Brief biology and pathophysiology of Tekt bundles.

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Cell Adhesion & Migration Pub Date : 2025-12-01 Epub Date: 2025-02-13 DOI:10.1080/19336918.2025.2465421

Jun Yin, Min Liu, Xiao Wang, Hongming Miao, Wenjuan He, Wei Liu, Zhongying Yu, Qinghua Zhang, Jialian Bai, Yimei Cheng, Bing Ni

引用次数: 0

Abstract

Tektins, a family of microtubule-stabilizing proteins, are critical for cilia and flagella assembly in mammals. They maintain doublet microtubule stability and ciliary/flagellar motility. Loss of Tekt1-5 causes microtubule instability, impaired motility, and diseases like infertility, retinal degeneration, Mainzer-Saldino syndrome, and diabetic nephropathy. Pathophysiological stimuli regulate Tektin expression through transcriptional, posttranscriptional, translational, and posttranslational modifications. This review summarizes the latest findings on Tektin functions and their role in diseases.

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Tektins是一个微管稳定蛋白家族，对哺乳动物纤毛和鞭毛的组装至关重要。它们维持双微管的稳定性和纤毛/鞭毛的运动性。Tekt1-5 的缺失会导致微管不稳定、运动能力受损以及不孕症、视网膜变性、Mainzer-Saldino 综合征和糖尿病肾病等疾病。病理生理刺激可通过转录、转录后、翻译和翻译后修饰调节 Tektin 的表达。本综述总结了有关泰克汀功能及其在疾病中作用的最新发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Adhesion & Migration CELL BIOLOGY-

CiteScore

6.40

自引率

0.00%

发文量

审稿时长

53 weeks

期刊介绍： Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field. Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.