FAM3A: a novel mitochondrial protein for the treatment of ischemic diseases.

IF 3.4 3区 生物学 Q3 CELL BIOLOGY
Ye Su, Xinggang Cui, Mei Li, Duzhe Jiang, Rui Chen, Ye Zhou
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引用次数: 0

Abstract

FAM3 metabolism-regulating signaling molecule A (FAM3A) is a mitochondrial protein belonging to the FAM3 gene family with the potential for the treatment of ischemic diseases. FAM3A promotes adenosine triphosphate (ATP) production and improves mitochondrial function by increasing ATP synthase activity and activating the protein kinase B-cyclic AMP-responsive element binding protein-forkhead box D3-ATP synthase regulatory loop, thereby reducing reactive oxygen species production and inhibiting oxidative stress-induced cell death. Additionally, FAM3A activates the nuclear factor erythroid 2-related factor 2 signaling pathway and upregulates the expression of antioxidant proteins, further enhancing the cellular oxidative defense capacity. During angiogenesis, FAM3A positively regulates vascular endothelial growth factor A and promotes endothelial cell migration, proliferation, and tube formation. FAM3A is closely related to atherosclerosis, ischemic encephalopathy, liver ischemia - reperfusion injury, myocardial ischemia, and acute kidney injury. FAM3A plays a role in the course of these diseases via multiple mechanisms, including the phosphatidylinositol 3-kinase/protein kinase B signaling pathway, effectively reducing the inflammatory response and oxidative stress, and influencing disease development. This review comprehensively examines the role of FAM3A in the pathophysiological processes of ischemic diseases across various organs.

FAM3A:一种治疗缺血性疾病的新型线粒体蛋白。
FAM3代谢调节信号分子A (FAM3A)是一种属于FAM3基因家族的线粒体蛋白,具有治疗缺血性疾病的潜力。FAM3A通过增加ATP合成酶活性,激活蛋白激酶b -环amp响应元件结合蛋白-叉头盒D3-ATP合成酶调控环,促进三磷酸腺苷(adenosine triphosphate, ATP)的产生,改善线粒体功能,从而减少活性氧的产生,抑制氧化应激诱导的细胞死亡。FAM3A激活核因子红系2相关因子2信号通路,上调抗氧化蛋白表达,进一步增强细胞氧化防御能力。在血管生成过程中,FAM3A正调控血管内皮生长因子A,促进内皮细胞迁移、增殖和成管。FAM3A与动脉粥样硬化、缺血性脑病、肝脏缺血再灌注损伤、心肌缺血、急性肾损伤密切相关。FAM3A通过多种机制参与这些疾病的发生过程,包括磷脂酰肌醇3-激酶/蛋白激酶B信号通路,有效降低炎症反应和氧化应激,影响疾病的发展。本文综述了FAM3A在各器官缺血性疾病病理生理过程中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell Cycle
Cell Cycle 生物-细胞生物学
CiteScore
7.70
自引率
2.30%
发文量
281
审稿时长
1 months
期刊介绍: Cell Cycle is a bi-weekly peer-reviewed journal of high priority research from all areas of cell biology. Cell Cycle covers all topics from yeast to man, from DNA to function, from development to aging, from stem cells to cell senescence, from metabolism to cell death, from cancer to neurobiology, from molecular biology to therapeutics. Our goal is fast publication of outstanding research.
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