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JNK3 inhibitors as promising pharmaceuticals with neuroprotective properties. JNK3 抑制剂是一种具有神经保护特性的有前途的药物。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-02-15 DOI: 10.1080/19336918.2024.2316576
Yibeini Wu, Yiling Zhao, Ziman Guan, Sajjad Esmaeili, Zhicheng Xiao, Diji Kuriakose
{"title":"JNK3 inhibitors as promising pharmaceuticals with neuroprotective properties.","authors":"Yibeini Wu, Yiling Zhao, Ziman Guan, Sajjad Esmaeili, Zhicheng Xiao, Diji Kuriakose","doi":"10.1080/19336918.2024.2316576","DOIUrl":"10.1080/19336918.2024.2316576","url":null,"abstract":"<p><p>The intensive study and investigation of neuroprotective therapy for central nervous system (CNS) diseases is ongoing. Due to shared mechanisms of neurodegeneration, a neuroprotective approach might offer benefits across multiple neurological disorders, despite variations in symptoms or injuries. C-Jun N-terminal Kinase 3 (JNK3) is found primarily in the CNS and is involved in physiological processes such as brain development, synapse formation, and memory formation. The potential of JNK3 as a target for pharmacological development holds promise for advancing neuroprotective therapies. Developing small molecule JNK3 inhibitors into drugs with neuroprotective qualities could facilitate neuronal restoration and self-repair. This review focuses on elucidating key neuroprotective mechanisms, exploring the interplay between neurodegenerative diseases and neuroprotection, and discussing advancements in JNK3 inhibitor drug development.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10878020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139734604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knockdown of PIK3R6 impedes the onset and advancement of clear cell renal cell carcinoma. 敲除 PIK3R6 会阻碍透明细胞肾细胞癌的发生和发展。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-06-03 DOI: 10.1080/19336918.2024.2353920
Jia Yang, Xiaoni Zhong, Xiaoling Gao, Wenyi Xie, Yaokai Chen, Yuanjiang Liao, Peilin Zhang
{"title":"Knockdown of PIK3R6 impedes the onset and advancement of clear cell renal cell carcinoma.","authors":"Jia Yang, Xiaoni Zhong, Xiaoling Gao, Wenyi Xie, Yaokai Chen, Yuanjiang Liao, Peilin Zhang","doi":"10.1080/19336918.2024.2353920","DOIUrl":"10.1080/19336918.2024.2353920","url":null,"abstract":"<p><p>In this research, we investigated the role of PIK3R6, a regulatory subunit of PI3Kγ, known for its tumor-promoting properties, in clear cell renal cell carcinoma (CCRCC). Utilizing the UALCAN website, we found PIK3R6 upregulated in CCRCC, correlating with lower survival rates. We compared PIK3R6 expression in CCRCC tumor tissues and adjacent normal tissues using immunohistochemistry. Post RNA interference-induced knockdown of PIK3R6 in 786-O and ACHN cell lines, we performed CCK-8, colony formation, Edu staining, flow cytometry, wound healing, and transwell assays. Results showed that PIK3R6 silencing reduced cell proliferation, migration, and invasion, and induced G0/G1 phase arrest and apoptosis. Molecular analysis revealed decreased CDK4, Cyclin D1, N-cadherin, Vimentin, Bcl-2, p-PI3K and p-AKT, with increased cleaved caspase-3, Bax, and E-cadherin levels in CCRCC cells. Moreover, inhibiting PIK3R6 hindered tumor growth. These findings suggest a significant role for PIK3R6 in CCRCC cell proliferation and metastasis, presenting it as a potential therapeutic target.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell adhesion and migration in disease: translational and therapeutic opportunities. 疾病中的细胞粘附和迁移：转化和治疗机会。
IF 3.3 3区 生物学
Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-06-11 DOI: 10.1080/19336918.2024.2362978
Kurt Anderson, Yolanda Calle-Patino, Aleksandar Ivetic, Maddy Parsons, Ferran Valderrama, Claire Wells, Ines Anton
{"title":"Cell adhesion and migration in disease: translational and therapeutic opportunities.","authors":"Kurt Anderson, Yolanda Calle-Patino, Aleksandar Ivetic, Maddy Parsons, Ferran Valderrama, Claire Wells, Ines Anton","doi":"10.1080/19336918.2024.2362978","DOIUrl":"10.1080/19336918.2024.2362978","url":null,"abstract":"<p><p>In September 2023 members of the cell adhesion and cell migration research community came together to share their latest research and consider how our work might be translated for clinical practice. Alongside invited speakers, selected speakers and poster presentations, the meeting also included a round table discussion of how we might overcome the challenges associated with research translation. This meeting report seeks to highlight the key outcomes of that discussion and spark interest in the cell adhesions and cell migration research community to cross the perceived valley of death and translate our work into therapeutic benefit.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11174059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of JNK/STAT3/NF-KB pathway-mediated migration and clonal formation of lung adenocarcinoma A549 cells by daphnetin. 萘丁抑制 JNK/STAT3/NF-KB 通路介导的肺腺癌 A549 细胞迁移和克隆形成。
IF 3.3 3区 生物学
Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-10-29 DOI: 10.1080/19336918.2024.2418049
Zhe Lv, Yuna Du, Huiqing Zhang, Hui Fang, Yujie Guo, Lifeng Zeng, Yiguo Chen, Dan Li, Rong Li
{"title":"Inhibition of JNK/STAT3/NF-KB pathway-mediated migration and clonal formation of lung adenocarcinoma A549 cells by daphnetin.","authors":"Zhe Lv, Yuna Du, Huiqing Zhang, Hui Fang, Yujie Guo, Lifeng Zeng, Yiguo Chen, Dan Li, Rong Li","doi":"10.1080/19336918.2024.2418049","DOIUrl":"10.1080/19336918.2024.2418049","url":null,"abstract":"<p><p>Daphnetin, a coumarin derivative isolated from Daphne odorifera, has anti-tumor effects. The MAPK, STAT3, and NF-κB signaling pathways are closely related to the pathogenesis of lung cancer. To investigate the effect of daphnetin on anti-lung adenocarcinoma A549 cells and its mechanism. The anti-tumor effects of daphnetin on the proliferation, clone formation, migration, and invasion of A549 lung adenocarcinoma cells were investigated. The results showed that daphnetin inhibited the proliferation, colony formation, migration, and invasion of A549 cells through the MAPK/STAT3/NF-KB pathway, and mainly inhibited the clonal formation and migration of A549 cells through the JNK pathway. These results provide a new research direction and theoretical basis for the use of daphnetin in the inhibition of lung adenocarcinoma.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression and molecular insights of lima1 in cholangiocarcinoma. lima1 在胆管癌中的表达和分子研究。
IF 3.3 3区 生物学
Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-07-30 DOI: 10.1080/19336918.2024.2383068
Halmurat Obulkasim, Ailiya Adili, Yu Liu, Shaobin Duan
{"title":"Expression and molecular insights of lima1 in cholangiocarcinoma.","authors":"Halmurat Obulkasim, Ailiya Adili, Yu Liu, Shaobin Duan","doi":"10.1080/19336918.2024.2383068","DOIUrl":"10.1080/19336918.2024.2383068","url":null,"abstract":"<p><p>Lim Domain and Actin Binding protein1 (lima1) influence cancer cell function. Thus far, functional role of lima1 in cholangiocarcinoma remains unknown. We used public databases, in vitro experiments, and multi-omics analysis to investigate the Lima1 in cholangiocarcinoma. Our results showed that lima1 expression is significantly upregulated and high levels of lima1 are significantly associated with vascular invasion in cholangiocarcinoma. Furthermore, lima1 knocking out inhibits the RBE cell invasion. Multi-omics data suggest that lima1 affect a broad spectrum of cancer related pathways, promoting tumor progression and metastatic ability in cholangiocarcinoma. This study provides insights into molecular associations of lima1 with tumorigenesist and establishes a preliminary picture of the correlation network in cholangiocarcinoma.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches. 利用综合生物信息学和实验方法阐明 MICAL1 在泛癌症中的作用。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-03-31 DOI: 10.1080/19336918.2024.2335682
Canxuan Li, Yunfei Xiao, Jianqiu Kong, Cong Lai, Zhiliang Chen, Zhuohang Li, Weibin Xie
{"title":"Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches.","authors":"Canxuan Li, Yunfei Xiao, Jianqiu Kong, Cong Lai, Zhiliang Chen, Zhuohang Li, Weibin Xie","doi":"10.1080/19336918.2024.2335682","DOIUrl":"10.1080/19336918.2024.2335682","url":null,"abstract":"<p><p>Molecule interacting with CasL 1 (MICAL1) is a crucial protein involved in cell motility, axon guidance, cytoskeletal dynamics, and gene transcription. This pan-cancer study analyzed MICAL1 across 33 cancer types using bioinformatics and experiments. Dysregulated expression, diagnostic potential, and prognostic value were assessed. Associations with tumor characteristics, immune factors, and drug sensitivity were explored. Enrichment analysis revealed MICAL1's involvement in metastasis, angiogenesis, metabolism, and immune pathways. Functional experiments demonstrated its impact on renal carcinoma cells. These findings position MICAL1 as a potential biomarker and therapeutic target in specific cancers, warranting further investigation into its role in cancer pathogenesis.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copine C plays a role in adhesion and streaming in Dictyostelium. Copine C 在竹荪的粘附和流变过程中发挥作用。
IF 3.3 3区 生物学
Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-02-20 DOI: 10.1080/19336918.2024.2315629
Rodney A Nichols, Amber D Ide, Cody T Morrison, Amber L Anger, Matthew J Buccilli, Cynthia K Damer
{"title":"Copine C plays a role in adhesion and streaming in <i>Dictyostelium</i>.","authors":"Rodney A Nichols, Amber D Ide, Cody T Morrison, Amber L Anger, Matthew J Buccilli, Cynthia K Damer","doi":"10.1080/19336918.2024.2315629","DOIUrl":"10.1080/19336918.2024.2315629","url":null,"abstract":"<p><p>Copines are a family of calcium-dependent membrane-binding proteins. To study these proteins, anull mutant for <i>cpnC</i> was created in <i>Dictyostelium</i>, which has six copines genes (<i>cpnA-cpnF</i>). During development, <i>cpnC<sup>-</sup></i> cells were able to aggregate, but did not form streams. Once aggregated into mounds, they formed large ring structures. <i>cpnC<sup>-</sup></i> cells were less adherent to plastic substrates, but more adherent to other cells. These phenotypes correlated with changes in adhesion protein expression with decreased expression of SibA and increased expression of CsaA in developing <i>cpnC<sup>-</sup></i> cells. We also measured the expression of RegA, a cAMP phosphodiesterase, and found that <i>cpnC<sup>-</sup></i> cells have reduced RegA expression. The reduced RegA expression in <i>cpnC<sup>-</sup></i> cells is most likely responsible for the observed phenotypes.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10880500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Galectin-1 overexpression induces normal fibroblasts translate into cancer-associated fibroblasts and attenuates the sensitivity of anlotinib in lung cancer. Galectin-1过表达可诱导正常成纤维细胞转化为癌症相关成纤维细胞，并降低肺癌患者对安罗替尼的敏感性。
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-04-01 DOI: 10.1080/19336918.2024.2335881
Lei Zhang, Wenbang Chen, Xiaojun Li, Gengming Wang, Fubao Xing, Xiao Zhu
{"title":"Galectin-1 overexpression induces normal fibroblasts translate into cancer-associated fibroblasts and attenuates the sensitivity of anlotinib in lung cancer.","authors":"Lei Zhang, Wenbang Chen, Xiaojun Li, Gengming Wang, Fubao Xing, Xiao Zhu","doi":"10.1080/19336918.2024.2335881","DOIUrl":"10.1080/19336918.2024.2335881","url":null,"abstract":"<p><p>We aimed to investigate galectin-1 overexpression induces normal fibroblasts (NFs) translates into cancer-associated fibroblasts (CAFs). Galectin-1 overexpression was conducted in Human embryonic lung fibroblasts (HFL1) cell. The motilities of H1299 and A549 cells were measured. Human umbilical vein endothelial cell (HUVEC) proliferation and tube formation ability were assessed. Tumor volume and tumor weight was recorded. Cells motilities were increased, while apoptosis rates were decreased after CMs co-cultured. B-cell lymphoma-2 (Bcl-2) expression level was increased, while Bcl2-associatedX (Bax) and cleaved-caspase3 decreased. CMs treatment enhanced HUVEC proliferation and tube formation. Tumor volume and weight in CMs treated mice were increased, and the sensitivity of anlotinib in co-cultured cells was decreased. Our results revealed that galectin-1 overexpression induced NFs translated into CAFs.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10986763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140334829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liquid biopsy: paving a new avenue for cancer research. 液体活检：为癌症研究开辟新途径
IF 3.3 3区 生物学
Cell Adhesion & Migration Pub Date : 2024-12-01 Epub Date: 2024-09-01 DOI: 10.1080/19336918.2024.2395807
Keerthi Kurma, Zahra Eslami-S, Catherine Alix-Panabières, Laure Cayrefourcq
{"title":"Liquid biopsy: paving a new avenue for cancer research.","authors":"Keerthi Kurma, Zahra Eslami-S, Catherine Alix-Panabières, Laure Cayrefourcq","doi":"10.1080/19336918.2024.2395807","DOIUrl":"10.1080/19336918.2024.2395807","url":null,"abstract":"<p><p>The current constraints associated with cancer diagnosis and molecular profiling, which rely on invasive tissue biopsies or clinical imaging, have spurred the emergence of the liquid biopsy field. Liquid biopsy involves the extraction of circulating tumor cells (CTCs), circulating free or circulating tumor DNA (cfDNA or ctDNA), circulating cell-free RNA (cfRNA), extracellular vesicles (EVs), and tumor-educated platelets (TEPs) from bodily fluid samples. Subsequently, these components undergo molecular characterization to identify biomarkers that are critical for early cancer detection, prognosis, therapeutic assessment, and post-treatment monitoring. These innovative biosources exhibit characteristics analogous to those of the primary tumor from which they originate or interact. This review comprehensively explores the diverse technologies and methodologies employed for processing these biosources, along with their principal clinical applications.</p>","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dsg2 ectodomain organization increases throughout desmosome assembly 在整个脱模小体组装过程中，Dsg2 外结构域的组织结构不断增强
IF 3.2 3区 生物学
Cell Adhesion & Migration Pub Date : 2024-04-02 DOI: 10.1080/19336918.2024.2333366
William F. Dean, Rose M. Albert, Tomasz J. Nawara, Melanie Ubil, Reena R. Beggs, Alexa L. Mattheyses
{"title":"Dsg2 ectodomain organization increases throughout desmosome assembly","authors":"William F. Dean, Rose M. Albert, Tomasz J. Nawara, Melanie Ubil, Reena R. Beggs, Alexa L. Mattheyses","doi":"10.1080/19336918.2024.2333366","DOIUrl":"https://doi.org/10.1080/19336918.2024.2333366","url":null,"abstract":"Desmosomes are intercellular junctions that regulate mechanical integrity in epithelia and cardiac muscle. Dynamic desmosome remodeling is essential for wound healing and development, yet the mecha...","PeriodicalId":9680,"journal":{"name":"Cell Adhesion & Migration","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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