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Cell Adhesion & Migration最新文献

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Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells. 角蛋白 19 可维持 E-cadherin 在细胞表面的定位，并稳定 MCF7 细胞的细胞间粘附性。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2020.1868694
Sarah Alsharif, Pooja Sharma, Karina Bursch, Rachel Milliken, Van Lam, Arwa Fallatah, Thuc Phan, Meagan Collins, Priya Dohlman, Sarah Tiufekchiev, Georges Nehmetallah, Christopher B Raub, Byung Min Chung
{"title":"Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells.","authors":"Sarah Alsharif, Pooja Sharma, Karina Bursch, Rachel Milliken, Van Lam, Arwa Fallatah, Thuc Phan, Meagan Collins, Priya Dohlman, Sarah Tiufekchiev, Georges Nehmetallah, Christopher B Raub, Byung Min Chung","doi":"10.1080/19336918.2020.1868694","DOIUrl":"10.1080/19336918.2020.1868694","url":null,"abstract":"<p><p>A cytoskeletal protein keratin 19 (K19) is highly expressed in breast cancer but its effects on breast cancer cell mechanics are unclear. In MCF7 cells where K19 expression is ablated,<i>we found that K19 is required to maintain rounded epithelial-like shape and tight cell-cell adhesion. A loss of K19 also lowered cell surface E-cadherin levels. Inhibiting internalization restored cell-cell adhesion of <i>KRT19</i></i>  knockout cells, suggesting that E-cadherin internalization contributed to defective adhesion. Ultimately, while K19 inhibited cell migration and invasion, it was required for cells to form colonies in suspension. Our results suggest that K19 stabilizes E-cadherin complexes at the cell membrane to maintain cell-cell adhesion which inhibits cell invasiveness but provides growth and survival advantages for circulating tumor cells.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38779085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The roles of serotonin in cell adhesion and migration, and cytoskeletal remodeling. 血清素在细胞粘附和迁移以及细胞骨架重塑中的作用。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1963574
Joe Anand Kumar John Jayakumar, Mitradas M Panicker
{"title":"The roles of serotonin in cell adhesion and migration, and cytoskeletal remodeling.","authors":"Joe Anand Kumar John Jayakumar, Mitradas M Panicker","doi":"10.1080/19336918.2021.1963574","DOIUrl":"10.1080/19336918.2021.1963574","url":null,"abstract":"<p><p>Serotonin is well known as a neurotransmitter. Its roles in neuronal processes such as learning, memory or cognition are well established, and also in disorders such as depression, schizophrenia, bipolar disorder, and dementia. However, its effects on adhesion and cytoskeletal remodelling which are strongly affected by 5-HT receptors, are not as well studied with some exceptions for e.g. platelet aggregation. Neuronal function is strongly dependent on cell-cell contacts and adhesion-related processes. Therefore the role played by serotonin in psychiatric illness, as well as in the positive and negative effects of neuropsychiatric drugs through cell-related adhesion can be of great significance. In this review, we explore the role of serotonin in some of these aspects based on recent findings.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8437456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39396843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Creation and use of organoids in biomedical research and healthcare: the bioethical and metabioethical issues. 类器官在生物医学研究和保健中的创造和使用:生物伦理学和代谢伦理学问题。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1996749
Henri-Corto Stoeklé, Achille Ivasilevitch, Geneviève Marignac, Christian Hervé
{"title":"Creation and use of organoids in biomedical research and healthcare: the bioethical and metabioethical issues.","authors":"Henri-Corto Stoeklé,&nbsp;Achille Ivasilevitch,&nbsp;Geneviève Marignac,&nbsp;Christian Hervé","doi":"10.1080/19336918.2021.1996749","DOIUrl":"https://doi.org/10.1080/19336918.2021.1996749","url":null,"abstract":"<p><p>In the field of bioethics, scientific articles have already been published, and have highlighted relatively pluralist reflections concerning the creation and use of organoids. This plurality, rather than simply reflecting the complexity of the subject, may also be a consequence of the multiple theoretical and practical frameworks applied. Moreover, the creation and use of organoids in biomedical research and healthcare is probably in its infancy. This phenomenon is likely to increase in amplitude. Bioethics may be able to provide it with an effective and pertinent moral meaning, provided that a veritable metabioethical reflection is developed in parallel, that is, a reflection on bioethics itself, to provide scientists and clinicians with the best possible assistance in their everyday practice.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39566397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Role of tight junction-associated MARVEL protein marvelD3 in migration and epithelial-mesenchymal transition of hepatocellular carcinoma. 紧密连接相关的MARVEL蛋白marvelD3在肝癌迁移和上皮间质转化中的作用。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1958441
Yanmeng Li, Teng Li, Donghu Zhou, Jia Wei, Zhenkun Li, Xiaojin Li, Siyu Jia, Qin Ouyang, Saiping Qi, Zhibin Chen, Bei Zhang, Jing Yu, Jidong Jia, Anjian Xu, Jian Huang
{"title":"Role of tight junction-associated MARVEL protein marvelD3 in migration and epithelial-mesenchymal transition of hepatocellular carcinoma.","authors":"Yanmeng Li,&nbsp;Teng Li,&nbsp;Donghu Zhou,&nbsp;Jia Wei,&nbsp;Zhenkun Li,&nbsp;Xiaojin Li,&nbsp;Siyu Jia,&nbsp;Qin Ouyang,&nbsp;Saiping Qi,&nbsp;Zhibin Chen,&nbsp;Bei Zhang,&nbsp;Jing Yu,&nbsp;Jidong Jia,&nbsp;Anjian Xu,&nbsp;Jian Huang","doi":"10.1080/19336918.2021.1958441","DOIUrl":"https://doi.org/10.1080/19336918.2021.1958441","url":null,"abstract":"<p><p>MarvelD3, a recently identified tight junction membrane protein, could be associated with hepatocellular carcinoma (HCC). We aimed to investigate the role of marvelD3 in Epithelial-Mesenchymal Transition (EMT) and migration of HCC and explore the underlying molecular mechanisms. First, we assessed marvlD3 expression in HCC and normal liver tissues and found loss of marvelD3 expression was significantly correlated with the occurrence and TNM stage of HCC. Second, we detected that marvelD3 was downregulated in HCC cells with transforming growth factor β1 and snail/slug-induced EMT. Finally, we analyzed expression of marvelD3 protein was significantly associated with EMT and the NF-κB signaling pathway. Our study demonstrated that MarvelD3 inhibited EMT and migration of HCC cells along with inhibiting NF-κB signaling pathway.<b>Abbreviations:</b><b>HCC</b>, Hepatocellular carcinoma; <b>TJ</b>, Tight junction; <b>MARVEL</b>, MAL and related proteins for vesicle trafficking and membrane link; <b>EMT</b>, Epithelial<b>-</b>mesenchymal transition; <b>NF-κB</b>, Nuclear factor kappa B; <b>TAMPs</b>, Tight junction-associated marvel proteins; <b>TGF-β1</b>, Transforming growth factor-β1; <b>MMP9</b>, matrix metallopeptidase 9; <b>RT-PCR</b>, Real-time PCR; <b>IHC</b>, Immunohistochemistry; <b>IF</b>, Immunofluorescence.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39267843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies. 流体剪切应力对成纤维细胞和干细胞平面和沟槽形貌的影响。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1713532
Xing Lei, Bin Liu, Hao Wu, Xiao Wu, Xiu-Li Wang, Yue Song, Shuai-Shuai Zhang, Jun-Qin Li, Long Bi, Guo-Xian Pei
{"title":"The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies.","authors":"Xing Lei,&nbsp;Bin Liu,&nbsp;Hao Wu,&nbsp;Xiao Wu,&nbsp;Xiu-Li Wang,&nbsp;Yue Song,&nbsp;Shuai-Shuai Zhang,&nbsp;Jun-Qin Li,&nbsp;Long Bi,&nbsp;Guo-Xian Pei","doi":"10.1080/19336918.2020.1713532","DOIUrl":"https://doi.org/10.1080/19336918.2020.1713532","url":null,"abstract":"<p><p>In this study, we aimed to study the effect of fluid shear stress on fibroblasts and BMSCs on plane and groove topographies. The results showed that 0.6-Hz stress had the greatest influence on the alignment, polarity, migration and adhesion of fibroblasts on plane by increasing the expression of reoriented actin and vinculin; whereas 1.0-Hz stress promoted differentiation of fibroblasts into myofibroblasts by increasing Col-I and α-SMA expression. Interestingly, under the given frequency stress, the groove structure strengthened the above characteristics of fibroblasts beyond adhesion, and promoted differentiation of BMSCs into myofibroblasts. The above results indicate that 0.6 Hz may improve the implant-tissue sealing, while 1.0-Hz stress probably causes the disordered fiber deposition around implants.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1713532","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37548019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
EpCAM-claudin-tetraspanin-modulated ovarian cancer progression and drug resistance. epcam -claudin-tetraspanin调控卵巢癌进展及耐药。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1732761
Zehra Tavsan, Hülya Ayar Kayalı
{"title":"EpCAM-claudin-tetraspanin-modulated ovarian cancer progression and drug resistance.","authors":"Zehra Tavsan,&nbsp;Hülya Ayar Kayalı","doi":"10.1080/19336918.2020.1732761","DOIUrl":"https://doi.org/10.1080/19336918.2020.1732761","url":null,"abstract":"ABSTRACT Alterations of cell adhesion are involved in cancer progression, but the mechanisms underlying the progression and cell adhesion have remained poorly understood. Focusing on the complex between EpCAM, claudins and tetraspanins, we described a sequence of events by which of the molecules associate each other in ovarian cancer. The interactions between molecules were evaluated by immunoprecipitations and then immunoblotting. To identify the effects of complex formation on the ovarian cancer progression, the different types of ovarian cancer cell lines were compared. In this study, we report the identification of the EpCAM-claudin-4 or −7-CD82 complex in the ovarian cancer progression and metastasis in vitro. Additionally, we demonstrated palmitoylation and intra- or extra-cellular regions are critically required for the complex formation. These results represent the first direct evidence for the link between the dynamism of cell adhesion molecules and ovarian cancer progression.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1732761","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37671733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The functions of kinesin and kinesin-related proteins in eukaryotes. 真核生物中运动蛋白及运动蛋白相关蛋白的功能。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1810939
Iftikhar Ali, Wei-Cai Yang
{"title":"The functions of kinesin and kinesin-related proteins in eukaryotes.","authors":"Iftikhar Ali,&nbsp;Wei-Cai Yang","doi":"10.1080/19336918.2020.1810939","DOIUrl":"https://doi.org/10.1080/19336918.2020.1810939","url":null,"abstract":"<p><p>Kinesins constitute a superfamily of ATP-driven microtubule motor enzymes that convert the chemical energy of ATP hydrolysis into mechanical work along microtubule tracks. Kinesins are found in all eukaryotic organisms and are essential to all eukaryotic cells, involved in diverse cellular functions such as microtubule dynamics and morphogenesis, chromosome segregation, spindle formation and elongation and transport of organelles. In this review, we explore recently reported functions of kinesins in eukaryotes and compare their specific cargoes in both plant and animal kingdoms to understand the possible roles of uncharacterized motors in a kingdom based on their reported functions in other kingdoms.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1810939","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38402777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role. SLPI通过调节板足/褶边和桥粒来促进细胞迁移，其中galectin - 4起重要作用。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1829264
Yusuke Mizutani, Daisuke Omagari, Manabu Hayatsu, Masaaki Nameta, Kazuo Komiyama, Yoshikazu Mikami, Tatsuo Ushiki
{"title":"SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role.","authors":"Yusuke Mizutani,&nbsp;Daisuke Omagari,&nbsp;Manabu Hayatsu,&nbsp;Masaaki Nameta,&nbsp;Kazuo Komiyama,&nbsp;Yoshikazu Mikami,&nbsp;Tatsuo Ushiki","doi":"10.1080/19336918.2020.1829264","DOIUrl":"https://doi.org/10.1080/19336918.2020.1829264","url":null,"abstract":"<p><p>To elucidate the underlying mechanism of secretory leukocyte protease inhibitor (SLPI)-induced cell migration, we compared SLPI-deleted human gingival carcinoma Ca9-22 (ΔSLPI) cells and original (wild-type: wt) Ca9-22 cells using several microscopic imaging methods and gene expression analysis. Our results indicated reduced migration of ΔSLPI cells compared to wtCa9-22 cells. The lamellipodia/dorsal ruffles were smaller and moved slower in ΔSLPI cells compared to wtCa9-22 cells. Furthermore, well-developed intermediate filament bundles were observed at the desmosome junction of ΔSLPI cells. In addition, <i>Galectin4</i> was strongly expressed in ΔSLPI cells, and its forced expression suppressed migration of wtCa9-22 cells. Taken together, SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1829264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38453883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The focal adhesion protein Integrin-Linked Kinase (ILK) as an important player in breast cancer pathogenesis. 局灶黏附蛋白整合素连接激酶(ILK)在乳腺癌发病机制中起重要作用。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1829263
Katerina Tsirtsaki, Vasiliki Gkretsi
{"title":"The focal adhesion protein Integrin-Linked Kinase (ILK) as an important player in breast cancer pathogenesis.","authors":"Katerina Tsirtsaki,&nbsp;Vasiliki Gkretsi","doi":"10.1080/19336918.2020.1829263","DOIUrl":"https://doi.org/10.1080/19336918.2020.1829263","url":null,"abstract":"<p><p>Cell-extracellular matrix interactions, or focal adhesions (FA), are crucial for tissue homeostasis but are also implicated in cancer. Integrin-Linked Kinase (ILK) is an abundantly expressed FA protein involved in multiple signaling pathways. Here, we reviewed the current literature on the role of ILK in breast cancer (BC). Articles included in vitro and in vivo experiments as well as studies in human BC samples. ILK attenuation via silencing or pharmaceutical inhibition, leads to apoptosis or inhibition of epithelial-to-mesenchymal transition, and cell invasion whereas ILK overexpression suppresses anoikis and promotes tumor growth and metastasis. Finally, ILK is upregulated in BC tumors and its expression is associated with grade, and metastasis. Therefore, ILK should be evaluated as a potential anti-cancer pharmaceutical target.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1829263","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38478130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2. 在p53缺失的情况下，KLF5通过miR-192靶向ZEB2调控肝癌细胞的上皮-间质转化。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2020-12-01 DOI: 10.1080/19336918.2020.1826216
Lan Sun, Xiaona Zhou, Yanmeng Li, Wei Chen, Shanna Wu, Bei Zhang, Jingyi Yao, Anjian Xu
{"title":"KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2.","authors":"Lan Sun,&nbsp;Xiaona Zhou,&nbsp;Yanmeng Li,&nbsp;Wei Chen,&nbsp;Shanna Wu,&nbsp;Bei Zhang,&nbsp;Jingyi Yao,&nbsp;Anjian Xu","doi":"10.1080/19336918.2020.1826216","DOIUrl":"https://doi.org/10.1080/19336918.2020.1826216","url":null,"abstract":"<p><p>Krüppel-like factor 5 (KLF5) can both promote and suppress cell migration, but the underlying mechanisms have not been elucidated. In this study, we show that the function of KLF5 in epithelial-mesenchymal transition (EMT) and migration of liver cancer cells depends on the status of the cellular tumor antigen p53 (p53). Furthermore, zinc finger E-box-binding homeobox 2 (ZEB2) is the main regulator of KLF5 in EMT in liver cancer cells in the context of p53 loss. Most importantly, the regulation of ZEB2 by p53 and KLF5 is indirect and that miR-192 mediates this regulation. Finally, we find that in invasive liver cancer, KLF5 is absent in the context of p53 loss or mutation.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2020.1826216","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38507019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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