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Statement of Retraction: Human umbilical cord mesenchymal stem cell-derived exosome-mediated transfer of microRNA-133b boosts trophoblast cell proliferation, migration and invasion in preeclampsia by restricting SGK1. 撤回声明：人脐带间充质干细胞衍生的外泌体介导的microRNA-133b转移通过限制SGK1促进滋养细胞增殖、迁移和侵袭子痫前期。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-11-01 Epub Date: 2025-05-19 DOI: 10.1080/15384101.2025.2506290
{"title":"Statement of Retraction: Human umbilical cord mesenchymal stem cell-derived exosome-mediated transfer of microRNA-133b boosts trophoblast cell proliferation, migration and invasion in preeclampsia by restricting SGK1.","authors":"","doi":"10.1080/15384101.2025.2506290","DOIUrl":"10.1080/15384101.2025.2506290","url":null,"abstract":"","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"i"},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-canonical functions of BCL-2 family members in energy metabolism and necrotic cell death regulation. BCL-2家族成员在能量代谢和坏死细胞死亡调控中的非规范功能。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-11-01 Epub Date: 2025-03-27 DOI: 10.1080/15384101.2025.2484868
Mohamed El-Mesery, Franziska Rudolf, Yannick Heimann, Georg Häcker, Thomas Brunner
{"title":"Non-canonical functions of BCL-2 family members in energy metabolism and necrotic cell death regulation.","authors":"Mohamed El-Mesery, Franziska Rudolf, Yannick Heimann, Georg Häcker, Thomas Brunner","doi":"10.1080/15384101.2025.2484868","DOIUrl":"10.1080/15384101.2025.2484868","url":null,"abstract":"<p><p>The large family of BCL-2 proteins plays a well-established role in the regulation of mitochondrial apoptosis pathway, and the crosstalk between death receptor signaling and mitochondrial apoptosis. Accumulating evidence suggests, however, that various BCL-2 family members are also involved in the regulation of apoptosis-unrelated necrotic forms of cell death, and even non-cell death processes. In this review, we discuss the emerging role of BCL-2 family members, and in particular BIM, in the regulation of mitochondrial dynamics, morphology and energy metabolism, and associated consequences for drug-inuced necrotic cell death.</p>","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"931-948"},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leaving the mark: FMOs as an emerging class of cytokinetic regulators. 留下印记：FMOs作为一种新兴的细胞动力学调节剂。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-11-01 Epub Date: 2025-04-08 DOI: 10.1080/15384101.2025.2485843
Léa Lacroix, Eugénie Goupil, Matthew J Smith, Jean-Claude Labbé
{"title":"Leaving the mark: FMOs as an emerging class of cytokinetic regulators.","authors":"Léa Lacroix, Eugénie Goupil, Matthew J Smith, Jean-Claude Labbé","doi":"10.1080/15384101.2025.2485843","DOIUrl":"10.1080/15384101.2025.2485843","url":null,"abstract":"<p><p>Posttranslational modification of proteins plays a fundamental role in cell biology. It provides cells a means to regulate the signaling, enzymatic or structural properties of proteins without continuous cycles of synthesis and degradation, offering multiple distinct functions to individual proteins in a rapid and reversible manner. Modifications can include phosphorylation, ubiquitination or methylation, which are widespread and simple to detect using current approaches. More challenging to identify, one modification of growing significance is the direct oxidation of cysteine and methionine side chains. Protein oxidation has long been known to occur spontaneously upon the accumulation of cellular reactive oxygen species (ROS), but new data are providing insight into the targeted oxidation of proteins by flavin-containing monooxygenases (FMOs). Here, we review how oxidation of cellular proteins can modulate their activity and consider potential roles for FMOs in the targeted modification of proteins shaping cell division, with a particular focus on two families of FMOs: MICAL and OSGIN.</p>","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"949-961"},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomes derived from mesenchymal stem cells ameliorate impaired glucose metabolism in myocardial Ischemia/reperfusion injury through miR-132-3p/PTEN/AKT pathway. 来自间充质干细胞的外泌体通过miR-132-3p/PTEN/AKT通路改善心肌缺血/再灌注损伤中的糖代谢受损。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-09-01 Epub Date: 2025-04-03 DOI: 10.1080/15384101.2025.2485834
Hongkun Wu, Yongpeng Hui, Xingkai Qian, Xueting Wang, Jianwei Xu, Feng Wang, Sisi Pan, Kaiyuan Chen, Zhou Liu, Weilong Gao, Jue Bai, Guiyou Liang
{"title":"Exosomes derived from mesenchymal stem cells ameliorate impaired glucose metabolism in myocardial Ischemia/reperfusion injury through miR-132-3p/PTEN/AKT pathway.","authors":"Hongkun Wu, Yongpeng Hui, Xingkai Qian, Xueting Wang, Jianwei Xu, Feng Wang, Sisi Pan, Kaiyuan Chen, Zhou Liu, Weilong Gao, Jue Bai, Guiyou Liang","doi":"10.1080/15384101.2025.2485834","DOIUrl":"10.1080/15384101.2025.2485834","url":null,"abstract":"<p><p>Exosomes secreted by mesenchymal stem cells (MSCs) have been considered as a novel biological therapy for myocardial ischemia/reperfusion injury (MIRI). However, the underlying mechanism of exosomes has not been completely established, especially in the early stage of MIRI. In this study, we primarily investigated the protective effect of exosomes on MIRI from both in vitro and ex vivo perspectives. Bioinformatic analysis was conducted to identify exosomal miRNA associated with myocardial protection, Genes and proteins related to functional studies and myocardial energy metabolism were analyzed and evaluated using techniques such as Polymerase Chain Re-action (PCR), Western blotting, double luciferase biochemical techniques, flow cytometry assay, etc. It was discovered that exosomes ameliorated cardiomyocyte injury t by delivery of miR-132-3p.This process reduced the expression of Phosphatase and tensin homolog (PTEN) mRNA and protein, enhanced the expression of phosphorylated protein kinase (pAKT), regulated the insulin signaling pathway, facilitated intracellular Glucose transporter 4 (GLUT4) protein membrane translocation, and enhanced glucose uptake and Adenosine Triphosphate (ATP) production. This study confirmed, for the first time, that MSC-EXO can provide myocardial protection in the early stages of MIRI through miR-132/PTEN/AKT pathway. This research establishes a theoretical and experimental foundation for the clinical application of MSC-derived exosomes.</p>","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"893-912"},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High GLP1R gene copy numbers associated with microsatellite instability for multiple cancers and with better survival probabilities for glioblastoma. 高GLP1R基因拷贝数与多种癌症的微卫星不稳定性和胶质母细胞瘤的更好生存概率相关。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-09-01 Epub Date: 2025-04-10 DOI: 10.1080/15384101.2025.2485873
Teresa M Thomas, Michael T Aboujaoude, Vayda R Barker, Mallika Varkhedi, Rahul Jain, George Blanck
{"title":"High GLP1R gene copy numbers associated with microsatellite instability for multiple cancers and with better survival probabilities for glioblastoma.","authors":"Teresa M Thomas, Michael T Aboujaoude, Vayda R Barker, Mallika Varkhedi, Rahul Jain, George Blanck","doi":"10.1080/15384101.2025.2485873","DOIUrl":"10.1080/15384101.2025.2485873","url":null,"abstract":"<p><p>While the Warburg effect is well-known and frequently studied, the molecular features that facilitate increased tumor cell glycolytic activity have yet to be extensively investigated. We hypothesized that amplification of genes encoding proteins related to glucose metabolism could be a mechanism to facilitate increased glycolysis. Thus, we applied a precision-guided copy number variation analysis approach to the GLP1R, AMFR, GCG, GPI, and ACTA1 genes across three different cancer types. Results indicated that higher CNs of GLP1R in glioblastoma were associated with better patient outcomes, while high CNs of GPI in lower-grade gliomas were associated with worse outcomes. Results also indicated that high microsatellite instability directly correlated with high CNs for most of the above indicated genes. These approaches to assessing tumor metabolism-related genes may lead to more accurate measures of patient risk and potential additional treatment options.</p>","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"913-921"},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statement of Retraction: LncRNA XIST promotes human lung adenocarcinoma cells to cisplatin resistance via let-7i/BAG-1 axis. 撤回声明：LncRNA XIST通过let-7i/BAG-1轴促进人肺腺癌细胞产生顺铂耐药。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-09-01 Epub Date: 2025-04-29 DOI: 10.1080/15384101.2025.2460938
{"title":"Statement of Retraction: LncRNA XIST promotes human lung adenocarcinoma cells to cisplatin resistance via let-7i/BAG-1 axis.","authors":"","doi":"10.1080/15384101.2025.2460938","DOIUrl":"10.1080/15384101.2025.2460938","url":null,"abstract":"","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"iii"},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statement of Retraction: Fascin1 mediated release of pro-inflammatory cytokines and invasion/migration in rheumatoid arthritis via the STAT3 pathway. 结论：在类风湿关节炎中，通过STAT3通路，Fascin1介导促炎细胞因子的释放和侵袭/迁移。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-09-01 Epub Date: 2025-03-26 DOI: 10.1080/15384101.2025.2460937
{"title":"Statement of Retraction: Fascin1 mediated release of pro-inflammatory cytokines and invasion/migration in rheumatoid arthritis via the STAT3 pathway.","authors":"","doi":"10.1080/15384101.2025.2460937","DOIUrl":"10.1080/15384101.2025.2460937","url":null,"abstract":"","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"ii"},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statement of Retraction: Knockdown of RNF183 suppressed proliferation of lung adenocarcinoma cells via inactivating the STAT3 signaling pathway. 撤回声明：敲除 RNF183 可通过使 STAT3 信号通路失活来抑制肺腺癌细胞的增殖。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-09-01 Epub Date: 2024-07-04 DOI: 10.1080/15384101.2024.2370723
{"title":"Statement of Retraction: Knockdown of RNF183 suppressed proliferation of lung adenocarcinoma cells via inactivating the STAT3 signaling pathway.","authors":"","doi":"10.1080/15384101.2024.2370723","DOIUrl":"10.1080/15384101.2024.2370723","url":null,"abstract":"","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"i"},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statement of Retraction: Cdc25C/cdc2/cyclin B, raf/MEK/ERK and PERK/eIF2α/CHOP pathways are involved in forskolin-induced growth inhibition of MM.1S cells by G2/M arrest and mitochondrion-dependent apoptosis. 撤回声明：Cdc25C/cdc2/cyclin B、raf/MEK/ERK和PERK/eIF2α/CHOP通路参与了福斯可林诱导的MM.1S细胞通过G2/M停滞和线粒体依赖性凋亡抑制生长的过程。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-07-01 Epub Date: 2024-07-04 DOI: 10.1080/15384101.2024.2370720
{"title":"Statement of Retraction: Cdc25C/cdc2/cyclin B, raf/MEK/ERK and PERK/eIF2α/CHOP pathways are involved in forskolin-induced growth inhibition of MM.1S cells by G2/M arrest and mitochondrion-dependent apoptosis.","authors":"","doi":"10.1080/15384101.2024.2370720","DOIUrl":"10.1080/15384101.2024.2370720","url":null,"abstract":"","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"iii"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statement of Retraction: miR-96-5p regulated TGF-β/SMAD signaling pathway and suppressed endometrial cell viability and migration via targeting TGFBR1. 撤稿声明：miR-96-5p 通过靶向 TGFBR1 调节 TGF-β/SMAD 信号通路，抑制子宫内膜细胞的活力和迁移。
IF 3.4 3区 生物学
Cell Cycle Pub Date : 2024-07-01 Epub Date: 2024-07-04 DOI: 10.1080/15384101.2024.2370717
{"title":"Statement of Retraction: miR-96-5p regulated TGF-β/SMAD signaling pathway and suppressed endometrial cell viability and migration via targeting TGFBR1.","authors":"","doi":"10.1080/15384101.2024.2370717","DOIUrl":"10.1080/15384101.2024.2370717","url":null,"abstract":"","PeriodicalId":9686,"journal":{"name":"Cell Cycle","volume":" ","pages":"i"},"PeriodicalIF":3.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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