Cell Adhesion & Migration最新文献_第4页

Directed movement toward, translocation along, penetration into and exit from vascular networks by breast cancer cells in 3D. 乳腺癌细胞向血管网络定向移动、沿血管网络移位、渗透和退出血管网络。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1957527

Deborah J Wessels, Claude Pujol, Nikash Pradhan, Daniel F Lusche, Luis Gonzalez, Sydney E Kelly, Elizabeth M Martin, Edward R Voss, Yang-Nim Park, Michael Dailey, Sonia L Sugg, Sneha Phadke, Amani Bashir, David R Soll

{"title":"Directed movement toward, translocation along, penetration into and exit from vascular networks by breast cancer cells in 3D.","authors":"Deborah J Wessels, Claude Pujol, Nikash Pradhan, Daniel F Lusche, Luis Gonzalez, Sydney E Kelly, Elizabeth M Martin, Edward R Voss, Yang-Nim Park, Michael Dailey, Sonia L Sugg, Sneha Phadke, Amani Bashir, David R Soll","doi":"10.1080/19336918.2021.1957527","DOIUrl":"https://doi.org/10.1080/19336918.2021.1957527","url":null,"abstract":"We developed a computer-assisted platform using laser scanning confocal microscopy to 3D reconstruct in real-time interactions between metastatic breast cancer cells and human umbilical vein endothelial cells (HUVECs). We demonstrate that MB-231 cancer cells migrate toward HUVEC networks, facilitated by filopodia, migrate along the network surfaces, penetrate into and migrate within the HUVEC networks, exit and continue migrating along network surfaces. The system is highly amenable to 3D reconstruction and computational analyses, and assessments of the effects of potential anti-metastasis monoclonal antibodies and other drugs. We demonstrate that an anti-RHAMM antibody blocks filopodium formation and all of the behaviors that we found take place between MB-231 cells and HUVEC networks.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2021.1957527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39267512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nicotinate-curcumin inhibits AngII-induced vascular smooth muscle cell phenotype switching by upregulating Daxx expression. 烟碱-姜黄素通过上调Daxx表达抑制血管平滑肌细胞表型转换。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1909899

Si-Yu Sun, Yu-Mei Cao, Yan-Jie Huo, Fei Qiu, Wen-Juan Quan, Chao-Ping He, Yu Chen, Duan-Fang Liao, Qin-Hui Tuo

引用次数: 3

Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells. 微管失稳是黑色素瘤细胞趋化性和跨内皮迁移的关键检查点，而不是T细胞。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1934958

Francesco Roncato, Ofer Regev, Sandeep Kumar Yadav, Ronen Alon

引用次数: 2

Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion. 非典型PKCs激活Vimentin促进前列腺癌细胞的运动和侵袭。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1882782

Wishrawana S Ratnayake, Christopher A Apostolatos, Sloan Breedy, Clare L Dennison, Robert Hill, Mildred Acevedo-Duncan

引用次数: 12

Group I p21-activated kinases in leukemia cell adhesion to fibronectin. I组p21活化激酶在白血病细胞对纤维连接蛋白粘附中的作用。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1872760

Kateřina Kuželová, Adam Obr, Pavla Röselová, Dana Grebeňová, Petra Otevřelová, Barbora Brodská, Aleš Holoubek

引用次数: 6

F4, a collagen XIX-derived peptide, inhibits tumor angiogenesis through αvβ3 and α5β1 integrin interaction. F4是一种胶原衍生肽，通过αvβ3和α5β1整合素相互作用抑制肿瘤血管生成。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1951425

Jean-Baptiste Oudart, Matthieu Villemin, Bertrand Brassart, Christèle Sellier, Christine Terryn, Aurélie Dupont-Deshorgue, Jean Claude Monboisse, François-Xavier Maquart, Laurent Ramont, Sylvie Brassart-Pasco

引用次数: 2

The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation. Netrin-1-Neogenin-1信号轴通过整合素-β1和局灶粘附激酶的激活控制神经母细胞瘤细胞的迁移。

IF 3.3 3区生物学

Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1892397

Andrea A Villanueva, Pilar Sanchez-Gomez, Ernesto Muñoz-Palma, Sofía Puvogel, Bárbara S Casas, Cecilia Arriagada, Isaac Peña-Villalobos, Pablo Lois, Manuel Ramírez Orellana, Fabiana Lubieniecki, Fernando Casco Claro, Iván Gallegos, Javier García-Castro, Vicente A Torres, Verónica Palma

{"title":"The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation.","authors":"Andrea A Villanueva, Pilar Sanchez-Gomez, Ernesto Muñoz-Palma, Sofía Puvogel, Bárbara S Casas, Cecilia Arriagada, Isaac Peña-Villalobos, Pablo Lois, Manuel Ramírez Orellana, Fabiana Lubieniecki, Fernando Casco Claro, Iván Gallegos, Javier García-Castro, Vicente A Torres, Verónica Palma","doi":"10.1080/19336918.2021.1892397","DOIUrl":"10.1080/19336918.2021.1892397","url":null,"abstract":"Neuroblastoma is a highly metastatic tumor that emerges from neural crest cell progenitors. Focal Adhesion Kinase (FAK) is a regulator of cell migration that binds to the receptor Neogenin-1 and is upregulated in neuroblastoma. Here, we show that Netrin-1 ligand binding to Neogenin-1 leads to FAK autophosphorylation and integrin β1 activation in a FAK dependent manner, thus promoting neuroblastoma cell migration. Moreover, Neogenin-1, which was detected in all tumor stages and was required for neuroblastoma cell migration, was found in a complex with integrin β1, FAK, and Netrin-1. Importantly, Neogenin-1 promoted neuroblastoma metastases in an immunodeficient mouse model. Taken together, these data show that Neogenin-1 is a metastasis-promoting protein that associates with FAK, activates integrin β1 and promotes neuroblastoma cell migration.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25483843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia. α-亚麻酸调节小胶质细胞吞噬和细胞外Tau蛋白的内体通路。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1898727

Smita Eknath Desale, Subashchandrabose Chinnathambi

{"title":"α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia.","authors":"Smita Eknath Desale, Subashchandrabose Chinnathambi","doi":"10.1080/19336918.2021.1898727","DOIUrl":"10.1080/19336918.2021.1898727","url":null,"abstract":"Microglia, the resident immune cells, were found to be activated to inflammatory phenotype in Alzheimer's disease (AD). The extracellular burden of amyloid-β plaques and Tau seed fabricate the activation of microglia. The seeding effect of extracellular Tau species is an emerging aspect to study about Tauopathies in AD. Tau seeds enhance the propagation of disease along with its contribution to microglia-mediated inflammation. The excessive neuroinflammation cumulatively hampers phagocytic function of microglia reducing the clearance of extracellular protein aggregates. Omega-3 fatty acids, especially docosahexaenoic acid and eicosapentaenoic acid, are recognized to induce anti-inflammatory phenotype of microglia. In addition to increased cytokine production, omega-3 fatty acids enhance phagocytic receptors expression in microglia. In this study, we have observed the phagocytosis of extracellular Tau in the presence of α-linolenic acid (ALA). The increased phagocytosis of extracellular Tau monomer and aggregates have been observed upon ALA exposure to microglia cells. After internalization, the degradation status of Tau has been studied with early and late endosomal markers Rab5 and Rab7. Further, the lysosome-mediated degradation of internalized Tau was studied with LAMP-2A, a lysosome marker. The enhanced migratory ability in the presence of ALA could be beneficial for microglia to access the target and clear it. The increased migration of microglia was found to induce the microtubule-organizing center repolarization. The data indicate that the dietary fatty acids ALA could significantly enhance phagocytosis and intracellular degradation of internalized Tau. Our results suggest that microglia could be influenced to reduce extracellular Tau seed with dietary fatty acids.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2021.1898727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25492209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Mast cell tryptase enhances wound healing by promoting migration in human bronchial epithelial cells. 肥大细胞胰蛋白酶通过促进人支气管上皮细胞的迁移来促进伤口愈合。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1950594

Sofia Mogren, Frida Berlin, Sangeetha Ramu, Asger Sverrild, Celeste Porsbjerg, Lena Uller, Cecilia K Andersson

{"title":"Mast cell tryptase enhances wound healing by promoting migration in human bronchial epithelial cells.","authors":"Sofia Mogren, Frida Berlin, Sangeetha Ramu, Asger Sverrild, Celeste Porsbjerg, Lena Uller, Cecilia K Andersson","doi":"10.1080/19336918.2021.1950594","DOIUrl":"https://doi.org/10.1080/19336918.2021.1950594","url":null,"abstract":"Epithelial damage and increase of intraepithelial mast cells (MC) are characteristics of asthma. The role of MC mediator tryptase and the protease-activated receptor-2 (PAR2) on epithelial wound healing is not fully investigated. Stimulation of bronchial epithelial cells (BECs) with tryptase promoted gap closure, migration and cellular speed compared to controls. Stimulated BECs had higher expression of migration marker CD151 compared to controls. Proliferation marker KI67 was upregulated in tryptase-stimulated BECs compared to controls. Treatment with PAR2 antagonist I-191 reduced gap closure, migration and cell speed compared to BECs stimulated with tryptase. We found that tryptase enhances epithelial wound healing by increased migration and proliferation, which is in part regulated via PAR2. Our data suggest that tryptase might be beneficial in tissue repair under baseline conditions. However, in a pathological context such as asthma with increased numbers of activated MCs, it might lead to epithelial remodeling and loss of function.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2021.1950594","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39221709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1. 长链非编码RNA ENST00000508435通过fxr1促进乳腺癌迁移

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2021-12-01 DOI: 10.1080/19336918.2021.1921402

Luying Li, Youping Jin, Xue Wang, Li Wang, Yangbai Sun, Yihong Luo, Xiaojian Ni, Qi Lu, Wenbo Wei, Xiuling Zhi, Jerry Yu, Wei Zhu, Ping Zhou

引用次数: 2