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Cell cycle regulated expression of the WHI7 Start repressor gene. 细胞周期调控 WHI7 启动抑制基因的表达。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-05-01 Epub Date: 2024-09-16 DOI: 10.1080/15384101.2024.2402192
Cristina Ros-Carrero, Mercè Gomar-Alba, J Carlos Igual
{"title":"Cell cycle regulated expression of the <i>WHI7</i> Start repressor gene.","authors":"Cristina Ros-Carrero, Mercè Gomar-Alba, J Carlos Igual","doi":"10.1080/15384101.2024.2402192","DOIUrl":"10.1080/15384101.2024.2402192","url":null,"abstract":"<p><p>Periodic transcriptional waves along the cell cycle ensure the accurate progression of the different cell cycle phases through the timely regulated expression of cell cycle proteins. The G1/S transition (Start) consists in the activation of a transcriptional program by G1 CDKs through the inactivation of Start transcriptional repressors, Whi5 and Whi7 in yeast or Rb in mammals. Here, we provide a comprehensive characterization of the transcriptional regulation of the Start repressor Whi7 in budding yeast. We found that <i>WHI7</i> is a cell cycle regulated gene that shows periodic expression peaking in G1. Our results demonstrate that the three cell cycle transcriptional programs related to G1 and their corresponding transcription factors are involved in the transcriptional control of <i>WHI7</i>. Specifically, we identified that the transcriptional regulators Swi5 and Mcm1-Yox1, which are involved in late M and early G1 expression, and the transcription factors MBF and SBF, which are responsible for G1/S expression, are able to associate and regulate the <i>WHI7</i> gene. In summary, in this work, we provide new mechanisms for the regulation of the Start repressor Whi7, which highlights the precise and complex control of the cell cycle machinery governing the G1/S transition.</p>","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"817-833"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statement of Retraction: Long non-coding RNA PCAT1 drives clear cell renal cell carcinoma by upregulating YAP via sponging miR-656 and miR-539. 撤回声明：长非编码RNA PCAT1通过海绵状miR-656和miR-539上调YAP，从而驱动透明细胞肾细胞癌。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-05-01 Epub Date: 2024-07-04 DOI: 10.1080/15384101.2024.2370713
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引用次数: 0
c-Jun and Fra-2 pair up to Myc-anistically drive HCC. c-Jun 和 Fra-2 配对，以 Myc-anistically 驱动 HCC。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-05-01 Epub Date: 2024-11-24 DOI: 10.1080/15384101.2024.2429968
Latifa Bakiri, Erwin F Wagner
{"title":"c-Jun and Fra-2 pair up to Myc-anistically drive HCC.","authors":"Latifa Bakiri, Erwin F Wagner","doi":"10.1080/15384101.2024.2429968","DOIUrl":"10.1080/15384101.2024.2429968","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC), a leading cause of cancer-related death with limited therapies, is a complex disease developing in a background of Hepatitis Virus infection or systemic conditions, such as the metabolic syndrome. Investigating HCC pathogenesis in model organisms is therefore crucial for developing novel diagnostic and therapeutic tools. Genetically engineered mouse models (GEMMs) have been instrumental in recapitulating the local and systemic features of HCC. Early studies using GEMMs and patient material implicated members of the dimeric Activator Protein-1 (AP-1) transcription factor family, such as c-Jun and c-Fos, in HCC formation. In a recent report, we described how switchable, hepatocyte-restricted expression of a single-chain c-Jun~Fra-2 protein, functionally mimicking the c-Jun/Fra-2 AP-1 dimer, results in spontaneous and largely reversible liver tumors in GEMMs. Dysregulated cell cycle, inflammation, and dyslipidemia are observed at early stages and tumors display molecular HCC signatures. We demonstrate that increased c-Myc expression is an essential molecular determinant of tumor formation that can be therapeutically targeted using the BET inhibitor JQ1. Here, we discuss these findings with additional results illustrating how AP-1 GEMMs can foster preclinical research on liver diseases with novel perspectives offered by the constantly increasing wealth of HCC-related datasets.</p>","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"834-842"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statement of Retraction: microRNA-192-5p is involved in nerve repair in rats with peripheral nerve injury by regulating XIAP. 撤回声明：microRNA-192-5p 通过调节 XIAP 参与周围神经损伤大鼠的神经修复。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-05-01 Epub Date: 2024-07-04 DOI: 10.1080/15384101.2024.2370711
{"title":"Statement of Retraction: microRNA-192-5p is involved in nerve repair in rats with peripheral nerve injury by regulating XIAP.","authors":"","doi":"10.1080/15384101.2024.2370711","DOIUrl":"10.1080/15384101.2024.2370711","url":null,"abstract":"","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"i"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of Concern: DDB2 association with PCNA is required for its degradation after UV-induced DNA damage. 关注表达：紫外线诱导 DNA 损伤后，PCNA 的降解需要 DDB2 与 PCNA 结合。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-05-01 Epub Date: 2024-09-27 DOI: 10.1080/15384101.2024.2396717
{"title":"Expression of Concern: DDB2 association with PCNA is required for its degradation after UV-induced DNA damage.","authors":"","doi":"10.1080/15384101.2024.2396717","DOIUrl":"10.1080/15384101.2024.2396717","url":null,"abstract":"","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"846"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statement of Retraction: MicroRNA-203 restrains epithelial-mesenchymal transition, invasion and migration of papillary thyroid cancer by downregulating AKT3. 撤回声明：MicroRNA-203通过下调AKT3抑制甲状腺乳头状癌的上皮-间质转化、侵袭和迁移
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-05-01 Epub Date: 2024-07-04 DOI: 10.1080/15384101.2024.2370714
{"title":"Statement of Retraction: MicroRNA-203 restrains epithelial-mesenchymal transition, invasion and migration of papillary thyroid cancer by downregulating AKT3.","authors":"","doi":"10.1080/15384101.2024.2370714","DOIUrl":"10.1080/15384101.2024.2370714","url":null,"abstract":"","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"iv"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell death in atherosclerosis 动脉粥样硬化中的细胞死亡
IF 4.3 3区 生物学
Cell Cycle Pub Date : 2024-04-27 DOI: 10.1080/15384101.2024.2344943
Dan Ni, Cai Lei, Minqi Liu, Jinfu Peng, Guanghui Yi, Zhongcheng Mo
{"title":"Cell death in atherosclerosis","authors":"Dan Ni, Cai Lei, Minqi Liu, Jinfu Peng, Guanghui Yi, Zhongcheng Mo","doi":"10.1080/15384101.2024.2344943","DOIUrl":"https://doi.org/10.1080/15384101.2024.2344943","url":null,"abstract":"A complex and evolutionary process that involves the buildup of lipids in the arterial wall and the invasion of inflammatory cells results in atherosclerosis. Cell death is a fundamental biological...","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"32 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140811319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of common molecular signatures and drug repurposing for COVID-19/Asthma comorbidity: ACE2 and multi-partite networks 发现COVID-19/哮喘合并症的共同分子特征和药物再利用：ACE2 和多方网络
IF 4.3 3区 生物学
Cell Cycle Pub Date : 2024-04-19 DOI: 10.1080/15384101.2024.2340859
Jiajun Xu, Raghad Abdulsalam Khaleel, Haider Kamil Zaidan, Ahmed Faisal Mutee, Khaled Fahmi Fawy, Anita Gehlot, Alaa Hashim Abbas, José Luis Arias Gonzáles, Ali H Amin, Maribel Carmen Ruiz-Balvin, Shima Imannezhad, Abolfazl Bahrami, Reza Akhavan-Sigari
{"title":"Discovery of common molecular signatures and drug repurposing for COVID-19/Asthma comorbidity: ACE2 and multi-partite networks","authors":"Jiajun Xu, Raghad Abdulsalam Khaleel, Haider Kamil Zaidan, Ahmed Faisal Mutee, Khaled Fahmi Fawy, Anita Gehlot, Alaa Hashim Abbas, José Luis Arias Gonzáles, Ali H Amin, Maribel Carmen Ruiz-Balvin, Shima Imannezhad, Abolfazl Bahrami, Reza Akhavan-Sigari","doi":"10.1080/15384101.2024.2340859","DOIUrl":"https://doi.org/10.1080/15384101.2024.2340859","url":null,"abstract":"Angiotensin-converting enzyme 2 (ACE2) is identified as the functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the ongoing global coronavir...","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"23 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140626958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of β3 subunit of the GABA type A receptor in triple negative breast cancer proliferation, migration, and cell cycle progression GABA A 型受体β3 亚基在三阴性乳腺癌增殖、迁移和细胞周期进展中的作用
IF 4.3 3区 生物学
Cell Cycle Pub Date : 2024-04-16 DOI: 10.1080/15384101.2024.2340912
J Bundy, J Shaw, M Hammel, J Nguyen, C Robbins, I Mercier, A Suryanarayanan
{"title":"Role of β3 subunit of the GABA type A receptor in triple negative breast cancer proliferation, migration, and cell cycle progression","authors":"J Bundy, J Shaw, M Hammel, J Nguyen, C Robbins, I Mercier, A Suryanarayanan","doi":"10.1080/15384101.2024.2340912","DOIUrl":"https://doi.org/10.1080/15384101.2024.2340912","url":null,"abstract":"Triple negative breast cancer (TNBC) is known for its heterogeneous nature and aggressive onset. The unresponsiveness to hormone therapies and immunotherapy and the toxicity of chemotherapeutics ac...","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"67 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells β-catenin信号增强导致的SIRT3抑制推动糖酵解，促进缺氧诱导的肝癌细胞生长
IF 4.3 3区 生物学
Cell Cycle Pub Date : 2024-04-16 DOI: 10.1080/15384101.2024.2340864
Rong Ma, Qing-Yuan Gao, Zhi-Teng Chen, Guang-Hong Liao, Shu-Tai Li, Jie-Wen Cai, Nian-Sang Luo, Hao Chen, Hai-Feng Zhang
{"title":"SIRT3 suppression resulting from the enhanced β-catenin signaling drives glycolysis and promotes hypoxia-induced cell growth in hepatocellular carcinoma cells","authors":"Rong Ma, Qing-Yuan Gao, Zhi-Teng Chen, Guang-Hong Liao, Shu-Tai Li, Jie-Wen Cai, Nian-Sang Luo, Hao Chen, Hai-Feng Zhang","doi":"10.1080/15384101.2024.2340864","DOIUrl":"https://doi.org/10.1080/15384101.2024.2340864","url":null,"abstract":"The precise mechanisms underlying the inhibitory effects of SIRT3, a mitochondrial sirtuin protein, on hepatocellular carcinoma (HCC) development, as well as its impact on mitochondrial respiration...","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":"25 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140590301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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