by decreased expression of immunosuppressive factors, including Arg-1, IL-10, and Fizz1. Furthermore,Fcgr2b knockdown enhanced the phagocytic and antigen-presenting capacities of TAMs, promoted ROS production, and improved their ability to kill melanoma cells in vitro. Transcriptomic analysis revealed thatFcgr2b knockdown predominantly affected key metabolic and signaling pathways, including the JAK-STAT and PPAR-γ pathways. Using classic pharmacological inhibitors (2-DG and C75), we confirmed that FCGR2B interference remodels glycolipid metabolism in TAMs, which is characterized primarily by attenuated fatty acid metabolism, accompanied by increased glycolysis and intracellular free fatty acid accumulation. Moreover, FCGR2B interference downregulated the fatty acid oxidation key enzyme CPT1a by inhibiting the JAK/STAT6/PPAR-γ signaling axis, thereby reducing fatty acid oxidation. Concomitantly, it alleviated endoplasmic reticulum stress via the IRE1/XBP1 pathway, ultimately attenuating the tumor-promoting phenotype of TAMs. Our findings delineate a mechanism by which FCGR2B integrates metabolic and signaling pathways to regulate TAM function, providing a mechanistic basis for targeting FCGR2B in cancer immunotherapy.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"1-21"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hormetic landscape: from evolutionary origination to mechanistic pathways in therapeutics. 放射景观：从进化起源到治疗学的机械途径。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-08-14 DOI: 10.1080/15384101.2026.2716406

Harshita Verma, Ajay Kumar Gupta, G Hema, Ratan Yadav, Anurag Kumar Mishra, Ananya Maurya, Jyoti Yadav, Adarsh Mishra, Sameer Mishra, Anshuman Prajapati

{"title":"The hormetic landscape: from evolutionary origination to mechanistic pathways in therapeutics.","authors":"Harshita Verma, Ajay Kumar Gupta, G Hema, Ratan Yadav, Anurag Kumar Mishra, Ananya Maurya, Jyoti Yadav, Adarsh Mishra, Sameer Mishra, Anshuman Prajapati","doi":"10.1080/15384101.2026.2716406","DOIUrl":"10.1080/15384101.2026.2716406","url":null,"abstract":"Hormesis is a biphasic dose-response, where mild stress triggers adaptive defense responses that increase cellular resilience. The hormesis is now recognized as a core concept with applications in toxicology, metabolism, aging, and evolutionary biology. A historical review, evolutionary explanations, and recent molecular insights led to the concept of hormesis as an anticipatory, \"predict-and-prepare\" strategy that allows organisms to adapt to changing conditions are addressed. The mitohormesis, autophagy, xenohormesis, epigenetic remodeling, and their interdependence with signaling pathways (Nrf2-KEAP1, AMPK-SIRT1, NF-κB, and heat-shock response). The stress-induced reversal of differentiation in basal metazoans also defy the irreversible aging concept demonstrate conservative plasticity programs. The relevance of translational research using toxin-derived therapeutics and lifestyle-based hormetic interventions are discussed, including challenges of the hormetic zone, inter-individual variability, and bioactivity cliffs. The future scope of integrating AI and ML into nonlinear modeling of precise hormetic dosing, with considerable applications in aging, regenerative medicine, and precision therapeutics.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"1-32"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13479830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional relevance of piRNA-PIWI axis in cancers: diagnostic and therapeutic avenues. piRNA-PIWI轴在癌症中的功能相关性：诊断和治疗途径。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-04-17 DOI: 10.1080/15384101.2026.2657402

Narendra Kumar Sharma, Sonam Chawla, Nitya Tiwari, Kavita R, Shefali Gulliya, Pawan Kumar Maurya, Tikam Chand Dakal

{"title":"Functional relevance of piRNA-PIWI axis in cancers: diagnostic and therapeutic avenues.","authors":"Narendra Kumar Sharma, Sonam Chawla, Nitya Tiwari, Kavita R, Shefali Gulliya, Pawan Kumar Maurya, Tikam Chand Dakal","doi":"10.1080/15384101.2026.2657402","DOIUrl":"10.1080/15384101.2026.2657402","url":null,"abstract":"Piwi-interacting RNAs (piRNAs) and PIWI proteins are emerging key players in the regulation of cancer gene expression and tumor biology. piRNAs (24-31 nucleotides), interact with PIWI proteins to regulate gene expression via epigenetic mechanisms, modulating cell proliferation, apoptosis, and metastasis. Dysregulated piRNA-PIWI axis is implicated across cancer types - breast, colorectal, genitourinary, etc., and correlates with tumor progression and poor patient outcomes. Notably, piRNAs influence cancer stem cell maintenance, contributing to tumor aggressiveness and therapeutic resistance. We also highlight the significant diagnostic and prognostic potential of piRNAs (e.g. piRNA-823) due to their unique expression profiles in cancerous tissues potentially contributing to early detection and disease monitoring. Additionally, noninvasive detection of piRNAs in extracellular vesicles offers promise for liquid biopsy applications, enabling real-time monitoring of cancer progression and treatment response. On the therapeutic front, piRNA-PIWI protein axis offers innovative avenues - modulating piRNA expression or restoring normal PIWI function can limit tumor growth, metastasis, etc. Despite cumulative evidence supporting their role in cancer, challenges remain in translating piRNA research into clinical practice (lack of standardized protocols, effective therapeutic strategies). Ongoing studies into elucidating molecular implications of piRNA-PIWI axis are crucial for tapping this axis for diagnostic and therapeutic applications.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"1-23"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0