Cell Cycle最新文献_第5页

Beyond translation: systematic insight of the multifaceted roles of GARS1 in cellular biology and disease. 超越翻译：GARS1在细胞生物学和疾病中的多方面作用的系统见解。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2025-12-15 DOI: 10.1080/15384101.2025.2594015

Gabriela Coronel Vargas, Erika Iervasi, Kateryna Tkachenko, Deianira Bellitto, Matteo Raineri, Tiziana Bachetti, Camillo Rosano

{"title":"Beyond translation: systematic insight of the multifaceted roles of GARS1 in cellular biology and disease.","authors":"Gabriela Coronel Vargas, Erika Iervasi, Kateryna Tkachenko, Deianira Bellitto, Matteo Raineri, Tiziana Bachetti, Camillo Rosano","doi":"10.1080/15384101.2025.2594015","DOIUrl":"10.1080/15384101.2025.2594015","url":null,"abstract":"Human glycyl-tRNA synthetase (GARS), encoded by the GARS1 gene, is a key protein within the aminoacyl-tRNA synthetases family, responsible for catalyzing the attachment of glycine to its corresponding tRNA during protein synthesis. While aminoacyl-tRNA synthetases are primarily known for their role in translation, emerging evidence indicates that they also have non-canonical functions in physiological and pathological processes, including metabolism, angiogenesis, immune responses, and inflammation. This review integrates glycyl-tRNA synthetase evolutionary origins, isoform biology, structure function relationships, immune roles, and cellular stress evidence across bladder, prostate, breast, colorectal, and hepatocellular tumors. Unlike prior papers about GARS, we (i) distinguish cytosolic vs mitochondrial GARS isoforms and their detection pitfalls; (ii) synthesize non-canonical mechanisms (neddylation interfaces, extracellular vesicles-mediated C-ter and N-ter peptides, CDH6-dependent signaling); and (iii) provide a comparative reliability map across cancers, identifying urinary bladder cancer as the most substantiated indication with convergent transcriptomic, proteomic, metabolic, and preliminary translational evidence. Current literature is dominated by correlative and in-vitro studies, and prospective clinical validation is scarce. GARS is a promising but incompletely defined oncologic and immunobiologic node; targeted, standardized, and clinically anchored studies are now feasible and necessary.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"1-26"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145755119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Migrasomes: new communicators between cells. 迁移体：细胞间新的通讯工具。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-04-08 DOI: 10.1080/15384101.2026.2655296

Junxian He, Jiazu Sa, Zhengjun Zhou, Ming Wang, Tao Li, Ligang Chen, Jie Zhou

{"title":"Migrasomes: new communicators between cells.","authors":"Junxian He, Jiazu Sa, Zhengjun Zhou, Ming Wang, Tao Li, Ligang Chen, Jie Zhou","doi":"10.1080/15384101.2026.2655296","DOIUrl":"10.1080/15384101.2026.2655296","url":null,"abstract":"Migrasomes are a recently discovered class of organelles, typically generated at the intersections and tips of retraction fibers (RFs) in migrating cells. These monolayer vesicular structures encapsulate a variety of bioactive molecules and have been shown to participate in essential physiological processes, including intercellular communication, embryonic development, immune microenvironment modulation, and mitochondrial homeostasis. Beyond their physiological roles, accumulating evidence has revealed that migrasomes are also closely associated with the pathogenesis of various diseases. These include kidney and retinal damage, vascular disorders, as well as the initiation and progression of multiple tumors such as glioma, osteosarcoma, liver cancer, and pancreatic cancer. Given their emerging significance in both normal physiology and disease, migrasomes hold promise as novel biomarkers and therapeutic targets, offering new avenues for research in cell biology and translational medicine.In this review, we summarize recent advances in migrasome research, with a particular emphasis on their involvement in disease mechanisms - an area of growing importance given the current limitations in clinical treatment. We also provide perspectives on future research directions and the potential translational applications of migrasomes.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"1-20"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13064567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyploid giant cancer cells: the hidden players in ovarian cancer progression and prognosis. 多倍体巨细胞：卵巢癌进展与预后的隐性参与者。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-05-19 DOI: 10.1080/15384101.2026.2675348

Sharanya Roy, Swastika Rakhshit, Sayak Chakraborty, Sampriti Chakraborty, Soumava Jana, Prasmita Sircar, Aditi Nayak

{"title":"Polyploid giant cancer cells: the hidden players in ovarian cancer progression and prognosis.","authors":"Sharanya Roy, Swastika Rakhshit, Sayak Chakraborty, Sampriti Chakraborty, Soumava Jana, Prasmita Sircar, Aditi Nayak","doi":"10.1080/15384101.2026.2675348","DOIUrl":"10.1080/15384101.2026.2675348","url":null,"abstract":"Polyploid giant cancer cells (PGCCs) showcase a unique and often undervalued subpopulation within tumors that performs a major role in promoting the aggressiveness and therapy resistance of ovarian cancer that is one of the deadliest cancers. These unusually large numbers of cells, which may be multinucleated or single-nucleated, typically arise when cancer cells are exposed to different stress conditions. Their formation begins through mechanisms like endoreplication, failed cytokinesis, or disrupted cell fusion. Functionally, in ovarian cancer, these PGCCs act as \"mother\" cells, generating heterogeneous sets of smaller, more resilient daughter cells through depolyploidization or meiosis. This unusual and unique capability induces a significant tumor relapse and reemergence. Moreover, they drive epithelial-to-mesenchymal transition (EMT), increasing invasiveness, metastatic ability, and ovarian tumor embolization. Their identification within circulating tumor cells (CTCs) is being examined as a biomarker for worse prognosis and disease progression. Importantly, ovarian PGCCs are inherently multidrug-resistant as they escape apoptosis, re-regulate metabolic activities, and actively efflux chemotherapeutic agents into the extracellular environment. These characteristics make them notably challenging to fully eliminate with conventional therapeutic strategies. Targeting PGCCs might offer a game-changing way to overcome therapeutic resistance and improve patient outcomes in advanced ovarian cancer.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"1-15"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13192095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated transcriptomic and metabolomic analyses provide mechanistic insights into the pro-proliferative role of DARS in human MPN cell models. 综合转录组学和代谢组学分析为DARS在人MPN细胞模型中的促增殖作用提供了机制见解。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-05-24 DOI: 10.1080/15384101.2026.2674079

Hao Xiong, Hanlu Zhang, Li Zhang, Xiaoping Wang, Fang Wan, Yanhong Li, Jun Bai, Jinping Zhang, Yuxian Wang, Lijuan Li, Liansheng Zhang

{"title":"Integrated transcriptomic and metabolomic analyses provide mechanistic insights into the pro-proliferative role of DARS in human MPN cell models.","authors":"Hao Xiong, Hanlu Zhang, Li Zhang, Xiaoping Wang, Fang Wan, Yanhong Li, Jun Bai, Jinping Zhang, Yuxian Wang, Lijuan Li, Liansheng Zhang","doi":"10.1080/15384101.2026.2674079","DOIUrl":"10.1080/15384101.2026.2674079","url":null,"abstract":"Previous studies have shown that DARS is highly expressed in patients with myeloproliferative neoplasms (MPN), and these patients have higher disease burdens. However, the mechanism by which DARS promotes the proliferation of MPN cells remains unclear. Here, we explored the tumor-intrinsic role of DARS in human MPN cell models and the associated molecular mechanisms using an integrated multi-omics approach. DARS depletion suppressed the proliferation of MPN cells in vitro and xenograft tumor growth in vivo, induced cell-cycle arrest, and promoted apoptosis. Metabolomic analysis identified 190 differential metabolites associated with DARS depletion in MPN cells, many of which were enriched in cancer-related pathways. Transcriptomic analysis showed that DARS depletion was associated with altered expression of more than 2,000 genes; integrated analysis of transcriptomic and metabolomic data indicated potential involvement of calcium signaling, pyrimidine metabolism, and nucleotide metabolism. Re-analysis of independent public MPN datasets further supported the association of DARS with disease context and immune-infiltration features. Overall, our results support a pro-proliferative role of DARS in human MPN cell models. DARS depletion was associated with PI3K/AKT-related transcriptional and metabolic alterations, and reactivation of PI3K/AKT partially rescued the phenotypic changes induced by DARS depletion.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"1-22"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13203022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploratory multi-omics links CCL2/TIMP1 axis to immunosuppressive TME in glioblastoma. 探索性多组学将CCL2/TIMP1轴与胶质母细胞瘤的免疫抑制TME联系起来。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-07-15 DOI: 10.1080/15384101.2026.2703934

Yunchang Yang, XiangXiang Cao, Nan Feng, Xinyao Kang, Yaofeng Wang, Yunqin Sun

{"title":"Exploratory multi-omics links CCL2/TIMP1 axis to immunosuppressive TME in glioblastoma.","authors":"Yunchang Yang, XiangXiang Cao, Nan Feng, Xinyao Kang, Yaofeng Wang, Yunqin Sun","doi":"10.1080/15384101.2026.2703934","DOIUrl":"10.1080/15384101.2026.2703934","url":null,"abstract":"Glioblastoma (GBM) is defined by extreme lethality and transcriptomic plasticity, but the signatures driving the most aggressive tumors remain incompletely defined. In this exploratory in silico study, TCGA-GBM patients were stratified using a strict 1-year overall survival threshold. We integrated differential expression analysis, WGCNA, single-cell RNA-seq, spatial transcriptomics, and virtual knockout simulations. A high-risk signature centered on CCL2 and TIMP1 was identified. Single-cell and spatial mapping linked these genes to an inflammatory, macrophage-enriched microenvironment. The signature inversely correlated with neuronal synapse mimicry scores, suggesting that extreme aggressiveness involves a macroscopic shift from differentiated neuronal states toward an undifferentiated inflammatory phenotype. Virtual perturbation modeling confirmed CCL2 and TIMP1 as highly interconnected network hubs. Despite limitations inherent to computational and retrospective cohorts, our rigorous multi-omics validation identifies the CCL2/TIMP1 axis as a driver of potential prognostic indicator. These findings generate the hypothesis that these mediators reflect a critical inflammatory, mesenchymal-like tumor microenvironment shift, warranting independent cohort validation and experimental investigation.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"1-35"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13374763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148444363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-01-21 DOI: 10.1080/15384101.2026.2614889

引用次数: 0

Celebrating 25 years of unraveling the mysteries of the cell cycle: a silver jubilee of cell biology. 庆祝揭开细胞周期之谜25周年：细胞生物学的银禧年。

IF 3.4 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-02-19 DOI: 10.1080/15384101.2026.2633023

Gaetano Santulli

引用次数: 0

ALDH18A1 fuels spermine biosynthesis to sustain ferroptosis resistance in cancer and ischemia-reperfusion injury. ALDH18A1为精胺生物合成提供燃料，维持癌症和缺血再灌注损伤中的铁凋亡抵抗。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-07-06 DOI: 10.1080/15384101.2026.2699556

Gaetano Santulli

引用次数: 0

Continuous growth hormone (GH) liver impact during the growth period in non-GH-deprived mice. 持续生长激素（GH）对非GH剥夺小鼠生长期间肝脏的影响。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-01-18 DOI: 10.1080/15384101.2026.2614018

Verónica G Piazza, Nadia S Cicconi, Mariana A Bojorge, Santiago De La Fuente, José L Aparicio, Belén E Berin, Myriam Núñez, Johanna G Miquet, Ana I Sotelo

{"title":"Continuous growth hormone (GH) liver impact during the growth period in non-GH-deprived mice.","authors":"Verónica G Piazza, Nadia S Cicconi, Mariana A Bojorge, Santiago De La Fuente, José L Aparicio, Belén E Berin, Myriam Núñez, Johanna G Miquet, Ana I Sotelo","doi":"10.1080/15384101.2026.2614018","DOIUrl":"10.1080/15384101.2026.2614018","url":null,"abstract":"Growth hormone (GH) is given to GH-deficient but also to non-GH-deprived children to promote growth. Since standard treatment requires tedious daily injections, long-release formulations are sought. However, non-GH-deficient conditions require higher dosing, which could entail cancer risk. To evaluate the hepatic pro-oncogenic potential of continuous GH under non-GH-deprived conditions, mice were implanted with osmotic minipumps for 5 wk during the growth period. GH secretion and hepatic actions are sexually dimorphic, thus both sexes were studied. Body growth was assessed since birth, whereas the impact on liver, a major GH target organ, was evaluated upon treatment ending, at 8 wk of age. Used dose, 6 µg/g BW, effective when given intermittently, failed to promote growth when infused continuously. Hepatocytes presented higher PCNA-stain, indicative of proliferation, in GH-treated males. STAT5 phosphorylation, related to somatic growth and metabolic GH actions, was not affected by continuous GH levels, whereas STAT3, associated with cellular growth and proliferation, was activated in females. In males, continuous GH treatment induced a female-like hepatic expression of IGF1 and cyclin D1, as well as that of MUPs and EGFR, showing that they are regulated by GH but, moreover, by the GH continuous concentration pattern. GHR and SOCS2 mRNA levels were upregulated by continuous GH in both sexes, whereas c-myc and CIS mRNA were mainly induced in female liver. These results indicate that although continuous GH administration in the used dose is not sufficient to promote growth in non-GH-deprived conditions, it may foster hepatic molecular signatures associated with potentially prooncogenic signaling in mice.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"1-19"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145997178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming. mitf驱动的黑色素瘤可塑性作为治疗耐药的核心机制：整合微环境信号、机械转导和代谢重编程。

IF 3.9 3区生物学

Cell Cycle Pub Date : 2026-12-01 Epub Date: 2026-06-15 DOI: 10.1080/15384101.2026.2684937

Monika Kisielewska, Sara Suwała, Małgorzata Drąg-Zalesińska, Nina Rembiałkowska

{"title":"MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.","authors":"Monika Kisielewska, Sara Suwała, Małgorzata Drąg-Zalesińska, Nina Rembiałkowska","doi":"10.1080/15384101.2026.2684937","DOIUrl":"10.1080/15384101.2026.2684937","url":null,"abstract":"Melanoma remains one of the most aggressive cancers, and although immune checkpoint blockade and MAPK-targeted therapies have transformed clinical management, durable responses occur in only a subset of patients. Converging evidence identifies microphthalmia-associated transcription factor (MITF) - dependent phenotype switching as a central, non-genetic mechanism enabling melanoma cells to escape therapy. Dynamic fluctuations in MITF activity permit transitions between differentiated, proliferative states and invasive, drug-resistant phenotypes. This review synthesizes emerging insights into the tumor microenvironmental, mechanical, and metabolic cues that regulate MITF states. These include cytokine-driven inflammatory signaling, hypoxia, cancer-associated fibroblasts, extracellular matrix remodeling, integrin - YAP/TAZ - mediated mechanotransduction, and metabolic reprogramming involving glycolysis - OXPHOS switching, lipid-regulated MITF control, and nutrient-stress responses. By integrating these pathways, MITF-dependent plasticity shapes melanoma adaptation and persistence under therapeutic pressure. Understanding this interconnected network provides a foundation for developing strategies to target phenotype switching and overcome treatment resistance.","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":"1-22"},"PeriodicalIF":3.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148249517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0