Cell Adhesion & Migration最新文献_第10页

The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells. 通过非典型蛋白激酶c激活的Cofilin调节肌动蛋白动力学调节结直肠癌细胞的转移。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2019-12-01 Epub Date: 2018-11-18 DOI: 10.1080/19336918.2018.1546513

S M Anisul Islam, Rekha Patel, Raja Reddy Bommareddy, Khandker Mohammad Khalid, Mildred Acevedo-Duncan

引用次数: 14

T lymphocytes migrate upstream after completing the leukocyte adhesion cascade. T淋巴细胞完成白细胞粘附级联后向上游迁移。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2019-12-01 Epub Date: 2019-03-17 DOI: 10.1080/19336918.2019.1587269

Nicholas R Anderson, Alexander Buffone, Daniel A Hammer

引用次数: 17

Protein kinase C Inhibitors selectively modulate dynamics of cell adhesion molecules and cell death in human colon cancer cells. 蛋白激酶C抑制剂选择性调节人结肠癌细胞粘附分子动力学和细胞死亡。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2019-12-01 Epub Date: 2018-10-11 DOI: 10.1080/19336918.2018.1530933

Muzaffer Dükel, Zehra Tavsan, Duygu Erdogan, Deniz Erkan Gök, Hulya Ayar Kayali

{"title":"Protein kinase C Inhibitors selectively modulate dynamics of cell adhesion molecules and cell death in human colon cancer cells.","authors":"Muzaffer Dükel, Zehra Tavsan, Duygu Erdogan, Deniz Erkan Gök, Hulya Ayar Kayali","doi":"10.1080/19336918.2018.1530933","DOIUrl":"https://doi.org/10.1080/19336918.2018.1530933","url":null,"abstract":"During development of colon cancer, Protein Kinase Cs (PKCs) are involved in regulation of many genes controlling several cellular mechanisms. Here, we examined the changes in cell adhesion molecules and PKCs for colorectal cancer progression. We identified that PKCs affected expression of EpCAM, claudins, tetraspanins. Treatment with low concentrations of PKC inhibitors resulted in decreased cell viability. In addition, immunoblotting and qRT-PCR analysis showed that apoptosis was inhibited while autophagy was induced by PKC inhibition in colon cancer cells. Furthermore, we observed decreased levels of intracellular Reactive Oxygen Species (ROS), lipid peroxidation and protein carbonyl, confirming the ROS-induced apoptosis. Taken together, our results reveal that PKC signalling modulates not only cell adhesion dynamics but also cell death-related mechanisms. Abbreviations: PKC: Protein Kinase C; EpCAM: Epithelial cell adhesion molecule; FBS: fetal bovine serum; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); CAM: cell adhesion molecule; ROS: reactive oxygen species.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"13 1","pages":"83-97"},"PeriodicalIF":3.2,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2018.1530933","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36559873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The effect of cytokines produced by human adipose tissue on monocyte adhesion to the endothelium 人脂肪组织产生的细胞因子对单核细胞粘附内皮的影响

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2019-01-01 DOI: 10.1080/19336918.2019.1644856

S. Cejkova, H. Kubátová, F. Thieme, L. Janousek, J. Fronek, R. Poledne, I. Králová Lesná

{"title":"The effect of cytokines produced by human adipose tissue on monocyte adhesion to the endothelium","authors":"S. Cejkova, H. Kubátová, F. Thieme, L. Janousek, J. Fronek, R. Poledne, I. Králová Lesná","doi":"10.1080/19336918.2019.1644856","DOIUrl":"https://doi.org/10.1080/19336918.2019.1644856","url":null,"abstract":"ABSTRACT Visceral adipose tissue (VAT) may play a critical role in atherosclerotic cardiovascular disease. The goal of this study was to determine the effect of human VAT-released pro‑inflammatory cytokines on monocyte adhesion to the endothelium. The cytokine effects on monocyte adhesion to the endothelial cells (ECs) were tested using adipose tissue-conditioned media (ATCM) prepared by culturing human VAT. The cytokines concentrations in ATCM, the cytokines expression and adhesion molecules in stimulated ECs were measured. The concentrations of IL-1β,TNF-α,MCP-1,IL-10,and RANTES measured in ATCM correlated positively with monocyte adhesiveness to ECs. Additionally, ATCM increased the adhesion molecules (ICAM-1, VCAM-1) gene expression. Selective inhibitors highlighted the importance of IL-1β and TNF-α in the process by a significant decrease in monocyte adhesion compared to ATCM preconditioning without inhibitors. Human VAT significantly increased monocyte adhesion to ECs. It was significantly influenced by IL-1β, TNF-α, MCP-1, IL-10, and RANTES, with IL-1β and TNF‑α having the strongest impact.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"13 1","pages":"293 - 302"},"PeriodicalIF":3.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2019.1644856","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43935771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Splicing factor-modulated generation of mechano growth factor regulates physiological processes in osteoblasts under mechanical stimuli 剪接因子调节机械生长因子的产生调节成骨细胞在机械刺激下的生理过程

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2019-01-01 DOI: 10.1080/19336918.2019.1686103

Qian Yi, Huan Liu, Jianguo Feng, Yanjiao Wu, Weichao Sun, Mengting Ou, Liling Tang

引用次数: 4

Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration AGR2的旁分泌信号传导刺激成纤维细胞中的RhoA功能并调节细胞延伸和迁移

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2019-01-01 DOI: 10.1080/19336918.2019.1685928

H. B. Mangukiya, H. Negi, S. B. Merugu, Qudsia Sehar, D. S. Mashausi, F. Yunus, Zhenghua Wu, Dawei Li

引用次数: 4

Predictable fibroblast tension generation by measuring compaction of anchored collagen matrices using microscopy and optical coherence tomography 通过使用显微镜和光学相干断层扫描测量锚定胶原基质的压实，可预测成纤维细胞张力的产生

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2019-01-01 DOI: 10.1080/19336918.2019.1644855

Melville B Vaughan, Gang Xu, Tracy L. Morris, Pratiksha Kshetri, Jing X Herwig

{"title":"Predictable fibroblast tension generation by measuring compaction of anchored collagen matrices using microscopy and optical coherence tomography","authors":"Melville B Vaughan, Gang Xu, Tracy L. Morris, Pratiksha Kshetri, Jing X Herwig","doi":"10.1080/19336918.2019.1644855","DOIUrl":"https://doi.org/10.1080/19336918.2019.1644855","url":null,"abstract":"ABSTRACT The anchored fibroblast-populated collagen matrix (aFPCM) is an appropriate model to study fibrocontractive disease mechanisms. Our goal was to determine if aFPCM height reduction (compaction) during development is sufficient to predict tension generation. Compaction was quantified daily by both traditional light microscopy and an optical coherence tomography (OCT) system. Contraction in aFPCM was revealed by releasing them from anchorage. We found that aFPCM contraction increase was correlated to the compaction increase. Cytochalasin D treatment reversibly inhibited compaction. Therefore, we demonstrated that aFPCM height reduction efficiently measures compaction, contraction, and relative maturity of the collagen matrix during development or treatment. In addition, we showed that OCT is suitable for effectively imaging the cross-sectional morphology of the aFPCM in culture. This study will pave the way for more efficient studies on the mechanisms of (and treatments that target) migration and contraction in wound healing and Dupuytren’s contracture in a tissue environment.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"13 1","pages":"303 - 314"},"PeriodicalIF":3.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2019.1644855","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45978409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Mathematical Models of Specific Cell Adhesion Phenomena 特定细胞粘附现象的数学模型

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2018-10-03 DOI: 10.1201/9781315138954-2

M. Hjortso, J. Roos

引用次数: 0

Kinetics of Ligand-Receptor Bond Formation 配体-受体键形成动力学

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2018-10-03 DOI: 10.1201/9781315138954-1

J. Roos, M. Hjortso

引用次数: 0

Adhesion structures in leukemia cells and their regulation by Src family kinases. 白血病细胞的粘附结构及其Src家族激酶的调控。

IF 3.2 3区生物学

Cell Adhesion & Migration Pub Date : 2018-05-04 Epub Date: 2017-08-18 DOI: 10.1080/19336918.2017.1344796

Pavla Röselová, Adam Obr, Aleš Holoubek, Dana Grebeňová, Kateřina Kuželová

{"title":"Adhesion structures in leukemia cells and their regulation by Src family kinases.","authors":"Pavla Röselová, Adam Obr, Aleš Holoubek, Dana Grebeňová, Kateřina Kuželová","doi":"10.1080/19336918.2017.1344796","DOIUrl":"https://doi.org/10.1080/19336918.2017.1344796","url":null,"abstract":"Interaction of leukemia blasts with the bone marrow extracellular matrix often results in protection of leukemia cells from chemotherapy and in persistence of the residual disease which is on the basis of subsequent relapses. The adhesion signaling pathways have been extensively studied in adherent cells as well as in mature haematopoietic cells, but the adhesion structures and signaling in haematopoietic stem and progenitor cells, either normal or malignant, are much less explored. We analyzed the interaction of leukemia cells with fibronectin (FN) using interference reflection microscopy, immunofluorescence, measurement of adherent cell fraction, real-time microimpedance measurement and live cell imaging. We found that leukemia cells form very dynamic adhesion structures similar to early stages of focal adhesions. In contrast to adherent cells, where Src family kinases (SFK) belong to important regulators of focal adhesion dynamics, we observed only minor effects of SFK inhibitor dasatinib on leukemia cell binding to FN. The relatively weak involvement of SFK in adhesion structure regulation might be associated with the lack of cytoskeletal mechanical tension in leukemia cells. On the other hand, active Lyn kinase was found to specifically localize to leukemia cell adhesion structures and a less firm cell attachment to FN was often associated with higher Lyn activity (this unexpectedly occurred also after cell treatment with the inhibitor SKI-1). Lyn thus may be important for signaling from integrin-associated complexes to other processes in leukemia cells.","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":"12 3","pages":"286-298"},"PeriodicalIF":3.2,"publicationDate":"2018-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336918.2017.1344796","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35143574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6